Q39128
PR
Gene name |
KAT1 (At5g46240, MPL12.2) |
Protein name |
Potassium channel KAT1 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G46240 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
7 structures for Q39128
71 variants for Q39128
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00714458 | 5 | W>C | No | 1000Genomes | |
| tmp_5_18746538_A_T | 8 | N>K | No | 1000Genomes | |
| ENSVATH00714457 | 10 | F>L | No | 1000Genomes | |
| ENSVATH03371703 | 31 | A>T | No | 1000Genomes | |
| ENSVATH03371701 | 34 | L>V | No | 1000Genomes | |
| ENSVATH00714456 | 48 | R>G | No | 1000Genomes | |
| ENSVATH07352138 | 57 | P>L | No | 1000Genomes | |
| tmp_5_18746147_T_G | 87 | K>T | No | 1000Genomes | |
| tmp_5_18746138_G_A | 90 | A>V | No | 1000Genomes | |
| ENSVATH03371692 | 91 | I>F | No | 1000Genomes | |
| tmp_5_18746122_G_A,T | 95 | D>E | No | 1000Genomes | |
| ENSVATH03371690 | 125 | S>N | No | 1000Genomes | |
| tmp_5_18746026_C_A | 127 | K>N | No | 1000Genomes | |
| tmp_5_18746018_G_A | 130 | A>V | No | 1000Genomes | |
| tmp_5_18746012_C_A | 132 | R>M | No | 1000Genomes | |
| tmp_5_18745905_A_G | 140 | F>L | No | 1000Genomes | |
| tmp_5_18745451_G_A | 208 | A>V | No | 1000Genomes | |
| ENSVATH07352119 | 226 | P>A | No | 1000Genomes | |
| ENSVATH12575089 | 233 | A>D | No | 1000Genomes | |
| ENSVATH12575089 | 233 | A>V | No | 1000Genomes | |
| ENSVATH12575088 | 240 | E>K | No | 1000Genomes | |
| ENSVATH00714449 | 266 | F>L | No | 1000Genomes | |
| ENSVATH03371657 | 328 | D>G | No | 1000Genomes | |
| tmp_5_18744843_T_C | 359 | I>V | No | 1000Genomes | |
| tmp_5_18744833_C_T | 362 | S>N | No | 1000Genomes | |
| ENSVATH12575067 | 373 | H>Y | No | 1000Genomes | |
| tmp_5_18744659_T_C | 393 | I>V | No | 1000Genomes | |
| ENSVATH00714442 | 434 | F>I | No | 1000Genomes | |
| tmp_5_18744449_C_T | 438 | A>T | No | 1000Genomes | |
| tmp_5_18744351_T_C | 470 | I>M | No | 1000Genomes | |
| ENSVATH07352100 | 470 | I>V | No | 1000Genomes | |
| tmp_5_18744172_A_T | 505 | I>K | No | 1000Genomes | |
| ENSVATH00714436 | 510 | T>S | No | 1000Genomes | |
| ENSVATH12574999 | 511 | S>R | No | 1000Genomes | |
| ENSVATH03371638 | 513 | H>Q | No | 1000Genomes | |
| ENSVATH03371637 | 516 | R>K | No | 1000Genomes | |
| tmp_5_18744075_A_T | 537 | D>E | No | 1000Genomes | |
| tmp_5_18744065_G_A | 541 | P>S | No | 1000Genomes | |
| tmp_5_18744061_G_C | 542 | T>S | No | 1000Genomes | |
| ENSVATH03371635 | 554 | E>G | No | 1000Genomes | |
| ENSVATH08560377 | 555 | D>G | No | 1000Genomes | |
| ENSVATH07352097 | 568 | I>L | No | 1000Genomes | |
| ENSVATH00714430 | 573 | V>E | No | 1000Genomes | |
| tmp_5_18743962_C_A | 575 | R>I | No | 1000Genomes | |
| ENSVATH03371632 | 580 | T>I | No | 1000Genomes | |
| ENSVATH03371632 | 580 | T>S | No | 1000Genomes | |
| ENSVATH12574998 | 581 | A>V | No | 1000Genomes | |
| tmp_5_18743935_C_T | 584 | S>N | No | 1000Genomes | |
| ENSVATH12574997 | 588 | D>N | No | 1000Genomes | |
| ENSVATH12574996 | 594 | P>Q | No | 1000Genomes | |
| tmp_5_18743878_A_G | 603 | I>T | No | 1000Genomes | |
| ENSVATH14599266 | 605 | P>L | No | 1000Genomes | |
| tmp_5_18743839_T_A | 616 | H>L | No | 1000Genomes | |
| ENSVATH07352095 | 620 | E>Q | No | 1000Genomes | |
| tmp_5_18743825_T_C | 621 | S>G | No | 1000Genomes | |
| ENSVATH00714428 | 624 | G>E | No | 1000Genomes | |
| ENSVATH00714427 | 629 | L>V | No | 1000Genomes | |
| ENSVATH07352094 | 631 | S>A | No | 1000Genomes | |
| tmp_5_18743771_G_A | 639 | L>F | No | 1000Genomes | |
| ENSVATH00714426 | 641 | S>N | No | 1000Genomes | |
| ENSVATH07352093 | 642 | E>D | No | 1000Genomes | |
| ENSVATH07352092 | 647 | C>Y | No | 1000Genomes | |
| ENSVATH07352091 | 654 | N>S | No | 1000Genomes | |
| ENSVATH07352091 | 654 | N>T | No | 1000Genomes | |
| tmp_5_18743716_T_C | 657 | N>S | No | 1000Genomes | |
| tmp_5_18743713_G_T | 658 | A>D | No | 1000Genomes | |
| tmp_5_18743714_C_T | 658 | A>T | No | 1000Genomes | |
| ENSVATH00714424 | 659 | E>G | No | 1000Genomes | |
| ENSVATH03371631 | 662 | D>Y | No | 1000Genomes | |
| ENSVATH03371630 | 664 | D>N | No | 1000Genomes | |
| tmp_5_18743660_A_G | 676 | S>P | No | 1000Genomes |
No associated diseases with Q39128
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| inward rectifier potassium channel activity | Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
18 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9UL51 | HCN2 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Homo sapiens (Human) | SS |
| Q9Y3Q4 | HCN4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Homo sapiens (Human) | EV |
| O60741 | HCN1 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Homo sapiens (Human) | SS |
| Q9P1Z3 | HCN3 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | Homo sapiens (Human) | SS |
| O88704 | Hcn1 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Mus musculus (Mouse) | SS |
| O88705 | Hcn3 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | Mus musculus (Mouse) | SS |
| O70507 | Hcn4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Mus musculus (Mouse) | SS |
| O88703 | Hcn2 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Mus musculus (Mouse) | EV |
| Q9JKA9 | Hcn2 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Rattus norvegicus (Rat) | SS |
| Q9JKA7 | Hcn4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Rattus norvegicus (Rat) | SS |
| Q9JKB0 | Hcn1 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Rattus norvegicus (Rat) | SS |
| Q9JKA8 | Hcn3 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | Rattus norvegicus (Rat) | SS |
| A2ZX97 | Os01g0718700 | Potassium channel KAT6 | Oryza sativa subsp japonica (Rice) | PR |
| Q6K3T2 | Os02g0245800 | Potassium channel KAT1 | Oryza sativa subsp japonica (Rice) | PR |
| Q9SKD7 | CNGC3 | Probable cyclic nucleotide-gated ion channel 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDR2 | CNGC19 | Putative cyclic nucleotide-gated ion channel 19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SU64 | CNGC16 | Probable cyclic nucleotide-gated ion channel 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P92960 | ATHB-4 | Potassium channel KAT3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSISWTRNFF | ERFCVEEYNI | DTIKQSSFLS | ADLLPSLGAR | INQSTKLRKH | IISPFNPRYR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AWEMWLVLLV | IYSAWICPFQ | FAFITYKKDA | IFIIDNIVNG | FFAIDIILTF | FVAYLDSHSY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLVDSPKKIA | IRYLSTWFAF | DVCSTAPFQP | LSLLFNYNGS | ELGFRILSML | RLWRLRRVSS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LFARLEKDIR | FNYFWIRCTK | LISVTLFAIH | CAGCFNYLIA | DRYPNPRKTW | IGAVYPNFKE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ASLWNRYVTA | LYWSITTLTT | TGYGDFHAEN | PREMLFDIFF | MMFNLGLTAY | LIGNMTNLVV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HWTSRTRTFR | DSVRAASEFA | SRNQLPHDIQ | DQMLSHICLK | FKTEGLKQQE | TLNNLPKAIR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SSIANYLFFP | IVHNIYLFQG | VSRNFLFQLV | SDIDAEYFPP | KEDIILQNEA | PTDLYILVSG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AVDFTVYVDG | HDQFQGKAVI | GETFGEVGVL | YYRPQPFTVR | TTELSQILRI | SRTSLMSAMH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AHADDGRVIM | NNLFMKLRGQ | QSIAIDDSNT | SGHENRDFKS | MGWEEWRDSR | KDGYGLDVTN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PTSDTALMDA | IHKEDTEMVK | KILKEQKIER | AKVERSSSET | AGRSYANDSS | KKDPYCSSSN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QIIKPCKREE | KRVTIHMMSE | SKNGKLILLP | SSIEELLRLA | SEKFGGCNFT | KITNADNAEI |
| 670 | |||||
| DDLDVIWDGD | HLYFSSN |