Q39019

PR
Gene name
ASK10 (HIR1, SK41)
Protein name
Shaggy-related protein kinase kappa
Names
AtHIR1, ASK-kappa, AtK-1, Shaggy-related protein kinase 41, AtSK41
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G09840
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-74 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

226-248 (Activation loop from InterPro)

Target domain

83-367 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q39019

Entry ID Method Resolution Chain Position Source
AF-Q39019-F1 Predicted AlphaFoldDB

17 variants for Q39019

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_3199521_C_T 2 A>T No 1000Genomes
ENSVATH04546639 5 G>E No 1000Genomes
tmp_1_3199505_C_A 7 G>V No 1000Genomes
ENSVATH00014325 10 V>I No 1000Genomes
ENSVATH04546638 24 S>N No 1000Genomes
ENSVATH01029031 35 E>V No 1000Genomes
ENSVATH10862828 68 T>A No 1000Genomes
ENSVATH10862827 88 V>I No 1000Genomes
tmp_1_3198836_C_G 130 M>I No 1000Genomes
ENSVATH10862563 152 V>A No 1000Genomes
ENSVATH04546624 192 C>F No 1000Genomes
tmp_1_3197622_C_T 290 V>I No 1000Genomes
tmp_1_3196605_T_C 363 I>V No 1000Genomes
tmp_1_3196536_G_A 386 L>F No 1000Genomes
tmp_1_3196194_C_A 396 G>C No 1000Genomes
ENSVATH10862041 398 P>L No 1000Genomes
ENSVATH04546604 419 L>F No 1000Genomes

No associated diseases with Q39019

4 regional properties for Q39019

Type Name Position InterPro Accession
domain Protein kinase domain 83 - 367 IPR000719
active_site Serine/threonine-protein kinase, active site 204 - 216 IPR008271
binding_site Protein kinase, ATP binding site 89 - 113 IPR017441
domain Glycogen synthase kinase 3, catalytic domain 78 - 370 IPR039192

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P18431 sgg Protein kinase shaggy Drosophila melanogaster (Fruit fly) SS
P49840 GSK3A Glycogen synthase kinase-3 alpha Homo sapiens (Human) PR
P49841 GSK3B Glycogen synthase kinase-3 beta Homo sapiens (Human) EV
Q80YS9 Stkld1 Serine/threonine kinase-like domain-containing protein STKLD1 Mus musculus (Mouse) PR
Q2NL51 Gsk3a Glycogen synthase kinase-3 alpha Mus musculus (Mouse) SS
Q9WV60 Gsk3b Glycogen synthase kinase-3 beta Mus musculus (Mouse) EV
P18265 Gsk3a Glycogen synthase kinase-3 alpha Rattus norvegicus (Rat) PR
P18266 Gsk3b Glycogen synthase kinase-3 beta Rattus norvegicus (Rat) PR
Q09595 R03D7.5 Putative serine/threonine-protein kinase R03D7.5 Caenorhabditis elegans PR
Q9U2Q9 gsk-3 Glycogen synthase kinase-3 Caenorhabditis elegans PR
Q9FVS6 ASK4 Shaggy-related protein kinase delta Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MASSGLGNGV GTSRSAKGLK SSSSSVDWLT RDLAETRIRD KVETDDERDS EPDIIDGAGA
70 80 90 100 110 120
EPGHVIRTTL RGRNGQSRQT VSYISEHVVG TGSFGMVFQA KCRETGEVVA IKKVLQDKRY
130 140 150 160 170 180
KNRELQIMQM LDHPNAVALK HSFFSRTDNE EVYLNLVLEF VPETVNRVAR SYSRTNQLMP
190 200 210 220 230 240
LIYVKLYTYQ ICRALAYIHN SFGLCHRDIK PQNLLVNPHT HQLKICDFGS AKVLVKGEPN
250 260 270 280 290 300
VSYICSRYYR APELIFGASE YTTAIDIWST GCVMAELLLG QPLFPGESGV DQLVEIIKVL
310 320 330 340 350 360
GTPTREEIKC MNPNYTEFKF PQIKPHPWHK VFQKRLPPEA VDLLCRFFQY SPNLRCTALE
370 380 390 400 410 420
ACIHPLFDEL RDPNTRLPNG RPLPPLFNFK PQELSGIPPE IVNRLVPEHA RKQNLFMALH
S