Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q39214

Entry ID Method Resolution Chain Position Source
AF-Q39214-F1 Predicted AlphaFoldDB

63 variants for Q39214

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_3_2228929_A_C 32 D>E No 1000Genomes
tmp_3_2228762_T_A 88 H>L No 1000Genomes
tmp_3_2228745_T_A 94 S>C No 1000Genomes
ENSVATH05788463 97 K>N No 1000Genomes
ENSVATH10536958 99 W>* No 1000Genomes
ENSVATH05788462 106 R>K No 1000Genomes
ENSVATH10536956 106 R>W No 1000Genomes
ENSVATH00310511 116 Q>K No 1000Genomes
tmp_3_2228669_C_T 119 G>E No 1000Genomes
tmp_3_2228628_T_C 133 K>E No 1000Genomes
ENSVATH13881483 144 A>V No 1000Genomes
tmp_3_2228454_G_T 191 P>T No 1000Genomes
ENSVATH00310508 215 K>Q No 1000Genomes
tmp_3_2228375_T_A 217 Q>L No 1000Genomes
tmp_3_2228322_A_C 235 Y>D No 1000Genomes
ENSVATH05788457 257 P>R No 1000Genomes
tmp_3_2228235_C_G 264 G>R No 1000Genomes
tmp_3_2228165_T_A 287 D>V No 1000Genomes
tmp_3_2228121_G_A 302 P>S No 1000Genomes
ENSVATH13881482 304 G>V No 1000Genomes
tmp_3_2228082_G_A 315 R>W No 1000Genomes
tmp_3_2228034_G_A 331 H>Y No 1000Genomes
ENSVATH10536915 375 G>D No 1000Genomes
tmp_3_2227820_G_C 402 T>S No 1000Genomes
ENSVATH00310506 403 L>* Following inoculation of two leaves per plant with 0.1 ml of 10 -8 cfu/ml bacteria in 10 mm mgso4 buffer using a blunt-tipped syringe. leaf collapse was scored at 20 hrs and again at 24 hrs after inoculation [20c and 12 hrs daylight] [EnsemblGenome] No 1000Genomes
tmp_3_2227798_G_C 409 N>K No 1000Genomes
ENSVATH10536884 418 S>T No 1000Genomes
tmp_3_2227623_C_T 468 V>M No 1000Genomes
tmp_3_2227545_G_A 494 P>S No 1000Genomes
tmp_3_2227485_C_T 514 V>I No 1000Genomes
tmp_3_2227460_T_A 522 D>V No 1000Genomes
ENSVATH13881480 535 E>G No 1000Genomes
ENSVATH00310505 541 G>S No 1000Genomes
tmp_3_2227337_G_A 563 S>F No 1000Genomes
tmp_3_2227289_C_T 579 S>N No 1000Genomes
ENSVATH10536882 585 A>V No 1000Genomes
ENSVATH05788454 612 S>P No 1000Genomes
tmp_3_2227184_G_T 614 T>K No 1000Genomes
tmp_3_2227145_A_G 627 V>A No 1000Genomes
tmp_3_2227139_A_G 629 L>S No 1000Genomes
tmp_3_2227110_T_A 639 I>F No 1000Genomes
tmp_3_2227101_G_A 642 L>F No 1000Genomes
ENSVATH00310504 662 E>D No 1000Genomes
tmp_3_2227018_A_T 669 N>K No 1000Genomes
tmp_3_2226944_G_A 694 A>V No 1000Genomes
ENSVATH13881478 697 E>G No 1000Genomes
ENSVATH10536879 698 L>I No 1000Genomes
ENSVATH05788452 701 N>H No 1000Genomes
ENSVATH00310502 703 G>W No 1000Genomes
tmp_3_2226752_C_A 758 S>I No 1000Genomes
ENSVATH05788451 761 K>* No 1000Genomes
ENSVATH13881477 772 P>S No 1000Genomes
tmp_3_2226690_G_C 779 Q>E No 1000Genomes
ENSVATH13881476 820 R>H No 1000Genomes
tmp_3_2226522_G_A 835 Q>* No 1000Genomes
tmp_3_2226500_A_T 842 V>D No 1000Genomes
ENSVATH05788449 877 Q>* No 1000Genomes
tmp_3_2226392_T_G 878 E>A No 1000Genomes
tmp_3_2226393_C_G 878 E>Q No 1000Genomes
tmp_3_2226357_C_T 890 E>K No 1000Genomes
tmp_3_2226353_C_G 891 R>P No 1000Genomes
tmp_3_2226332_A_C 898 V>G No 1000Genomes
ENSVATH13881454 901 S>P No 1000Genomes

No associated diseases with Q39214

5 regional properties for Q39214

Type Name Position InterPro Accession
domain Homeobox domain 143 - 207 IPR001356
conserved_site Homeobox protein, antennapedia type, conserved site 134 - 139 IPR001827
conserved_site Homeobox, conserved site 178 - 201 IPR017970
domain Homeobox domain, metazoa 167 - 178 IPR020479-1
domain Homeobox domain, metazoa 182 - 201 IPR020479-2

Functions

Description
EC Number
Subcellular Localization
  • Endomembrane system ; Peripheral membrane protein
  • Cell membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
extrinsic component of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ADP binding Binding to ADP, adenosine 5'-diphosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

1 GO annotations of biological process

Name Definition
plant-type hypersensitive response The rapid, localized death of plant cells in response to invasion by a pathogen.

21 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
F1MHT9 NLRC4 NLR family CARD domain-containing protein 4 Bos taurus (Bovine) SS
O14727 APAF1 Apoptotic protease-activating factor 1 Homo sapiens (Human) EV
Q9NPP4 NLRC4 NLR family CARD domain-containing protein 4 Homo sapiens (Human) SS
Q3UP24 Nlrc4 NLR family CARD domain-containing protein 4 Mus musculus (Mouse) EV
F1M649 Nlrc4 NLR family CARD domain-containing protein 4 Rattus norvegicus (Rat) SS
O22727 At1g61190 Probable disease resistance protein At1g61190 Arabidopsis thaliana (Mouse-ear cress) PR
O64790 At1g61300 Probable disease resistance protein At1g61300 Arabidopsis thaliana (Mouse-ear cress) PR
O64973 RPS5 Disease resistance protein RPS5 Arabidopsis thaliana (Mouse-ear cress) PR
P0C8S1 RPP8L2 Probable disease resistance RPP8-like protein 2 Arabidopsis thaliana (Mouse-ear cress) PR
P60838 SUMM2 Disease resistance protein SUMM2 Arabidopsis thaliana (Mouse-ear cress) PR
Q38834 RPP13L4 Disease resistance RPP13-like protein 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q8W3K3 At1g58400 Putative disease resistance protein At1g58400 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C646 RXW24L Probable disease resistance protein RXW24L Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJB5 RPP8L3 Disease resistance RPP8-like protein 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRR4 RPPL1 Putative disease resistance RPP13-like protein 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9T048 At4g27190 Disease resistance protein At4g27190 Arabidopsis thaliana (Mouse-ear cress) PR
Q9XIF0 At1g59780 Putative disease resistance protein At1g59780 Arabidopsis thaliana (Mouse-ear cress) PR
F4J339 RPP1 Probable disease resistance protein RPP1 Arabidopsis thaliana (Mouse-ear cress) PR
O64789 At1g61310 Probable disease resistance protein At1g61310 Arabidopsis thaliana (Mouse-ear cress) PR
Q940K0 UNI Disease resistance protein UNI Arabidopsis thaliana (Mouse-ear cress) PR
Q9I9H8 apaf1 Apoptotic protease-activating factor 1 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MASATVDFGI GRILSVLENE TLLLSGVHGE IDKMKKELLI MKSFLEDTHK HGGNGSTTTT
70 80 90 100 110 120
TQLFQTFVAN TRDLAYQIED ILDEFGYHIH GYRSCAKIWR AFHFPRYMWA RHSIAQKLGM
130 140 150 160 170 180
VNVMIQSISD SMKRYYHSEN YQAALLPPID DGDAKWVNNI SESSLFFSEN SLVGIDAPKG
190 200 210 220 230 240
KLIGRLLSPE PQRIVVAVVG MGGSGKTTLS ANIFKSQSVR RHFESYAWVT ISKSYVIEDV
250 260 270 280 290 300
FRTMIKEFYK EADTQIPAEL YSLGYRELVE KLVEYLQSKR YIVVLDDVWT TGLWREISIA
310 320 330 340 350 360
LPDGIYGSRV MMTTRDMNVA SFPYGIGSTK HEIELLKEDE AWVLFSNKAF PASLEQCRTQ
370 380 390 400 410 420
NLEPIARKLV ERCQGLPLAI ASLGSMMSTK KFESEWKKVY STLNWELNNN HELKIVRSIM
430 440 450 460 470 480
FLSFNDLPYP LKRCFLYCSL FPVNYRMKRK RLIRMWMAQR FVEPIRGVKA EEVADSYLNE
490 500 510 520 530 540
LVYRNMLQVI LWNPFGRPKA FKMHDVIWEI ALSVSKLERF CDVYNDDSDG DDAAETMENY
550 560 570 580 590 600
GSRHLCIQKE MTPDSIRATN LHSLLVCSSA KHKMELLPSL NLLRALDLED SSISKLPDCL
610 620 630 640 650 660
VTMFNLKYLN LSKTQVKELP KNFHKLVNLE TLNTKHSKIE ELPLGMWKLK KLRYLITFRR
670 680 690 700 710 720
NEGHDSNWNY VLGTRVVPKI WQLKDLQVMD CFNAEDELIK NLGCMTQLTR ISLVMVRREH
730 740 750 760 770 780
GRDLCDSLNK IKRIRFLSLT SIDEEEPLEI DDLIATASIE KLFLAGKLER VPSWFNTLQN
790 800 810 820 830 840
LTYLGLRGSQ LQENAILSIQ TLPRLVWLSF YNAYMGPRLR FAQGFQNLKI LEIVQMKHLT
850 860 870 880 890 900
EVVIEDGAMF ELQKLYVRAC RGLEYVPRGI ENLINLQELH LIHVSNQLVE RIRGEGSVDR
910 920
SRVKHIPAIK HYFRTDNGSF YVSLSS