Q3E8W4

PR
Gene name
ANX2 (At5g28680, F4I4.60)
Protein name
Receptor-like protein kinase ANXUR2
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G28680
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

450-519 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

662-669 (Activation loop from InterPro)

Target domain

521-794 (Protein kinase domain)

Relief mechanism

Assay

680-687 (Activation loop from InterPro)

Target domain

521-794 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

4 structures for Q3E8W4

Entry ID Method Resolution Chain Position Source
5Y92 X-ray 200 A A 28-414 PDB
6A5C X-ray 168 A A 21-450 PDB
6FIH X-ray 108 A A 27-431 PDB
AF-Q3E8W4-F1 Predicted AlphaFoldDB

104 variants for Q3E8W4

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH07108637 6 R>P No 1000Genomes
tmp_5_10721976_C_T 13 C>Y No 1000Genomes
ENSVATH07108636 15 F>L No 1000Genomes
ENSVATH11348671 30 I>N No 1000Genomes
ENSVATH11348671 30 I>T No 1000Genomes
ENSVATH07108635 37 S>L No 1000Genomes
ENSVATH11348670 38 E>G No 1000Genomes
tmp_5_10721902_C_T 38 E>K No 1000Genomes
tmp_5_10721892_A_G 41 V>A No 1000Genomes
tmp_5_10721885_T_G 43 Q>H No 1000Genomes
ENSVATH07108634 46 K>R No 1000Genomes
ENSVATH11348669 58 P>R No 1000Genomes
tmp_5_10721788_C_G 76 V>L No 1000Genomes
ENSVATH07108633 85 T>I No 1000Genomes
ENSVATH07108632 86 A>T No 1000Genomes
ENSVATH07108631 87 P>Q No 1000Genomes
ENSVATH00661633 89 T>K No 1000Genomes
ENSVATH07108629 93 P>S No 1000Genomes
ENSVATH03169932 112 T>I No 1000Genomes
ENSVATH07108626 121 F>I No 1000Genomes
tmp_5_10721634_T_C 127 D>G No 1000Genomes
ENSVATH00661631 128 L>F No 1000Genomes
ENSVATH00661631 128 L>V No 1000Genomes
tmp_5_10721618_G_T 132 S>R No 1000Genomes
ENSVATH03169931 138 I>M No 1000Genomes
tmp_5_10721548_G_A 156 P>S No 1000Genomes
ENSVATH07108624 158 E>D No 1000Genomes
tmp_5_10721527_T_C 163 S>G No 1000Genomes
tmp_5_10721514_G_A 167 T>I No 1000Genomes
ENSVATH03169930 186 P>L No 1000Genomes
ENSVATH03169930 186 P>Q No 1000Genomes
ENSVATH07108618 193 T>I No 1000Genomes
ENSVATH07108617 197 V>L No 1000Genomes
ENSVATH14353143 204 S>L No 1000Genomes
ENSVATH07108614 209 A>V No 1000Genomes
tmp_5_10721212_C_T 268 V>I No 1000Genomes
tmp_5_10721203_C_T 271 A>T No 1000Genomes
ENSVATH11348603 273 A>T No 1000Genomes
tmp_5_10721196_G_A 273 A>V No 1000Genomes
ENSVATH11348602 318 A>G No 1000Genomes
ENSVATH07108611 324 V>L No 1000Genomes
ENSVATH11348601 332 R>K No 1000Genomes
tmp_5_10721001_G_A 338 T>I No 1000Genomes
ENSVATH14353142 343 I>L No 1000Genomes
ENSVATH03169928 349 G>A No 1000Genomes
ENSVATH11348600 352 I>T No 1000Genomes
ENSVATH11348599 354 T>I No 1000Genomes
tmp_5_10720939_C_T 359 A>T No 1000Genomes
tmp_5_10720923_G_A 364 A>V No 1000Genomes
ENSVATH07108610 368 G>V No 1000Genomes
tmp_5_10720909_C_G 369 G>R No 1000Genomes
tmp_5_10720869_A_G 382 F>S No 1000Genomes
ENSVATH11348597 387 Y>F No 1000Genomes
ENSVATH14353141 392 L>I No 1000Genomes
ENSVATH14353140 397 I>V No 1000Genomes
tmp_5_10720806_A_G 403 M>T No 1000Genomes
tmp_5_10720792_C_T 408 G>S No 1000Genomes
ENSVATH14353139 423 K>I No 1000Genomes
ENSVATH07108608 433 T>I No 1000Genomes
tmp_5_10720696_C_T 440 A>T No 1000Genomes
ENSVATH14353137 447 L>S No 1000Genomes
tmp_5_10720669_A_C 449 C>G No 1000Genomes
tmp_5_10720626_G_A 463 S>L No 1000Genomes
tmp_5_10720597_G_A 473 L>F No 1000Genomes
ENSVATH11348596 480 H>Y No 1000Genomes
ENSVATH11348595 481 T>I No 1000Genomes
tmp_5_10720548_G_A 489 S>L No 1000Genomes
ENSVATH00661627 494 N>H No 1000Genomes
ENSVATH07108607 507 R>Q No 1000Genomes
tmp_5_10720479_G_A 512 S>F No 1000Genomes
ENSVATH07108604 518 T>S No 1000Genomes
tmp_5_10720438_C_T 526 V>I No 1000Genomes
tmp_5_10720383_G_C 544 T>R No 1000Genomes
ENSVATH07108601 552 N>S No 1000Genomes
tmp_5_10720318_T_G 566 I>L No 1000Genomes
tmp_5_10720249_C_G 589 E>Q No 1000Genomes
ENSVATH07108597 607 Y>H No 1000Genomes
ENSVATH07108596 608 N>Y No 1000Genomes
ENSVATH11348502 618 R>Q No 1000Genomes
ENSVATH07108595 623 A>T No 1000Genomes
tmp_5_10720008_G_C 669 T>S No 1000Genomes
tmp_5_10719973_C_T 681 V>I No 1000Genomes
ENSVATH11348501 699 L>F No 1000Genomes
tmp_5_10719871_C_T 715 V>I No 1000Genomes
tmp_5_10719796_A_T 740 C>S No 1000Genomes
ENSVATH14353104 742 R>H No 1000Genomes
ENSVATH07108587 748 D>E No 1000Genomes
ENSVATH11348500 770 A>V No 1000Genomes
ENSVATH11348499 784 M>I No 1000Genomes
tmp_5_10719623_T_A 797 L>F No 1000Genomes
tmp_5_10719615_G_A 800 T>I No 1000Genomes
tmp_5_10719609_T_C 802 D>G No 1000Genomes
tmp_5_10719601_G_T 805 R>S No 1000Genomes
ENSVATH14353102 807 R>* No 1000Genomes
tmp_5_10719594_C_T 807 R>Q No 1000Genomes
ENSVATH07108584 810 S>R No 1000Genomes
ENSVATH07108583 813 G>D No 1000Genomes
ENSVATH07108582 818 L>I No 1000Genomes
ENSVATH07108581 819 G>C No 1000Genomes
tmp_5_10719511_C_A 835 D>Y No 1000Genomes
tmp_5_10719490_A_C 842 S>A No 1000Genomes
ENSVATH07108580 850 S>C No 1000Genomes
ENSVATH03169927 855 P>L No 1000Genomes
tmp_5_10719441_C_T 858 R>Q No 1000Genomes

No associated diseases with Q3E8W4

9 regional properties for Q3E8W4

Type Name Position InterPro Accession
domain SNF2, N-terminal 244 - 511 IPR000330
domain SANT/Myb domain 878 - 927 IPR001005-1
domain SANT/Myb domain 979 - 1041 IPR001005-2
domain Helicase, C-terminal 534 - 687 IPR001650
domain Helicase superfamily 1/2, ATP-binding domain 227 - 419 IPR014001
domain ISWI, HAND domain 795 - 874 IPR015194
domain SLIDE domain 935 - 1045 IPR015195
domain SANT domain 877 - 929 IPR017884
domain Isw1/2, N-terminal 228 - 448 IPR044754

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
pollen tube tip The region at growing end of the pollen tube cell, where polarized growth occurs.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

1 GO annotations of biological process

Name Definition
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).

58 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q07407 htl Fibroblast growth factor receptor homolog 1 Drosophila melanogaster (Fruit fly) PR
Q9Y616 IRAK3 Interleukin-1 receptor-associated kinase 3 Homo sapiens (Human) PR
P53667 LIMK1 LIM domain kinase 1 Homo sapiens (Human) PR
P53671 LIMK2 LIM domain kinase 2 Homo sapiens (Human) PR
Q06418 TYRO3 Tyrosine-protein kinase receptor TYRO3 Homo sapiens (Human) SS
P22607 FGFR3 Fibroblast growth factor receptor 3 Homo sapiens (Human) EV
P21802 FGFR2 Fibroblast growth factor receptor 2 Homo sapiens (Human) EV
P11362 FGFR1 Fibroblast growth factor receptor 1 Homo sapiens (Human) EV
P22455 FGFR4 Fibroblast growth factor receptor 4 Homo sapiens (Human) SS
P09619 PDGFRB Platelet-derived growth factor receptor beta Homo sapiens (Human) EV
P10721 KIT Mast/stem cell growth factor receptor Kit Homo sapiens (Human) EV
P16234 PDGFRA Platelet-derived growth factor receptor alpha Homo sapiens (Human) EV
P07333 CSF1R Macrophage colony-stimulating factor 1 receptor Homo sapiens (Human) SS
Q8K4B2 Irak3 Interleukin-1 receptor-associated kinase 3 Mus musculus (Mouse) PR
Q8CFA1 Irak2 Interleukin-1 receptor-associated kinase-like 2 Mus musculus (Mouse) PR
O54785 Limk2 LIM domain kinase 2 Mus musculus (Mouse) PR
Q4QQS0 Irak2 Interleukin-1 receptor-associated kinase-like 2 Rattus norvegicus (Rat) PR
O08680 Epha3 Ephrin type-A receptor 3 Rattus norvegicus (Rat) SS
P54757 Epha5 Ephrin type-A receptor 5 Rattus norvegicus (Rat) SS
P54759 Epha7 Ephrin type-A receptor 7 Rattus norvegicus (Rat) SS
P09759 Ephb1 Ephrin type-B receptor 1 Rattus norvegicus (Rat) SS
P0C0K7 Ephb6 Ephrin type-B receptor 6 Rattus norvegicus (Rat) SS
Q19238 F09A5.2 Putative tyrosine-protein kinase F09A5.2 Caenorhabditis elegans SS
Q9LSV3 WAKL16 Putative wall-associated receptor kinase-like 16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STF0 LECRKS3 Receptor like protein kinase S.3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M342 WAKL15 Wall-associated receptor kinase-like 15 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LYN6 At3g56050 Probable inactive receptor-like protein kinase At3g56050 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VZJ9 CRCK2 Calmodulin-binding receptor-like cytoplasmic kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q0WNY5 WAKL18 Wall-associated receptor kinase-like 18 Arabidopsis thaliana (Mouse-ear cress) PR
Q94C25 At5g20050 Probable receptor-like protein kinase At5g20050 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTC0 PBL19 Probable serine/threonine-protein kinase PBL19 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FIL7 CRCK1 Calmodulin-binding receptor-like cytoplasmic kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGG3 At1g51820 Probable LRR receptor-like serine/threonine-protein kinase At1g51820 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGI2 At1g67720 Probable LRR receptor-like serine/threonine-protein kinase At1g67720 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGW2 PAM74 Probable LRR receptor-like serine/threonine-protein kinase PAM74 Arabidopsis thaliana (Mouse-ear cress) PR
P43293 PBL11 Probable serine/threonine-protein kinase PBL11 Arabidopsis thaliana (Mouse-ear cress) PR
P43298 TMK1 Receptor protein kinase TMK1 Arabidopsis thaliana (Mouse-ear cress) PR
P93050 BSH Probable LRR receptor-like serine/threonine-protein kinase RKF3 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LPS5 SERK5 Somatic embryogenesis receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWW0 ALE2 Receptor-like serine/threonine-protein kinase ALE2 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWZ5 SD25 G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FN93 At5g59680 Probable LRR receptor-like serine/threonine-protein kinase At5g59680 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FN94 At5g59670 Receptor-like protein kinase At5g59670 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LIG2 At3g21340 Receptor-like protein kinase At3g21340 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LPZ9 SD113 G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LRP3 At3g17420 Probable receptor-like protein kinase At3g17420 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M2S4 LECRKS4 L-type lectin-domain containing receptor kinase S.4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SNA3 At3g46340 Putative receptor-like protein kinase At3g46340 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQR3 At2g14510 Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ASQ5 CRCK3 Calmodulin-binding receptor-like cytoplasmic kinase 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FLW0 At5g24010 Probable receptor-like protein kinase At5g24010 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SCZ4 FER Receptor-like protein kinase FERONIA Arabidopsis thaliana (Mouse-ear cress) PR
Q9SXB4 At1g11300 G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 Arabidopsis thaliana (Mouse-ear cress) PR
Q84JQ4 PRK2 Pollen receptor-like kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q93ZS4 NIK3 Protein NSP-INTERACTING KINASE 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AG2 SERK1 Somatic embryogenesis receptor kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
O64477 At2g19130 G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 Arabidopsis thaliana (Mouse-ear cress) SS
Q9XIC7 SERK2 Somatic embryogenesis receptor kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MNEKLRILFS FLCFFYVLLV SPSQSNGQDI SLSCGASEPA VDQDKKKWEP DTKFLKTPNT
70 80 90 100 110 120
VHAPATYQDP SLLSTVPYMT SRIFTAPATY EIPVKGDKRH MLRLHFYPST YTGLNILDSY
130 140 150 160 170 180
FSVAANDLTL LSNFSAAITC QALTQAYLVR EYSLAPSEKD VLSIIFTPSD KHPKAFAFIN
190 200 210 220 230 240
GIEVIPMPEL FDTASLVGFS DQTSDTKTAN LQTMFRLNVG GQDIPGSQDS GGLTRTWYND
250 260 270 280 290 300
APYIFSAGLG VTLQASNNFR IDYQKMPVST APADVYKTAR SQGPNGDINM KSNLTWMFQV
310 320 330 340 350 360
DTNFTYIMRL HFCEFQLAKI NQKVFNIFIN NRTAQGDTNP ADILGWTGGK GIPTYKDYAI
370 380 390 400 410 420
YVDANTGGGG EEISLQMTPS TFGQPEYYDS QLNGLEIFKI DTMKNLAGPN PKPSPMQANE
430 440 450 460 470 480
DVKKDFQGDK RITAFVIGSA GGVAAVLFCA LCFTMYQRKR KFSGSDSHTS SWLPIYGNSH
490 500 510 520 530 540
TSATKSTISG KSNNGSHLSN LAAGLCRRFS LSEIKHGTHN FDESNVIGVG GFGKVYKGVI
550 560 570 580 590 600
DGGTKVAIKK SNPNSEQGLN EFETEIELLS RLRHKHLVSL IGYCDEGGEM CLIYDYMSLG
610 620 630 640 650 660
TLREHLYNTK RPQLTWKRRL EIAIGAARGL HYLHTGAKYT IIHRDVKTTN ILLDENWVAK
670 680 690 700 710 720
VSDFGLSKTG PNMNGGHVTT VVKGSFGYLD PEYFRRQQLT EKSDVYSFGV VLFEVLCARP
730 740 750 760 770 780
ALNPSLSKEQ VSLGDWAMNC KRKGTLEDII DPNLKGKINP ECLKKFADTA EKCLSDSGLD
790 800 810 820 830 840
RPTMGDVLWN LEFALQLQET ADGSRHRTPS NGGGSVDLGG GGGGVTVNIS AGESDLGDDL
850
SSEENSGIFS QIVNPKGR