Q32L27

PR
Gene name
UBE2Q2
Protein name
Ubiquitin-conjugating enzyme E2 Q2
Names
E2 ubiquitin-conjugating enzyme Q2, Ubiquitin carrier protein Q2, Ubiquitin-protein ligase Q2
Species
Bos taurus (Bovine)
KEGG Pathway
bta:511631
EC number
2.3.2.23: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

118-206 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q32L27

Entry ID Method Resolution Chain Position Source
AF-Q32L27-F1 Predicted AlphaFoldDB

51 variants for Q32L27

Variant ID(s) Position Change Description Diseaes Association Provenance
rs434312964 3 V>G No EVA
rs473025730 9 E>A No EVA
rs441703368 9 E>D No EVA
rs475562834 12 F>L No EVA
rs461878736 12 F>V No EVA
rs444230435 14 A>E No EVA
rs457906637 15 S>A No EVA
rs457906637 15 S>P No EVA
rs440293539 16 I>M No EVA
rs460362921 24 F>L No EVA
rs469509326 41 P>T No EVA
rs483218979 43 P>T No EVA
rs465592100 47 G>A No EVA
rs132738989 48 S>I No EVA
rs132738989 48 S>T No EVA
rs134935455 50 H>L No EVA
rs134935455 50 H>P No EVA
rs134935455 50 H>R No EVA
rs136326618 51 S>A No EVA
rs136326618 51 S>P No EVA
rs475535882 53 P>A No EVA
rs444141767 56 L>R No EVA
rs471445660 58 L>P No EVA
rs471445660 58 L>R No EVA
rs440230116 59 H>P No EVA
rs440230116 59 H>R No EVA
rs460276952 60 C>G No EVA
rs480377883 60 C>S No EVA
rs442800218 61 N>H No EVA
rs462954268 61 N>S No EVA
rs483143734 62 I>L No EVA
rs445324747 63 T>R No EVA
rs448236961 64 E>D No EVA
rs379986206 90 E>Q No EVA
rs458402636 126 M>I No EVA
rs478730970 129 E>G No EVA
rs209572777 132 I>V No EVA
rs481264909 143 E>* No EVA
rs449965299 152 K>* No EVA
rs432920919 173 S>* No EVA
rs473188507 174 D>V No EVA
rs461894327 186 S>* No EVA
rs441879465 186 S>A No EVA
rs444377136 187 Q>R No EVA
rs482468012 279 G>R No EVA
rs451109455 280 W>C No EVA
rs464824320 288 S>L No EVA
rs451760727 311 N>H No EVA
rs471916592 312 Q>K No EVA
rs440638547 323 N>S No EVA
rs460782934 324 S>P No EVA

No associated diseases with Q32L27

1 regional properties for Q32L27

Type Name Position InterPro Accession
domain Ubiquitin-conjugating enzyme E2 171 - 335 IPR000608

Functions

Description
EC Number 2.3.2.23 Aminoacyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ubiquitin conjugating enzyme activity Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.
ubiquitin-protein transferase activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.

2 GO annotations of biological process

Name Definition
protein K48-linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P61085 UBE2K Ubiquitin-conjugating enzyme E2 K Bos taurus (Bovine) PR
Q32LD2 UBE2T Ubiquitin-conjugating enzyme E2 T Bos taurus (Bovine) PR
Q32PA5 UBE2C Ubiquitin-conjugating enzyme E2 C Bos taurus (Bovine) PR
Q1RML1 UBE2S Ubiquitin-conjugating enzyme E2 S Bos taurus (Bovine) SS
Q7Z7E8 UBE2Q1 Ubiquitin-conjugating enzyme E2 Q1 Homo sapiens (Human) PR
A1L167 UBE2QL1 Ubiquitin-conjugating enzyme E2Q-like protein 1 Homo sapiens (Human) PR
A0PJN4 Ube2ql1 Ubiquitin-conjugating enzyme E2Q-like protein 1 Mus musculus (Mouse) PR
Q7TSS2 Ube2q1 Ubiquitin-conjugating enzyme E2 Q1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MSVSGLKAEL KFLASIFDKN HERFRIVSWK LDELHCQFLV PPPAPPGSPH SPPPPLTLHC
70 80 90 100 110 120
NITESYPSSS PIWFVDSDDP NLTSVLERLE DTKNNNSNGT TEEVTSEEEE EEEMAEDIED
130 140 150 160 170 180
LDHYEMKEEE PISGKKSEDE GIEKENLAIL EKIRKTQRQD HLNGAVSGSV QASDRLMKEL
190 200 210 220 230 240
RDIYRSQSYK TGIYSVELIN DSLYDWHVKL QKVDPDSPLH SDLQILKEKE GIEYILLNFS
250 260 270 280 290 300
FKDNFPFDPP FVRVVLPVLS GGYVLGGGAL CMELLTKQGW SSAYSIESVI MQINATLVKG
310 320 330 340
KARVQFGANK NQYNLARAQQ SYNSIVQIHE KNGWYTPPKE DG