Q32L34
Gene name |
HMGB4 |
Protein name |
High mobility group protein B4 |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:539195 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q32L34
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q32L34-F1 | Predicted | AlphaFoldDB |
9 variants for Q32L34
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs441218776 | 15 | S>C | No | EVA | |
| rs450802982 | 37 | G>C | No | EVA | |
| rs482173561 | 92 | A>T | No | EVA | |
| rs452670623 | 137 | V>A | No | EVA | |
| rs437292095 | 153 | Y>F | No | EVA | |
| rs800321702 | 158 | S>T | No | EVA | |
| rs476656326 | 188 | D>A | No | EVA | |
| rs457138657 | 189 | T>I | No | EVA | |
| rs435346083 | 194 | N>H | No | EVA |
No associated diseases with Q32L34
2 regional properties for Q32L34
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | High mobility group box domain | 8 - 80 | IPR009071-1 |
| domain | High mobility group box domain | 92 - 162 | IPR009071-2 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding, bending | The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0II87 | TFAM | Transcription factor A, mitochondrial | Bos taurus (Bovine) | PR |
| P17480 | UBTF | Nucleolar transcription factor 1 | Homo sapiens (Human) | EV |
| Q00059 | TFAM | Transcription factor A, mitochondrial | Homo sapiens (Human) | PR |
| P40630 | Tfam | Transcription factor A, mitochondrial | Mus musculus (Mouse) | PR |
| Q3USZ2 | Ubtfl1 | Upstream-binding factor 1-like protein 1 | Mus musculus (Mouse) | PR |
| P25976 | Ubtf | Nucleolar transcription factor 1 | Mus musculus (Mouse) | PR |
| Q5D144 | TFAM | Transcription factor A, mitochondrial | Sus scrofa (Pig) | PR |
| P25977 | Ubtf | Nucleolar transcription factor 1 | Rattus norvegicus (Rat) | PR |
| Q9T012 | HMGB13 | High mobility group B protein 13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SUP7 | HMGB6 | High mobility group B protein 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGKRDQLKPK | ANVSSYIHFL | LNYRNKFKEQ | QPNTYLGFKE | FSRKCSEKWR | SISKHEKAKY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EALAKLDKAR | YQEEMMNYFG | RRKKRRKRDP | HAPRRPPSSF | LLFCQDHYAQ | LKSENPSWSV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VQVAKASGKM | WSAKTDVDKQ | PYEQRAALLR | AKYREELSVY | RNQFNARKTC | LQESATNQCR |
| 190 | |||||
| EFEQAESDTT | DGSN |