Q32PA5

PR
Gene name
UBE2C (UBCH10)
Protein name
Ubiquitin-conjugating enzyme E2 C
Names
(E3-independent) E2 ubiquitin-conjugating enzyme C, E2 ubiquitin-conjugating enzyme C, Ubiquitin carrier protein C, Ubiquitin-protein ligase C
Species
Bos taurus (Bovine)
KEGG Pathway
bta:506962
EC number
2.3.2.23: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q32PA5

Entry ID Method Resolution Chain Position Source
AF-Q32PA5-F1 Predicted AlphaFoldDB

60 variants for Q32PA5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs448048240 2 A>P No EVA
rs460086621 3 S>C No EVA
rs478846741 5 N>T No EVA
rs445840466 7 D>A No EVA
rs464441554 10 A>P No EVA
rs450018867 20 A>G No EVA
rs437921708 20 A>T No EVA
rs450625592 79 Y>D No EVA
rs436215236 84 E>G No EVA
rs454763188 85 F>L No EVA
rs434822363 87 S>R No EVA
rs474187030 87 S>R No EVA
rs471922621 91 Y>H No EVA
rs476025096 96 V>E No EVA
rs476025096 96 V>G No EVA
rs463918062 96 V>L No EVA
rs438511663 98 F>L No EVA
rs438511663 98 F>V No EVA
rs461619719 99 L>H No EVA
rs479449663 100 T>P No EVA
rs458627370 102 C>W No EVA
rs450511426 103 Y>* No EVA
rs476939196 103 Y>S No EVA
rs468976482 105 P>T No EVA
rs448361207 106 N>K No EVA
rs466878225 108 D>A No EVA
rs466878225 108 D>G No EVA
rs434758863 109 T>N No EVA
rs453274366 110 Q>P No EVA
rs471809528 111 G>R No EVA
rs457431918 112 N>K No EVA
rs475961796 114 C>G No EVA
rs443035058 116 D>G No EVA
rs455221432 117 I>M No EVA
rs473728317 118 L>R No EVA
rs439973236 119 K>I No EVA
rs476826708 121 K>R No EVA
rs444049955 122 W>G No EVA
rs481019670 124 A>T No EVA
rs448216227 125 L>M No EVA
rs478914653 127 D>V No EVA
rs445949489 129 R>T No EVA
rs432357850 135 I>T No EVA
rs457417459 137 S>R No EVA
rs469520706 139 L>P No EVA
rs481467027 141 E>D No EVA
rs467129311 149 N>H No EVA
rs434155013 151 H>Y No EVA
rs438231653 156 W>* No EVA
rs456678956 156 W>* No EVA
rs456678956 156 W>C No EVA
rs474571925 159 P>S No EVA
rs474571925 159 P>T No EVA
rs474413445 166 L>P No EVA
rs441438401 169 T>P No EVA
rs460012092 170 Y>* No EVA
rs478537124 173 Q>K No EVA
rs445585615 173 Q>R No EVA
rs463304018 178 D>A No EVA
rs481886454 180 P>S No EVA

No associated diseases with Q32PA5

2 regional properties for Q32PA5

Type Name Position InterPro Accession
domain Ubiquitin-conjugating enzyme E2 30 - 175 IPR000608
active_site Ubiquitin-conjugating enzyme, active site 103 - 118 IPR023313

Functions

Description
EC Number 2.3.2.23 Aminoacyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
anaphase-promoting complex A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ubiquitin conjugating enzyme activity Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.
ubiquitin-protein transferase activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.

9 GO annotations of biological process

Name Definition
anaphase-promoting complex-dependent catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
exit from mitosis The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.
free ubiquitin chain polymerization The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin monomers. These chains are not conjugated to a protein.
protein K11-linked ubiquitination A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains.
protein K48-linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
regulation of mitotic metaphase/anaphase transition Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q1RML1 UBE2S Ubiquitin-conjugating enzyme E2 S Bos taurus (Bovine) SS
P61085 UBE2K Ubiquitin-conjugating enzyme E2 K Bos taurus (Bovine) PR
Q32LD2 UBE2T Ubiquitin-conjugating enzyme E2 T Bos taurus (Bovine) PR
Q32L27 UBE2Q2 Ubiquitin-conjugating enzyme E2 Q2 Bos taurus (Bovine) PR
O00762 UBE2C Ubiquitin-conjugating enzyme E2 C Homo sapiens (Human) PR
Q9D1C1 Ube2c Ubiquitin-conjugating enzyme E2 C Mus musculus (Mouse) PR
10 20 30 40 50 60
MASQNRDPVA ASVAAARKGA EPSGGAARGP VGKRLQQELM TLMMSGDKGI SAFPESDNLF
70 80 90 100 110 120
KWVGTIHGAA GTVYEDLRYK LSLEFPSGYP YNAPTVKFLT PCYHPNVDTQ GNICLDILKD
130 140 150 160 170
KWSALYDVRT ILLSIQSLLG EPNIDSPLNT HAAELWKNPT AFKKYLQETY SKQVSSQDP