AiPD: Autoinhibited Protein Database

Q38SD2

Gene name	LRRK1 (KIAA1790)
Protein name	Leucine-rich repeat serine/threonine-protein kinase 1
Names	EC 2.7.11.1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:79705
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class	LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE EMS1 (PTHR48055)

Descriptions

Leucine-rich repeat serine/threonine-protein kinase 1 (LRRK1) is a protein involved in the negative regulation of bone mass, acting through the maturation of osteoclasts. In contrast to the mechanism of autoinhibition that occurs in LRRK2, the autoinhibition of LRRK1 is mediated by a steric mechanism involving the ANK domain, which blocks access to the active site of the kinase domain in a dimer-dependent manner. In contrast, the interaction of the N-terminal LRR domain with the N-lobe of the kinase domain contributes to the alleviation of autoinhibition by changing its position relative to the WD40 domain, exposing the exposure of the active site of the kinase domain. The autoinhibited dimer of LRRK1 could be stabilized by a loop (1791-1907) in the WD40 domain. In addition, the kinase activity of LRRK1 is also regulated by the interaction of its COR-B loop with the kinase domain. Phosphorylation of three residues (S1064, T1074, and S1075) in the autoinhibitory COR-B loop significantly increases the kinase activity of LRRK1. Phosphorylation by Rab7a, resulting in the F1065A mutation, also alleviates the autoinhibited state of LRRK1.

Autoinhibitory domains (AIDs)

Target domain	1263-1265 (N-lobe of kinase domain)
Relief mechanism	Partner binding, Cleavage
Assay	Structural analysis, Deletion assay

AID

50-55 (ANK domain)

Target domain

1263-1265 (N-lobe of kinase domain)

Relief mechanism

Partner binding (Interaction with Rab7a that induces phosphorylation at F1065), Cleavage (Removal of a loop in the WD40 domain, positioned at 1791-1907)

Assay

Structural analysis, Deletion assay

Target domain	1242-1525 (Kinase domain)
Relief mechanism	PTM, Partner binding, Cleavage
Assay	Structural analysis, Deletion assay

AID

1048-1082 (COR-B loop)

Target domain

1242-1525 (Kinase domain)

Relief mechanism

PTM (Phosphorylation at S1064, T1074, and S1075), Partner binding (Interaction with Rab7a that induces phosphorylation at F1065), Cleavage (Removal of a loop in the WD40 domain, positioned at 1791-1907)

Assay

Structural analysis, Deletion assay

Accessory elements

1408-1429 (Activation loop from InterPro)

Target domain	1263-1265 (N-lobe of kinase domain)
Relief mechanism
Assay

References

Reimer JM et al. (2023) "Structure of LRRK1 and mechanisms of autoinhibition and activation", Nature structural & molecular biology, 30, 1735-1745

Autoinhibited structure

Activated structure

5 structures for Q38SD2

Entry ID	Method	Resolution	Chain	Position	Source
8E04	EM	380 A	A	20-2015	PDB
8E05	EM	460 A	A/B	1-2015	PDB
8E06	EM	430 A	A	1-2015	PDB
8FAC	EM	392 A	A	1-2015	PDB
AF-Q38SD2-F1	Predicted				AlphaFoldDB

1993 variants for Q38SD2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV003365632 rs201543283 RCV001988892	4	M>V	Inborn genetic diseases [ClinVar]	Yes	ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV002155620 rs200799740 RCV003025493	102	M>I	Inborn genetic diseases [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
RCV002008010 RCV003418273 RCV003264358 rs370235958	194	V>M	LRRK1-related condition Inborn genetic diseases [ClinVar]	Yes	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs368091026 RCV003339906 RCV002030943	215	R>Q	Variant assessed as Somatic; MODERATE impact. Inborn genetic diseases [NCI-TCGA, ClinVar]	Yes	ClinVar ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD
RCV002548341 rs113989128 RCV000970015	224	I>V	Inborn genetic diseases [ClinVar]	Yes	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV002563640 rs145072406 RCV001942187	241	I>L	Inborn genetic diseases [ClinVar]	Yes	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs749068051 RCV001886038 RCV002552206	287	A>G	Inborn genetic diseases [ClinVar]	Yes	ClinVar ExAC dbSNP gnomAD
RCV002561542 rs372555242 RCV001974714	375	N>S	Inborn genetic diseases [ClinVar]	Yes	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs199792081 RCV002556437 RCV001923485	586	E>D	Inborn genetic diseases [ClinVar]	Yes	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV001906414 rs150261606 RCV003264222	703	P>L	Inborn genetic diseases [ClinVar]	Yes	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
RCV002573552 COSM4053477 RCV002025042 COSM4053475 rs377308921	773	T>M	Variant assessed as Somatic; MODERATE impact. Inborn genetic diseases [NCI-TCGA, ClinVar]	Yes	NCI-TCGA Cosmic ClinVar 1000Genomes ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD
RCV002561498 RCV001946388 rs202077818	829	V>M	Inborn genetic diseases [ClinVar]	Yes	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs766875506 CA393966307 RCV000625749	929	E>*	Osteosclerotic metaphyseal dysplasia [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
VAR_086690	929	E>del	OSMD [UniProt]	Yes	UniProt
RCV002551070 rs185373027 RCV001870773	940	S>C	Inborn genetic diseases [ClinVar]	Yes	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
RCV001887773 rs368618286 RCV002547910	1006	M>V	Inborn genetic diseases [ClinVar]	Yes	ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV001925922 rs751191439 RCV003264250	1200	R>Q	Inborn genetic diseases [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
rs564175632 RCV003170195 RCV001968161	1202	F>Y	Inborn genetic diseases [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
rs1258583719 RCV002227891	1494	R>*	Variant assessed as Somatic; HIGH impact. Osteosclerotic metaphyseal dysplasia [NCI-TCGA, ClinVar]	Yes	ClinVar NCI-TCGA dbSNP gnomAD
rs770946839 RCV002551626 RCV001877071	1760	S>F	Inborn genetic diseases [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
RCV002489349 RCV000960070 rs34876840	1796	P>H	Osteosclerotic metaphyseal dysplasia [ClinVar]	Yes	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV002561510 RCV001955173 rs1301904566	1934	E>D	Inborn genetic diseases [ClinVar]	Yes	ClinVar TOPMed dbSNP gnomAD
rs370701948 RCV002552935 RCV001871480	1945	I>T	Inborn genetic diseases [ClinVar]	Yes	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs886038213 CA10586702 RCV001795385	1980	E>missing	Osteosclerotic metaphyseal dysplasia [ClinVar]	Yes	ClinGen ClinVar dbSNP
RCV001794939 rs2141168796	1991	A>missing	Osteosclerotic metaphyseal dysplasia [ClinVar]	Yes	ClinVar dbSNP
rs781273894	2	A>T		No	ExAC TOPMed gnomAD
rs779491648	4	M>I		No	ExAC gnomAD
rs201543283	4	M>L		No	ESP ExAC TOPMed gnomAD
rs1191189390	4	M>T		No	TOPMed
RCV002041255 rs748591648	5	S>L		No	ClinVar ExAC dbSNP gnomAD
rs772698984	6	Q>*		No	ExAC gnomAD
rs1596149153	7	R>S		No	Ensembl
rs201657615	8	P>L		No	ExAC TOPMed gnomAD
rs373263143	8	P>S		No	ESP TOPMed gnomAD
rs950488806	9	P>L		No	TOPMed gnomAD
rs950488806	9	P>R		No	TOPMed gnomAD
rs1438369630	10	S>G		No	TOPMed gnomAD
rs1422179063	10	S>Q	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1186222914	10	S>R		No	gnomAD
rs1429951456	11	M>R		No	TOPMed gnomAD
rs1429951456	11	M>T		No	TOPMed gnomAD
rs1366267504	11	M>V		No	TOPMed gnomAD
rs2042077612	12	Y>C		No	gnomAD
rs759385351	13	W>*		No	ExAC TOPMed gnomAD
rs776094214	13	W>L		No	ExAC gnomAD
rs1228726751	14	C>*		No	TOPMed gnomAD
RCV001938098 rs982310051	14	C>S		No	ClinVar TOPMed dbSNP gnomAD
TCGA novel	14	C>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs866662547	14	C>Y		No	Ensembl
rs1304274213	15	V>L		No	TOPMed
rs1389883248	16	G>V		No	gnomAD
rs180759486	17	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM3420175 rs1397828747	18	E>D	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated TOPMed gnomAD
rs1357600166	19	E>A		No	TOPMed gnomAD
rs1396018485	19	E>K		No	gnomAD
rs2042078545	21	A>V		No	TOPMed
rs1410381418	22	V>G		No	TOPMed
rs2042078587	22	V>M		No	TOPMed
rs2042078672	23	C>Y		No	TOPMed
rs1342350922	25	E>Q		No	gnomAD
rs767752687	26	R>C		No	ExAC TOPMed gnomAD
rs756110175	26	R>H		No	ExAC TOPMed gnomAD
rs767752687	26	R>S		No	ExAC TOPMed gnomAD
rs753949506	27	A>T		No	ExAC TOPMed gnomAD
rs755378549	30	T>M		No	ExAC TOPMed gnomAD
rs755378549	30	T>R		No	ExAC TOPMed gnomAD
rs376424624	31	L>P		No	ESP ExAC TOPMed gnomAD
rs376424624	31	L>R		No	ESP ExAC TOPMed gnomAD
rs2042079260	32	N>D		No	gnomAD
rs1596149347	32	N>S		No	Ensembl
rs2141653359	33	G>A		No	Ensembl
rs778209303	33	G>S		No	ExAC TOPMed gnomAD
rs1054254534	34	A>V		No	TOPMed
rs1011877404	35	G>A		No	TOPMed gnomAD
rs1011877404	35	G>E		No	TOPMed gnomAD
rs1442417412	36	D>Y		No	gnomAD
rs1018256609	37	T>M		No	TOPMed gnomAD
rs1377840329	38	G>D		No	TOPMed gnomAD
rs1377840329	38	G>V		No	TOPMed gnomAD
rs1386565028	39	G>C		No	TOPMed gnomAD
rs1455503071	39	G>D		No	gnomAD
rs1386565028	39	G>R		No	TOPMed gnomAD
rs1386565028	39	G>S		No	TOPMed gnomAD
rs753089141	41	P>L		No	ExAC TOPMed gnomAD
rs753089141	41	P>Q		No	ExAC TOPMed gnomAD
rs1296797976	41	P>S		No	TOPMed
rs1346090652	42	S>F		No	TOPMed
rs2031116479	44	R>P		No	TOPMed
TCGA novel rs2031116479	44	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs1385978407	45	G>V		No	gnomAD
rs2031118023	46	G>D		No	TOPMed
rs2031117780	46	G>S		No	TOPMed gnomAD
rs998158742	47	D>N		No	TOPMed
rs2031118961	48	P>L		No	TOPMed
rs777607829	48	P>S		No	ExAC TOPMed gnomAD
rs777607829	48	P>T		No	ExAC TOPMed gnomAD
rs954117551	49	A>P		No	TOPMed gnomAD
rs954117551	49	A>S		No	TOPMed gnomAD
rs954117551	49	A>T		No	TOPMed gnomAD
rs1007479203	50	A>E		No	TOPMed gnomAD
rs1007479203	50	A>V		No	TOPMed gnomAD
rs2031119712	51	R>L		No	TOPMed
rs1360870166	52	S>A		No	TOPMed gnomAD
rs1293448832	52	S>C		No	TOPMed gnomAD
rs1314649839	53	R>H		No	TOPMed gnomAD
rs756857060	54	R>T		No	1000Genomes ExAC TOPMed gnomAD
rs564533545 RCV001971862	54	R>W		No	ClinVar 1000Genomes TOPMed dbSNP gnomAD
rs2031122033	55	T>M		No	gnomAD
rs2031122479	57	G>A		No	TOPMed
TCGA novel	57	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs941012164	59	R>C		No	TOPMed gnomAD
RCV001981813 rs780551753	59	R>H		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs2031123612	61	A>S		No	TOPMed gnomAD
rs1350030008	61	A>V		No	gnomAD
rs918823575	62	Y>C		No	TOPMed gnomAD
rs918823575	62	Y>F		No	TOPMed gnomAD
rs915826670 RCV001910187	63	R>K		No	ClinVar TOPMed dbSNP gnomAD
rs915826670	63	R>T		No	TOPMed gnomAD
rs2031124641	64	R>G		No	Ensembl
rs948639431 RCV001900062	64	R>L		No	ClinVar TOPMed dbSNP
rs948639431	64	R>P		No	TOPMed
rs1189245756	65	G>E		No	TOPMed gnomAD
rs2031125255	65	G>R		No	TOPMed
rs1281309106	66	D>E		No	TOPMed gnomAD
rs1481018763	66	D>N		No	TOPMed gnomAD
rs1481018763	66	D>Y		No	TOPMed gnomAD
RCV002076432 rs528714330	67	R>C		No	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs528714330	67	R>G		No	1000Genomes ExAC TOPMed gnomAD
rs2031126507	67	R>H		No	Ensembl
rs1054604781	68	G>A		No	TOPMed
RCV001985236 rs56289455	68	G>C		No	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
RCV002125034 rs56289455	68	G>S		No	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs2031127555	69	G>S		No	Ensembl
rs914448297	70	A>S		No	TOPMed gnomAD
rs914448297	70	A>T		No	TOPMed gnomAD
rs934768991	71	R>G		No	TOPMed gnomAD
rs1326828605	71	R>P		No	TOPMed
rs934768991	71	R>W		No	TOPMed gnomAD
rs1443319958	72	D>E		No	TOPMed gnomAD
rs2141653682	75	E>Q		No	Ensembl
rs2031130166	76	E>A		No	TOPMed
rs945844784	76	E>D		No	TOPMed
rs1053194090	76	E>K		No	TOPMed
RCV001981333 rs893166977	77	A>G		No	ClinVar TOPMed dbSNP gnomAD
rs768515004	77	A>T		No	ExAC TOPMed gnomAD
rs893166977	77	A>V		No	TOPMed gnomAD
RCV001864924 rs1249255322	79	D>G		No	ClinVar TOPMed dbSNP gnomAD
rs1456154770	79	D>N		No	TOPMed gnomAD
rs1456154770	79	D>Y		No	TOPMed gnomAD
rs562434357	80	Q>*		No	1000Genomes TOPMed gnomAD
rs562434357	80	Q>E		No	1000Genomes TOPMed gnomAD
rs562434357	80	Q>K		No	1000Genomes TOPMed gnomAD
rs1340750957	81	C>Y		No	TOPMed gnomAD
rs761654387	84	Q>P		No	ExAC TOPMed gnomAD
rs796076773	85	L>M		No	TOPMed gnomAD
rs997739606	86	E>K		No	gnomAD
RCV001971132 rs28468535	87	K>E		No	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs758349602	87	K>T		No	Ensembl
rs755637633	88	G>S		No	ExAC gnomAD
RCV001997059 rs779865899	90	L>P		No	ClinVar ExAC dbSNP gnomAD
rs779865899	90	L>R		No	ExAC gnomAD
rs2031713947	90	L>V		No	gnomAD
rs370948444	94	P>L		No	ESP ExAC TOPMed gnomAD
rs202037702	94	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed
rs901489770	95	A>T		No	TOPMed gnomAD
rs377500835	96	A>D		No	ESP ExAC TOPMed gnomAD
rs377500835	96	A>G		No	ESP ExAC TOPMed gnomAD
rs773149239	97	Y>C		No	ExAC TOPMed gnomAD
rs1309717731	97	Y>H		No	gnomAD
rs2031715971	100	L>P		No	TOPMed
rs1460054859	101	E>D		No	TOPMed gnomAD
rs775753659 RCV002040397	104	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs775753659	104	R>G		No	ExAC TOPMed gnomAD
rs1427176646	104	R>H		No	TOPMed gnomAD
TCGA novel rs1427176646	104	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1449166266	105	Y>*		No	gnomAD
rs1596234842	105	Y>S		No	Ensembl
rs1567214660	106	L>V		No	Ensembl
rs1187686666	107	L>F		No	gnomAD
rs202052348 RCV002021726	108	S>N		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs575177605	110	R>K		No	1000Genomes ExAC gnomAD
rs774548299	110	R>S		No	ExAC TOPMed gnomAD
rs2031718367	112	V>M		No	TOPMed
rs2031718507	114	L>V		No	TOPMed
rs2031718645	115	P>S		No	Ensembl
rs951902777	116	T>I		No	gnomAD
rs1467463832	116	T>P		No	Ensembl
rs2031719556	117	E>K		No	Ensembl
rs750884820	119	T>M		No	ExAC
rs1383049081	120	D>E		No	gnomAD
rs1185218356	121	D>A		No	TOPMed
rs1433919455	121	D>H		No	gnomAD
rs1433919455	121	D>N		No	gnomAD
rs1364561496	122	N>D		No	gnomAD
rs1364561496	122	N>H		No	gnomAD
rs1215618264	122	N>I		No	gnomAD
rs1215618264	122	N>S		No	gnomAD
rs1215618264	122	N>T		No	gnomAD
rs753606461	125	V>L		No	ExAC TOPMed gnomAD
rs753606461 RCV001872926	125	V>M		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs754657738	128	A>E		No	ExAC TOPMed gnomAD
TCGA novel	128	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs754657738 COSM5848860 COSM5848858	128	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs776974790	129	Y>C		No	ExAC TOPMed gnomAD
rs758151687	130	F>L		No	ExAC gnomAD
rs200045067	133	T>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2031723466	136	V>L		No	TOPMed
rs201198678	137	Q>R		No	ExAC TOPMed gnomAD
rs2031723958	138	E>K		No	TOPMed gnomAD
COSM3815663 COSM4923959 rs775524685 COSM4923961 COSM3815665	139	L>F	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs374355989	140	L>V		No	ESP ExAC TOPMed gnomAD
COSM3886696 COSM3886694	142	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1260718403	146	P>L		No	TOPMed gnomAD
rs762328731	146	P>S		No	ExAC gnomAD
rs763758358	147	C>R		No	1000Genomes ExAC TOPMed gnomAD
rs536752090	148	S>I		No	1000Genomes ExAC TOPMed gnomAD
rs536752090	148	S>N		No	1000Genomes ExAC TOPMed gnomAD
rs1261409516	148	S>R		No	gnomAD
rs1436826237	149	P>L		No	TOPMed
COSM5277250 COSM5277252	151	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs756058323	151	R>Q		No	ExAC TOPMed gnomAD
COSM3386775 COSM3386777 rs552211004	151	R>W	Variant assessed as Somatic; MODERATE impact. pancreas [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1400336345	153	L>R		No	TOPMed gnomAD
rs1174295697	154	N>I		No	gnomAD
rs1412103908	157	L>Q		No	TOPMed gnomAD
rs2141669802 RCV001887459	159	L>F		No	ClinVar Ensembl dbSNP
rs752855869	163	R>*		No	ExAC TOPMed gnomAD
RCV001889550 rs200548454	163	R>Q		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs778159326	164	G>V		No	ExAC gnomAD
COSM4053457 COSM4053455	168	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1457392995	168	V>F		No	TOPMed
rs1457392995	168	V>I		No	TOPMed
rs2032002385	169	V>L		No	TOPMed
rs1032895584	171	L>F		No	TOPMed gnomAD
rs1032895584	171	L>I		No	TOPMed gnomAD
rs202112893 COSM199319	175	T>M	large_intestine [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs2032003446	176	H>R		No	gnomAD
rs1207247731	177	G>E		No	gnomAD
rs1484726939	177	G>R		No	TOPMed gnomAD
TCGA novel	178	A>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs554667646	180	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs767351188	181	E>A		No	ExAC gnomAD
rs761442314	181	E>Q		No	ExAC TOPMed gnomAD
rs773030697	182	S>R		No	ExAC gnomAD
rs757738305	183	Y>C		No	ExAC gnomAD
rs753664394 COSM959603	184	A>T	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs919254235	185	V>F		No	gnomAD
rs1404204859	185	V>G		No	gnomAD
rs919254235	185	V>L		No	gnomAD
rs751875924	186	R>G		No	ExAC gnomAD
rs757519760	186	R>S		No	ExAC gnomAD
rs1357929316	187	K>R		No	TOPMed gnomAD
rs2032006656	189	E>A		No	TOPMed
rs930941488	189	E>D		No	TOPMed gnomAD
rs746264958	189	E>Q		No	ExAC TOPMed gnomAD
rs1596241797	190	F>Y		No	Ensembl
rs756374275	193	I>N		No	ExAC gnomAD
rs370235958	194	V>L		No	ESP ExAC TOPMed gnomAD
rs201889926 COSM959605 COSM2200425	195	R>C	Variant assessed as Somatic; MODERATE impact. central_nervous_system endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
COSM959607 rs773830700	195	R>H	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs201889926	195	R>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2032008547	198	L>V		No	Ensembl
rs1884063698	199	Y>*		No	gnomAD
rs747840699	200	A>S		No	ExAC gnomAD
rs747840699	200	A>T		No	ExAC gnomAD
rs771745497	200	A>V		No	ExAC TOPMed gnomAD
rs766026615	201	A>T		No	ExAC gnomAD
rs1161513298	202	I>M		No	gnomAD
rs35985016 RCV002167046	203	K>E		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1458359895	203	K>M		No	gnomAD
TCGA novel	205	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs759520031	205	G>R		No	ExAC gnomAD
rs769939723	206	N>H		No	Ensembl
rs769871825	208	D>N		No	ExAC gnomAD
rs1205832502	211	I>M		No	gnomAD
rs2032034285	212	F>L		No	TOPMed gnomAD
rs557184600	215	R>G		No	1000Genomes ExAC gnomAD
rs368091026	215	R>L		No	ESP ExAC TOPMed gnomAD
rs557184600	215	R>W		No	1000Genomes ExAC gnomAD
rs1417277255	217	G>R		No	gnomAD
TCGA novel	217	G>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1596242577 TCGA novel	218	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs767489943	219	Y>S		No	ExAC gnomAD
rs1428019785	221	C>S		No	TOPMed gnomAD
rs1428019785	221	C>Y		No	TOPMed gnomAD
rs1253523506	222	S>C		No	TOPMed gnomAD
rs1398112465	222	S>P		No	gnomAD
rs2032036272	223	Y>C		No	TOPMed
rs2032036603	226	L>V		No	TOPMed
rs766808583	228	S>N		No	ExAC gnomAD
rs1359433750	228	S>R		No	gnomAD
COSM4053461 COSM4053463	229	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs754234882	230	D>A		No	ExAC TOPMed gnomAD
rs754234882	230	D>G		No	ExAC TOPMed gnomAD
rs755289273	231	P>A		No	ExAC gnomAD
rs2141670682	231	P>L		No	Ensembl
rs755289273	231	P>S		No	ExAC gnomAD
rs755289273 RCV001943528	231	P>T		No	ClinVar ExAC dbSNP gnomAD
rs1321549084	238	K>N		No	gnomAD
rs1282669597	238	K>R		No	gnomAD
rs1282669597	238	K>T		No	gnomAD
rs145072406	241	I>F		No	1000Genomes ESP ExAC TOPMed gnomAD
rs558815397	241	I>T		No	1000Genomes ExAC TOPMed gnomAD
rs145072406	241	I>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs201348332	243	A>D		No	ExAC TOPMed gnomAD
rs780846312	245	P>T		No	ExAC gnomAD
rs1489194935	246	L>S		No	gnomAD
rs924383338	247	P>H		No	TOPMed gnomAD
rs745664601	248	S>G		No	ExAC gnomAD
rs1428568069	248	S>T		No	gnomAD
rs369239695	251	P>A		No	1000Genomes ESP TOPMed gnomAD
rs200690035	251	P>L		No	1000Genomes ExAC TOPMed gnomAD
rs369239695	251	P>S		No	1000Genomes ESP TOPMed gnomAD
COSM3987866 COSM3987868	254	T>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1437413884	254	T>S		No	TOPMed gnomAD
rs2033103774	257	R>C		No	TOPMed
rs1324210109	257	R>H		No	TOPMed
rs747061264	259	K>E		No	ExAC gnomAD
rs770982171 COSM4406082 COSM4406080	261	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs776892472	262	H>Y		No	ExAC TOPMed gnomAD
rs369330842	263	L>H		No	ESP ExAC TOPMed
rs765643116	268	V>E		No	ExAC gnomAD
rs763339239	269	D>A		No	ExAC gnomAD
rs1439992221	269	D>E		No	TOPMed gnomAD
rs2033105932	269	D>H		No	TOPMed gnomAD
rs752048498	274	I>V		No	ExAC TOPMed gnomAD
rs756776320	275	D>A		No	ExAC TOPMed gnomAD
rs199863201	276	I>S		No	1000Genomes ExAC
rs1164314445	278	C>R		No	gnomAD
rs750140074	279	Q>H		No	ExAC gnomAD
rs1408267488	280	I>V		No	TOPMed gnomAD
rs1333528063	281	T>M		No	TOPMed gnomAD
rs2033107521	282	E>K		No	gnomAD
TCGA novel	283	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs755805466	283	L>I		No	ExAC TOPMed gnomAD
rs1429167452	284	D>H		No	TOPMed
rs1380348674	286	S>F		No	gnomAD
rs779802602 RCV001881899	286	S>P		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs2141691592 RCV001970614	287	A>P		No	ClinVar Ensembl dbSNP
rs749068051	287	A>V		No	ExAC gnomAD
rs754733732	288	N>K		No	ExAC gnomAD
rs1046335520	291	A>E		No	TOPMed gnomAD
rs2033108674	291	A>T		No	gnomAD
rs1046335520	291	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
TCGA novel	292	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2033109024	292	T>I		No	TOPMed
rs373434869	293	L>P		No	ESP ExAC TOPMed gnomAD
rs373434869	293	L>R		No	ESP ExAC TOPMed gnomAD
rs1259431781	293	L>V		No	TOPMed gnomAD
rs1202661217	294	P>S		No	gnomAD
rs1398231033	296	V>A		No	TOPMed gnomAD
rs1334256380	296	V>I		No	gnomAD
rs1188757802	298	P>L		No	gnomAD
COSM3499719 COSM3499717	298	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs776656740	303	N>S		No	ExAC TOPMed gnomAD
rs745902377	304	L>V		No	ExAC gnomAD
rs201297016	305	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs775625158	305	R>W		No	ExAC TOPMed gnomAD
rs1404679405	306	K>N		No	gnomAD
rs2141691698	307	L>V		No	Ensembl
rs1277823709	308	N>Y		No	TOPMed
TCGA novel	310	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs769053443	311	D>N		No	ExAC gnomAD
rs762350334	313	H>L		No	ExAC TOPMed gnomAD
rs762350334	313	H>P		No	ExAC TOPMed gnomAD
rs762350334	313	H>R		No	ExAC TOPMed gnomAD
rs1270878753	314	L>V		No	TOPMed gnomAD
rs766132517	315	G>R		No	1000Genomes ExAC gnomAD
rs574940704	316	E>K		No	1000Genomes ExAC TOPMed gnomAD
rs574940704	316	E>Q		No	1000Genomes ExAC TOPMed gnomAD
rs778760210	317	L>P		No	ExAC TOPMed gnomAD
rs1405888383	318	P>L		No	TOPMed
rs1445730152	319	G>D		No	TOPMed gnomAD
RCV002004310 rs2141691789	319	G>H		No	ClinVar Ensembl dbSNP
rs1261488928	319	G>R		No	TOPMed gnomAD
rs1261488928	319	G>S		No	TOPMed gnomAD
rs376445041	320	V>L		No	ESP ExAC TOPMed gnomAD
rs376445041	320	V>M		No	ESP ExAC TOPMed gnomAD
rs1480137858	321	Q>P		No	gnomAD
rs2141691813	322	S>T		No	Ensembl
rs769809859	323	S>*		No	ExAC TOPMed gnomAD
rs1195530604	323	S>P		No	Ensembl
RCV000880312 rs184008590	324	D>E		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
TCGA novel rs2033115026	325	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs2033115270	327	I>F		No	gnomAD
rs1267255810	331	L>P		No	gnomAD
rs770384623	332	L>V		No	ExAC TOPMed gnomAD
rs1296621966	333	E>K		No	TOPMed gnomAD
rs562018856	334	I>T		No	1000Genomes ExAC gnomAD
rs2033176484	334	I>V		No	Ensembl
rs1441786750	336	I>V		No	gnomAD
TCGA novel	337	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1308229623	338	S>G		No	TOPMed gnomAD
rs368549166 RCV001977304	338	S>R		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1162564377	340	K>N		No	gnomAD
rs1443887829	340	K>R		No	gnomAD
rs1351595378	341	L>F		No	TOPMed gnomAD
rs1490853664	342	S>P		No	TOPMed gnomAD
TCGA novel	344	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1447370113	344	L>V		No	TOPMed
rs1397593141	345	P>R		No	gnomAD
rs866765967	345	P>S		No	gnomAD
rs866765967	345	P>T		No	gnomAD
rs1448546235	346	P>A		No	gnomAD
rs1448546235	346	P>S		No	gnomAD
rs187360115	347	G>E		No	1000Genomes
TCGA novel rs1310385882	348	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1418693007	349	L>W		No	Ensembl
rs762797401	350	H>Y		No	ExAC TOPMed gnomAD
rs763873193	351	L>F		No	ExAC gnomAD
rs751540811	352	S>L		No	ExAC TOPMed gnomAD
rs2033179466	354	L>V		No	gnomAD
rs150351407	355	Q>E		No	1000Genomes ExAC TOPMed gnomAD
rs2141693546	356	K>Q		No	Ensembl
rs1596268585	357	L>R		No	Ensembl
rs767309864	358	T>R		No	ExAC gnomAD
rs1459224772	359	A>T		No	TOPMed gnomAD
rs1199543291	360	S>T		No	gnomAD
COSM2200438 COSM2200440	362	N>I	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs753981637	363	C>S		No	ExAC TOPMed gnomAD
rs1482604307	365	E>Q		No	Ensembl
rs779206703	366	K>Q		No	ExAC gnomAD
rs1424330941	367	L>*		No	gnomAD
rs748365815 RCV001933945	367	L>M		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs372847198	369	E>*		No	1000Genomes ESP ExAC TOPMed gnomAD
rs372847198 RCV002130506 COSM1375687	369	E>K	large_intestine [Cosmic]	No	cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs368813810	373	A>V		No	ESP ExAC gnomAD
rs566606745	374	T>A		No	1000Genomes ExAC gnomAD
rs566606745	374	T>P		No	1000Genomes ExAC gnomAD
rs566606745	374	T>S		No	1000Genomes ExAC gnomAD
rs765224234	376	W>R		No	ExAC gnomAD
rs1489302353	377	I>T		No	TOPMed
rs200469257 RCV001874078	378	G>A		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs200469257	378	G>D		No	ExAC TOPMed gnomAD
rs1243857037	379	L>S		No	TOPMed gnomAD
rs778089814	380	R>Q		No	ExAC gnomAD
rs758667510	380	R>W		No	ExAC TOPMed gnomAD
rs2033191949	382	L>V		No	TOPMed gnomAD
rs2141693825 RCV001946453	384	E>*		No	ClinVar Ensembl dbSNP
rs1229067054	385	L>I		No	TOPMed
rs547363177	386	D>V		No	ExAC gnomAD
rs1489266948	387	I>L		No	gnomAD
rs757510968	387	I>M		No	ExAC TOPMed gnomAD
rs1193689209	387	I>T		No	TOPMed gnomAD
rs1476817125 RCV001919958	390	N>S		No	ClinVar TOPMed dbSNP gnomAD
RCV001933952 rs371086173	391	K>I		No	ClinVar ESP ExAC dbSNP gnomAD
rs769386932	393	T>A		No	ExAC gnomAD
rs1291141402	393	T>I		No	gnomAD
rs769386932	393	T>S		No	ExAC gnomAD
rs2141693881	394	E>*		No	Ensembl
rs2033194969	395	L>P		No	TOPMed
rs1391841773	396	P>R		No	TOPMed
COSM2200453 COSM2200451	396	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs200253977	397	A>S		No	1000Genomes ExAC TOPMed gnomAD
rs200253977	397	A>T		No	1000Genomes ExAC TOPMed gnomAD
rs1420851289 COSM959613	397	A>V	endometrium [Cosmic]	No	cosmic curated TOPMed gnomAD
rs768329041	398	L>V		No	ExAC gnomAD
rs549021266	399	F>L		No	1000Genomes ExAC TOPMed gnomAD
rs761682123	400	L>V		No	ExAC TOPMed gnomAD
rs771748188	401	H>Y		No	ExAC gnomAD
rs1306810748	402	S>P		No	TOPMed gnomAD
rs2033196586	405	S>A		No	Ensembl
rs2033196715	405	S>F		No	Ensembl
rs773266521	406	L>F		No	ExAC gnomAD
rs1217292614	407	N>D		No	gnomAD
rs760495714	407	N>S		No	ExAC TOPMed gnomAD
COSM959615	408	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs375638857	412	S>C		No	TOPMed gnomAD
rs375638857	412	S>F		No	TOPMed gnomAD
RCV000892937 rs55739947	416	L>M		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1218547521	416	L>Q		No	gnomAD
rs1177097335	418	V>A		No	gnomAD
rs763083060	418	V>L		No	ExAC TOPMed gnomAD
RCV001944801 rs538150906	420	P>L		No	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs1209278460	426	P>A		No	TOPMed
rs1349991935	426	P>R		No	TOPMed gnomAD
TCGA novel	427	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs767732473	428	K>I		No	ExAC TOPMed gnomAD
rs767732473	428	K>T		No	ExAC TOPMed gnomAD
rs1453654500	429	C>R		No	TOPMed gnomAD
rs201450091	429	C>Y		No	1000Genomes
TCGA novel	430	C>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1318234747	430	C>F		No	gnomAD
rs2033276081	436	A>V		No	TOPMed
TCGA novel	437	L>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1188820322	438	E>G		No	gnomAD
rs1476877345	439	C>F		No	gnomAD
rs1476877345	439	C>Y		No	gnomAD
rs1317836448	441	P>A		No	TOPMed
rs754548120	442	D>E		No	ExAC TOPMed gnomAD
rs2033277373	442	D>N		No	TOPMed
rs1015865458 RCV002012762	442	D>V		No	ClinVar TOPMed dbSNP gnomAD
TCGA novel	444	M>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM5159291 COSM1375689	445	A>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2033278238	445	A>S		No	gnomAD
rs747881165	445	A>V		No	ExAC gnomAD
rs758006341	446	V>A		No	ExAC gnomAD
rs758006341	446	V>G		No	ExAC gnomAD
rs1174654799	446	V>I		No	TOPMed gnomAD
rs993194467	447	F>L		No	TOPMed gnomAD
rs76152020	448	W>L		No	Ensembl
rs2033279349	449	K>E		No	TOPMed gnomAD
rs2033279468	450	N>S		No	Ensembl
rs1157264053	451	H>L		No	Ensembl
RCV001974536 rs777438481	452	L>P		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs2033280122	453	K>*		No	TOPMed
COSM6141652 COSM6141654	453	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1486538796	453	K>R		No	TOPMed gnomAD
rs1487100650	454	D>E		No	TOPMed
rs200529094	454	D>N		No	1000Genomes ExAC TOPMed gnomAD
rs200529094	454	D>Y		No	1000Genomes ExAC TOPMed gnomAD
rs2033280662	456	D>G		No	TOPMed
COSM282559	457	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1346889073	459	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
TCGA novel	460	N>T	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs113678526 RCV000947652	461	A>T		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs531721861	462	L>F		No	1000Genomes ExAC gnomAD
rs768909431	463	K>E		No	ExAC TOPMed gnomAD
rs1487597371	463	K>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs2033281795	464	E>Q		No	Ensembl
rs371606687	466	P>L		No	1000Genomes ExAC TOPMed gnomAD
rs1264026847 COSM4699232 COSM4699234	466	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
TCGA novel	467	L>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1269637042	467	L>R		No	TOPMed gnomAD
rs1478879427	470	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1174095366	473	D>A		No	gnomAD
rs1174095366	473	D>V		No	gnomAD
TCGA novel	474	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2033426302	475	L>H		No	Ensembl
rs1321714856	476	M>K		No	gnomAD
rs772177705	476	M>L		No	ExAC TOPMed gnomAD
rs772177705	476	M>V		No	ExAC TOPMed gnomAD
rs773371877	477	F>L		No	ExAC gnomAD
rs1488899950	479	R>T		No	TOPMed gnomAD
rs1198284104	481	Q>R		No	TOPMed gnomAD
rs1456270070	483	N>Y		No	gnomAD
rs1251076782	485	L>V		No	gnomAD
rs377571378	486	A>V		No	ESP ExAC TOPMed gnomAD
rs1232533272	487	A>S		No	TOPMed gnomAD
rs1323910825	490	P>S		No	TOPMed gnomAD
rs753186926	491	Q>R		No	ExAC TOPMed gnomAD
rs1169485935	494	W>R		No	TOPMed gnomAD
rs2033428973	497	R>T		No	TOPMed
rs2033429191	499	L>I		No	Ensembl
rs757916117	501	T>I		No	ExAC gnomAD
rs1394823786	504	L>R		No	gnomAD
rs2033430021	510	G>A		No	Ensembl
rs566734053	511	K>E		No	1000Genomes ExAC TOPMed gnomAD
RCV001945546 rs770937949	511	K>N		No	ClinVar ExAC dbSNP gnomAD
rs1335513063	511	K>R		No	gnomAD
rs1270102762	512	N>S		No	TOPMed
COSM5212675 COSM1477913	513	E>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1049141464	513	E>K		No	TOPMed gnomAD
rs2141700870	514	D>Y		No	Ensembl
rs770108501	516	L>P		No	ExAC gnomAD
rs2033481892	517	K>E		No	gnomAD
rs1365834896	518	T>M		No	TOPMed gnomAD
rs1567233858	519	K>N		No	Ensembl
RCV001981986 rs774941330	520	R>C		No	ClinVar ExAC dbSNP gnomAD
rs2033482549	520	R>H		No	Ensembl
COSM3969001 COSM3969003	521	I>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs868044422	521	I>V		No	Ensembl
rs767129254	523	F>V		No	ExAC gnomAD
rs375733293	524	F>L		No	1000Genomes ExAC TOPMed gnomAD
rs1267137737	526	T>I		No	TOPMed gnomAD
rs777091251	527	R>G		No	TOPMed gnomAD
rs1226232670	528	G>D		No	TOPMed
rs1245703001	529	R>C		No	TOPMed gnomAD
rs765898071	529	R>L		No	ExAC gnomAD
rs754659010	530	Q>H		No	ExAC TOPMed gnomAD
rs200499483	531	R>C		No	ESP ExAC TOPMed gnomAD
RCV001983596 rs200499483	531	R>G		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs2033484669	531	R>H		No	Ensembl
rs2033484883	532	S>P		No	Ensembl
rs781229505	533	G>R		No	ExAC TOPMed gnomAD
rs781229505	533	G>W		No	ExAC TOPMed gnomAD
rs780075028	534	T>I		No	ExAC gnomAD
rs780075028	534	T>S		No	ExAC gnomAD
rs1013772472	535	E>D		No	TOPMed gnomAD
rs1327622975	536	A>T		No	gnomAD
rs1464285760	537	A>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA
rs2033486005	537	A>P		No	TOPMed
rs2141708186	538	S>C		No	Ensembl
rs904019203	541	E>K		No	TOPMed gnomAD
rs772736703	543	P>L		No	ExAC TOPMed gnomAD
rs55798315 RCV000968486	543	P>S		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs763899406	544	A>T		No	TOPMed gnomAD
rs2033760973	545	F>S		No	TOPMed gnomAD
rs2033761084	546	L>P		No	Ensembl
TCGA novel	547	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1296485632	548	E>V		No	TOPMed gnomAD
rs1459531837	549	S>P		No	TOPMed gnomAD
rs776409174	552	V>F		No	ExAC gnomAD
rs776409174	552	V>I		No	ExAC gnomAD
rs759169632	553	L>F		No	ExAC TOPMed gnomAD
rs1423124755	554	C>Y		No	TOPMed
rs769390447	555	L>V		No	ExAC gnomAD
rs762674468	557	D>N		No	ExAC TOPMed gnomAD
rs764032483	560	L>I		No	ExAC gnomAD
rs764032483	560	L>V		No	ExAC gnomAD
rs761695009	561	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs761695009	561	D>Y		No	ExAC TOPMed gnomAD
rs1198339219	562	T>I		No	TOPMed gnomAD
rs766339820	563	V>F		No	ExAC TOPMed gnomAD
rs766339820	563	V>I		No	ExAC TOPMed gnomAD
rs1262313834	564	P>L		No	TOPMed
rs867186599	564	P>S		No	TOPMed gnomAD
RCV001985306 rs867186599	564	P>T		No	ClinVar TOPMed dbSNP gnomAD
rs141522582	566	S>L		No	1000Genomes ExAC gnomAD
rs1373918258	567	V>I		No	gnomAD
rs753116269	568	C>F		No	ExAC TOPMed gnomAD
rs1304804237	568	C>R		No	TOPMed
TCGA novel	570	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1403388422	571	K>E		No	TOPMed
rs2033765412	572	S>G		No	TOPMed
rs758773787	572	S>N		No	ExAC
COSM4826930 COSM4826932	574	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1026190245	576	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1026190245	576	L>I		No	gnomAD
rs780592294	576	L>P		No	ExAC gnomAD
rs1319866402	577	Y>C		No	gnomAD
rs1319866402	577	Y>F		No	gnomAD
rs2033766607	578	L>M		No	gnomAD
rs745344763	579	G>V		No	ExAC gnomAD
rs779750560	582	P>A		No	ExAC gnomAD
rs1270375539	584	L>V		No	TOPMed gnomAD
COSM6141649 COSM6141651	585	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs538821865	585	R>P		No	1000Genomes ExAC TOPMed gnomAD
rs538821865 RCV002032100	585	R>Q		No	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs768546791	585	R>W		No	1000Genomes ExAC TOPMed gnomAD
rs1275278452	587	L>V		No	gnomAD
rs771907397	588	P>L		No	ExAC gnomAD
rs771907397	588	P>R		No	ExAC gnomAD
rs759743498	589	P>H		No	ExAC gnomAD
rs759743498	589	P>R		No	ExAC gnomAD
rs773225777	589	P>S		No	ExAC TOPMed gnomAD
rs2033812975	593	Q>L		No	Ensembl
rs1251231353	595	G>S		No	gnomAD
rs2033813542	596	N>S		No	TOPMed
RCV001900833 rs2033813786	597	L>F		No	ClinVar TOPMed dbSNP
rs1455216844	598	W>*		No	Ensembl
rs1455216844	598	W>S		No	Ensembl
rs2033814151	599	Q>*		No	TOPMed
rs2033814151	599	Q>K		No	TOPMed
rs1419500207	600	L>P		No	gnomAD
RCV001910933 rs763061068	602	T>I		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs536343284	604	D>E		No	1000Genomes ExAC gnomAD
COSM4053464 COSM4053466	605	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2033814795	606	T>A		No	TOPMed
rs376893013	609	N>S		No	ESP ExAC TOPMed gnomAD
COSM4925081 COSM4925079	611	P>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1299227526	612	A>T		No	TOPMed gnomAD
rs767970862	614	I>T		No	ExAC gnomAD
rs1412937940	615	Q>E		No	gnomAD
rs2141709839	615	Q>R		No	Ensembl
rs755662621	617	E>K		No	ExAC TOPMed gnomAD
rs80186667	618	G>A		No	Ensembl
COSM959617	618	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1389322413	619	P>L		No	TOPMed
rs2033836110	620	K>R		No	TOPMed gnomAD
rs753290789	621	A>V		No	ExAC gnomAD
rs754452197	622	M>T		No	ExAC gnomAD
rs1471655500	624	S>F		No	TOPMed gnomAD
rs200770615	624	S>T		No	1000Genomes ExAC TOPMed gnomAD
COSM2200499 COSM2200498 rs747828168	627	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
RCV001895518 rs753941048	627	R>H		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs753941048	627	R>L		No	ExAC TOPMed gnomAD
rs1245381002	628	A>G		No	TOPMed
rs1176065275 COSM5350241 COSM5350242	629	Q>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs1006607984 RCV001892954	630	L>R		No	ClinVar TOPMed dbSNP gnomAD
rs779184003 COSM1213957	631	R>Q	large_intestine [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
RCV002048456 rs192470343	631	R>W		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1347137222	632	K>Q		No	TOPMed gnomAD
rs749390141	633	A>V		No	ExAC TOPMed gnomAD
rs2033839853	635	K>M		No	Ensembl
rs1596286684	635	K>Q		No	TOPMed
rs762074642	636	C>F		No	ExAC TOPMed gnomAD
rs762074642	636	C>Y		No	ExAC TOPMed gnomAD
rs1305528910	637	K>R		No	gnomAD
rs1320984844	638	L>Q		No	Ensembl
rs772234195	639	M>I		No	ExAC gnomAD
COSM699631 COSM1646651	640	K>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2033840823	641	M>I		No	TOPMed
rs2033840973	642	I>N		No	Ensembl
rs918407051	643	I>L		No	TOPMed
rs918407051	643	I>V		No	TOPMed
COSM1375691 COSM5158930 rs375903897	644	V>M	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs2033841599	645	G>S		No	TOPMed
rs377316707	646	P>S		No	ESP ExAC gnomAD
rs377316707	646	P>T		No	ESP ExAC gnomAD
rs764768964	647	P>L		No	ExAC TOPMed gnomAD
TCGA novel	647	P>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM3499729 COSM3499727	647	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs200971195	648	R>C		No	ExAC TOPMed gnomAD
rs777502572	648	R>H		No	ExAC TOPMed gnomAD
TCGA novel	648	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs777502572	648	R>P		No	ExAC TOPMed gnomAD
rs1188594611	649	Q>H		No	TOPMed gnomAD
rs2033842452	650	G>S		No	TOPMed
rs949321749	653	T>A		No	Ensembl
rs2033842901	653	T>I		No	Ensembl
rs34885781	654	L>I		No	gnomAD
rs2033843754	657	I>L		No	TOPMed
rs781346039	657	I>M		No	ExAC gnomAD
rs530260600	660	T>K		No	1000Genomes ExAC TOPMed gnomAD
COSM4475303 RCV001919286 rs530260600 COSM4475302	660	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ClinVar 1000Genomes ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs1392637520	661	G>E		No	TOPMed gnomAD
rs1164323692	661	G>W		No	TOPMed gnomAD
rs779074952	662	R>K		No	ExAC gnomAD
rs2033844987	662	R>S		No	TOPMed
rs2033845095	663	A>V		No	TOPMed
rs748140184	664	P>R		No	ExAC gnomAD
rs1276075553	665	Q>E		No	TOPMed
TCGA novel	665	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs773362599	666	V>L		No	ExAC TOPMed gnomAD
rs773362599	666	V>M		No	ExAC TOPMed gnomAD
rs2033846366	668	H>L		No	gnomAD
rs1332242404	668	H>Y		No	TOPMed gnomAD
COSM4148340 rs2141710821	669	G>*	thyroid [Cosmic]	No	cosmic curated Ensembl
rs777044065	669	G>A		No	ExAC gnomAD
rs935196455	670	E>D		No	TOPMed
TCGA novel	670	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
RCV001958290 rs745630986	672	T>missing		No	ClinVar dbSNP
rs760065482	672	T>A		No	ExAC gnomAD
rs760065482	672	T>P		No	ExAC gnomAD
rs765611843	676	T>A		No	ExAC gnomAD
rs2141710869	677	K>R		No	Ensembl
rs1235154576	678	W>G		No	gnomAD
rs1415877583	683	P>L		No	TOPMed gnomAD
rs1166776778	684	A>V		No	gnomAD
TCGA novel	687	R>E	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM3499730 COSM3499732	690	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs919588747	690	V>F		No	Ensembl
rs755804910	691	E>G		No	ExAC gnomAD
TCGA novel	691	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2033946833 RCV001864587	691	E>Q		No	ClinVar Ensembl dbSNP
RCV001876479 rs200409352	692	S>T		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs201243082	693	V>M		No	ExAC TOPMed gnomAD
rs1567241312	694	E>G		No	Ensembl
rs76435780	696	N>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs141102052 RCV000963337	697	V>I		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1344347761	700	I>V		No	TOPMed
rs896004560	701	G>R		No	TOPMed gnomAD
rs770051407	702	G>A		No	ExAC TOPMed gnomAD
COSM3886699 COSM3886697	702	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1393261925	704	A>G		No	gnomAD
rs769240723	705	S>I		No	ExAC gnomAD
rs774033253	706	M>I		No	ExAC gnomAD
rs761343909	707	A>T		No	ExAC gnomAD
TCGA novel	710	N>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1287711282	711	Q>K		No	gnomAD
rs1259266503	713	F>C		No	TOPMed
rs767215413	713	F>V		No	ExAC gnomAD
rs2033950214	714	F>L		No	gnomAD
rs78191111	715	T>R		No	Ensembl
rs766053466	716	D>E		No	ExAC TOPMed gnomAD
rs760582606	716	D>G		No	ExAC gnomAD
rs758131541	716	D>Y		No	Ensembl
rs753818870	718	A>T		No	ExAC gnomAD
rs1328893943	721	V>A		No	TOPMed
rs199919214	721	V>L		No	ESP ExAC TOPMed gnomAD
RCV002047822 rs199919214	721	V>M		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1285293554	724	W>*		No	gnomAD
COSM1323737	725	N>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1297141389	726	L>V		No	TOPMed
COSM4053469 COSM4053471 rs891430665	727	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1455548471	730	E>G		No	gnomAD
rs1198900798	731	E>K		No	gnomAD
rs1198900798	731	E>Q		No	gnomAD
rs2033953814	732	A>V		No	TOPMed gnomAD
rs370663048	733	V>M		No	ESP ExAC TOPMed gnomAD
rs996103849	735	N>H		No	Ensembl
rs2033954489	735	N>S		No	TOPMed
rs562726580 RCV002120540	736	L>V		No	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs1461201082	738	F>L		No	gnomAD
rs746593625	741	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs2033955141	741	L>H		No	gnomAD
rs769293742	742	N>S		No	ExAC gnomAD
rs2033955564	743	I>N		No	TOPMed
rs371661382	744	E>*		No	ESP ExAC TOPMed gnomAD
rs371661382	744	E>K		No	ESP ExAC TOPMed gnomAD
rs1567242360	746	K>M		No	Ensembl
rs2034009123	747	A>T		No	TOPMed
rs1371799804	749	N>D		No	TOPMed gnomAD
rs772262731	750	A>T		No	ExAC TOPMed gnomAD
RCV001914906 rs141579296	751	V>M		No	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs887555486	753	L>P		No	TOPMed
rs760948329	756	G>R		No	Ensembl
rs1172054475	757	T>M		No	TOPMed
COSM433601 COSM5200933	758	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1014001464	759	L>R		No	Ensembl
rs1230489888	759	L>V		No	TOPMed gnomAD
rs2034011945	760	D>N		No	TOPMed
rs199817137	761	L>F		No	ESP ExAC TOPMed gnomAD
rs896287484	762	I>F		No	TOPMed gnomAD
rs765670323	762	I>T		No	ExAC gnomAD
rs2034012746	763	E>K		No	TOPMed
rs2034013235	765	K>N		No	TOPMed
rs1200186227	765	K>R		No	TOPMed gnomAD
rs1200186227	765	K>T		No	TOPMed gnomAD
rs1186256525	767	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs753053998 COSM3815674 COSM3815672	767	R>H	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs753053998	767	R>P		No	ExAC TOPMed gnomAD
rs2034014085	770	R>K		No	Ensembl
RCV001892357 rs201803929	771	I>T		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs373497333	772	A>V		No	ESP ExAC TOPMed gnomAD
TCGA novel	774	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1018773132	775	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
rs368099995	775	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs368099995	775	R>P		No	ESP ExAC TOPMed gnomAD
rs768495809	778	V>A		No	ExAC TOPMed gnomAD
rs768495809	778	V>E		No	ExAC TOPMed gnomAD
rs2034016684	778	V>M		No	TOPMed
rs1231380055	780	A>T		No	gnomAD
rs2141101055	780	A>V		No	Ensembl
rs572305968	783	R>C		No	1000Genomes ExAC TOPMed gnomAD
rs777040315	783	R>H		No	ExAC TOPMed gnomAD
rs759855609	784	S>T		No	ExAC TOPMed gnomAD
rs1258652050	784	S>Y		No	TOPMed gnomAD
rs1466528093	785	P>H		No	gnomAD
rs1252856565	786	S>C		No	gnomAD
rs1252856565	786	S>F		No	gnomAD
rs367783860 COSM959624	787	G>S	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs752076949	788	S>P		No	ExAC gnomAD
TCGA novel	790	A>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1567242706	791	T>A		No	TOPMed gnomAD
rs1167430688	791	T>I		No	gnomAD
COSM3886700 COSM3886702	792	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2034020368	797	T>A		No	gnomAD
rs756811495	797	T>I		No	ExAC TOPMed gnomAD
rs2034020634	798	F>C		No	Ensembl
rs2141101125	798	F>L		No	Ensembl
rs2034020759	799	K>T		No	Ensembl
rs780703616	800	H>N		No	ExAC gnomAD
rs745342762	800	H>Q		No	ExAC TOPMed gnomAD
rs780703616	800	H>Y		No	ExAC gnomAD
rs2141102369	802	H>Q		No	Ensembl
rs1276599427	802	H>Y		No	gnomAD
rs1040913056	803	E>G		No	Ensembl
rs1040913056	803	E>V		No	Ensembl
COSM2200542 COSM959626	805	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2034073805	809	L>P		No	gnomAD
rs372434815	810	E>K		No	ESP ExAC gnomAD
rs866015235	811	G>S		No	Ensembl
rs200114885	814	G>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs774702868	814	G>V		No	ExAC gnomAD
rs766532218 COSM4053480 COSM4053478	816	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed
rs762111517	816	R>L		No	ExAC TOPMed gnomAD
rs762111517	816	R>P		No	ExAC TOPMed gnomAD
rs762111517	816	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs761403767	817	Q>H		No	gnomAD
rs2034076259	819	I>T		No	Ensembl
rs1213306218	819	I>V		No	gnomAD
rs750927387	820	F>L		No	ExAC gnomAD
rs1263333149	821	H>L		No	TOPMed gnomAD
rs760146211	821	H>Y		No	ExAC gnomAD
COSM3386780 rs1050845680 COSM3386778	822	V>I	Variant assessed as Somatic; MODERATE impact. pancreas [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs1050845680	822	V>L		No	TOPMed gnomAD
rs941918894	826	M>L		No	Ensembl
rs778637944	826	M>T		No	ExAC gnomAD
rs2034078064	827	K>E		No	Ensembl
rs373879296	827	K>R		No	ESP ExAC TOPMed gnomAD
TCGA novel	828	D>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1596294295	828	D>A		No	Ensembl
rs1399654915	829	V>A		No	TOPMed gnomAD
rs200452644	830	G>S		No	1000Genomes ExAC TOPMed gnomAD
rs186890317	831	S>N		No	1000Genomes
rs1415786642	832	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1596294339	832	T>P		No	Ensembl
rs370572047	833	I>N		No	ESP TOPMed
rs749260427	833	I>V		No	ExAC TOPMed gnomAD
rs768937081	834	G>S		No	ExAC TOPMed gnomAD
rs1478755633	835	C>S		No	TOPMed
rs1596294380	835	C>W		No	Ensembl
rs1366577662	837	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs774547176	837	R>Q		No	ExAC TOPMed gnomAD
rs2034081222	838	L>M		No	TOPMed
rs1007554321	841	R>Q		No	TOPMed gnomAD
rs375374079	841	R>W		No	ESP ExAC TOPMed gnomAD
rs1329603545	844	P>H		No	gnomAD
rs759150062	845	R>G		No	ExAC TOPMed gnomAD
TCGA novel	845	R>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1596294939	847	Y>S		No	Ensembl
rs775330321	848	L>M		No	ExAC TOPMed gnomAD
rs775330321	848	L>V		No	ExAC TOPMed gnomAD
rs762727247	849	S>R		No	ExAC TOPMed
rs763773289 COSM98988	852	E>K	stomach [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs751385962	853	A>T		No	ExAC TOPMed gnomAD
rs1023999423	854	V>A		No	Ensembl
rs368404584	854	V>L		No	ESP ExAC TOPMed gnomAD
rs368404584 RCV001991418	854	V>M		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
TCGA novel	859	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs750298507	860	R>C		No	ExAC TOPMed gnomAD
RCV001988799 COSM959628 rs142470911	860	R>H	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ClinVar 1000Genomes ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs981947042	861	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs778989938	861	R>H		No	ExAC TOPMed gnomAD
TCGA novel	863	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs777797735	863	R>Q		No	ExAC TOPMed gnomAD
rs758619910	863	R>W		No	ExAC TOPMed gnomAD
rs915301795	864	D>H		No	1000Genomes TOPMed gnomAD
rs915301795	864	D>N		No	1000Genomes TOPMed gnomAD
rs202089769	865	D>H		No	ExAC TOPMed gnomAD
rs202089769 RCV002125828	865	D>N		No	ClinVar ExAC TOPMed dbSNP gnomAD
RCV002173199 rs56003881	866	D>N		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs374008052	867	V>L		No	ESP ExAC TOPMed gnomAD
rs374008052	867	V>M		No	ESP ExAC TOPMed gnomAD
rs1274852106	868	Q>*		No	gnomAD
rs560090431	868	Q>L		No	TOPMed gnomAD
rs560090431	868	Q>R		No	TOPMed gnomAD
rs1179791606	869	Y>C		No	gnomAD
rs1258675580	870	L>P		No	gnomAD
rs762496843	871	T>M		No	ExAC gnomAD
rs773874591	872	D>G		No	ExAC gnomAD
rs2034105491	872	D>Y		No	Ensembl
rs1169332520	876	E>*		No	gnomAD
rs1169332520	876	E>K		No	gnomAD
rs1169332520	876	E>Q		No	gnomAD
rs761710931	877	Q>E		No	ExAC TOPMed gnomAD
rs1464705980	879	V>G		No	gnomAD
rs1222722240	879	V>M		No	TOPMed
COSM5209538 COSM433603	880	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs531640499	880	E>D		No	1000Genomes ExAC gnomAD
rs767199367	880	E>G		No	ExAC gnomAD
rs1304862195	880	E>K		No	gnomAD
rs1304862195	880	E>Q		No	gnomAD
rs767199367	880	E>V		No	ExAC gnomAD
rs1296705143	881	Q>H		No	gnomAD
rs201854079	882	T>M		No	1000Genomes ExAC TOPMed gnomAD
rs752784877	883	P>S		No	ExAC gnomAD
rs758457191	884	D>H		No	ExAC TOPMed gnomAD
rs758457191	884	D>N		No	ExAC TOPMed gnomAD
rs997852963	886	D>N		No	TOPMed gnomAD
rs757689685	887	I>M		No	ExAC gnomAD
rs77112930	888	K>R		No	Ensembl
rs2141103392	889	D>E		No	Ensembl
rs1189823477	889	D>G		No	gnomAD
rs1451916944	889	D>N		No	gnomAD
rs866448925	890	Y>H		No	Ensembl
rs746169733	891	E>K		No	ExAC TOPMed gnomAD
rs2034110305	893	L>V		No	TOPMed
rs1466315314	895	S>L		No	gnomAD
rs747624120	896	A>V		No	ExAC TOPMed gnomAD
rs200667677	898	S>N		No	1000Genomes ExAC TOPMed gnomAD
rs200667677	898	S>T		No	1000Genomes ExAC TOPMed gnomAD
rs2034161280	899	F>C		No	gnomAD
rs1247341695	900	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs2141104648	901	I>M		No	Ensembl
rs1224886642	901	I>T		No	TOPMed
rs1596296664	903	T>P		No	Ensembl
rs1482022169	904	G>D		No	gnomAD
rs2034162012	904	G>S		No	Ensembl
rs1596296692	905	T>P		No	Ensembl
rs1180277045	905	T>S		No	TOPMed gnomAD
rs1412669248	907	L>I		No	gnomAD
rs770680533	907	L>P		No	ExAC TOPMed gnomAD
rs1596296729	909	F>S		No	Ensembl
rs1050786363	910	P>L		No	gnomAD
rs765181449	912	T>P		No	ExAC gnomAD
rs774309946	915	G>S		No	ExAC TOPMed gnomAD
rs1003990525	920	Y>C		No	Ensembl
rs2034164808	921	F>L		No	Ensembl
rs2034164929	922	L>R		No	TOPMed gnomAD
rs200062338	923	D>H		No	1000Genomes ExAC TOPMed gnomAD
rs200062338	923	D>N		No	1000Genomes ExAC TOPMed gnomAD
COSM959632	926	W>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs766875506	929	E>K		No	ExAC TOPMed gnomAD
rs766875506	929	E>Q		No	ExAC TOPMed gnomAD
rs2034165777	930	C>Y		No	TOPMed gnomAD
rs1596296819	933	R>M		No	Ensembl
TCGA novel	936	N>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1182311678	939	G>C		No	Ensembl
rs754220038	939	G>D		No	ExAC gnomAD
rs185373027	940	S>F		No	1000Genomes ExAC TOPMed gnomAD
rs755449019	940	S>P		No	ExAC gnomAD
rs757918696	941	R>Q		No	ExAC TOPMed gnomAD
rs747666136 RCV001902644	941	R>W		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs2034167443	946	N>K		No	Ensembl
rs2034167749	948	V>M		No	TOPMed
TCGA novel	949	I>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1183522126	950	R>T		No	gnomAD
rs1596296895	951	A>T		No	Ensembl
rs746639649	951	A>V		No	ExAC gnomAD
rs190712554	953	D>E		No	1000Genomes ExAC gnomAD
rs201392064	955	R>K		No	1000Genomes ExAC gnomAD
rs769677938	955	R>S		No	ExAC gnomAD
rs775494533	956	M>L		No	ExAC TOPMed gnomAD
rs1349039201	958	L>Q		No	TOPMed
rs1285701374	959	V>G		No	TOPMed
rs988874365	959	V>L		No	Ensembl
rs761840209	961	T>I		No	ExAC gnomAD
rs761840209	961	T>N		No	ExAC gnomAD
rs796226537	964	T>E		No	Ensembl
rs767685227	964	T>M		No	ExAC TOPMed gnomAD
COSM4053484 COSM4053486	965	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1304950127	966	Q>L		No	Ensembl
rs1343031369	967	T>A		No	TOPMed gnomAD
rs41531245 RCV002082476	967	T>M		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs369170053	968	E>K		No	gnomAD
rs2034172256	969	E>Q		No	TOPMed gnomAD
rs947265550	971	Y>C		No	TOPMed gnomAD
rs374599598	972	F>L		No	ESP ExAC TOPMed gnomAD
rs1178431017	972	F>L		No	TOPMed gnomAD
RCV002036677 rs201547686	974	F>L		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs2034172925	974	F>Y		No	TOPMed
rs559037479	976	A>S		No	1000Genomes ExAC TOPMed gnomAD
rs559037479	976	A>T		No	1000Genomes ExAC TOPMed gnomAD
rs2034173400	976	A>V		No	TOPMed
COSM2200584 COSM2200582 rs939724696	981	A>T	Variant assessed as Somatic; MODERATE impact. central_nervous_system [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes NCI-TCGA TOPMed gnomAD
rs2141104979	983	P>A		No	Ensembl
COSM2200585 COSM2200587 rs369265377	984	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs2034174505	985	A>T		No	TOPMed gnomAD
rs1323525873	986	N>H		No	TOPMed
RCV002047743 rs2141105006	986	N>K		No	ClinVar Ensembl dbSNP
RCV002033030 rs199709127	986	N>S		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs377315974	987	D>E		No	ESP ExAC TOPMed gnomAD
rs768678229	988	S>C		No	ExAC TOPMed gnomAD
rs768678229	988	S>G		No	ExAC TOPMed gnomAD
rs1184817709	992	P>L		No	gnomAD
rs2141122311 RCV002008826	994	L>V		No	ClinVar Ensembl dbSNP
COSM1646649 COSM699627	997	S>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1364842626	997	S>P		No	gnomAD
rs2035055800	998	K>E		No	TOPMed
rs2035055947	998	K>I		No	TOPMed gnomAD
rs1457821862	1000	G>D		No	gnomAD
rs2035056520	1002	D>N		No	TOPMed
rs769865724	1002	D>V		No	ExAC
rs764652283	1004	H>R		No	ExAC TOPMed gnomAD
rs2035057482	1005	G>D		No	TOPMed
rs761362971	1005	G>S		No	ExAC TOPMed gnomAD
rs2035057868	1006	M>T		No	Ensembl
rs367709807	1007	R>Q		No	ESP ExAC TOPMed gnomAD
rs370459525 COSM4053487 COSM4053489	1007	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1272354949	1008	H>Y		No	TOPMed gnomAD
rs1436285093	1009	P>S		No	TOPMed gnomAD
rs2035059099	1013	T>A		No	Ensembl
rs754811151	1015	Q>H		No	ExAC TOPMed gnomAD
rs2035059498	1016	R>W		No	Ensembl
rs1596316921	1017	V>E		No	Ensembl
TCGA novel	1019	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1176301432	1019	K>T		No	TOPMed gnomAD
rs1251670485	1020	M>I		No	gnomAD
rs2035060003	1020	M>R		No	TOPMed
rs2035060418	1022	F>L		No	TOPMed gnomAD
rs781362754	1023	V>I		No	ExAC TOPMed gnomAD
rs2035060707	1024	P>A		No	TOPMed gnomAD
rs770068206	1025	V>I		No	ExAC TOPMed gnomAD
rs368567214	1026	G>A		No	ESP ExAC TOPMed gnomAD
rs1299019662	1032	I>K		No	gnomAD
rs1247301494 RCV001902806	1032	I>M		No	ClinVar TOPMed dbSNP gnomAD
rs1299019662	1032	I>T		No	gnomAD
rs749693795	1034	R>Q		No	ExAC TOPMed gnomAD
rs372293144	1034	R>W		No	ESP TOPMed gnomAD
rs1245145585	1035	M>I		No	gnomAD
rs768987575	1035	M>T		No	ExAC gnomAD
rs538312065	1038	S>I		No	1000Genomes ExAC TOPMed gnomAD
rs538312065	1038	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs766117523	1040	A>V		No	ExAC TOPMed gnomAD
rs2035063823	1045	Q>L		No	TOPMed
rs1265360267	1048	E>G		No	gnomAD
rs1208647497	1054	K>E		No	gnomAD
rs1246733997	1055	S>G		No	gnomAD
COSM1300959 rs748456823	1058	R>K	Variant assessed as Somatic; MODERATE impact. urinary_tract [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs2035214274	1059	K>N		No	TOPMed gnomAD
rs2035214454	1061	T>P		No	Ensembl
rs1351909744	1062	I>L		No	TOPMed gnomAD
rs1351909744	1062	I>V		No	TOPMed gnomAD
COSM4053490 COSM4053492	1066	T>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	1067	G>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1178570157	1068	N>K		No	gnomAD
rs2035215310	1070	R>G		No	Ensembl
rs1431147853	1070	R>K		No	gnomAD
COSM261855	1071	N>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs376281560	1072	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs765787797	1072	R>H		No	ExAC gnomAD
rs776235920	1073	C>Y		No	ExAC gnomAD
rs2035216151	1074	S>G		No	gnomAD
rs759296759	1074	S>N		No	ExAC TOPMed gnomAD
rs2035216378	1076	F>L		No	gnomAD
rs2035216496	1077	R>*		No	TOPMed
rs2035216783	1078	V>M		No	Ensembl
rs1018354863	1082	Q>H		No	TOPMed gnomAD
rs1304931060	1083	T>A		No	TOPMed gnomAD
rs539691388 RCV002161480	1084	I>T		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs2035217377	1085	Y>D		No	TOPMed
rs1393239281	1086	W>C		No	TOPMed gnomAD
rs2035217511	1087	Q>*		No	Ensembl
rs1596320974	1088	E>G		No	Ensembl
COSM2200620 rs752554538 COSM2200618	1088	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1321235742	1090	L>F		No	TOPMed gnomAD
rs1287460559	1090	L>H		No	gnomAD
rs1321235742	1090	L>V		No	TOPMed gnomAD
rs1596321002	1092	V>G		No	Ensembl
rs1324636253	1096	G>E		No	gnomAD
rs1266729329	1097	G>C		No	gnomAD
rs1319288561	1097	G>D		No	gnomAD
rs1266729329	1097	G>S		No	gnomAD
rs200404538	1099	L>F		No	1000Genomes ESP ExAC TOPMed gnomAD
rs200404538	1099	L>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1428684279	1102	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs2035287557	1102	E>D		No	TOPMed
rs371351101	1105	D>E		No	ESP ExAC TOPMed gnomAD
RCV002078397 rs78587240	1105	D>N		No	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs200111263	1106	V>L		No	gnomAD
rs200111263	1106	V>M		No	gnomAD
rs1055979271	1107	N>Y		No	TOPMed
rs1396900032	1109	K>Q		No	TOPMed
RCV001980349 rs2141128456	1112	K>Q		No	ClinVar Ensembl dbSNP
rs2035289511	1113	S>N		No	TOPMed
rs762543442	1113	S>R		No	ExAC TOPMed gnomAD
rs768286875 COSM271369	1114	G>R	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs2035290072	1115	G>E		No	Ensembl
rs41425846	1118	I>M		No	ExAC TOPMed gnomAD
rs2035290715	1120	C>W		No	Ensembl
COSM3420178 COSM3420176	1121	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs773055907	1121	Q>R		No	ExAC TOPMed gnomAD
rs1459904257	1124	V>E		No	TOPMed gnomAD
RCV001883045 rs373841325	1125	R>G		No	ClinVar ESP TOPMed dbSNP gnomAD
rs2035291515	1126	D>E		No	Ensembl
COSM4816556 COSM4816554	1128	S>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2035291823	1129	A>D		No	Ensembl
rs2035291659	1129	A>P		No	TOPMed
rs2035292134	1131	A>V		No	gnomAD
rs765327562	1134	T>A		No	ExAC gnomAD
rs61733312	1134	T>K		No	ExAC TOPMed gnomAD
COSM255292 rs61733312	1134	T>M	central_nervous_system [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs61733312	1134	T>R		No	ExAC TOPMed gnomAD
rs1455038791	1135	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs764322028	1135	D>Y		No	ExAC gnomAD
rs1401599388	1137	V>A		No	TOPMed gnomAD
rs537781752	1137	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1202181508	1139	S>A		No	TOPMed gnomAD
TCGA novel	1139	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM3499736 COSM3499738	1142	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	1143	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2035295313	1143	Q>P		No	Ensembl
TCGA novel	1147	A>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs376554922	1147	A>S		No	ExAC TOPMed gnomAD
rs376554922	1147	A>T		No	ExAC TOPMed gnomAD
rs747816549	1149	T>K		No	ExAC TOPMed gnomAD
rs1596326746	1149	T>P		No	Ensembl
rs2035455837	1151	T>I		No	TOPMed
rs2035456492	1154	D>G		No	TOPMed
rs1290143171	1154	D>N		No	TOPMed gnomAD
rs762983452	1155	G>R		No	ExAC TOPMed gnomAD
rs768759171	1156	T>M		No	ExAC gnomAD
rs765489207	1157	P>L		No	Ensembl
rs1283656818	1158	L>V		No	gnomAD
rs767789230	1159	M>V		No	ExAC TOPMed gnomAD
rs1470869746	1161	Q>E		No	Ensembl
rs1281214969	1162	Y>C		No	gnomAD
rs761113327	1163	V>L		No	ExAC TOPMed gnomAD
rs761113327	1163	V>M		No	ExAC TOPMed gnomAD
rs2141132820	1164	P>S		No	Ensembl
rs1222833998	1167	V>I		No	gnomAD
rs2141132873	1169	E>G		No	Ensembl
rs755387791	1169	E>K		No	ExAC gnomAD
rs755387791	1169	E>Q		No	ExAC gnomAD
rs1472484324	1174	Q>P		No	gnomAD
rs1161712901	1175	H>D		No	gnomAD
rs369305577	1176	T>M		No	ESP ExAC TOPMed gnomAD
rs1307730712	1177	D>E		No	TOPMed gnomAD
COSM4922915 COSM4922913	1177	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs758062446	1178	P>L		No	ExAC TOPMed gnomAD
rs758062446	1178	P>R		No	ExAC TOPMed gnomAD
rs960673143	1178	P>S		No	Ensembl
rs960673143	1178	P>T		No	Ensembl
rs777394343	1179	S>N		No	ExAC gnomAD
rs777394343	1179	S>T		No	ExAC gnomAD
rs374717787	1181	K>R		No	ESP ExAC TOPMed gnomAD
rs2035461405	1182	S>P		No	TOPMed
rs1245205004	1183	E>K		No	TOPMed gnomAD
rs2035462081	1184	D>N		No	TOPMed
rs200666835	1185	V>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs200666835	1185	V>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs866854209	1185	V>M		No	gnomAD
RCV001938185 rs373432119	1186	Q>R		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
COSM699625 COSM1646648	1187	Y>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs774585715	1189	D>A		No	ExAC gnomAD
rs769551074	1189	D>H		No	ExAC TOPMed gnomAD
rs769551074	1189	D>N		No	ExAC TOPMed gnomAD
rs532404694	1190	M>L		No	1000Genomes ExAC gnomAD
rs1182348413	1190	M>T		No	TOPMed gnomAD
rs532404694	1190	M>V		No	1000Genomes ExAC gnomAD
rs1367751693	1191	E>D		No	Ensembl
rs773533129	1191	E>K		No	ExAC gnomAD
rs760991902	1192	D>E		No	ExAC gnomAD
rs1460242604	1195	L>R		No	gnomAD
rs754107420	1196	T>M		No	ExAC TOPMed gnomAD
COSM3886703 COSM3886705	1197	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs369473298	1198	I>M		No	ESP ExAC TOPMed gnomAD
RCV002011624 rs1050305838	1198	I>V		No	ClinVar TOPMed dbSNP gnomAD
rs566023115	1199	E>K		No	1000Genomes ExAC gnomAD
rs777443874	1200	R>W		No	ExAC TOPMed gnomAD
rs267604401	1201	D>N		No	Ensembl
rs2035470096	1203	I>M		No	TOPMed gnomAD
TCGA novel	1207	R>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs781044673	1207	R>K		No	ExAC gnomAD
COSM3987869 COSM3987871	1208	H>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1596327227	1208	H>P		No	TOPMed
rs1596327227	1208	H>R		No	TOPMed
rs769826948	1209	P>A		No	ExAC gnomAD
rs774546820 COSM3401592 COSM3401594	1209	P>L	Variant assessed as Somatic; MODERATE impact. central_nervous_system [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs2141133179 RCV001970134	1211	L>missing		No	ClinVar dbSNP
rs2035472094	1211	L>F		No	Ensembl
rs773373328	1212	P>L		No	ExAC TOPMed gnomAD
rs773373328	1212	P>R		No	ExAC TOPMed gnomAD
rs772254004	1212	P>S		No	ExAC gnomAD
rs2035473432	1213	V>A		No	TOPMed
rs199624259	1213	V>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs199624259 RCV001889966	1213	V>M		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs370568105	1214	P>L		No	ESP ExAC TOPMed gnomAD
TCGA novel	1216	Q>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs775945942	1216	Q>P		No	ExAC gnomAD
rs2035474283	1217	E>D		No	gnomAD
COSM6141646 COSM6141648	1217	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2035474433	1221	E>K		No	Ensembl
RCV001927570 rs751030086	1226	D>N		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs2035475124	1227	F>L		No	TOPMed
rs370451042	1228	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP NCI-TCGA gnomAD
rs2035475693	1229	A>P		No	Ensembl
rs2035551848	1232	F>C		No	TOPMed
rs1296908321	1234	E>D		No	TOPMed gnomAD
rs2035552288	1234	E>K		No	TOPMed
rs2035552288	1234	E>Q		No	TOPMed
rs1376209745	1235	N>D		No	TOPMed gnomAD
rs375762978	1236	S>N		No	ESP ExAC TOPMed gnomAD
rs370150056	1237	K>N		No	ESP ExAC gnomAD
rs373500031 RCV002043765	1239	E>Q		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1429110266	1240	H>D		No	TOPMed gnomAD
rs1391459204	1240	H>Q		No	gnomAD
RCV001870506 rs1429110266	1240	H>Y		No	ClinVar TOPMed dbSNP gnomAD
rs780403145	1241	S>I		No	ExAC gnomAD
rs377311326	1241	S>R		No	ESP ExAC TOPMed gnomAD
rs547256891	1242	E>K		No	1000Genomes ExAC TOPMed gnomAD
rs1596329517	1243	D>N		No	Ensembl
rs558530256	1244	E>K		No	ExAC TOPMed gnomAD
rs558530256	1244	E>Q		No	ExAC TOPMed gnomAD
rs1048503724	1245	G>S		No	Ensembl
rs772735483	1246	S>N		No	ExAC gnomAD
rs2035558359	1247	V>A		No	gnomAD
rs200086296	1247	V>I		No	1000Genomes ExAC TOPMed gnomAD
COSM6076724 COSM6076722	1249	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1567271146	1250	Q>E		No	Ensembl
rs1567271167	1251	G>S		No	Ensembl
rs373729202	1252	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs758309073	1256	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
COSM98989 rs201939674	1257	I>V	stomach [Cosmic]	No	cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs1596329644	1258	Y>S		No	Ensembl
rs200606953	1259	R>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs200606953 RCV002088502	1259	R>Q		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs750451092	1259	R>W		No	ExAC TOPMed gnomAD
rs2035561045	1260	A>S		No	TOPMed
RCV002023332 rs199933427	1261	R>Q		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs780250032	1261	R>W		No	ExAC TOPMed gnomAD
rs2035561515	1263	Q>*		No	TOPMed
rs2035561665	1264	G>S		No	TOPMed
rs1338947308	1266	P>S		No	gnomAD
rs966424843	1267	V>M		No	Ensembl
rs2035562257	1268	A>V		No	Ensembl
rs779284426	1269	V>I		No	ExAC TOPMed gnomAD
rs2035562719	1270	K>E		No	gnomAD
rs748630672	1271	R>C		No	ExAC TOPMed gnomAD
rs748630672	1271	R>G		No	ExAC TOPMed gnomAD
rs199804667 COSM959634 RCV001922161	1271	R>H	endometrium [Cosmic]	No	cosmic curated ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs199804667	1271	R>P		No	ESP ExAC TOPMed gnomAD
rs748630672	1271	R>S		No	ExAC TOPMed gnomAD
rs911429879	1272	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
rs1184937563	1277	F>C		No	gnomAD
rs778455063 COSM4699246 COSM4699244	1277	F>I	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
rs1413148326	1277	F>L		No	TOPMed
rs1487742727	1278	K>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs893772249	1279	N>K		No	TOPMed gnomAD
rs2035565605	1281	A>S		No	gnomAD
rs1474867399	1281	A>V		No	gnomAD
rs539324349	1282	N>K		No	1000Genomes ExAC gnomAD
rs752497934	1283	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs752497934	1283	V>L		No	ExAC TOPMed gnomAD
rs1466480542	1284	P>A		No	gnomAD
rs145412332	1284	P>L		No	1000Genomes TOPMed gnomAD
rs145412332	1284	P>Q		No	1000Genomes TOPMed gnomAD
COSM4995548 COSM4995550	1287	T>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1433263726	1287	T>S		No	TOPMed gnomAD
rs765481948	1288	M>T		No	ExAC TOPMed gnomAD
rs2035580324	1289	L>P		No	Ensembl
rs1301601156	1290	R>K		No	gnomAD
rs1363417994	1291	H>N		No	gnomAD
rs895020670	1292	L>M		No	Ensembl
rs2035580980	1292	L>P		No	TOPMed gnomAD
rs1335061632	1293	R>Q		No	TOPMed gnomAD
COSM5462428 COSM5462426 rs367837232	1293	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs1310793939	1295	T>I		No	gnomAD
rs2035582349	1296	D>A		No	Ensembl
rs778478182	1296	D>N		No	ExAC TOPMed gnomAD
rs1289159562	1297	A>T		No	gnomAD
rs757799461	1298	M>I		No	ExAC gnomAD
rs1210847045	1298	M>T		No	gnomAD
rs201354127	1298	M>V		No	1000Genomes ExAC TOPMed gnomAD
rs780853666	1299	K>T		No	ExAC gnomAD
COSM5717826 COSM5717828	1302	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs966747263	1303	E>K		No	TOPMed
rs2035583922	1304	F>L		No	Ensembl
rs745327307 RCV001924928	1305	R>G		No	ClinVar ExAC dbSNP gnomAD
TCGA novel	1305	R>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2035584057	1305	R>Q		No	TOPMed gnomAD
COSM3499744 COSM3499742 rs745327307	1305	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
COSM4053496 COSM4053498	1307	E>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1387346638	1307	E>D		No	gnomAD
rs575599729	1308	A>T		No	1000Genomes ExAC gnomAD
rs1163597995	1308	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1389600474	1309	S>G		No	gnomAD
rs1333289419	1310	M>T		No	TOPMed gnomAD
rs768518027	1312	H>Q		No	ExAC TOPMed gnomAD
rs774091908	1313	A>T		No	ExAC TOPMed gnomAD
RCV002015664 rs761740855 COSM5362907 COSM5362909	1313	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs1032474692	1314	L>M		No	TOPMed gnomAD
rs1251097645	1315	Q>*		No	gnomAD
rs1337938231	1316	H>Q		No	gnomAD
COSM3499747 COSM3499745	1317	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2035586523	1317	P>T		No	TOPMed gnomAD
rs564762598	1320	V>L		No	1000Genomes ExAC TOPMed gnomAD
rs564762598	1320	V>M		No	1000Genomes ExAC TOPMed gnomAD
rs1343146624	1321	A>T		No	TOPMed
RCV001867793 COSM124206 rs759654951	1321	A>V	upper_aerodigestive_tract [Cosmic]	No	cosmic curated ClinVar ExAC TOPMed dbSNP gnomAD
rs1381857016	1322	L>F		No	TOPMed gnomAD
rs764587553	1324	G>A		No	ExAC gnomAD
rs1372221915	1324	G>R		No	TOPMed gnomAD
rs1372221915	1324	G>S		No	TOPMed gnomAD
rs1172705479	1325	I>T		No	gnomAD
rs2035588745	1325	I>V		No	Ensembl
COSM3815678 COSM3815680	1326	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs751906540	1326	S>G		No	ExAC gnomAD
rs757854467	1326	S>T		No	ExAC
rs1596330624	1328	H>P		No	Ensembl
rs965565930	1328	H>Y		No	TOPMed gnomAD
rs1380724814	1329	P>L		No	gnomAD
rs1294484281	1330	L>R		No	gnomAD
rs1325029974	1331	C>Y		No	gnomAD
rs1029846060	1333	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs768226866	1335	E>D		No	ExAC gnomAD
rs1370626875	1335	E>G		No	TOPMed gnomAD
rs918860460	1336	L>F		No	Ensembl
rs918860460	1336	L>V		No	Ensembl
rs1483658995	1337	A>T		No	TOPMed gnomAD
rs772060404	1337	A>V		No	ExAC gnomAD
rs200335851	1338	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs200335851	1338	P>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1424097791	1340	S>C		No	gnomAD
rs1230648334	1343	N>K		No	gnomAD
rs1360380885	1344	T>A		No	TOPMed gnomAD
rs1360380885	1344	T>S		No	TOPMed gnomAD
rs2035594377	1345	V>L		No	Ensembl
rs1251141495	1347	S>F		No	TOPMed
RCV001953961 rs779620336	1348	E>A		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs750960615	1348	E>K		No	ExAC TOPMed gnomAD
rs750960615	1348	E>Q		No	ExAC TOPMed gnomAD
TCGA novel	1349	N>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2035596234	1350	A>D		No	Ensembl
RCV000967395 rs77202443	1350	A>T		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1304127213	1351	R>G		No	gnomAD
rs566579135	1352	D>E		No	ExAC TOPMed gnomAD
rs1567272318	1352	D>N		No	Ensembl
rs55727462	1352	D>V		No	ExAC TOPMed gnomAD
TCGA novel	1353	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1297029520	1356	I>V		No	gnomAD
rs1379186022	1357	P>T		No	gnomAD
rs1206866127	1360	H>N		No	TOPMed
rs1314503355	1366	I>M		No	gnomAD
rs1567274364	1366	I>N	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1281760625	1366	I>T		No	gnomAD
rs1447669595	1366	I>V		No	TOPMed gnomAD
rs2035711710	1371	A>D		No	gnomAD
rs760940198	1371	A>P		No	ExAC gnomAD
rs760940198	1371	A>T		No	ExAC gnomAD
rs766947451	1372	S>L		No	ExAC TOPMed gnomAD
rs766947451	1372	S>W		No	ExAC TOPMed gnomAD
rs1354255288	1374	L>P		No	TOPMed
rs1203719103	1375	A>V		No	gnomAD
rs368406955	1376	Y>C		No	ESP ExAC TOPMed gnomAD
rs1178672341	1378	H>Q		No	gnomAD
rs758064403	1379	K>N		No	ExAC gnomAD
rs1304499816	1380	K>R		No	Ensembl
rs763640946	1381	N>K		No	ExAC TOPMed gnomAD
rs1183240932	1384	F>I		No	gnomAD
COSM3420179 COSM3420181	1389	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs956247305	1392	I>V		No	TOPMed gnomAD
TCGA novel	1393	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2035716118	1394	V>L		No	TOPMed gnomAD
rs2035716597	1395	W>C		No	TOPMed gnomAD
rs1403131690	1395	W>R		No	gnomAD
rs2035716747	1396	S>F		No	TOPMed
rs2035717159	1397	L>F		No	TOPMed
rs1415733977	1398	D>V		No	TOPMed
rs2141140546	1399	V>G		No	Ensembl
RCV002009237 rs756048864	1399	V>I		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs779146929	1400	K>*		No	ExAC TOPMed gnomAD
rs779146929	1400	K>E		No	ExAC TOPMed gnomAD
rs748220756	1400	K>T		No	ExAC gnomAD
rs772400768	1401	E>Q		No	ExAC gnomAD
rs1232673293	1402	H>P		No	TOPMed
rs1379599094	1402	H>Q		No	gnomAD
rs2035719020	1402	H>Y		No	TOPMed
rs1213816191	1403	I>V		No	TOPMed gnomAD
rs757356517	1407	L>P		No	ExAC gnomAD
rs757356517	1407	L>R		No	ExAC gnomAD
rs1261894228	1409	D>E		No	gnomAD
rs2035721261	1409	D>G		No	gnomAD
rs41527944	1410	Y>*		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1211781027 RCV001890815	1411	G>R		No	ClinVar dbSNP gnomAD
rs1254240956	1412	I>F		No	TOPMed
COSM3499753 rs558517232 COSM3499751	1413	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA gnomAD
COSM215599 rs763849093	1421	A>T	central_nervous_system [Cosmic]	No	cosmic curated ExAC gnomAD
COSM2156666 COSM2156664 rs767219901	1424	V>M	Variant assessed as Somatic; MODERATE impact. central_nervous_system [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs750184775	1425	E>G		No	ExAC gnomAD
rs1296053613	1425	E>K		No	gnomAD
rs1038771788	1428	P>T		No	TOPMed
rs780131853	1429	G>A		No	ExAC gnomAD
rs780131853	1429	G>D		No	ExAC gnomAD
TCGA novel	1430	Y>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1326547383	1434	E>*		No	Ensembl
rs752860998	1434	E>A		No	ExAC TOPMed gnomAD
rs1348226308	1437	P>S		No	TOPMed gnomAD
rs199787324 RCV001981432	1438	R>C		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs777857679	1438	R>H		No	ExAC TOPMed gnomAD
rs371409478	1439	I>V		No	ESP ExAC TOPMed gnomAD
rs1157031419	1440	V>I		No	TOPMed gnomAD
rs2035728059	1443	E>Q		No	Ensembl
rs771887826	1446	D>Y		No	ExAC TOPMed gnomAD
rs772974207	1447	M>I		No	ExAC gnomAD
rs1443987546	1450	Y>C		No	TOPMed gnomAD
rs1448841245	1452	M>I		No	TOPMed gnomAD
rs2035840467	1452	M>T		No	gnomAD
rs61733306	1455	Y>*		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1408511714	1456	E>K		No	gnomAD
TCGA novel rs2035842834	1462	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs1330683300	1462	R>H		No	TOPMed gnomAD
rs765212080	1463	P>A		No	ExAC TOPMed gnomAD
rs751661175	1464	A>V		No	ExAC gnomAD
rs559486146	1468	H>Q		No	ExAC TOPMed gnomAD
rs756290924	1471	Q>H		No	ExAC TOPMed gnomAD
rs750667752	1471	Q>L		No	ExAC TOPMed gnomAD
rs780409265	1472	I>T		No	ExAC TOPMed gnomAD
rs2035844672	1474	K>E		No	TOPMed
rs1567276891	1475	K>N		No	TOPMed gnomAD
rs1399409229	1478	K>N		No	gnomAD
rs755499854	1478	K>R		No	ExAC TOPMed gnomAD
COSM699621 COSM1646646	1480	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs377318134	1480	I>N		No	ESP ExAC TOPMed gnomAD
COSM959638	1481	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs747660022	1481	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
RCV001965690 rs2035845790	1482	P>L		No	ClinVar TOPMed dbSNP gnomAD
rs2035845790	1482	P>Q		No	TOPMed gnomAD
rs2035846282	1485	G>R		No	TOPMed
rs201964335	1487	P>L		No	ESP ExAC TOPMed gnomAD
rs1197526686	1488	E>K		No	gnomAD
rs1197526686	1488	E>Q		No	gnomAD
rs1246033369	1489	E>*		No	gnomAD
rs1277995966	1489	E>D		No	gnomAD
rs1201085096	1491	Q>K		No	1000Genomes gnomAD
rs367806940	1493	R>P		No	ESP ExAC TOPMed gnomAD
rs367806940 RCV001906415	1493	R>Q		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs374925554	1493	R>W		No	ESP ExAC TOPMed gnomAD
rs775480216	1494	R>L		No	ExAC TOPMed gnomAD
rs775480216	1494	R>P		No	ExAC TOPMed gnomAD
rs775480216	1494	R>Q		No	ExAC TOPMed gnomAD
rs1187939898	1495	L>M		No	gnomAD
rs2141144473	1496	Q>R		No	Ensembl
rs767617347 COSM171440	1497	A>V	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs756382869	1498	L>F		No	ExAC gnomAD
rs376349366	1500	M>L		No	ESP ExAC TOPMed gnomAD
rs755347885	1501	E>K		No	ExAC gnomAD
rs1396270675	1502	C>*		No	TOPMed gnomAD
rs2035849580	1503	W>*		No	TOPMed
rs779096886	1505	T>S		No	ExAC gnomAD
rs1220993308	1507	P>S		No	gnomAD
rs1378059560	1510	R>*		No	TOPMed gnomAD
rs1378059560	1510	R>G		No	TOPMed gnomAD
rs2035912573	1510	R>Q		No	TOPMed
rs909700518	1511	P>L		No	TOPMed gnomAD
rs749075771	1512	L>P		No	ExAC gnomAD
rs749075771	1512	L>Q		No	ExAC gnomAD
rs1349671116	1513	A>D		No	gnomAD
rs761689956	1516	V>A		No	ExAC gnomAD
rs2035913766	1516	V>M		No	TOPMed
rs771073835	1517	V>M		No	ExAC gnomAD
rs765366973	1518	S>R		No	ExAC gnomAD
rs759816169	1518	S>T		No	ExAC
rs2035914868	1520	M>I		No	Ensembl
rs753181668	1521	K>M		No	ExAC TOPMed gnomAD
RCV001929237 rs753181668	1521	K>R		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs2035915220	1523	P>L		No	TOPMed gnomAD
COSM4932196 COSM4932194	1525	F>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs764746962	1526	A>V		No	ExAC gnomAD
TCGA novel	1527	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs369644113	1527	T>I		No	ESP ExAC TOPMed gnomAD
RCV002010190 rs2141146629	1528	F>L		No	ClinVar Ensembl dbSNP
rs1436564385	1529	M>T		No	gnomAD
COSM2200724 COSM959640	1529	M>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2035916292	1530	Y>C		No	Ensembl
rs2141146653	1533	C>R		No	Ensembl
TCGA novel	1534	C>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2141146664	1534	C>Y		No	1000Genomes
rs1347163852	1536	K>T		No	TOPMed gnomAD
TCGA novel	1537	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1177495292	1538	T>A		No	TOPMed gnomAD
rs2035917156	1539	A>V		No	TOPMed
rs377128940	1540	F>L		No	ESP TOPMed gnomAD
rs749127854	1540	F>S		No	ExAC TOPMed gnomAD
rs779646604	1540	F>V		No	ExAC TOPMed gnomAD
COSM4827086 COSM4827084	1542	S>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM282561	1543	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1345169860	1543	S>P		No	TOPMed gnomAD
rs1373624280	1545	G>C		No	Ensembl
rs1373624280	1545	G>R		No	Ensembl
rs1465581413	1546	Q>R		No	gnomAD
rs1316812128	1547	E>D		No	TOPMed gnomAD
rs754789492	1548	Y>N		No	ExAC gnomAD
rs778638365	1549	T>A		No	ExAC gnomAD
rs1378137531	1550	V>M		No	TOPMed gnomAD
rs2035919622	1552	F>L		No	TOPMed
rs771844282	1554	D>N		No	ExAC gnomAD
rs776831970	1556	K>E		No	ExAC TOPMed gnomAD
rs1567278927	1556	K>N		No	Ensembl
rs1335332740	1558	E>D		No	gnomAD
COSM699619 COSM1646645	1558	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs531262021	1559	S>A		No	1000Genomes ExAC TOPMed gnomAD
rs778249403	1559	S>Y		No	gnomAD
COSM5178767 COSM1375696	1560	R>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs774839951	1563	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1357322729	1563	T>P		No	TOPMed gnomAD
rs2036154581	1564	V>E		No	TOPMed
rs1364955563	1566	N>D		No	gnomAD
rs2036155502	1568	E>K		No	TOPMed gnomAD
rs2036155635	1569	K>T		No	Ensembl
rs1220581195	1570	G>R		No	gnomAD
rs761200124	1571	L>F		No	ExAC TOPMed gnomAD
rs1288624627	1572	M>I		No	gnomAD
COSM6076713 COSM6076715	1572	M>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1214844164	1572	M>R		No	TOPMed gnomAD
rs765878640	1572	M>V		No	ExAC gnomAD
rs371591965	1574	V>L		No	ESP TOPMed gnomAD
rs371591965	1574	V>M		No	ESP TOPMed gnomAD
rs61733307	1577	M>I		No	ExAC TOPMed gnomAD
TCGA novel	1577	M>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1484972951	1578	C>Y		No	TOPMed
rs2036157220	1579	C>S		No	Ensembl
rs1194473412	1580	P>S		No	gnomAD
COSM1300963	1582	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1379874070	1582	M>L		No	TOPMed gnomAD
rs1156549086	1583	K>N		No	gnomAD
rs752579784	1583	K>R		No	ExAC gnomAD
RCV001955771 rs2141154262	1585	S>N		No	ClinVar Ensembl dbSNP
rs758106459	1585	S>R		No	ExAC TOPMed gnomAD
rs757198351	1587	Q>H		No	ExAC TOPMed gnomAD
rs1442511934	1589	Q>*		No	gnomAD
rs2141154307	1589	Q>R		No	Ensembl
rs749368396	1590	V>A		No	ExAC TOPMed gnomAD
rs2036159011	1590	V>I		No	TOPMed gnomAD
rs2036159501	1591	Q>R		No	TOPMed
rs769036375	1593	S>C		No	ExAC gnomAD
rs1311911108	1593	S>P		No	gnomAD
rs2036159888	1594	L>M		No	TOPMed
rs2141154365	1594	L>R		No	Ensembl
rs748349627	1597	A>G		No	ExAC gnomAD
rs748349627	1597	A>V		No	ExAC gnomAD
rs1214343969	1598	T>I		No	gnomAD
rs773558472	1599	E>K		No	ExAC TOPMed gnomAD
rs747368593	1600	D>H		No	ExAC gnomAD
rs747368593	1600	D>N		No	ExAC gnomAD
rs777102768	1601	Q>E		No	ExAC gnomAD
RCV001910683 rs759987456	1601	Q>L		No	ClinVar ExAC dbSNP gnomAD
rs759987456	1601	Q>R		No	ExAC gnomAD
rs2141156873	1604	Y>H		No	Ensembl
rs779968095	1605	I>M		No	Ensembl
rs1253802771	1607	T>I		No	TOPMed gnomAD
TCGA novel	1608	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2036250396	1608	L>V		No	TOPMed
rs1255284630	1612	C>S		No	TOPMed gnomAD
rs761675199	1615	N>S		No	ExAC gnomAD
rs2141156925	1616	T>A		No	Ensembl
rs1465226737	1616	T>I		No	gnomAD
rs1465226737	1616	T>K		No	gnomAD
rs767370051	1617	P>S		No	ExAC gnomAD
rs2036251893	1618	Q>K		No	TOPMed gnomAD
rs756045028	1619	Q>H		No	ExAC gnomAD
rs2036252196	1619	Q>K		No	Ensembl
rs2141156955	1619	Q>R		No	Ensembl
rs765244575	1620	A>V		No	ExAC gnomAD
rs1567285251	1621	L>W		No	Ensembl
TCGA novel	1622	D>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1000097370	1624	P>L		No	Ensembl
rs903026949	1624	P>S		No	TOPMed gnomAD
rs753877975	1626	V>A		No	gnomAD
COSM4970009 COSM4970011 rs778024046	1627	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1033347216	1629	C>S		No	Ensembl
rs2036254147	1631	L>*		No	gnomAD
COSM5178768 COSM1375698	1632	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs552313052	1633	V>M		No	1000Genomes ExAC TOPMed gnomAD
rs1484812789	1634	P>A		No	gnomAD
rs1567285333	1634	P>L		No	Ensembl
TCGA novel	1634	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2036255295	1635	V>A		No	Ensembl
rs932536919	1636	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
RCV001355138 rs746379912	1637	K>*		No	ClinVar ExAC dbSNP gnomAD
rs746379912	1637	K>E		No	ExAC gnomAD
COSM959642	1637	K>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs770281170	1637	K>R		No	ExAC TOPMed gnomAD
rs2036468764	1640	S>P		No	TOPMed gnomAD
rs1471018022	1642	L>R		No	TOPMed gnomAD
rs2036469044	1643	V>I		No	Ensembl
rs1359787858	1645	A>V		No	TOPMed gnomAD
rs1412941091	1646	G>D		No	TOPMed gnomAD
rs572219729	1648	A>S		No	1000Genomes ExAC TOPMed gnomAD
rs572219729 RCV002014704	1648	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinVar 1000Genomes ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs764163827	1649	D>N		No	ExAC TOPMed gnomAD
rs1185932993	1651	L>P		No	Ensembl
rs762084426	1652	V>L		No	ExAC gnomAD
rs767727219	1653	A>T		No	ExAC TOPMed gnomAD
rs750797544	1653	A>V		No	ExAC TOPMed gnomAD
rs76666049	1654	V>G		No	ExAC gnomAD
rs754370308	1655	F>V		No	ExAC gnomAD
rs74775581	1656	P>A		No	ExAC gnomAD
rs74775581	1656	P>S		No	ExAC gnomAD
TCGA novel	1657	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs200281447	1657	V>M		No	ExAC TOPMed gnomAD
rs370180202	1659	R>P		No	ESP ExAC TOPMed gnomAD
rs370180202	1659	R>Q		No	ESP ExAC TOPMed gnomAD
COSM4053507 COSM4053505 rs1015630432	1659	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs770791811	1660	G>A		No	ExAC TOPMed gnomAD
TCGA novel	1660	G>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs770791811 RCV001998392	1660	G>D		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs1412835234	1660	G>S		No	gnomAD
rs1596359228	1661	T>A		No	Ensembl
rs769709976	1661	T>N		No	ExAC gnomAD
rs1596359228	1661	T>P		No	Ensembl
rs373755921	1662	P>L		No	ESP ExAC gnomAD
rs570984561	1664	D>N		No	Ensembl
rs1484921427	1665	S>C		No	gnomAD
rs1484921427	1665	S>G		No	gnomAD
rs1190652512	1665	S>R		No	TOPMed gnomAD
rs750686458	1666	C>Y		No	ExAC gnomAD
rs760737980	1667	S>F		No	ExAC TOPMed gnomAD
rs760737980	1667	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs2036475933	1668	Y>*		No	Ensembl
rs2036475790	1668	Y>S		No	gnomAD
rs2141163286 RCV001929049	1670	C>G		No	ClinVar Ensembl dbSNP
rs2141163286	1670	C>S		No	Ensembl
COSM1375700 COSM5130294	1670	C>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1302269451	1671	S>*		No	TOPMed gnomAD
rs371053735	1671	S>T		No	ESP ExAC TOPMed gnomAD
rs555149433	1672	H>Q		No	TOPMed gnomAD
rs375652666	1672	H>R		No	ESP ExAC TOPMed gnomAD
rs779529883	1674	A>T		No	ExAC gnomAD
rs2036476787	1676	R>S		No	TOPMed
rs1356555427	1677	S>F		No	TOPMed
rs2036477041	1678	K>R		No	TOPMed
TCGA novel	1679	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2036477334	1680	S>N		No	Ensembl
COSM959646 rs777107638	1682	A>T	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
RCV001904355 rs368322542	1682	A>V		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs745649117	1683	D>Y		No	ExAC gnomAD
rs1166044505	1685	D>G		No	TOPMed
rs370749356	1686	A>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs370749356	1686	A>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs772139995	1687	R>Q		No	ExAC TOPMed gnomAD
rs373893782	1687	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs1213403128	1689	N>I		No	TOPMed gnomAD
rs1281510100	1690	P>L		No	gnomAD
rs2036479949	1691	Y>C		No	Ensembl
rs2036479708	1691	Y>H		No	Ensembl
rs2036480477	1694	K>Q		No	Ensembl
rs2036480943	1696	M>I		No	Ensembl
rs957642850	1696	M>T		No	TOPMed
rs189062191	1700	N>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs189062191	1700	N>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs913687680	1702	G>D		No	Ensembl
COSM1735675 RCV002088628 rs78605716	1702	G>S	pancreas [Cosmic]	No	cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs372292557 RCV002026000	1703	S>Y		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1400025585	1705	V>I		No	gnomAD
rs1596359545	1710	G>E		No	Ensembl
rs758909087	1711	P>L		No	ExAC gnomAD
rs1316190212	1711	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs751022115	1715	V>I		No	ExAC TOPMed gnomAD
rs2036483848	1717	D>A		No	TOPMed gnomAD
rs780680269	1717	D>N		No	ExAC TOPMed gnomAD
rs745716119	1718	C>F		No	ExAC
rs1304619504	1719	A>T		No	gnomAD
rs2036484338	1719	A>V		No	Ensembl
rs76740676	1720	S>P		No	Ensembl
rs1222535802	1724	C>S		No	gnomAD
rs2036485106	1725	R>G		No	TOPMed
rs779753081	1726	R>L		No	ExAC gnomAD
rs779753081	1726	R>Q		No	ExAC gnomAD
rs77374252	1726	R>W		No	Ensembl
rs2141163568	1727	L>V		No	Ensembl
rs2141163581	1728	E>G		No	Ensembl
rs1194569505	1730	Y>*		No	TOPMed gnomAD
rs374196433	1730	Y>C		No	ESP ExAC gnomAD
rs2141163590	1730	Y>H		No	Ensembl
rs771231472	1731	M>T		No	ExAC gnomAD
COSM4932755 COSM4932757 rs921178428	1731	M>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1469472150	1732	A>V		No	gnomAD
rs2141163629	1733	P>S		No	Ensembl
rs775143193	1735	M>I		No	TOPMed gnomAD
rs765702635	1735	M>T		No	ExAC TOPMed gnomAD
rs3829706 RCV000879392	1735	M>V		No	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs1391730839	1737	T>A		No	gnomAD
COSM1640190 rs939725500 COSM1640192	1737	T>M	Variant assessed as Somatic; MODERATE impact. stomach [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs2036487593	1738	S>*		No	gnomAD
COSM959650 rs763615713	1740	V>M	endometrium [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs549997085	1741	C>*		No	1000Genomes ExAC gnomAD
rs1228022677	1742	S>N		No	TOPMed
rs1351947491	1742	S>R		No	gnomAD
rs1348798423	1744	E>G		No	TOPMed gnomAD
rs751124500	1744	E>K		No	ExAC gnomAD
rs756702653	1745	G>C		No	ExAC TOPMed gnomAD
rs1337102657	1745	G>D		No	gnomAD
rs756702653	1745	G>S		No	ExAC TOPMed gnomAD
rs2036489109	1747	G>R		No	Ensembl
rs1390431435	1748	E>K		No	TOPMed
rs750110863	1748	E>V		No	ExAC
rs755701846	1750	V>F		No	ExAC TOPMed gnomAD
rs755701846	1750	V>I		No	ExAC TOPMed gnomAD
rs754980135	1751	V>G		No	ExAC gnomAD
rs373452117	1751	V>I		No	ESP ExAC TOPMed gnomAD
rs1036301171	1752	W>L		No	TOPMed
rs1409394167	1754	L>M		No	TOPMed gnomAD
rs1023161317	1756	D>N		No	Ensembl
rs1165040188	1757	K>Q		No	gnomAD
rs766954384	1759	N>S		No	TOPMed
rs766954384	1759	N>T		No	TOPMed
rs2141163805	1760	S>A		No	Ensembl
rs770946839	1760	S>Y		No	ExAC TOPMed gnomAD
rs1331291177	1761	L>F		No	gnomAD
rs373287839	1763	M>L		No	ESP ExAC TOPMed gnomAD
rs770129962	1763	M>T		No	ExAC gnomAD
rs1003141890	1766	S>F		No	Ensembl
rs1357947247	1767	T>I		No	TOPMed gnomAD
rs763381102	1768	T>A		No	ExAC gnomAD
rs763381102	1768	T>P		No	ExAC gnomAD
rs2141163866	1768	T>S		No	Ensembl
TCGA novel	1770	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs762344317	1770	Q>R		No	ExAC TOPMed gnomAD
rs2036493750	1771	L>P		No	gnomAD
rs2036494044	1773	A>G		No	TOPMed gnomAD
rs2036494044	1773	A>V		No	TOPMed gnomAD
rs201726240	1774	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs749917918	1777	C>W		No	ExAC TOPMed gnomAD
rs146084570	1778	G>R		No	1000Genomes ExAC gnomAD
rs3764738 RCV002210770	1779	V>D		No	ClinVar 1000Genomes ExAC dbSNP gnomAD
rs751445121	1779	V>F		No	ExAC TOPMed gnomAD
rs779167127	1780	P>S		No	ExAC gnomAD
rs1299597590	1781	S>T		No	Ensembl
rs2141163958	1784	R>G		No	Ensembl
rs1397616623	1784	R>T		No	gnomAD
COSM5135565 COSM1375702	1786	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2036496378	1786	M>T		No	TOPMed gnomAD
TCGA novel	1786	M>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs745940472	1789	V>A		No	ExAC gnomAD
rs536296948	1789	V>L		No	1000Genomes ExAC TOPMed gnomAD
COSM470423 rs536296948	1789	V>M	kidney Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs749481480	1790	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs780403978	1790	R>W		No	ExAC TOPMed gnomAD
rs768937350	1791	P>S		No	ExAC gnomAD
rs2036497816	1793	D>V		No	gnomAD
rs1270951065	1793	D>Y		No	TOPMed gnomAD
rs368408781	1794	T>A		No	ESP ExAC TOPMed gnomAD
RCV001997559 rs772559934	1794	T>M		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs368408781	1794	T>P		No	ESP ExAC TOPMed gnomAD
rs1596360339	1795	E>D		No	Ensembl
rs753519057 RCV002016988	1797	P>L		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs1333712810	1797	P>S		No	gnomAD
TCGA novel	1798	A>G	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs764953988	1798	A>T		No	ExAC gnomAD
rs752524474	1802	T>M		No	ExAC TOPMed gnomAD
rs752524474	1802	T>R		No	ExAC TOPMed gnomAD
VAR_040674	1803	A>T		No	UniProt
rs912178976	1804	N>D		No	gnomAD
rs200557780	1804	N>K		No	TOPMed gnomAD
rs750583241	1804	N>S		No	ExAC gnomAD
rs199974382	1805	P>L		No	1000Genomes ExAC TOPMed gnomAD
rs1485930820	1807	V>A		No	gnomAD
COSM4833774 COSM4833776 rs749480379	1809	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs2036501336	1810	G>E		No	gnomAD
rs2036501221	1810	G>R		No	gnomAD
rs1319081084	1811	D>Y		No	TOPMed gnomAD
rs768906258	1812	S>P		No	ExAC TOPMed gnomAD
rs35787282 RCV002135663	1814	A>T		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1349850721	1814	A>V		No	gnomAD
rs2036502391	1815	D>Y		No	TOPMed
rs377185660 RCV001940229	1816	V>M		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs2036502966	1817	S>T		No	Ensembl
rs1248109013	1818	I>V		No	TOPMed gnomAD
rs1455010578	1819	M>I		No	gnomAD
rs764939883	1819	M>T		No	ExAC TOPMed gnomAD
COSM959652 rs368591954	1819	M>V	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs2141164235	1820	Y>*		No	Ensembl
rs1158867051	1821	S>G		No	TOPMed gnomAD
VAR_040675	1824	L>F		No	UniProt
rs2141164255	1824	L>R		No	Ensembl
rs775190189	1826	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1372045084	1830	I>M		No	gnomAD
rs542657977	1830	I>T		No	1000Genomes ExAC TOPMed gnomAD
rs1441885748	1831	H>Q		No	TOPMed gnomAD
rs1387083676	1831	H>Y		No	TOPMed gnomAD
rs757198165	1832	Q>E		No	ExAC TOPMed gnomAD
RCV000953700 rs35128996	1835	L>F		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs755191615	1837	D>H		No	ExAC TOPMed gnomAD
rs755191615	1837	D>N		No	ExAC TOPMed gnomAD
rs1483594310	1839	C>G		No	TOPMed
rs779170016	1841	M>T		No	ExAC TOPMed gnomAD
rs2036506840	1841	M>V		No	Ensembl
rs1254447279	1842	S>Y		No	TOPMed gnomAD
rs1359017884	1844	Y>N		No	TOPMed
rs1285277039	1845	S>Y		No	TOPMed
rs201730508	1846	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
VAR_040676	1847	S>N		No	UniProt
rs968761875	1849	P>R		No	TOPMed
rs1021604666	1849	P>S		No	gnomAD
RCV000893714 rs41525944	1850	R>C		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
COSM554333 rs200771530 RCV002143539	1850	R>H	lung [Cosmic]	No	cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs200771530	1850	R>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs41525944	1850	R>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1167224033	1852	A>P		No	TOPMed gnomAD
rs776071685	1853	A>S		No	ExAC TOPMed gnomAD
rs776071685	1853	A>T		No	ExAC TOPMed gnomAD
rs769383028	1854	R>S		No	ExAC TOPMed gnomAD
rs2036509650	1854	R>T		No	TOPMed
rs61733308	1855	S>A		No	TOPMed gnomAD
RCV001997772 rs2141164457	1855	S>C		No	ClinVar Ensembl dbSNP
rs61733308	1855	S>P		No	TOPMed gnomAD
rs61733308	1855	S>T		No	TOPMed gnomAD
rs1393040389	1856	P>L		No	gnomAD
rs1393040389	1856	P>R		No	gnomAD
rs1415696374	1857	S>T		No	TOPMed
rs34874770 RCV002191681	1858	S>N		No	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs1251572799	1860	P>S		No	TOPMed gnomAD
rs774234138	1861	S>G		No	ExAC
rs761904263	1861	S>I		No	ExAC TOPMed gnomAD
rs767454605	1863	P>S		No	ExAC gnomAD
rs753910283	1864	A>P		No	ExAC gnomAD
rs1381987505	1865	S>G		No	gnomAD
rs1396906691	1868	S>T		No	gnomAD
TCGA novel	1869	V>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2036512516	1869	V>M		No	TOPMed
rs758557491	1870	P>L		No	ExAC
rs752966389	1870	P>S		No	ExAC gnomAD
TCGA novel	1871	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs778168227	1873	T>S		No	ExAC gnomAD
rs565686156	1874	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1414704844	1875	C>F		No	TOPMed gnomAD
rs1414704844	1875	C>Y		No	TOPMed gnomAD
rs769380465	1876	E>G		No	ExAC TOPMed gnomAD
rs369774424 RCV001974779	1876	E>K		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs931027800	1879	D>E		No	TOPMed gnomAD
rs1463294287	1880	M>K		No	gnomAD
rs373539914	1881	L>R		No	ESP TOPMed
rs2036515093	1883	T>A		No	Ensembl
rs3764740	1883	T>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs3764740	1883	T>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1214470436	1884	P>S		No	gnomAD
rs2141164642	1885	G>D		No	Ensembl
rs377202593	1885	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs1175694807	1886	A>V		No	TOPMed
COSM470425	1888	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1292951232	1889	D>E		No	gnomAD
rs770606570	1889	D>N		No	ExAC TOPMed gnomAD
rs760461091	1893	H>N		No	ExAC TOPMed gnomAD
rs1206245367	1893	H>R		No	gnomAD
rs760461091	1893	H>Y		No	ExAC TOPMed gnomAD
rs1484972583	1896	T>I		No	gnomAD
rs763228498	1897	P>L		No	ExAC gnomAD
rs370127139	1897	P>S		No	ESP ExAC TOPMed gnomAD
rs370127139	1897	P>T		No	ESP ExAC TOPMed gnomAD
TCGA novel	1898	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs764270132	1898	M>T		No	ExAC gnomAD
rs1475147925	1898	M>V		No	TOPMed gnomAD
rs367810590	1899	D>E		No	ESP ExAC TOPMed gnomAD
TCGA novel rs2036519004	1899	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs537362756	1900	G>R		No	1000Genomes ExAC TOPMed gnomAD
rs2036519586	1901	E>D		No	TOPMed
rs756523500	1901	E>G		No	ExAC gnomAD
rs558418183	1901	E>K		No	1000Genomes ExAC TOPMed gnomAD
rs558418183	1901	E>Q		No	1000Genomes ExAC TOPMed gnomAD
rs1432762901	1902	T>I		No	gnomAD
rs779676368 RCV002048897	1903	F>C		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs1359707750	1904	S>R		No	gnomAD
rs748772285	1905	Q>*		No	ExAC gnomAD
rs778727638	1905	Q>H		No	ExAC TOPMed gnomAD
rs768468458	1905	Q>P		No	ExAC TOPMed gnomAD
rs1322423534	1909	A>G		No	TOPMed
rs2036520882	1909	A>P		No	TOPMed gnomAD
COSM2200812 COSM1375704	1909	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs372723036	1910	V>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1237101451	1912	I>L		No	gnomAD
rs772824076	1912	I>M		No	ExAC TOPMed gnomAD
rs770769016	1914	A>T		No	ExAC TOPMed gnomAD
rs745598708	1914	A>V		No	TOPMed gnomAD
rs775588013 COSM199343	1915	V>I	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs775588013	1915	V>L		No	ExAC TOPMed gnomAD
rs1252115722	1919	I>L		No	gnomAD
rs1252115722	1919	I>V		No	gnomAD
rs762998404	1921	V>I		No	ExAC gnomAD
rs2036522856	1922	P>R		No	TOPMed
rs961288295	1922	P>S		No	Ensembl
rs2036522984	1923	R>K		No	TOPMed
COSM3815689 COSM3815687	1923	R>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2141164860	1923	R>W		No	Ensembl
COSM1678714 rs780922727	1924	R>C	large_intestine [Cosmic]	No	cosmic curated ExAC gnomAD
COSM4053508 rs1472884841 COSM959658	1924	R>H	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs1472884841	1924	R>P		No	gnomAD
rs774451516	1925	G>D		No	ExAC TOPMed gnomAD
rs369056591	1925	G>S		No	ESP ExAC TOPMed gnomAD
VAR_040677	1927	D>G		No	UniProt
rs2036547989	1927	D>H		No	gnomAD
TCGA novel	1928	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2036548207	1929	I>V		No	Ensembl
rs201481845	1930	V>I		No	1000Genomes ESP ExAC TOPMed gnomAD
rs201481845	1930	V>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1257955496	1931	I>V		No	TOPMed gnomAD
rs200916884	1934	E>K		No	gnomAD
rs200916884	1934	E>Q		No	gnomAD
rs944767940	1935	K>E		No	TOPMed gnomAD
rs1291492431	1936	D>Y		No	gnomAD
rs2924835 RCV001652123	1938	G>D		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV002075507 rs386787404	1938	G>E		No	ClinVar Ensembl dbSNP
COSM4053511 COSM4053509 rs765835793	1939	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs752310046	1940	Q>R		No	ExAC gnomAD
rs753312283	1941	R>L		No	ExAC TOPMed gnomAD
rs753312283	1941	R>P		No	ExAC TOPMed gnomAD
COSM5507036 rs753312283 COSM5507034	1941	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
RCV002140868 rs373695236	1941	R>W		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
TCGA novel	1942	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs756852396	1943	R>*		No	ExAC gnomAD
rs756852396	1943	R>G		No	ExAC gnomAD
RCV001917793 rs376808685	1943	R>Q		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs375414450 RCV002041286	1947	V>I		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs375414450	1947	V>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs772079009	1949	K>E		No	ExAC gnomAD
rs1296137445	1951	R>*		No	gnomAD
rs777863487	1951	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
COSM959660 rs771248375	1955	P>L	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1396628347	1956	H>R		No	gnomAD
rs773797200	1958	V>M		No	ExAC gnomAD
rs766950839	1960	V>L		No	ExAC TOPMed gnomAD
rs766950839	1960	V>M		No	ExAC TOPMed gnomAD
rs2036666358	1963	A>T		No	TOPMed
RCV001914323 rs371594206	1964	V>M		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
COSM6141643 COSM6141645	1965	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1227064013	1965	V>M		No	gnomAD
TCGA novel	1966	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1484313302	1967	K>*		No	gnomAD
RCV002030757 rs200845343	1968	D>N		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs765208232	1972	C>Y		No	ExAC gnomAD
rs752623884	1973	T>I		No	ExAC gnomAD
rs1183697480	1974	F>V		No	gnomAD
rs1414732689	1975	E>D		No	gnomAD
rs916569957	1979	T>A		No	TOPMed
rs1160827713	1980	E>D		No	Ensembl
rs757416596	1980	E>Q		No	ExAC gnomAD
COSM1608139 rs781380711	1982	C>Y	liver [Cosmic]	No	cosmic curated ExAC gnomAD
rs1431526955	1984	A>T		No	gnomAD
rs1445097736	1985	V>A		No	gnomAD
rs200452795 RCV002024899	1985	V>I		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs200452795	1985	V>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2036669580	1987	R>K		No	Ensembl
rs999534552	1988	G>S		No	gnomAD
rs551580410	1991	A>T		No	1000Genomes ExAC TOPMed gnomAD
rs769097011	1991	A>V		No	ExAC gnomAD
rs1596367302	1994	F>V		No	Ensembl
rs748618009	1995	D>H		No	ExAC TOPMed gnomAD
rs748618009	1995	D>N		No	ExAC TOPMed gnomAD
rs200799960	1996	I>V		No	1000Genomes ExAC gnomAD
rs760287550	1998	Y>H		No	ExAC TOPMed gnomAD
rs2036671093	1999	Q>H		No	TOPMed
rs2036671208	2000	S>F		No	Ensembl
COSM1158163 rs983155331	2002	E>D	pancreas [Cosmic]	No	cosmic curated Ensembl
rs3752321	2002	E>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs3752321	2002	E>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1451056831	2005	G>S		No	gnomAD
TCGA novel	2006	R>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs377568599	2006	R>Q		No	ESP ExAC TOPMed gnomAD
rs373483365	2006	R>W		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1452560841	2009	A>D		No	gnomAD
rs2036673118	2009	A>T		No	Ensembl
rs1452560841	2009	A>V		No	gnomAD
RCV002001211 rs780306812	2012	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs370159409	2012	R>H		No	ESP ExAC TOPMed gnomAD
rs370159409	2012	R>L		No	ESP ExAC TOPMed gnomAD
rs748705944	2013	K>Q		No	ExAC gnomAD
rs1209685115	2014	R>I		No	TOPMed
rs1209685115	2014	R>K		No	TOPMed
rs1596367537	2016	R>E		No	Ensembl
rs1360508923	2016	R>L		No	TOPMed gnomAD

1 associated diseases with Q38SD2

[MIM: 615198]: Osteosclerotic metaphyseal dysplasia (OSMD)

An autosomal recessive skeletal dysplasia characterized by osteosclerosis at multiple skeletal sites, predominantly at the metaphyses of the long bones and vertebral bodies. . Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID

An autosomal recessive skeletal dysplasia characterized by osteosclerosis at multiple skeletal sites, predominantly at the metaphyses of the long bones and vertebral bodies. . Note=The disease is caused by variants affecting the gene represented in this entry.

8 regional properties for Q38SD2

Type	Name	Position	InterPro Accession
domain	C2 domain	1 - 98	IPR000008-1
domain	C2 domain	668 - 794	IPR000008-2
domain	C2 domain	1535 - 1664	IPR000008-3
domain	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	562 - 612	IPR002219
domain	MUN domain	1002 - 1521	IPR010439
domain	Munc13 homology 1	1102 - 1245	IPR014770
domain	Mammalian uncoordinated homology 13, domain 2	1354 - 1521	IPR014772
domain	Protein Unc-13, C2B domain	685 - 811	IPR037302

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm
PANTHER Family	PTHR48055	LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE EMS1
PANTHER Subfamily	PTHR48055:SF13	LEUCINE-RICH REPEAT SERINE_THREONINE-PROTEIN KINASE 1
PANTHER Protein Class	transmembrane signal receptor
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

6 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GTP binding	Binding to GTP, guanosine triphosphate.
identical protein binding	Binding to an identical protein or proteins.
metal ion binding	Binding to a metal ion.
protein serine kinase activity	Catalysis of the reactions
protein serine/threonine kinase activity	Catalysis of the reactions

8 GO annotations of biological process

Name	Definition
bone resorption	The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of peptidyl-tyrosine phosphorylation	Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
osteoclast development	The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
phosphorylation	The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of canonical Wnt signaling pathway	Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
positive regulation of intracellular signal transduction	Any process that activates or increases the frequency, rate or extent of intracellular signal transduction.
positive regulation of peptidyl-tyrosine phosphorylation	Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.

74 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A2VDU3	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	Bos taurus (Bovine)	SS
Q4TVR5	DSTYK	Dual serine/threonine and tyrosine protein kinase	Bos taurus (Bovine)	PR
Q3SZJ2	RIPK2	Receptor-interacting serine/threonine-protein kinase 2	Bos taurus (Bovine)	PR
Q3MHH9	ECM2	Extracellular matrix protein 2	Bos taurus (Bovine)	PR
P58874	OPTC	Opticin	Bos taurus (Bovine)	PR
Q24K06	LRRC10	Leucine-rich repeat-containing protein 10	Bos taurus (Bovine)	PR
Q6XUX0	DSTYK	Dual serine/threonine and tyrosine protein kinase	Gallus gallus (Chicken)	PR
P83104	Takl1	Putative mitogen-activated protein kinase kinase kinase 7-like	Drosophila melanogaster (Fruit fly)	PR
Q95UN8	slpr	Mitogen-activated protein kinase kinase kinase	Drosophila melanogaster (Fruit fly)	EV
Q9V780	Lap1	Protein lap1	Drosophila melanogaster (Fruit fly)	PR
O43353	RIPK2	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (Human)	PR
Q02779	MAP3K10	Mitogen-activated protein kinase kinase kinase 10	Homo sapiens (Human)	SS
Q8NB16	MLKL	Mixed lineage kinase domain-like protein	Homo sapiens (Human)	EV
Q16584	MAP3K11	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (Human)	EV
P00540	MOS	Proto-oncogene serine/threonine-protein kinase mos	Homo sapiens (Human)	PR
Q5TCX8	MAP3K21	Mitogen-activated protein kinase kinase kinase 21	Homo sapiens (Human)	PR
Q6XUX3	DSTYK	Dual serine/threonine and tyrosine protein kinase	Homo sapiens (Human)	PR
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	Homo sapiens (Human)	SS
Q9NYL2	MAP3K20	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (Human)	PR
P80192	MAP3K9	Mitogen-activated protein kinase kinase kinase 9	Homo sapiens (Human)	SS
Q96NW7	LRRC7	Leucine-rich repeat-containing protein 7	Homo sapiens (Human)	PR
Q8IWT6	LRRC8A	Volume-regulated anion channel subunit LRRC8A	Homo sapiens (Human)	PR
Q9HCJ2	LRRC4C	Leucine-rich repeat-containing protein 4C	Homo sapiens (Human)	PR
Q9UFC0	LRWD1	Leucine-rich repeat and WD repeat-containing protein 1	Homo sapiens (Human)	PR
Q96L50	LRR1	Leucine-rich repeat protein 1	Homo sapiens (Human)	PR
Q86UN2	RTN4RL1	Reticulon-4 receptor-like 1	Homo sapiens (Human)	PR
Q8IWK6	ADGRA3	Adhesion G protein-coupled receptor A3	Homo sapiens (Human)	PR
Q7L1W4	LRRC8D	Volume-regulated anion channel subunit LRRC8D	Homo sapiens (Human)	PR
Q96FE5	LINGO1	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1	Homo sapiens (Human)	PR
Q8TDW0	LRRC8C	Volume-regulated anion channel subunit LRRC8C	Homo sapiens (Human)	PR
Q80XI6	Map3k11	Mitogen-activated protein kinase kinase kinase 11	Mus musculus (Mouse)	PR
Q8VDG6	Map3k21	Mitogen-activated protein kinase kinase kinase 21	Mus musculus (Mouse)	PR
P58801	Ripk2	Receptor-interacting serine/threonine-protein kinase 2	Mus musculus (Mouse)	PR
Q62073	Map3k7	Mitogen-activated protein kinase kinase kinase 7	Mus musculus (Mouse)	EV
Q3U1V8	Map3k9	Mitogen-activated protein kinase kinase kinase 9	Mus musculus (Mouse)	SS
Q9D2Y4	Mlkl	Mixed lineage kinase domain-like protein	Mus musculus (Mouse)	SS
Q9ESL4	Map3k20	Mitogen-activated protein kinase kinase kinase 20	Mus musculus (Mouse)	PR
P00536	Mos	Proto-oncogene serine/threonine-protein kinase mos	Mus musculus (Mouse)	PR
Q66L42	Map3k10	Mitogen-activated protein kinase kinase kinase 10	Mus musculus (Mouse)	SS
A6H694	Lrrc63	Leucine-rich repeat-containing protein 63	Mus musculus (Mouse)	PR
Q9D9Q0	Lrrc69	Leucine-rich repeat-containing protein 69	Mus musculus (Mouse)	PR
Q8BGI7	Lrrc39	Leucine-rich repeat-containing protein 39	Mus musculus (Mouse)	PR
Q7TT36	Adgra3	Adhesion G protein-coupled receptor A3	Mus musculus (Mouse)	PR
P59383	Lrrn4	Leucine-rich repeat neuronal protein 4	Mus musculus (Mouse)	PR
Q9D1T0	Lingo1	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1	Mus musculus (Mouse)	PR
Q8R502	Lrrc8c	Volume-regulated anion channel subunit LRRC8C	Mus musculus (Mouse)	PR
Q80WG5	Lrrc8a	Volume-regulated anion channel subunit LRRC8A	Mus musculus (Mouse)	PR
Q8K0S5	Rtn4rl1	Reticulon-4 receptor-like 1	Mus musculus (Mouse)	PR
Q80TE7	Lrrc7	Leucine-rich repeat-containing protein 7	Mus musculus (Mouse)	PR
Q5DU41	Lrrc8b	Volume-regulated anion channel subunit LRRC8B	Mus musculus (Mouse)	PR
Q5RKR3	Islr2	Immunoglobulin superfamily containing leucine-rich repeat protein 2	Mus musculus (Mouse)	PR
Q8C031	Lrrc4c	Leucine-rich repeat-containing protein 4C	Mus musculus (Mouse)	PR
P0C8E4	Map3k7	Mitogen-activated protein kinase kinase kinase 7	Rattus norvegicus (Rat)	SS
Q66HA1	Map3k11	Mitogen-activated protein kinase kinase kinase 11	Rattus norvegicus (Rat)	PR
D3ZG83	Map3k10	Mitogen-activated protein kinase kinase kinase 10	Rattus norvegicus (Rat)	SS
P00539	Mos	Proto-oncogene serine/threonine-protein kinase mos	Rattus norvegicus (Rat)	PR
P70587	Lrrc7	Leucine-rich repeat-containing protein 7	Rattus norvegicus (Rat)	PR
Q4V8G0	Lrrc63	Leucine-rich repeat-containing protein 63	Rattus norvegicus (Rat)	PR
Q80WD0	Rtn4rl1	Reticulon-4 receptor-like 1	Rattus norvegicus (Rat)	PR
Q9TZM3	lrk-1	Leucine-rich repeat serine/threonine-protein kinase 1	Caenorhabditis elegans	SS
Q9FPR3	EDR1	Serine/threonine-protein kinase EDR1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q2MHE4	HT1	Serine/threonine/tyrosine-protein kinase HT1	Arabidopsis thaliana (Mouse-ear cress)	PR
O22558	STY8	Serine/threonine-protein kinase STY8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8RWL6	STY17	Serine/threonine-protein kinase STY17	Arabidopsis thaliana (Mouse-ear cress)	PR
F4JTP5	STY46	Serine/threonine-protein kinase STY46	Arabidopsis thaliana (Mouse-ear cress)	PR
Q05609	CTR1	Serine/threonine-protein kinase CTR1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SHI4	RLP3	Receptor-like protein 3	Arabidopsis thaliana (Mouse-ear cress)	SS
Q5G5E0	PIRL5	Plant intracellular Ras-group-related LRR protein 5	Arabidopsis thaliana (Mouse-ear cress)	PR
C0LGE4	At1g12460	Probable LRR receptor-like serine/threonine-protein kinase At1g12460	Arabidopsis thaliana (Mouse-ear cress)	PR
Q0WR59	At5g10020	Probable inactive receptor kinase At5g10020	Arabidopsis thaliana (Mouse-ear cress)	PR
Q67E00	dstyk	Dual serine/threonine and tyrosine protein kinase	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
B0JZ65	lrwd1	Leucine-rich repeat and WD repeat-containing protein 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q68F79	lrrc8e	Volume-regulated anion channel subunit LRRC8E	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
B0R160	lrwd1	Leucine-rich repeat and WD repeat-containing protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MAGMSQRPPS	MYWCVGPEES	AVCPERAMET	LNGAGDTGGK	PSTRGGDPAA	RSRRTEGIRA
70	80	90	100	110	120
AYRRGDRGGA	RDLLEEACDQ	CASQLEKGQL	LSIPAAYGDL	EMVRYLLSKR	LVELPTEPTD
130	140	150	160	170	180
DNPAVVAAYF	GHTAVVQELL	ESLPGPCSPQ	RLLNWMLALA	CQRGHLGVVK	LLVLTHGADP
190	200	210	220	230	240
ESYAVRKNEF	PVIVRLPLYA	AIKSGNEDIA	IFLLRHGAYF	CSYILLDSPD	PSKHLLRKYF
250	260	270	280	290	300
IEASPLPSSY	PGKTALRVKW	SHLRLPWVDL	DWLIDISCQI	TELDLSANCL	ATLPSVIPWG
310	320	330	340	350	360
LINLRKLNLS	DNHLGELPGV	QSSDEIICSR	LLEIDISSNK	LSHLPPGFLH	LSKLQKLTAS
370	380	390	400	410	420
KNCLEKLFEE	ENATNWIGLR	KLQELDISDN	KLTELPALFL	HSFKSLNSLN	VSRNNLKVFP
430	440	450	460	470	480
DPWACPLKCC	KASRNALECL	PDKMAVFWKN	HLKDVDFSEN	ALKEVPLGLF	QLDALMFLRL
490	500	510	520	530	540
QGNQLAALPP	QEKWTCRQLK	TLDLSRNQLG	KNEDGLKTKR	IAFFTTRGRQ	RSGTEAASVL
550	560	570	580	590	600
EFPAFLSESL	EVLCLNDNHL	DTVPPSVCLL	KSLSELYLGN	NPGLRELPPE	LGQLGNLWQL
610	620	630	640	650	660
DTEDLTISNV	PAEIQKEGPK	AMLSYLRAQL	RKAEKCKLMK	MIIVGPPRQG	KSTLLEILQT
670	680	690	700	710	720
GRAPQVVHGE	ATIRTTKWEL	QRPAGSRAKV	ESVEFNVWDI	GGPASMATVN	QCFFTDKALY
730	740	750	760	770	780
VVVWNLALGE	EAVANLQFWL	LNIEAKAPNA	VVLVVGTHLD	LIEAKFRVER	IATLRAYVLA
790	800	810	820	830	840
LCRSPSGSRA	TGFPDITFKH	LHEISCKSLE	GQEGLRQLIF	HVTCSMKDVG	STIGCQRLAG
850	860	870	880	890	900
RLIPRSYLSL	QEAVLAEQQR	RSRDDDVQYL	TDRQLEQLVE	QTPDNDIKDY	EDLQSAISFL
910	920	930	940	950	960
IETGTLLHFP	DTSHGLRNLY	FLDPIWLSEC	LQRIFNIKGS	RSVAKNGVIR	AEDLRMLLVG
970	980	990	1000	1010	1020
TGFTQQTEEQ	YFQFLAKFEI	ALPVANDSYL	LPHLLPSKPG	LDTHGMRHPT	ANTIQRVFKM
1030	1040	1050	1060	1070	1080
SFVPVGFWQR	FIARMLISLA	EMDLQLFENK	KNTKSRNRKV	TIYSFTGNQR	NRCSTFRVKR
1090	1100	1110	1120	1130	1140
NQTIYWQEGL	LVTFDGGYLS	VESSDVNWKK	KKSGGMKIVC	QSEVRDFSAM	AFITDHVNSL
1150	1160	1170	1180	1190	1200
IDQWFPALTA	TESDGTPLME	QYVPCPVCET	AWAQHTDPSE	KSEDVQYFDM	EDCVLTAIER
1210	1220	1230	1240	1250	1260
DFISCPRHPD	LPVPLQELVP	ELFMTDFPAR	LFLENSKLEH	SEDEGSVLGQ	GGSGTVIYRA
1270	1280	1290	1300	1310	1320
RYQGQPVAVK	RFHIKKFKNF	ANVPADTMLR	HLRATDAMKN	FSEFRQEASM	LHALQHPCIV
1330	1340	1350	1360	1370	1380
ALIGISIHPL	CFALELAPLS	SLNTVLSENA	RDSSFIPLGH	MLTQKIAYQI	ASGLAYLHKK
1390	1400	1410	1420	1430	1440
NIIFCDLKSD	NILVWSLDVK	EHINIKLSDY	GISRQSFHEG	ALGVEGTPGY	QAPEIRPRIV
1450	1460	1470	1480	1490	1500
YDEKVDMFSY	GMVLYELLSG	QRPALGHHQL	QIAKKLSKGI	RPVLGQPEEV	QFRRLQALMM
1510	1520	1530	1540	1550	1560
ECWDTKPEKR	PLALSVVSQM	KDPTFATFMY	ELCCGKQTAF	FSSQGQEYTV	VFWDGKEESR
1570	1580	1590	1600	1610	1620
NYTVVNTEKG	LMEVQRMCCP	GMKVSCQLQV	QRSLWTATED	QKIYIYTLKG	MCPLNTPQQA
1630	1640	1650	1660	1670	1680
LDTPAVVTCF	LAVPVIKKNS	YLVLAGLADG	LVAVFPVVRG	TPKDSCSYLC	SHTANRSKFS
1690	1700	1710	1720	1730	1740
IADEDARQNP	YPVKAMEVVN	SGSEVWYSNG	PGLLVIDCAS	LEICRRLEPY	MAPSMVTSVV
1750	1760	1770	1780	1790	1800
CSSEGRGEEV	VWCLDDKANS	LVMYHSTTYQ	LCARYFCGVP	SPLRDMFPVR	PLDTEPPAAS
1810	1820	1830	1840	1850	1860
HTANPKVPEG	DSIADVSIMY	SEELGTQILI	HQESLTDYCS	MSSYSSSPPR	QAARSPSSLP
1870	1880	1890	1900	1910	1920
SSPASSSSVP	FSTDCEDSDM	LHTPGAASDR	SEHDLTPMDG	ETFSQHLQAV	KILAVRDLIW
1930	1940	1950	1960	1970	1980
VPRRGGDVIV	IGLEKDSGAQ	RGRVIAVLKA	RELTPHGVLV	DAAVVAKDTV	VCTFENENTE
1990	2000	2010
WCLAVWRGWG	AREFDIFYQS	YEELGRLEAC	TRKRR