Q32LP0
SS
Gene name |
FERMT3 (KIND3, URP2) |
Protein name |
Fermitin family homolog 3 |
Names |
Kindlin-3 , Unc-112-related protein 2 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:525159 |
EC number |
|
Protein Class |
|
Descriptions
Kindlin-3 is a member of the kindlin family of focal adhesion proteins which bind to integrin beta-chain cytoplasmic domains to regulate integrin function. kindlin-3 is maintained in a homotrimer state, which is different from the monomer that binds integrin β cytoplasmic tails. The trimer formation of kindlin-3 results in an autoinhibited state, as the integrin-binding pocket is blocked by the pleckstrin homology (PH) domain of another protomer. Mutations disrupting the trimer interface (Q471A, A475F, S478A) lead to increased integrin-mediated cell adhesion and spreading, indicating relief from autoinhibition. This autoinhibition regulates kindlin-3’s role in integrin activation and signaling, with implications for diseases like leukocyte adhesion deficiency (LAD) III and cancer.
Autoinhibitory domains (AIDs)
Target domain |
567-665 (F3 subdomain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q32LP0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q32LP0-F1 | Predicted | AlphaFoldDB |
324 variants for Q32LP0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs471866087 | 2 | A>V | No | EVA | |
| rs463939563 | 4 | M>R | No | EVA | |
| rs463939563 | 4 | M>T | No | EVA | |
| rs482257465 | 6 | T>A | No | EVA | |
| rs442849172 | 7 | A>D | No | EVA | |
| rs442849172 | 7 | A>G | No | EVA | |
| rs461374551 | 10 | D>E | No | EVA | |
| rs479977254 | 11 | Y>N | No | EVA | |
| rs446615184 | 11 | Y>S | No | EVA | |
| rs477237135 | 12 | I>F | No | EVA | |
| rs469329058 | 13 | D>A | No | EVA | |
| rs469329058 | 13 | D>G | No | EVA | |
| rs450814751 | 13 | D>Y | No | EVA | |
| rs435969488 | 14 | S>L | No | EVA | |
| rs454528081 | 15 | S>A | No | EVA | |
| rs454528081 | 15 | S>P | No | EVA | |
| rs433662950 | 16 | W>L | No | EVA | |
| rs466597783 | 16 | W>R | No | EVA | |
| rs471806236 | 17 | E>D | No | EVA | |
| rs452132095 | 17 | E>G | No | EVA | |
| rs438990908 | 18 | L>R | No | EVA | |
| rs476166867 | 19 | R>G | No | EVA | |
| rs442769240 | 19 | R>Q | No | EVA | |
| rs461357337 | 20 | V>E | No | EVA | |
| rs461357337 | 20 | V>G | No | EVA | |
| rs440523164 | 21 | F>I | No | EVA | |
| rs440523164 | 21 | F>V | No | EVA | |
| rs459083094 | 22 | I>L | No | EVA | |
| rs450753377 | 22 | I>M | No | EVA | |
| rs477175606 | 22 | I>R | No | EVA | |
| rs462789430 | 23 | G>R | No | EVA | |
| rs447939409 | 24 | E>D | No | EVA | |
| rs481383447 | 24 | E>G | No | EVA | |
| rs481383447 | 24 | E>V | No | EVA | |
| rs433599581 | 25 | E>D | No | EVA | |
| rs466575650 | 25 | E>G | No | EVA | |
| rs445684505 | 26 | D>A | No | EVA | |
| rs464126555 | 26 | D>E | No | EVA | |
| rs432518913 | 27 | P>R | No | EVA | |
| rs476062663 | 28 | E>G | No | EVA | |
| rs457561777 | 28 | E>K | No | EVA | |
| rs436700605 | 29 | A>S | No | EVA | |
| rs440460153 | 31 | S>* | No | EVA | |
| rs473389042 | 31 | S>A | No | EVA | |
| rs440460153 | 31 | S>L | No | EVA | |
| rs471103902 | 32 | L>F | No | EVA | |
| rs471103902 | 32 | L>I | No | EVA | |
| rs444216873 | 32 | L>P | No | EVA | |
| rs481316995 | 33 | T>N | No | EVA | |
| rs462753821 | 33 | T>P | No | EVA | |
| rs462753821 | 33 | T>S | No | EVA | |
| rs448366917 | 35 | R>S | No | EVA | |
| rs478396748 | 36 | V>A | No | EVA | |
| rs445623077 | 37 | T>P | No | EVA | |
| rs437662477 | 39 | E>G | No | EVA | |
| rs450956358 | 40 | S>A | No | EVA | |
| rs450956358 | 40 | S>T | No | EVA | |
| rs469590762 | 41 | H>P | No | EVA | |
| rs436624401 | 41 | H>Q | No | EVA | |
| rs469590762 | 41 | H>R | No | EVA | |
| rs473724381 | 44 | G>W | No | EVA | |
| rs433927954 | 45 | V>L | No | EVA | |
| rs452548218 | 48 | K>Q | No | EVA | |
| rs471037685 | 50 | V>G | No | EVA | |
| rs463060292 | 53 | I>S | No | EVA | |
| rs479309868 | 58 | D>V | No | EVA | |
| rs446370426 | 59 | W>C | No | EVA | |
| rs464521680 | 60 | S>* | No | EVA | |
| rs450085723 | 61 | D>A | No | EVA | |
| rs450085723 | 61 | D>V | No | EVA | |
| rs453779723 | 64 | I>L | No | EVA | |
| rs472261198 | 65 | W>C | No | EVA | |
| rs433070426 | 66 | W>G | No | EVA | |
| rs433070426 | 66 | W>R | No | EVA | |
| rs451631865 | 67 | E>A | No | EVA | |
| rs476184935 | 68 | Q>H | No | EVA | |
| rs443250353 | 70 | R>G | No | EVA | |
| rs461805537 | 71 | Q>R | No | EVA | |
| rs442195656 | 72 | W>C | No | EVA | |
| rs473916470 | 72 | W>G | No | EVA | |
| rs460752253 | 74 | L>R | No | EVA | |
| rs479304639 | 76 | T>A | No | EVA | |
| rs479304639 | 76 | T>P | No | EVA | |
| rs446283259 | 77 | H>P | No | EVA | |
| rs458483297 | 77 | H>Q | No | EVA | |
| rs483056829 | 78 | W>G | No | EVA | |
| rs483056829 | 78 | W>R | No | EVA | |
| rs450013297 | 79 | T>P | No | EVA | |
| rs480528850 | 80 | L>R | No | EVA | |
| rs465799953 | 81 | D>E | No | EVA | |
| rs447739672 | 81 | D>N | No | EVA | |
| rs470114336 | 83 | Y>* | No | EVA | |
| rs451486740 | 83 | Y>C | No | EVA | |
| rs451486740 | 83 | Y>F | No | EVA | |
| rs433000320 | 83 | Y>N | No | EVA | |
| rs451486740 | 83 | Y>S | No | EVA | |
| rs455331574 | 85 | I>T | No | EVA | |
| rs436751273 | 85 | I>V | No | EVA | |
| rs473853150 | 86 | L>R | No | EVA | |
| rs472759445 | 87 | A>G | No | EVA | |
| rs453052489 | 87 | A>P | No | EVA | |
| rs483316591 | 88 | D>A | No | EVA | |
| rs458345925 | 88 | D>H | No | EVA | |
| rs443543781 | 89 | A>P | No | EVA | |
| rs447678260 | 91 | L>R | No | EVA | |
| rs480471545 | 91 | L>V | No | EVA | |
| rs478023427 | 92 | F>Y | No | EVA | |
| rs445049932 | 93 | F>C | No | EVA | |
| rs470023351 | 94 | G>R | No | EVA | |
| rs455669000 | 95 | P>A | No | EVA | |
| rs467345169 | 96 | Q>R | No | EVA | |
| rs434401012 | 97 | H>N | No | EVA | |
| rs452990574 | 97 | H>P | No | EVA | |
| rs471526181 | 97 | H>Q | No | EVA | |
| rs451887525 | 99 | P>H | No | EVA | |
| rs443896899 | 100 | V>G | No | EVA | |
| rs462313843 | 101 | I>T | No | EVA | |
| rs480408178 | 102 | L>P | No | EVA | |
| rs441186384 | 104 | L>P | No | EVA | |
| rs459762732 | 106 | N>T | No | EVA | |
| rs478354826 | 107 | R>G | No | EVA | |
| rs444953923 | 109 | A>G | No | EVA | |
| rs482043630 | 110 | L>P | No | EVA | |
| rs449186052 | 111 | R>L | No | EVA | |
| rs434337466 | 112 | L>H | No | EVA | |
| rs467684275 | 112 | L>V | No | EVA | |
| rs446434693 | 114 | A>P | No | EVA | |
| rs464981990 | 116 | F>L | No | EVA | |
| rs432045326 | 117 | S>P | No | EVA | |
| rs457021396 | 118 | Q>P | No | EVA | |
| rs476819340 | 120 | L>P | No | EVA | |
| rs455843656 | 121 | F>L | No | EVA | |
| rs437395078 | 121 | F>L | No | EVA | |
| rs441121393 | 122 | Q>H | No | EVA | |
| rs474333305 | 122 | Q>P | No | EVA | |
| rs459757912 | 123 | A>G | No | EVA | |
| rs471813469 | 124 | M>K | No | EVA | |
| rs438885797 | 125 | V>M | No | EVA | |
| rs463851504 | 132 | S>G | No | EVA | |
| rs453551070 | 176 | A>G | No | EVA | |
| rs465644228 | 177 | S>* | No | EVA | |
| rs432309890 | 178 | F>C | No | EVA | |
| rs442938493 | 181 | M>I | No | EVA | |
| rs475836967 | 181 | M>L | No | EVA | |
| rs455054571 | 184 | H>L | No | EVA | |
| rs455054571 | 184 | H>P | No | EVA | |
| rs473176722 | 185 | F>S | No | EVA | |
| rs440211272 | 186 | S>P | No | EVA | |
| rs458823954 | 189 | A>P | No | EVA | |
| rs476560157 | 189 | A>V | No | EVA | |
| rs477352852 | 193 | A>P | No | EVA | |
| rs443977054 | 195 | Y>S | No | EVA | |
| rs462374937 | 212 | R>L | No | EVA | |
| rs876488326 | 218 | S>P | No | EVA | |
| rs133866516 | 223 | T>P | No | EVA | |
| rs448072627 | 225 | L>R | No | EVA | |
| rs136662179 | 229 | W>G | No | EVA | |
| rs460089188 | 230 | L>P | No | EVA | |
| rs472275624 | 231 | D>E | No | EVA | |
| rs439260932 | 233 | S>* | No | EVA | |
| rs457874432 | 235 | C>G | No | EVA | |
| rs477618617 | 238 | Q>L | No | EVA | |
| rs477618617 | 238 | Q>P | No | EVA | |
| rs451141541 | 245 | D>G | No | EVA | |
| rs463206138 | 246 | T>P | No | EVA | |
| rs481729171 | 250 | R>S | No | EVA | |
| rs448844391 | 254 | Y>H | No | EVA | |
| rs466927362 | 257 | F>C | No | EVA | |
| rs433999060 | 258 | D>A | No | EVA | |
| rs446084180 | 259 | L>M | No | EVA | |
| rs464682744 | 260 | D>H | No | EVA | |
| rs437707866 | 260 | D>V | No | EVA | |
| rs456184712 | 262 | K>Q | No | EVA | |
| rs435135129 | 277 | W>G | No | EVA | |
| rs453676330 | 278 | D>A | No | EVA | |
| rs472221269 | 282 | E>G | No | EVA | |
| rs439302664 | 287 | T>P | No | EVA | |
| rs471155415 | 290 | E>* | No | EVA | |
| rs444668632 | 290 | E>A | No | EVA | |
| rs444668632 | 290 | E>G | No | EVA | |
| rs463166924 | 291 | M>K | No | EVA | |
| rs475351873 | 292 | M>I | No | EVA | |
| rs442333916 | 293 | V>G | No | EVA | |
| rs460554111 | 295 | A>S | No | EVA | |
| rs478844027 | 295 | A>V | No | EVA | |
| rs482575017 | 296 | A>G | No | EVA | |
| rs458099466 | 296 | A>P | No | EVA | |
| rs468385231 | 298 | Q>R | No | EVA | |
| rs460840436 | 299 | Y>S | No | EVA | |
| rs472373327 | 300 | H>Y | No | EVA | |
| rs439563694 | 303 | K>* | No | EVA | |
| rs458034441 | 305 | S>P | No | EVA | |
| rs482914384 | 310 | V>L | No | EVA | |
| rs381858901 | 316 | T>I | No | EVA | |
| rs450148825 | 328 | S>T | No | EVA | |
| rs461933719 | 331 | E>G | No | EVA | |
| rs480507410 | 332 | V>A | No | EVA | |
| rs466087615 | 337 | S>* | No | EVA | |
| rs447511379 | 337 | S>A | No | EVA | |
| rs447511379 | 337 | S>P | No | EVA | |
| rs432698900 | 338 | A>S | No | EVA | |
| rs469816474 | 343 | L>P | No | EVA | |
| rs469816474 | 343 | L>R | No | EVA | |
| rs445205365 | 346 | L>R | No | EVA | |
| rs469756907 | 351 | E>A | No | EVA | |
| rs481911207 | 351 | E>D | No | EVA | |
| rs467619562 | 409 | V>A | No | EVA | |
| rs482573938 | 414 | Q>E | No | EVA | |
| rs463980474 | 416 | F>V | No | EVA | |
| rs439025135 | 424 | S>A | No | EVA | |
| rs478396143 | 425 | P>H | No | EVA | |
| rs458667858 | 426 | E>D | No | EVA | |
| rs440151115 | 427 | G>C | No | EVA | |
| rs454528770 | 428 | M>I | No | EVA | |
| rs473065020 | 428 | M>L | No | EVA | |
| rs479518237 | 445 | M>I | No | EVA | |
| rs460995826 | 454 | G>D | No | EVA | |
| rs442455860 | 456 | T>N | No | EVA | |
| rs475385278 | 459 | D>A | No | EVA | |
| rs457269042 | 460 | S>R | No | EVA | |
| rs438676500 | 469 | I>N | No | EVA | |
| rs471482066 | 470 | L>V | No | EVA | |
| rs434506031 | 471 | A>G | No | EVA | |
| rs474145003 | 475 | L>P | No | EVA | |
| rs455750298 | 476 | Q>H | No | EVA | |
| rs437213728 | 481 | G>V | No | EVA | |
| rs445202971 | 484 | G>C | No | EVA | |
| rs466429000 | 485 | S>A | No | EVA | |
| rs447928252 | 485 | S>C | No | EVA | |
| rs466429000 | 485 | S>P | No | EVA | |
| rs466429000 | 485 | S>T | No | EVA | |
| rs448868008 | 486 | G>A | No | EVA | |
| rs461078409 | 486 | G>R | No | EVA | |
| rs463338377 | 487 | N>D | No | EVA | |
| rs463338377 | 487 | N>H | No | EVA | |
| rs471517209 | 487 | N>K | No | EVA | |
| rs438311326 | 487 | N>S | No | EVA | |
| rs438311326 | 487 | N>T | No | EVA | |
| rs459473010 | 488 | H>N | No | EVA | |
| rs441013260 | 488 | H>P | No | EVA | |
| rs473984076 | 488 | H>Q | No | EVA | |
| rs437305948 | 490 | Q>H | No | EVA | |
| rs455851114 | 490 | Q>P | No | EVA | |
| rs455851114 | 490 | Q>R | No | EVA | |
| rs476698339 | 491 | G>R | No | EVA | |
| rs466516682 | 493 | D>A | No | EVA | |
| rs447964917 | 493 | D>E | No | EVA | |
| rs466516682 | 493 | D>G | No | EVA | |
| rs433147124 | 493 | D>H | No | EVA | |
| rs468766443 | 494 | A>G | No | EVA | |
| rs435813245 | 494 | A>P | No | EVA | |
| rs450234915 | 495 | S>P | No | EVA | |
| rs481977258 | 496 | A>P | No | EVA | |
| rs444838289 | 497 | E>A | No | EVA | |
| rs444838289 | 497 | E>G | No | EVA | |
| rs463424581 | 497 | E>Q | No | EVA | |
| rs459509750 | 499 | L>P | No | EVA | |
| rs474099740 | 500 | N>H | No | EVA | |
| rs443377000 | 500 | N>K | No | EVA | |
| rs461924039 | 500 | N>S | No | EVA | |
| rs461924039 | 500 | N>T | No | EVA | |
| rs451821096 | 501 | P>R | No | EVA | |
| rs476776311 | 501 | P>S | No | EVA | |
| rs472571837 | 502 | Y>H | No | EVA | |
| rs472571837 | 502 | Y>N | No | EVA | |
| rs454091148 | 502 | Y>S | No | EVA | |
| rs456686238 | 506 | A>G | No | EVA | |
| rs438177010 | 509 | F>C | No | EVA | |
| rs438177010 | 509 | F>Y | No | EVA | |
| rs469910976 | 510 | Q>E | No | EVA | |
| rs444874755 | 512 | K>Q | No | EVA | |
| rs477640035 | 516 | K>R | No | EVA | |
| rs455008651 | 519 | T>P | No | EVA | |
| rs435298229 | 526 | H>P | No | EVA | |
| rs474663850 | 527 | Q>* | No | EVA | |
| rs456121194 | 529 | V>L | No | EVA | |
| rs445939764 | 537 | A>G | No | EVA | |
| rs464504640 | 537 | A>T | No | EVA | |
| rs433794919 | 542 | I>V | No | EVA | |
| rs448156613 | 545 | W>C | No | EVA | |
| rs466803837 | 545 | W>R | No | EVA | |
| rs481565511 | 547 | S>P | No | EVA | |
| rs463005098 | 548 | L>P | No | EVA | |
| rs477188780 | 553 | I>S | No | EVA | |
| rs459120542 | 557 | V>G | No | EVA | |
| rs440682029 | 559 | R>G | No | EVA | |
| rs476656156 | 576 | L>Q | No | EVA | |
| rs439624657 | 579 | I>S | No | EVA | |
| rs472922955 | 581 | L>F | No | EVA | |
| rs435816040 | 586 | V>G | No | EVA | |
| rs436859007 | 593 | S>R | No | EVA | |
| rs456543537 | 593 | S>T | No | EVA | |
| rs469666277 | 595 | M>I | No | EVA | |
| rs444838344 | 596 | R>G | No | EVA | |
| rs444838344 | 596 | R>S | No | EVA | |
| rs466051350 | 598 | W>G | No | EVA | |
| rs447564592 | 600 | V>F | No | EVA | |
| rs447564592 | 600 | V>I | No | EVA | |
| rs480546524 | 603 | D>A | No | EVA | |
| rs449863487 | 606 | Q>P | No | EVA | |
| rs482796260 | 607 | V>E | No | EVA | |
| rs446175159 | 608 | A>P | No | EVA | |
| rs479120921 | 608 | A>V | No | EVA | |
| rs460555863 | 616 | N>T | No | EVA | |
| rs441951794 | 617 | V>A | No | EVA | |
| rs444626570 | 633 | I>M | No | EVA | |
| rs470991636 | 635 | G>V | No | EVA | |
| rs439290722 | 641 | T>S | No | EVA | |
| rs453731993 | 648 | E>G | No | EVA | |
| rs435178187 | 649 | E>G | No | EVA | |
| rs468502386 | 650 | L>P | No | EVA | |
| rs456415884 | 651 | D>E | No | EVA | |
| rs437865556 | 652 | E>G | No | EVA | |
| rs464377675 | 653 | D>A | No | EVA | |
| rs464377675 | 653 | D>V | No | EVA | |
| rs445744001 | 657 | Q>K | No | EVA | |
| rs479163696 | 657 | Q>R | No | EVA | |
| rs467019306 | 658 | L>R | No | EVA | |
| rs448516097 | 659 | T>P | No | EVA | |
| rs463118761 | 662 | H>N | No | EVA | |
| rs444714373 | 662 | H>P | No | EVA | |
| rs477462543 | 662 | H>Q | No | EVA | |
| rs458992120 | 663 | E>G | No | EVA | |
| rs440584860 | 666 | F>G | No | EVA |
1 associated diseases with Q32LP0
[MIM: 243800]: Johanson-Blizzard syndrome (JBS)
This disorder includes congenital exocrine pancreatic insufficiency, multiple malformations such as nasal wing aplasia, and intellectual disability. Pancreas of individuals with JBS do not express UBR1 and show intrauterine-onset destructive pancreatitis. . Note=The disease is caused by variants affecting the gene represented in this entry.
Without disease ID
- This disorder includes congenital exocrine pancreatic insufficiency, multiple malformations such as nasal wing aplasia, and intellectual disability. Pancreas of individuals with JBS do not express UBR1 and show intrauterine-onset destructive pancreatitis. . Note=The disease is caused by variants affecting the gene represented in this entry.
4 regional properties for Q32LP0
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell projection | A prolongation or process extending from a cell, e.g. a flagellum or axon. |
| cell-substrate junction | A cell junction that forms a connection between a cell and the extracellular matrix. |
| podosome | An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| integrin binding | Binding to an integrin. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cell-matrix adhesion | The binding of a cell to the extracellular matrix via adhesion molecules. |
| integrin activation | The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands. |
| integrin-mediated signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| leukocyte cell-cell adhesion | The attachment of a leukocyte to another cell via adhesion molecules. |
| platelet aggregation | The adhesion of one platelet to one or more other platelets via adhesion molecules. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| regulation of cell-cell adhesion mediated by integrin | Any process that modulates the frequency, rate, or extent of cell-cell adhesion mediated by integrin. |
| substrate adhesion-dependent cell spreading | The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9VZI3 | Fit1 | Unc-112-related protein | Drosophila melanogaster (Fruit fly) | SS |
| Q96AC1 | FERMT2 | Fermitin family homolog 2 | Homo sapiens (Human) | SS |
| Q9BQL6 | FERMT1 | Fermitin family homolog 1 | Homo sapiens (Human) | SS |
| Q86UX7 | FERMT3 | Fermitin family homolog 3 | Homo sapiens (Human) | EV |
| Q9Y4G6 | TLN2 | Talin-2 | Homo sapiens (Human) | SS |
| Q9Y490 | TLN1 | Talin-1 | Homo sapiens (Human) | EV |
| P59113 | Fermt1 | Fermitin family homolog 1 | Mus musculus (Mouse) | SS |
| Q8CIB5 | Fermt2 | Fermitin family homolog 2 | Mus musculus (Mouse) | SS |
| Q8K1B8 | Fermt3 | Fermitin family homolog 3 | Mus musculus (Mouse) | SS |
| P26039 | Tln1 | Talin-1 | Mus musculus (Mouse) | EV |
| Q18685 | unc-112 | Protein unc-112 | Caenorhabditis elegans | SS |
| F1Q8X5 | fermt2 | Fermitin family homolog 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGMKTATGD | YIDSSWELRV | FIGEEDPEAE | SLTLRVTGES | HIGGVLLKIV | EEIKRKQDWS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DHAIWWEQKR | QWLLQTHWTL | DKYGILADAR | LFFGPQHRPV | ILRLPNRRAL | RLRASFSQPL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FQAMVAICRL | LSIRHPEEMS | LLRAPEKEKK | KKKEKEPEEE | VYDLTKVVLV | GGVAPASFRG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MPAHFSDSAQ | TEACYHMLSR | PQPPPDPLLL | QRLPRPSSLL | DKTQLHSRWL | DSSRCLMQQG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IKAGDTLWLR | FKYYSFFDLD | PKTDPVRLTQ | LYEQARWDLL | LEEIDCTEEE | MMVFAALQYH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| INKLSQSGEV | DEPAGTDSGL | DDLDLALSNL | EVKLEGSAPT | DMLDSLTTIP | ELKDHLRIFR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PRKLTLKGYR | QHWVVFKETT | LSYYKSQDEA | PGEPIQQLNL | KGCEVVPDVN | VSGQKFCIKL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LVPSPEGMSE | IYLRCQDEQQ | YARWMAGCRL | ASKGRTMADS | SYSSEVQAIL | AFLSLQRTGG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GGGGSGNHPQ | GPDASAEGLN | PYGLVAPRFQ | RKFKAKQLTP | RILEAHQNVA | QLSLSEAQLR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FIQAWQSLPD | FGISYVVVRF | KGSRKDEILG | IANNRLIRID | LSVGDVVKTW | RFSNMRQWNV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NWDIRQVAIE | FDEHINVAFS | CVSASCRIVH | EYIGGYIFLS | TRERARGEEL | DEDLFLQLTG |
| GHEAF |