Q39032

PR
Gene name
PLC1 (ATHATPLC1G, At5g58670, MZN1.12)
Protein name
Phosphoinositide phospholipase C 1
Names
Phosphoinositide phospholipase PLC1, AtPLC1, AtPLC1S, PI-PLC1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G58670
EC number
3.1.4.11: Phosphoric diester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

128-366 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q39032

Entry ID Method Resolution Chain Position Source
AF-Q39032-F1 Predicted AlphaFoldDB

38 variants for Q39032

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_5_23706657_T_C 32 D>G No 1000Genomes
ENSVATH12845239 38 R>M No 1000Genomes
ENSVATH12845238 43 E>D No 1000Genomes
tmp_5_23706590_T_A 54 E>D No 1000Genomes
ENSVATH12845237 80 I>M No 1000Genomes
tmp_5_23706502_C_T 84 G>R No 1000Genomes
ENSVATH00741260 87 R>G No 1000Genomes
ENSVATH07446266 97 L>M No 1000Genomes
ENSVATH07446265 119 G>R No 1000Genomes
tmp_5_23706277_T_C 135 I>V No 1000Genomes
ENSVATH12845235 151 L>I No 1000Genomes
ENSVATH07446264 159 G>E No 1000Genomes
ENSVATH07446263 160 K>R No 1000Genomes
ENSVATH07446259 210 K>R No 1000Genomes
ENSVATH14639664 215 V>M No 1000Genomes
tmp_5_23705832_T_C 229 E>G No 1000Genomes
tmp_5_23705748_G_A 257 T>I No 1000Genomes
ENSVATH07446256 269 T>I No 1000Genomes
ENSVATH07446257 269 T>S No 1000Genomes
tmp_5_23705709_C_A 270 R>I No 1000Genomes
ENSVATH07446255 288 S>G No 1000Genomes
tmp_5_23705567_C_T 294 R>K No 1000Genomes
tmp_5_23705522_T_C 309 K>R No 1000Genomes
tmp_5_23705507_C_T 314 G>E No 1000Genomes
ENSVATH00741259 333 A>T No 1000Genomes
ENSVATH07446254 342 K>R No 1000Genomes
tmp_5_23705308_C_T 380 M>I No 1000Genomes
tmp_5_23705140_A_T 409 L>M No 1000Genomes
tmp_5_23705130_T_G 412 N>T No 1000Genomes
tmp_5_23705110_A_C 419 F>V No 1000Genomes
ENSVATH14639661 422 C>F No 1000Genomes
tmp_5_23704958_C_G 441 G>A No 1000Genomes
tmp_5_23704948_C_G 444 M>I No 1000Genomes
ENSVATH07446251 454 Y>F No 1000Genomes
ENSVATH14639659 464 G>E No 1000Genomes
tmp_5_23704728_G_A 472 T>I No 1000Genomes
tmp_5_23704629_C_T 505 C>Y No 1000Genomes
tmp_5_23704595_C_A 516 Q>H No 1000Genomes

No associated diseases with Q39032

4 regional properties for Q39032

Type Name Position InterPro Accession
domain C2 domain 414 - 541 IPR000008
domain Phosphatidylinositol-specific phospholipase C, X domain 105 - 249 IPR000909
domain Phospholipase C, phosphatidylinositol-specific, Y domain 293 - 410 IPR001711
binding_site EF-Hand 1, calcium-binding site 32 - 44 IPR018247

Functions

Description
EC Number 3.1.4.11 Phosphoric diester hydrolases
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
phosphatidylinositol phospholipase C activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
phospholipase C activity Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.

7 GO annotations of biological process

Name Definition
abscisic acid-activated signaling pathway The series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription.
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
response to abscisic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
response to cold Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
response to salt stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
response to water deprivation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.

43 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32383 PLC1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P08487 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Bos taurus (Bovine) EV SS
P10895 PLCD1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Bos taurus (Bovine) SS
Q1RML2 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Bos taurus (Bovine) PR
P10894 PLCB1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Bos taurus (Bovine) SS
Q2VRL0 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Gallus gallus (Chicken) PR
P19174 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Homo sapiens (Human) EV
Q8N3E9 PLCD3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 Homo sapiens (Human) SS
P16885 PLCG2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Homo sapiens (Human) SS
Q15111 PLCL1 Inactive phospholipase C-like protein 1 Homo sapiens (Human) PR
Q9UPR0 PLCL2 Inactive phospholipase C-like protein 2 Homo sapiens (Human) PR
Q86YW0 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Homo sapiens (Human) PR
P51178 PLCD1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Homo sapiens (Human) EV
Q9BRC7 PLCD4 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 Homo sapiens (Human) SS
Q00722 PLCB2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 Homo sapiens (Human) EV
Q01970 PLCB3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Homo sapiens (Human) EV
Q9NQ66 PLCB1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Homo sapiens (Human) EV
Q9P212 PLCE1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Homo sapiens (Human) SS
Q15147 PLCB4 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 Homo sapiens (Human) PR
Q8K2J0 Plcd3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 Mus musculus (Mouse) PR
Q8K394 Plcl2 Inactive phospholipase C-like protein 2 Mus musculus (Mouse) PR
Q8K4S1 Plce1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Mus musculus (Mouse) SS
Q8R3B1 Plcd1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Mus musculus (Mouse) SS
P51432 Plcb3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Mus musculus (Mouse) SS
Q62077 Plcg1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Mus musculus (Mouse) SS
A3KGF7 Plcb2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 Mus musculus (Mouse) PR
Q9Z1B3 Plcb1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Mus musculus (Mouse) SS
Q7YRU3 PLCZ 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Sus scrofa (Pig) PR
P10686 Plcg1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Rattus norvegicus (Rat) EV
P24135 Plcg2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Rattus norvegicus (Rat) SS
O89040 Plcb2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 Rattus norvegicus (Rat) PR
P10688 Plcd1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Rattus norvegicus (Rat) SS
P10687 Plcb1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Rattus norvegicus (Rat) SS
Q99P84 Plce1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Rattus norvegicus (Rat) EV
Q99JE6 Plcb3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Rattus norvegicus (Rat) SS
G5EBH0 egl-8 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 Caenorhabditis elegans SS
Q56W08 PLC3 Phosphoinositide phospholipase C 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q6NMA7 PLC9 Phosphoinositide phospholipase C 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GV43 PLC6 Phosphoinositide phospholipase C 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q944C2 PLC5 Phosphoinositide phospholipase C 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STZ3 PLC8 Phosphoinositide phospholipase C 8 Arabidopsis thaliana (Mouse-ear cress) PR
Q944C1 PLC4 Phosphoinositide phospholipase C 4 Arabidopsis thaliana (Mouse-ear cress) PR
A5D6R3 plcd3a 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MKESFKVCFC CVRNFKVKSS EPPEEIKNLF HDYSQDDRMS ADEMLRFVIQ VQGETHADIN
70 80 90 100 110 120
YVKDIFHRLK HHGVFHPRGI HLEGFYRYLL SDFNSPLPLT REVWQDMNQP LSHYFLYTGH
130 140 150 160 170 180
NSYLTGNQLN SNSSIEPIVK ALRNGVRVIE LDLWPNSSGK EAEVRHGGTL TSREDLQKCL
190 200 210 220 230 240
NVVKENAFQV SAYPVVLTLE DHLTPILQKK VAKMVSKTFG GSLFQCTDET TECFPSPESL
250 260 270 280 290 300
KNKILISTKP PKEYLQTQIS KGSTTDESTR AKKISDAEEQ VQEEDEESVA IEYRDLISIH
310 320 330 340 350 360
AGNRKGGLKN CLNGDPNRVI RLSMSEQWLE TLAKTRGPDL VKFTQRNLLR IFPKTTRFDS
370 380 390 400 410 420
SNYDPLVGWI HGAQMVAFNM QSHGRYLWMM QGMFKANGGC GYVKKPDVLL SNGPEGEIFD
430 440 450 460 470 480
PCSQNLPIKT TLKVKIYTGE GWNMDFPLDH FDRYSPPDFY AKVGIAGVPL DTASYRTEID
490 500 510 520 530 540
KDEWFPIWDK EFEFPLRVPE LSLLCITVKD YDSNTQNDFA GQTCFPLSEV RPGIRAVRLH
550 560
DRAGEVYKHV RLLMRFVLEP R