Q2V452
SS
Gene name |
CIPK3 (PKS12, SnRK3.17, At2g26980, T20P8.3) |
Protein name |
CBL-interacting serine/threonine-protein kinase 3 |
Names |
EC 2.7.11.1 , SNF1-related kinase 3.17 , SOS2-like protein kinase PKS12 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G26980 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
AMP-activated protein kinase (AMPK) acts as an energy sensor, being activated by metabolic stresses and regulating cellular metabolism. AMPK is a heterotrimer consisting of a catalytic alpha subunit and two regulatory subunits, beta and gamma. AMPK alpha subunit contains an autoinhibitory domain that inhibits the N-terminal kinase domain. Autoinhibitory region of AMPK alpha are not only responsible for kinase autoinhibition, but may also be responsible for full-length kinase degradation.
Autoinhibitory domains (AIDs)
Target domain |
14-269 (Protein kinase domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
154-184 (Activation loop from InterPro)
Target domain |
14-269 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Pang T et al. (2007) "Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits", The Journal of biological chemistry, 282, 495-506
- Hardie DG et al. (2012) "AMP-activated protein kinase: a target for drugs both ancient and modern", Chemistry & biology, 19, 1222-36
- Li YY et al. (2013) "Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice", Toxicology and applied pharmacology, 273, 325-34
- Oakhill JS et al. (2009) "Structure and function of AMP-activated protein kinase", Acta physiologica (Oxford, England), 196, 3-14
- Pang T et al. (2008) "Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells", The Journal of biological chemistry, 283, 16051-60
- Scott JW et al. (2014) "ATP sensitive bi-quinoline activator of the AMP-activated protein kinase", Biochemical and biophysical research communications, 443, 435-40
Autoinhibited structure
Activated structure
1 structures for Q2V452
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2V452-F1 | Predicted | AlphaFoldDB |
23 variants for Q2V452
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_2_11517917_C_A | 64 | A>S | No | 1000Genomes | |
| tmp_2_11517884_C_T | 75 | V>I | No | 1000Genomes | |
| tmp_2_11517747_A_T | 88 | F>Y | No | 1000Genomes | |
| ENSVATH05602056 | 91 | L>M | No | 1000Genomes | |
| tmp_2_11517730_C_A | 94 | V>F | No | 1000Genomes | |
| ENSVATH01903874 | 147 | S>A | No | 1000Genomes | |
| tmp_2_11517011_T_G,A | 187 | N>I | No | 1000Genomes | |
| tmp_2_11517011_T_G,A | 187 | N>T | No | 1000Genomes | |
| tmp_2_11517002_C_A | 190 | G>V | No | 1000Genomes | |
| ENSVATH05602044 | 207 | V>A | No | 1000Genomes | |
| ENSVATH05602036 | 263 | V>I | No | 1000Genomes | |
| ENSVATH05602033 | 281 | R>K | No | 1000Genomes | |
| tmp_2_11516133_C_A | 281 | R>S | No | 1000Genomes | |
| ENSVATH01903861 | 286 | M>K | No | 1000Genomes | |
| ENSVATH00250264 | 295 | D>N | No | 1000Genomes | |
| ENSVATH13423913 | 312 | I>V | No | 1000Genomes | |
| tmp_2_11515805_C_G | 339 | E>Q | No | 1000Genomes | |
| tmp_2_11515798_C_G | 341 | R>T | No | 1000Genomes | |
| tmp_2_11515750_T_G | 357 | E>A | No | 1000Genomes | |
| ENSVATH14558051 | 380 | A>V | No | 1000Genomes | |
| ENSVATH01903856 | 392 | I>V | No | 1000Genomes | |
| ENSVATH00250260 | 411 | T>S | No | 1000Genomes | |
| ENSVATH13423910 | 441 | K>* | No | 1000Genomes |
No associated diseases with Q2V452
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
71 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q02066 | Abscisic acid-inducible protein kinase | Triticum aestivum (Wheat) | PR | |
| Q5GLH2 | TRIB2 | Tribbles homolog 2 | Bos taurus (Bovine) | SS |
| Q0VCE3 | TRIB3 | Tribbles homolog 3 | Bos taurus (Bovine) | SS |
| Q3SZW1 | TSSK1B | Testis-specific serine/threonine-protein kinase 1 | Bos taurus (Bovine) | PR |
| O61661 | grp | Serine/threonine-protein kinase grp | Drosophila melanogaster (Fruit fly) | SS |
| Q92519 | TRIB2 | Tribbles homolog 2 | Homo sapiens (Human) | SS |
| Q96RU7 | TRIB3 | Tribbles homolog 3 | Homo sapiens (Human) | PR |
| Q14680 | MELK | Maternal embryonic leucine zipper kinase | Homo sapiens (Human) | EV |
| Q96RU8 | TRIB1 | Tribbles homolog 1 | Homo sapiens (Human) | EV |
| Q13131 | PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Homo sapiens (Human) | EV |
| Q96RG2 | PASK | PAS domain-containing serine/threonine-protein kinase | Homo sapiens (Human) | EV |
| P54646 | PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Homo sapiens (Human) | EV |
| Q9BXA7 | TSSK1B | Testis-specific serine/threonine-protein kinase 1 | Homo sapiens (Human) | PR |
| Q15831 | STK11 | Serine/threonine-protein kinase STK11 | Homo sapiens (Human) | PR |
| O60285 | NUAK1 | NUAK family SNF1-like kinase 1 | Homo sapiens (Human) | PR |
| Q9NRH2 | SNRK | SNF-related serine/threonine-protein kinase | Homo sapiens (Human) | SS |
| P57059 | SIK1 | Serine/threonine-protein kinase SIK1 | Homo sapiens (Human) | PR |
| Q96RR4 | CAMKK2 | Calcium/calmodulin-dependent protein kinase kinase 2 | Homo sapiens (Human) | PR |
| Q8K4K3 | Trib2 | Tribbles homolog 2 | Mus musculus (Mouse) | SS |
| Q8BRK8 | Prkaa2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Mus musculus (Mouse) | SS |
| Q61241 | Tssk1b | Testis-specific serine/threonine-protein kinase 1 | Mus musculus (Mouse) | PR |
| Q8K4K2 | Trib3 | Tribbles homolog 3 | Mus musculus (Mouse) | SS |
| Q61846 | Melk | Maternal embryonic leucine zipper kinase | Mus musculus (Mouse) | PR |
| O54863 | Tssk2 | Testis-specific serine/threonine-protein kinase 2 | Mus musculus (Mouse) | PR |
| Q5EG47 | Prkaa1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Mus musculus (Mouse) | SS |
| Q8K4K4 | Trib1 | Tribbles homolog 1 | Mus musculus (Mouse) | SS |
| Q641K5 | Nuak1 | NUAK family SNF1-like kinase 1 | Mus musculus (Mouse) | PR |
| Q8C078 | Camkk2 | Calcium/calmodulin-dependent protein kinase kinase 2 | Mus musculus (Mouse) | PR |
| Q28948 | PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Sus scrofa (Pig) | SS |
| Q9WTQ6 | Trib3 | Tribbles homolog 3 | Rattus norvegicus (Rat) | SS |
| Q09137 | Prkaa2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Rattus norvegicus (Rat) | EV |
| P54645 | Prkaa1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Rattus norvegicus (Rat) | EV |
| Q5QNM6 | CIPK13 | Putative CBL-interacting protein kinase 13 | Oryza sativa subsp japonica (Rice) | PR |
| Q5JLQ9 | CIPK30 | CBL-interacting protein kinase 30 | Oryza sativa subsp japonica (Rice) | PR |
| Q5N942 | SAPK4 | Serine/threonine-protein kinase SAPK4 | Oryza sativa subsp japonica (Rice) | PR |
| Q852Q0 | OSK3 | Serine/threonine protein kinase OSK3 | Oryza sativa subsp. japonica (Rice) | SS |
| Q75LR7 | SAPK1 | Serine/threonine-protein kinase SAPK1 | Oryza sativa subsp japonica (Rice) | PR |
| Q75H77 | SAPK10 | Serine/threonine-protein kinase SAPK10 | Oryza sativa subsp japonica (Rice) | PR |
| Q7Y0B9 | SAPK8 | Serine/threonine-protein kinase SAPK8 | Oryza sativa subsp japonica (Rice) | PR |
| Q7XQP4 | SAPK7 | Serine/threonine-protein kinase SAPK7 | Oryza sativa subsp japonica (Rice) | PR |
| Q852Q2 | OSK1 | Serine/threonine protein kinase OSK1 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6ZLP5 | CIPK23 | CBL-interacting protein kinase 23 | Oryza sativa subsp japonica (Rice) | PR |
| Q0D4J7 | SAPK2 | Serine/threonine-protein kinase SAPK2 | Oryza sativa subsp japonica (Rice) | PR |
| Q8LIG4 | CIPK3 | CBL-interacting protein kinase 3 | Oryza sativa subsp japonica (Rice) | PR |
| Q852Q1 | OSK4 | Serine/threonine protein kinase OSK4 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6ERS4 | CIPK16 | CBL-interacting protein kinase 16 | Oryza sativa subsp japonica (Rice) | PR |
| P0C5D6 | SAPK3 | Serine/threonine-protein kinase SAPK3 | Oryza sativa subsp japonica (Rice) | PR |
| Q75V57 | SAPK9 | Serine/threonine-protein kinase SAPK9 | Oryza sativa subsp japonica (Rice) | PR |
| Q2RAX3 | CIPK33 | CBL-interacting protein kinase 33 | Oryza sativa subsp japonica (Rice) | PR |
| Q2QY53 | CIPK32 | CBL-interacting protein kinase 32 | Oryza sativa subsp japonica (Rice) | PR |
| Q21017 | kin-29 | Serine/threonine-protein kinase kin-29 | Caenorhabditis elegans | SS |
| P45894 | aak-1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Caenorhabditis elegans | SS |
| Q95ZQ4 | aak-2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Caenorhabditis elegans | SS |
| P43291 | SRK2A | Serine/threonine-protein kinase SRK2A | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93VD3 | CIPK23 | CBL-interacting serine/threonine-protein kinase 23 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C958 | SRK2B | Serine/threonine-protein kinase SRK2B | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M9E9 | SRK2C | Serine/threonine-protein kinase SRK2C | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64812 | SRK2J | Serine/threonine-protein kinase SRK2J | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38997 | KIN10 | SNF1-related protein kinase catalytic subunit alpha KIN10 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| P92958 | KIN11 | SNF1-related protein kinase catalytic subunit alpha KIN11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q39192 | SRK2D | Serine/threonine-protein kinase SRK2D | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q940H6 | SRK2E | Serine/threonine-protein kinase SRK2E | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43292 | SRK2G | Serine/threonine-protein kinase SRK2G | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDI3 | CIPK24 | CBL-interacting serine/threonine-protein kinase 24 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FLZ3 | KIN12 | SNF1-related protein kinase catalytic subunit alpha KIN12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CG0 | CIPK21 | CBL-interacting serine/threonine-protein kinase 21 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FFP9 | SRK2H | Serine/threonine-protein kinase SRK2H | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q39193 | SRK2I | Serine/threonine-protein kinase SRK2I | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O22971 | CIPK13 | CBL-interacting serine/threonine-protein kinase 13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O65554 | CIPK6 | CBL-interacting serine/threonine-protein kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FJ54 | CIPK20 | CBL-interacting serine/threonine-protein kinase 20 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNRRQQVKRR | VGKYEVGRTI | GEGTFAKVKF | ARNSETGEPV | ALKILDKEKV | LKHKMAEQIR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| REIATMKLIK | HPNVVQLYEV | MASKTKIFII | LEYVTGGELF | DKIVNDGRMK | EDEARRYFQQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LIHAVDYCHS | RGVYHRDLKP | ENLLLDSYGN | LKISDFGLSA | LSQQVRDDGL | LHTSCGTPNY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VAPEVLNDRG | YDGATADMWS | CGVVLYVLLA | GYLPFDDSNL | MNLYKKISSG | EFNCPPWLSL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GAMKLITRIL | DPNPMTRVTP | QEVFEDEWFK | KDYKPPVFEE | RDDSNMDDID | AVFKDSEEHL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VTEKREEQPA | AINAFEIISM | SRGLNLENLF | DPEQEFKRET | RITLRGGANE | IIEKIEEAAK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PLGFDVQKKN | YKMRLENVKA | GRKGNLNVAT | EIFQVAPSLH | MVQVSKSKGD | TLEFHKFYKK |
| 430 | 440 | ||||
| LSNSLEQVVW | TNNEVKKETA | K |