Q2VUH7

SS
Gene name
Dixdc1 (Ccd1)
Protein name
Dixin
Names
Coiled-coil protein DIX1 , Coiled-coil-DIX1 , DIX domain-containing protein 1
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:363062
EC number
Protein Class

Descriptions

Coiled-coil protein DIX1 (Ccd1, Dixin) is an important positive regulator activating the canonical Wnt signaling pathway. The DIX domain of Ccd1 functions as a switching hub in the Wnt pathway via dynamic polymerization. Homopolymerization of the DIX domain is regulated by insertion of loop β1-β2 of the DIX domain into the head-to-tail interface, preventing the formation of head-to-tail helical filaments and consequently inhibiting its transcriptional activity. The autoinhibition of Ccd1 is relieved by co-expression of Dvl, binding to DISC1, and Cdk25- or MARK1/4-mediated phosphorylation.

Autoinhibitory domains (AIDs)

603-619 (β1-β2 loop) SS

Target domain

650-659 (β3-β4 loop)

Relief mechanism

Partner binding, PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2VUH7

Entry ID Method Resolution Chain Position Source
AF-Q2VUH7-F1 Predicted AlphaFoldDB

No variants for Q2VUH7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2VUH7

No associated diseases with Q2VUH7

2 regional properties for Q2VUH7

Type Name Position InterPro Accession
domain DIX domain 600 - 682 IPR001158
domain Calponin homology domain 20 - 127 IPR001715

Functions

Description
EC Number
Subcellular Localization
  • Cell junction, focal adhesion
  • Cytoplasm, cytoskeleton, stress fiber
  • Cytoplasm
  • Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis
  • Associated with actin stress fiber at the filament ends
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
axon terminus Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
stress fiber A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.

5 GO annotations of molecular function

Name Definition
actin binding Binding to monomeric or multimeric forms of actin, including actin filaments.
frizzled binding Binding to a frizzled (fz) receptor.
gamma-tubulin binding Binding to the microtubule constituent protein gamma-tubulin.
mitogen-activated protein kinase kinase kinase binding Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase.
protein domain specific binding Binding to a specific domain of a protein.

12 GO annotations of biological process

Name Definition
canonical Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
cell proliferation in forebrain The creation of greater cell numbers in the forebrain due to cell division of progenitor cells.
cerebellar cortex development The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
cerebral cortex cell migration The orderly movement of cells from one site to another in the cerebral cortex.
cerebral cortex radially oriented cell migration The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain.
forebrain ventricular zone progenitor cell division The mitotic division of a basal progenitor giving rise to two neurons.
negative regulation of neuron differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
positive regulation of axonogenesis Any process that activates or increases the frequency, rate or extent of axonogenesis.
positive regulation of JNK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
positive regulation of Wnt signaling pathway Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
regulation of actin cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of microtubule cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q155Q3 DIXDC1 Dixin Homo sapiens (Human) SS
Q80Y83 Dixdc1 Dixin Mus musculus (Mouse) EV
Q804T6 dixdc1a Dixin-A Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MLACLTRGNL LDVLQEGFNE QQLQAYVAWV NAQLKKRPSV KPVQDLRQDL RDGVILAYLI
70 80 90 100 110 120
EIVAGEKLSG VQLSPSNQQE MKSNVERVLQ FVASKNIRMH QTSAKDIVEG NLKSIMRLVL
130 140 150 160 170 180
ALAAHFKPGS SRTVSQGRDS RTSVQSHQPH CATAVAQGAA AALADVCHDV SRSGRDVFRY
190 200 210 220 230 240
RQRNASVDEE IENPYWSVRA LVQQYEGQQR SPSESSCSSL TSPSPIHSAK SESIITQSEE
250 260 270 280 290 300
KADFVIIPSE GIENRTDETG SPLSRDWRPG SPGTYLEATW EEQLLEQQEH LEKEMEEAKK
310 320 330 340 350 360
MISGLQALLL NGSLPEDEQE RPVALCEPGV NPEEQLIIIR SRLDQSMEEN QDLKKELLKC
370 380 390 400 410 420
KQEARNLQGI KDALQQRLTQ QDTSVLQLKQ ELLRANMDKD ELHNQNVDLQ RKLDERNRLL
430 440 450 460 470 480
GEYKKDLGQK DRLLQQQQAK LEDALRKLSD ASYQQVDLER ELEQKDVLLA HRVKGDTDEV
490 500 510 520 530 540
TNYNSHSSQR NGFVLPVAGR AATTATHRGP QSSDLQLVRD ALRSLRNSFS GHDPQHHTID
550 560 570 580 590 600
SLEQGISSLI ERLHVIETQK KQERKVRGRS PRNQASSEYR ASWPPNSTLP HSQSSPAVSN
610 620 630 640 650 660
TCTKVLYFTD RSLTPFMVNI PKRLGEVTLK DFKAAIDREG SHRYHFKALD PEFGTVKEEV
670 680
FHDDDAIPGW EGKIVAWVED HREN