Q38834

PR
Gene name
RPP13L4
Protein name
Disease resistance RPP13-like protein 4
Names
Disease resistance protein ZAR1, Protein HOPZ-ACTIVATED RESISTANCE 1, AtZAR1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G50950
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-181 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for Q38834

Entry ID Method Resolution Chain Position Source
6J5T EM 340 A C/F/G/L/O 1-852 PDB
6J5U EM 390 A A 1-852 PDB
6J5V EM 425 A A 1-852 PDB
6J5W EM 370 A A 1-852 PDB
6J6I EM 370 A C/F/G/L/O 1-852 PDB
AF-Q38834-F1 Predicted AlphaFoldDB

45 variants for Q38834

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH00413850 36 S>T No 1000Genomes
ENSVATH02488679 37 E>K No 1000Genomes
ENSVATH02488681 40 Y>F No 1000Genomes
ENSVATH02488680 40 Y>H No 1000Genomes
ENSVATH12703455 61 L>F No 1000Genomes
ENSVATH00413851 61 L>H No 1000Genomes
ENSVATH02488682 64 D>H No 1000Genomes
ENSVATH02488683 69 V>L No 1000Genomes
tmp_3_18936347_A_G 74 D>G No 1000Genomes
ENSVATH06292039 87 G>R No 1000Genomes
ENSVATH06292039 87 G>W No 1000Genomes
tmp_3_18936410_C_T 95 A>V No 1000Genomes
ENSVATH02488686 123 T>K No 1000Genomes
ENSVATH02488687 134 E>K No 1000Genomes
ENSVATH02488688 136 I>R No 1000Genomes
ENSVATH12703464 138 P>T No 1000Genomes
tmp_3_18936547_G_T 141 V>F No 1000Genomes
ENSVATH00413855 179 D>E No 1000Genomes
tmp_3_18936757_C_T 211 R>C No 1000Genomes
tmp_3_18936788_C_A 221 S>Y No 1000Genomes
ENSVATH06292045 258 L>M No 1000Genomes
ENSVATH12703475 279 K>N No 1000Genomes
ENSVATH06292048 309 D>N No 1000Genomes
ENSVATH14418051 369 L>H No 1000Genomes
tmp_3_18937388_C_T 421 T>M No 1000Genomes
ENSVATH00413862 434 Q>K No 1000Genomes
ENSVATH00413863 448 W>C No 1000Genomes
ENSVATH00413864 452 R>G No 1000Genomes
tmp_3_18937513_T_G 463 S>A No 1000Genomes
ENSVATH02488691 503 S>L No 1000Genomes
ENSVATH00413866 505 S>A No 1000Genomes
tmp_3_18937661_G_C 512 C>S No 1000Genomes
ENSVATH02488692 557 D>E No 1000Genomes
ENSVATH12703479 582 I>M No 1000Genomes
ENSVATH00413869 584 S>R No 1000Genomes
ENSVATH06292054 682 N>K No 1000Genomes
ENSVATH12703480 716 I>V No 1000Genomes
ENSVATH06292056 732 I>L No 1000Genomes
ENSVATH14418053 734 A>T No 1000Genomes
ENSVATH02488694 739 H>L No 1000Genomes
tmp_3_18938446_G_A 774 G>S No 1000Genomes
tmp_3_18938477_G_A 784 W>* No 1000Genomes
ENSVATH14418054 807 D>H No 1000Genomes
tmp_3_18938632_G_T 836 D>Y No 1000Genomes
ENSVATH06292059 837 V>I No 1000Genomes

No associated diseases with Q38834

4 regional properties for Q38834

Type Name Position InterPro Accession
domain Protein kinase domain 13 - 313 IPR000719
conserved_site Mitogen-activated protein (MAP) kinase, conserved site 47 - 155 IPR003527
active_site Serine/threonine-protein kinase, active site 139 - 151 IPR008271
binding_site Protein kinase, ATP binding site 19 - 43 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane
  • Nucleus
  • Associates with the plasma membrane in the presence of the Xanthomonas campestris effector XopAC/AvrAC
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ADP binding Binding to ADP, adenosine 5'-diphosphate.
protein self-association Binding to a domain within the same polypeptide.

3 GO annotations of biological process

Name Definition
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
defense response to Gram-negative bacterium Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
regulation of immune response Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

20 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
F1MHT9 NLRC4 NLR family CARD domain-containing protein 4 Bos taurus (Bovine) SS
O14727 APAF1 Apoptotic protease-activating factor 1 Homo sapiens (Human) EV
Q9NPP4 NLRC4 NLR family CARD domain-containing protein 4 Homo sapiens (Human) SS
Q3UP24 Nlrc4 NLR family CARD domain-containing protein 4 Mus musculus (Mouse) EV
F1M649 Nlrc4 NLR family CARD domain-containing protein 4 Rattus norvegicus (Rat) SS
O22727 At1g61190 Probable disease resistance protein At1g61190 Arabidopsis thaliana (Mouse-ear cress) PR
O64790 At1g61300 Probable disease resistance protein At1g61300 Arabidopsis thaliana (Mouse-ear cress) PR
O64973 RPS5 Disease resistance protein RPS5 Arabidopsis thaliana (Mouse-ear cress) PR
P0C8S1 RPP8L2 Probable disease resistance RPP8-like protein 2 Arabidopsis thaliana (Mouse-ear cress) PR
P60838 SUMM2 Disease resistance protein SUMM2 Arabidopsis thaliana (Mouse-ear cress) PR
Q39214 RPM1 Disease resistance protein RPM1 Arabidopsis thaliana (Mouse-ear cress) PR
Q8W3K3 At1g58400 Putative disease resistance protein At1g58400 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C646 RXW24L Probable disease resistance protein RXW24L Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJB5 RPP8L3 Disease resistance RPP8-like protein 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRR4 RPPL1 Putative disease resistance RPP13-like protein 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9T048 At4g27190 Disease resistance protein At4g27190 Arabidopsis thaliana (Mouse-ear cress) PR
Q9XIF0 At1g59780 Putative disease resistance protein At1g59780 Arabidopsis thaliana (Mouse-ear cress) PR
O64789 At1g61310 Probable disease resistance protein At1g61310 Arabidopsis thaliana (Mouse-ear cress) PR
Q940K0 UNI Disease resistance protein UNI Arabidopsis thaliana (Mouse-ear cress) PR
Q9I9H8 apaf1 Apoptotic protease-activating factor 1 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MVDAVVTVFL EKTLNILEEK GRTVSDYRKQ LEDLQSELKY MQSFLKDAER QKRTNETLRT
70 80 90 100 110 120
LVADLRELVY EAEDILVDCQ LADGDDGNEQ RSSNAWLSRL HPARVPLQYK KSKRLQEINE
130 140 150 160 170 180
RITKIKSQVE PYFEFITPSN VGRDNGTDRW SSPVYDHTQV VGLEGDKRKI KEWLFRSNDS
190 200 210 220 230 240
QLLIMAFVGM GGLGKTTIAQ EVFNDKEIEH RFERRIWVSV SQTFTEEQIM RSILRNLGDA
250 260 270 280 290 300
SVGDDIGTLL RKIQQYLLGK RYLIVMDDVW DKNLSWWDKI YQGLPRGQGG SVIVTTRSES
310 320 330 340 350 360
VAKRVQARDD KTHRPELLSP DNSWLLFCNV AFAANDGTCE RPELEDVGKE IVTKCKGLPL
370 380 390 400 410 420
TIKAVGGLLL CKDHVYHEWR RIAEHFQDEL RGNTSETDNV MSSLQLSYDE LPSHLKSCIL
430 440 450 460 470 480
TLSLYPEDCV IPKQQLVHGW IGEGFVMWRN GRSATESGED CFSGLTNRCL IEVVDKTYSG
490 500 510 520 530 540
TIITCKIHDM VRDLVIDIAK KDSFSNPEGL NCRHLGISGN FDEKQIKVNH KLRGVVSTTK
550 560 570 580 590 600
TGEVNKLNSD LAKKFTDCKY LRVLDISKSI FDAPLSEILD EIASLQHLAC LSLSNTHPLI
610 620 630 640 650 660
QFPRSMEDLH NLQILDASYC QNLKQLQPCI VLFKKLLVLD MTNCGSLECF PKGIGSLVKL
670 680 690 700 710 720
EVLLGFKPAR SNNGCKLSEV KNLTNLRKLG LSLTRGDQIE EEELDSLINL SKLMSISINC
730 740 750 760 770 780
YDSYGDDLIT KIDALTPPHQ LHELSLQFYP GKSSPSWLSP HKLPMLRYMS ICSGNLVKMQ
790 800 810 820 830 840
EPFWGNENTH WRIEGLMLSS LSDLDMDWEV LQQSMPYLRT VTANWCPELE SFAIEDVGFR
850
GGVWMKTPLH RT