AiPD: Autoinhibited Protein Database

Q3C1V8

Gene name	BSX (BSX1)
Protein name	Brain-specific homeobox protein homolog
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:390259
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

25-233 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

25-233 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q3C1V8

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3C1V8-F1	Predicted				AlphaFoldDB

220 variants for Q3C1V8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA229933654 rs576258778	2	N>S		No	ClinGen 1000Genomes TOPMed gnomAD
CA383052101 rs1179625870	3	L>F		No	ClinGen gnomAD
rs955475699 CA229933652	4	N>S		No	ClinGen TOPMed gnomAD
CA229933650 rs1029550213	8	P>L		No	ClinGen TOPMed
CA383052068 rs1439418098	8	P>S		No	ClinGen gnomAD
rs765193214 CA383052060	10	H>N		No	ClinGen ExAC gnomAD
CA383052055 rs1184036619	10	H>Q		No	ClinGen TOPMed gnomAD
rs765193214 CA6332261	10	H>Y		No	ClinGen ExAC gnomAD
CA6332260 rs62624971	11	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6332259 rs768854926	11	P>L		No	ClinGen ExAC TOPMed gnomAD
rs768854926 CA6332258	11	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs1016708679 CA229933642	12	A>E		No	ClinGen TOPMed
rs757728928 CA229933644	12	A>T		No	ClinGen Ensembl
rs772444026 CA6332255	16	R>K		No	ClinGen ExAC gnomAD
rs1378432579 CA383052013	18	T>A		No	ClinGen gnomAD
TCGA novel	19	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383051996 rs1300536241	20	F>L		No	ClinGen gnomAD
rs1401359393 CA383051990	21	F>S		No	ClinGen gnomAD
TCGA novel	23	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383051947 rs1167419308	27	L>R		No	ClinGen gnomAD
CA6332249 rs752446127	30	P>H		No	ClinGen ExAC gnomAD
rs752446127 CA6332248	30	P>R		No	ClinGen ExAC gnomAD
CA383051925 rs1489291592	31	K>E		No	ClinGen TOPMed gnomAD
TCGA novel	32	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1216096022 CA383051912	33	L>M		No	ClinGen gnomAD
rs1013887404 CA229933626	35	E>D		No	ClinGen TOPMed
CA6332246 rs754833961	36	V>G		No	ClinGen ExAC gnomAD
CA383051882 rs1266986766	37	A>V		No	ClinGen gnomAD
CA383051879 rs1245297185	38	P>S		No	ClinGen gnomAD
rs951758481 CA229933623	39	D>E		No	ClinGen TOPMed gnomAD
rs1025941553 CA229933622	41	F>L		No	ClinGen gnomAD
CA383051852 rs768056175	42	A>S		No	ClinGen TOPMed gnomAD
rs768056175 CA229933620	42	A>T		No	ClinGen TOPMed gnomAD
rs373485666 CA6332245	42	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	44	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383051828 rs1188571521	46	A>S		No	ClinGen TOPMed gnomAD
CA229933615 rs867300572	48	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA383051816 rs867300572	48	R>P		No	ClinGen TOPMed gnomAD
CA383051817 rs1392515601	48	R>W		No	ClinGen gnomAD
CA383051813 rs1458692731	49	V>M		No	ClinGen TOPMed gnomAD
CA383051804 rs1282767803	50	P>L		No	ClinGen TOPMed
CA6332242 rs776770866	50	P>T		No	ClinGen ExAC gnomAD
rs760833595 CA6332240	55	G>R		No	ClinGen ExAC TOPMed gnomAD
CA383051776 rs760833595	55	G>S		No	ClinGen ExAC TOPMed gnomAD
rs200026871 CA6332239	56	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA383051766 rs1591412259	56	Y>F		No	ClinGen Ensembl
rs971109678 CA383051762	57	P>H		No	ClinGen TOPMed gnomAD
rs971109678 CA229933607	57	P>L		No	ClinGen TOPMed gnomAD
rs772352727 CA383051763	57	P>S		No	ClinGen ExAC gnomAD
rs772352727 CA6332238	57	P>T		No	ClinGen ExAC gnomAD
CA383051760 rs746254703	58	L>I		No	ClinGen ExAC gnomAD
rs774634223 CA6332236	58	L>P		No	ClinGen ExAC gnomAD
TCGA novel	58	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6332237 rs746254703	58	L>V		No	ClinGen ExAC gnomAD
rs771464195 CA6332235	59	M>I		No	ClinGen ExAC gnomAD
rs1263460514 CA383051752	59	M>T		No	ClinGen gnomAD
rs1206981683 CA383051743	60	P>L		No	ClinGen TOPMed
CA383051737 rs1318588912	61	T>I		No	ClinGen gnomAD
CA383051739 rs1318588912	61	T>K		No	ClinGen gnomAD
rs749798967 CA6332234 COSM3720991	62	P>H	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs749798967 CA383051732	62	P>L		No	ClinGen ExAC gnomAD
rs1277012025 CA383051734	62	P>S		No	ClinGen gnomAD
rs1591412238 CA383051730	63	T>A		No	ClinGen Ensembl
rs1332439935 CA383051726	63	T>N		No	ClinGen gnomAD
CA383051725 rs1301494761	64	L>I		No	ClinGen gnomAD
CA229933599 rs867242555	66	A>D		No	ClinGen gnomAD
rs199643758 CA6332233	66	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA383051709 rs867242555	66	A>V		No	ClinGen gnomAD
CA383051701 rs1324370038	68	H>D		No	ClinGen gnomAD
CA6332231 rs372663917	68	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA229933594 rs1012698643	69	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA383051686 rs1474440435	70	H>R		No	ClinGen gnomAD
rs913951255 CA229933589	77	D>N		No	ClinGen TOPMed gnomAD
rs780996854 CA6332229	78	H>Y		No	ClinGen ExAC gnomAD
rs1341636588 CA383051623	79	H>R		No	ClinGen TOPMed gnomAD
rs1275457879 CA383051614	80	H>L		No	ClinGen gnomAD
CA383051617 rs1200374244	80	H>Y		No	ClinGen gnomAD
rs1054734813 CA229933586	81	P>H		No	ClinGen Ensembl
COSM924143 rs868246509 CA229933584	87	S>*	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs769363288	88	G>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1373728995 CA383051552	88	G>E		No	ClinGen gnomAD
TCGA novel	89	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA229933175 rs531543505	89	M>V		No	ClinGen 1000Genomes
CA6332212 rs747676261	90	P>L		No	ClinGen ExAC gnomAD
CA6332211 rs780910505	91	V>A		No	ClinGen ExAC gnomAD
CA6332209 rs746684796	92	P>S		No	ClinGen ExAC TOPMed gnomAD
rs779880586 CA6332208	93	A>E		No	ClinGen ExAC TOPMed gnomAD
rs779880586 CA383051523	93	A>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	93	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750290566 CA6332206	95	F>L		No	ClinGen ExAC gnomAD
CA383051496 rs1216809676	97	H>N		No	ClinGen gnomAD
CA6332205 rs757240710	97	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA6332203 rs552397073	98	P>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1285248435 CA383051468	99	Q>R		No	ClinGen gnomAD
CA229933163 rs527625117	100	H>Q		No	ClinGen 1000Genomes gnomAD
CA383051441 rs1353583094	101	A>S		No	ClinGen gnomAD
TCGA novel	101	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759781325 CA6332201	102	E>*		No	ClinGen ExAC TOPMed gnomAD
rs759781325 CA229933160	102	E>K		No	ClinGen ExAC TOPMed gnomAD
CA6332200 rs751751270	102	E>V		No	ClinGen ExAC gnomAD
rs1360180060 CA383051424	103	L>M		No	ClinGen gnomAD
CA383051406 rs1406829322	104	P>R		No	ClinGen gnomAD
CA383051374 rs1162515428	106	K>N		No	ClinGen gnomAD
rs371977061 CA6332198	107	H>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs773804908 CA6332197	107	H>R		No	ClinGen ExAC gnomAD
CA383051335 rs1482864599	109	R>C		No	ClinGen TOPMed gnomAD
rs560461493 CA6332195	109	R>H		No	ClinGen 1000Genomes ExAC gnomAD
rs560461493 CA6332196	109	R>P		No	ClinGen 1000Genomes ExAC gnomAD
CA383051342 rs1482864599	109	R>S		No	ClinGen TOPMed gnomAD
CA6332194 rs776273119	110	R>S		No	ClinGen ExAC gnomAD
rs867818183 CA229933147	111	R>H		No	ClinGen Ensembl
rs768105541 CA6332193	114	R>L		No	ClinGen ExAC TOPMed gnomAD
rs768105541 CA383051269	114	R>P		No	ClinGen ExAC TOPMed gnomAD
rs1223340807 CA383051262	115	T>M		No	ClinGen gnomAD
CA229933145 rs368119965	118	S>Y		No	ClinGen ESP TOPMed
CA6332192 rs375774927	119	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA6332191 rs775040824	120	S>L		No	ClinGen ExAC gnomAD
rs778722255 CA6332188	126	E>A		No	ClinGen ExAC gnomAD
TCGA novel	126	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1268600726 CA383051117	127	K>M		No	ClinGen gnomAD
rs1438885382 CA383051100	128	R>S		No	ClinGen gnomAD
rs1350191897 CA383051086	129	F>L		No	ClinGen gnomAD
TCGA novel	130	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757183629 CA6332187	131	I>N		No	ClinGen ExAC gnomAD
rs368494973 CA229933138	131	I>V		No	ClinGen 1000Genomes ESP TOPMed gnomAD
COSM1185004 rs1379770999 CA383051041	133	R>C	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA383051039 rs1466704692 COSM202724	133	R>H	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
COSM686784 rs1477179313 CA383050988	137	T>S	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
TCGA novel	139	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755017837 CA6332184	140	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	141	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6332183 rs751764889	141	V>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	143	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	143	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6332182 rs766532036	143	L>V		No	ClinGen ExAC gnomAD
CA6332181 rs758741098	145	T>K		No	ClinGen ExAC gnomAD
rs568625630 CA229933125	150	S>F		No	ClinGen gnomAD
CA6332178 rs762392801	152	T>M		No	ClinGen ExAC gnomAD
CA6332157 rs375711614	157	W>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1282363649 CA383050740	158	F>L		No	ClinGen TOPMed
rs1310626813 CA383050746	158	F>L		No	ClinGen gnomAD
CA383050737 rs1421153785	159	Q>*		No	ClinGen gnomAD
rs1159698686 CA383050721	161	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA383050722 rs1382544218	161	R>W		No	ClinGen gnomAD
CA383050717 rs1357349355 COSM1352093	162	R>W	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
TCGA novel	163	M>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6332154 rs773997887	168	Q>H		No	ClinGen ExAC gnomAD
CA6332155 rs759132794	168	Q>P		No	ClinGen ExAC gnomAD
CA6332153 rs770672530	170	R>L		No	ClinGen ExAC gnomAD
CA383050641 rs1208925987	173	Q>*		No	ClinGen gnomAD
CA6332152 rs201802674	173	Q>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs769586039 CA383050630 CA6332150	174	D>E		No	ClinGen ExAC gnomAD
CA229932794 rs779549267	174	D>H		No	ClinGen ExAC TOPMed gnomAD
rs779549267 CA6332151	174	D>N		No	ClinGen ExAC TOPMed gnomAD
CA383050600 rs1405895704	178	A>G		No	ClinGen gnomAD
CA6332149 rs748182063	178	A>T		No	ClinGen ExAC gnomAD
rs779981498 CA6332148	179	P>L		No	ClinGen ExAC TOPMed gnomAD
CA383050577 rs138024906	180	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1310608194 CA383050565	181	G>A		No	ClinGen gnomAD
rs746016226 CA6332146	181	G>R		No	ClinGen ExAC TOPMed gnomAD
CA383050570 rs746016226	181	G>W		No	ClinGen ExAC TOPMed gnomAD
rs1401456769 CA383050559	182	P>S		No	ClinGen gnomAD
rs373020747 CA6332145	183	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA383050533 rs1289794346	184	S>N		No	ClinGen gnomAD
rs771510552 CA229932779	184	S>R		No	ClinGen Ensembl
CA6332141 rs756568088	186	E>G		No	ClinGen ExAC gnomAD
rs778269524 CA6332142	186	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA383050492 rs1472122264	187	G>A		No	ClinGen TOPMed gnomAD
CA383050487 rs1565347550	188	S>G		No	ClinGen Ensembl
CA6332138 rs766948506	188	S>I		No	ClinGen ExAC gnomAD
rs766948506 CA6332139	188	S>N		No	ClinGen ExAC gnomAD
rs759077853 CA383050475	188	S>R		No	ClinGen ExAC TOPMed gnomAD
CA6332135 rs765993014	189	P>R		No	ClinGen ExAC TOPMed gnomAD
rs751163059 CA6332136	189	P>S		No	ClinGen ExAC gnomAD
rs759317554	190	R>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1009896463 CA229932764	190	R>G		No	ClinGen Ensembl
rs1565347536 CA383050458	190	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA6332133 rs772877086	191	G>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA383050448 rs1591410578	191	G>D		No	ClinGen Ensembl
CA6332132 rs772877086	191	G>S		No	ClinGen ExAC TOPMed gnomAD
CA383050415 rs1267007568	193	E>D		No	ClinGen gnomAD
rs761594912 CA383050400	195	A>P		No	ClinGen ExAC TOPMed gnomAD
rs761594912 CA6332130	195	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1219988058 CA383050380	196	T>I		No	ClinGen gnomAD
CA229932755 rs11601189	196	T>P		No	ClinGen gnomAD
CA229932749 rs1018888705	197	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1360235106 CA383050362	198	A>S		No	ClinGen gnomAD
rs889133735 CA6332127	199	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA383050345 rs1295711287	199	E>V		No	ClinGen gnomAD
rs991747229 CA229932743	201	R>W		No	ClinGen TOPMed gnomAD
CA6332125 rs199952953	203	S>I		No	ClinGen 1000Genomes ExAC gnomAD
rs779177549 CA6332124	204	L>P		No	ClinGen ExAC TOPMed gnomAD
CA6332123 rs771057177	206	A>S		No	ClinGen ExAC TOPMed gnomAD
rs749585711 CA6332122	207	G>A		No	ClinGen ExAC TOPMed gnomAD
rs749585711 CA383050260	207	G>D		No	ClinGen ExAC TOPMed gnomAD
TCGA novel CA383050268 rs1591410536	207	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
rs1191596426 CA383050213	211	L>M		No	ClinGen gnomAD
CA383050195 rs1467958276	212	T>I		No	ClinGen gnomAD
rs755527912 CA6332117	214	P>A		No	ClinGen ExAC gnomAD
rs1222330297 CA383050177	214	P>L		No	ClinGen TOPMed gnomAD
rs751038152 CA6332116	216	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs765939808 CA6332115	217	E>*		No	ClinGen ExAC gnomAD
CA383050123 rs1332527279	218	V>L		No	ClinGen gnomAD
CA383050094 rs1303835573	220	I>F		No	ClinGen TOPMed gnomAD
CA383050098 rs1303835573	220	I>L		No	ClinGen TOPMed gnomAD
CA383050090 rs1442040239	220	I>T		No	ClinGen gnomAD
CA6332112 rs750101490	221	G>A		No	ClinGen ExAC gnomAD
CA383050075 rs1208540196	221	G>R		No	ClinGen TOPMed gnomAD
rs764871812 CA6332111	223	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs776621311 CA6332109	224	G>A		No	ClinGen ExAC gnomAD
rs1460631990 CA383050036	224	G>R		No	ClinGen gnomAD
CA383050023 rs1174520206	225	E>Q		No	ClinGen gnomAD
TCGA novel	225	E>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6332108 rs764094953	226	L>P		No	ClinGen ExAC gnomAD
rs760764887 CA6332107	227	G>D		No	ClinGen ExAC gnomAD
CA6332104 RCV000947395 rs61737277	231	H>Q		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA6332103 rs199711565	232	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA383049959 rs199711565	232	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	233	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383049954 rs1346537386	233	L>I		No	ClinGen gnomAD

No associated diseases with Q3C1V8

4 regional properties for Q3C1V8

Type	Name	Position	InterPro Accession
domain	Homeobox domain	108 - 172	IPR001356
conserved_site	Homeobox, conserved site	143 - 166	IPR017970
domain	Homeobox domain, metazoa	132 - 143	IPR020479-1
domain	Homeobox domain, metazoa	147 - 166	IPR020479-2

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription regulator complex	A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

3 GO annotations of molecular function

Name	Definition
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

5 GO annotations of biological process

Name	Definition
eating behavior	The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.
locomotory behavior	The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
mammary gland involution	The tissue remodeling that removes differentiated mammary epithelia during weaning.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q6RFL5	BSX	Brain-specific homeobox protein homolog	Gallus gallus (Chicken)	PR
O60479	DLX3	Homeobox protein DLX-3	Homo sapiens (Human)	PR
P56179	DLX6	Homeobox protein DLX-6	Homo sapiens (Human)	PR
Q9HBU1	BARX1	Homeobox protein BarH-like 1	Homo sapiens (Human)	PR
Q9UMQ3	BARX2	Homeobox protein BarH-like 2	Homo sapiens (Human)	PR
Q810B3	Bsx	Brain-specific homeobox protein homolog	Mus musculus (Mouse)	PR
Q9ER42	Barx1	Homeobox protein BarH-like 1	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MNLNFTSPLH	PASSQRPTSF	FIEDILLHKP	KPLREVAPDH	FASSLASRVP	LLDYGYPLMP
70	80	90	100	110	120
TPTLLAPHAH	HPLHKGDHHH	PYFLTTSGMP	VPALFPHPQH	AELPGKHCRR	RKARTVFSDS
130	140	150	160	170	180
QLSGLEKRFE	IQRYLSTPER	VELATALSLS	ETQVKTWFQN	RRMKHKKQLR	KSQDEPKAPD
190	200	210	220	230
GPESPEGSPR	GSEAATAAEA	RLSLPAGPFV	LTEPEDEVDI	GDEGELGSGP	HVL