Q3E989
SS
Gene name |
PME54 (ARATH54, At5g20860, F22D1.30) |
Protein name |
Probable pectinesterase/pectinesterase inhibitor 54 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G20860 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
251-492 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q3E989
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3E989-F1 | Predicted | AlphaFoldDB |
58 variants for Q3E989
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_7079065_C_T | 5 | D>N | No | 1000Genomes | |
| tmp_5_7079058_A_G | 7 | V>A | No | 1000Genomes | |
| tmp_5_7078996_G_T | 28 | P>T | No | 1000Genomes | |
| tmp_5_7078968_C_A | 37 | R>M | No | 1000Genomes | |
| tmp_5_7078909_G_C | 57 | H>D | No | 1000Genomes | |
| tmp_5_7078801_G_A | 93 | L>F | No | 1000Genomes | |
| tmp_5_7078798_C_G | 94 | V>L | No | 1000Genomes | |
| tmp_5_7078794_G_A | 95 | S>F | No | 1000Genomes | |
| tmp_5_7078334_G_C,A | 114 | R>G | No | 1000Genomes | |
| tmp_5_7078334_G_C,A | 114 | R>W | No | 1000Genomes | |
| ENSVATH10895225 | 117 | K>I | No | 1000Genomes | |
| ENSVATH07004818 | 121 | R>G | No | 1000Genomes | |
| tmp_5_7078223_T_C | 151 | M>V | No | 1000Genomes | |
| tmp_5_7078199_C_A | 159 | D>Y | No | 1000Genomes | |
| ENSVATH07004817 | 163 | D>H | No | 1000Genomes | |
| ENSVATH07004816 | 167 | S>T | No | 1000Genomes | |
| tmp_5_7078168_G_A | 169 | S>F | No | 1000Genomes | |
| ENSVATH07004815 | 171 | S>A | No | 1000Genomes | |
| ENSVATH07004813 | 177 | S>T | No | 1000Genomes | |
| ENSVATH00636034 | 178 | Q>K | No | 1000Genomes | |
| tmp_5_7078134_C_T | 180 | M>I | No | 1000Genomes | |
| tmp_5_7078136_T_A | 180 | M>L | No | 1000Genomes | |
| tmp_5_7078133_C_T | 181 | D>N | No | 1000Genomes | |
| ENSVATH07004810 | 188 | S>R | No | 1000Genomes | |
| tmp_5_7078100_T_C | 192 | T>A | No | 1000Genomes | |
| ENSVATH03088391 | 192 | T>S | No | 1000Genomes | |
| ENSVATH07004809 | 197 | I>F | No | 1000Genomes | |
| ENSVATH07004808 | 204 | K>M | No | 1000Genomes | |
| tmp_5_7078039_C_T | 212 | R>Q | No | 1000Genomes | |
| tmp_5_7078014_T_A | 220 | R>S | No | 1000Genomes | |
| ENSVATH07004806 | 224 | G>S | No | 1000Genomes | |
| ENSVATH00636032 | 227 | R>K | No | 1000Genomes | |
| tmp_5_7077987_G_T | 229 | H>Q | No | 1000Genomes | |
| tmp_5_7077973_T_C | 234 | K>R | No | 1000Genomes | |
| ENSVATH07004805 | 235 | D>E | No | 1000Genomes | |
| ENSVATH07004804 | 238 | G>E | No | 1000Genomes | |
| ENSVATH00636031 | 258 | T>S | No | 1000Genomes | |
| tmp_5_7077803_C_T | 263 | D>N | No | 1000Genomes | |
| ENSVATH14114382 | 264 | D>N | No | 1000Genomes | |
| tmp_5_7077761_T_C | 277 | T>A | No | 1000Genomes | |
| ENSVATH00636030 | 290 | I>M | No | 1000Genomes | |
| tmp_5_7077611_G_C | 298 | P>R | No | 1000Genomes | |
| tmp_5_7077612_G_A | 298 | P>S | No | 1000Genomes | |
| tmp_5_7077608_C_G | 299 | R>T | No | 1000Genomes | |
| tmp_5_7077550_A_C | 318 | C>W | No | 1000Genomes | |
| ENSVATH07004792 | 338 | E>G | No | 1000Genomes | |
| tmp_5_7077482_A_G | 341 | I>T | No | 1000Genomes | |
| ENSVATH07004789 | 398 | T>A | No | 1000Genomes | |
| tmp_5_7077269_T_A | 412 | Y>F | No | 1000Genomes | |
| ENSVATH14114381 | 431 | D>N | No | 1000Genomes | |
| ENSVATH10895172 | 434 | I>V | No | 1000Genomes | |
| ENSVATH03088388 | 437 | G>E | No | 1000Genomes | |
| ENSVATH00636027 | 447 | D>E | No | 1000Genomes | |
| tmp_5_7077129_T_C | 459 | K>E | No | 1000Genomes | |
| ENSVATH07004786 | 472 | T>A | No | 1000Genomes | |
| tmp_5_7076941_T_G | 496 | E>D | No | 1000Genomes | |
| ENSVATH10895169 | 500 | N>T | No | 1000Genomes | |
| ENSVATH10895168 | 502 | F>L | No | 1000Genomes |
No associated diseases with Q3E989
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGVIDMVLFW | VLLVNALLIV | DASSRNMPFA | YQNEMQRHCS | STKYTSLCVQ | NLREFRHGSL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DGLDFVSFLV | NKTISDSNLL | IPPLSSSMGS | SKLVSLEDST | YTLPSPSVSD | SCERLMKMST |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RRLRQAMEAL | NGSSRKRHTK | HDVQTWLSAA | MTFQQACKDS | ILDSGGSSSA | SAISHISQKM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DHLSRLVSNS | LTLVDTIMKN | PKPKTKSTAL | PRWVTAGERR | LLVGRARAHV | VVAKDGSGDY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RTVMEAVTAA | HGNGKDLTVI | VGDDSATGGT | SVPDTATMTV | TGDGFIARDI | GIKNIAGPRG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HQAIALSITS | DQSVLYRCSI | SGYQDTLYAA | ALRQFYRECD | IYGTIDFIFG | NAAAVFQSCN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IFLRRPHGVK | AYNVILANGR | TDQRQNTGFA | LHSCRIRTDS | DLSPVKHKYS | SYLGRPWRKY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SRAIVMESYI | DDAIAEGGWA | GWLDSGDEVL | KTLYFGEFKN | YGPKARISKR | VTWEGFHSIG |
| 490 | 500 | 510 | |||
| FEEANYFSVV | KRRNGEDVTN | GFKYKFKIKI | QI |