Q2TBL8
Gene name |
CDK10 |
Protein name |
Cyclin-dependent kinase 10 |
Names |
Cell division protein kinase 10 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:615171 |
EC number |
2.7.11.22: Protein-serine/threonine kinases |
Protein Class |
|

Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
178-201 (Activation loop from InterPro)
Target domain |
29-337 (Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure

Activated structure

1 structures for Q2TBL8
Entry ID | Method | Resolution | Chain | Position | Source |
---|---|---|---|---|---|
AF-Q2TBL8-F1 | Predicted | AlphaFoldDB |
126 variants for Q2TBL8
Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
---|---|---|---|---|---|
rs476492548 | 3 | E>G | No | EVA | |
rs438630760 | 6 | P>S | No | EVA | |
rs458670841 | 8 | Q>P | No | EVA | |
rs440415766 | 11 | L>S | No | EVA | |
rs460397471 | 14 | V>F | No | EVA | |
rs460397471 | 14 | V>L | No | EVA | |
rs480385757 | 18 | G>C | No | EVA | |
rs442764074 | 23 | P>H | No | EVA | |
rs463294926 | 26 | H>P | No | EVA | |
rs458840584 | 42 | R>L | No | EVA | |
rs479171700 | 51 | V>E | No | EVA | |
rs460728291 | 65 | L>M | No | EVA | |
rs480967410 | 67 | K>Q | No | EVA | |
rs449475010 | 68 | V>E | No | EVA | |
rs469509804 | 75 | D>Y | No | EVA | |
rs447359418 | 102 | V>G | No | EVA | |
rs449659431 | 105 | G>A | No | EVA | |
rs481105013 | 105 | G>W | No | EVA | |
rs432210313 | 107 | H>D | No | EVA | |
rs445872256 | 110 | S>R | No | EVA | |
rs465885820 | 111 | I>S | No | EVA | |
rs479442998 | 118 | C>S | No | EVA | |
rs448266775 | 121 | D>A | No | EVA | |
rs436454505 | 127 | E>G | No | EVA | |
rs456474577 | 129 | M>T | No | EVA | |
rs470152290 | 135 | E>Q | No | EVA | |
rs432659729 | 137 | Q>H | No | EVA | |
rs435092428 | 138 | V>D | No | EVA | |
rs468829528 | 143 | L>R | No | EVA | |
rs473003183 | 153 | H>P | No | EVA | |
rs473003183 | 153 | H>R | No | EVA | |
rs447782957 | 202 | Y>D | No | EVA | |
rs467826870 | 202 | Y>S | No | EVA | |
rs436416621 | 205 | P>H | No | EVA | |
rs436416621 | 205 | P>R | No | EVA | |
rs450100442 | 206 | E>V | No | EVA | |
rs470478414 | 208 | L>R | No | EVA | |
rs132710145 | 209 | L>R | No | EVA | |
rs452647354 | 210 | G>A | No | EVA | |
rs432601090 | 210 | G>R | No | EVA | |
rs452647354 | 210 | G>V | No | EVA | |
rs137104503 | 212 | T>P | No | EVA | |
rs434965668 | 214 | Q>E | No | EVA | |
rs454654989 | 220 | M>L | No | EVA | |
rs475696136 | 222 | A>P | No | EVA | |
rs451480137 | 226 | I>L | No | EVA | |
rs471122839 | 227 | L>Q | No | EVA | |
rs439662123 | 228 | A>T | No | EVA | |
rs459825867 | 234 | K>T | No | EVA | |
rs473423513 | 236 | L>R | No | EVA | |
rs482277389 | 243 | I>L | No | EVA | |
rs451006964 | 243 | I>N | No | EVA | |
rs451006964 | 243 | I>S | No | EVA | |
rs458233404 | 245 | Q>P | No | EVA | |
rs446543365 | 247 | D>V | No | EVA | |
rs477962850 | 247 | D>Y | No | EVA | |
rs435227568 | 248 | L>P | No | EVA | |
rs469282105 | 250 | V>G | No | EVA | |
rs437865479 | 251 | Q>* | No | EVA | |
rs433751713 | 254 | G>R | No | EVA | |
rs433751713 | 254 | G>W | No | EVA | |
rs453377081 | 255 | T>A | No | EVA | |
rs473524624 | 255 | T>S | No | EVA | |
rs475926601 | 256 | P>H | No | EVA | |
rs461935277 | 256 | P>S | No | EVA | |
rs444667688 | 257 | S>R | No | EVA | |
rs458422802 | 258 | E>A | No | EVA | |
rs458422802 | 258 | E>G | No | EVA | |
rs478491178 | 260 | I>S | No | EVA | |
rs447038762 | 262 | P>A | No | EVA | |
rs447038762 | 262 | P>S | No | EVA | |
rs482655175 | 263 | G>A | No | EVA | |
rs444825561 | 264 | F>S | No | EVA | |
rs465225047 | 266 | Q>R | No | EVA | |
rs478913952 | 269 | L>Q | No | EVA | |
rs478913952 | 269 | L>R | No | EVA | |
rs467372316 | 270 | A>D | No | EVA | |
rs447405150 | 270 | A>P | No | EVA | |
rs436126977 | 293 | A>P | No | EVA | |
rs455706677 | 293 | A>V | No | EVA | |
rs469309454 | 294 | G>D | No | EVA | |
rs469309454 | 294 | G>V | No | EVA | |
rs451642378 | 296 | R>C | No | EVA | |
rs451642378 | 296 | R>G | No | EVA | |
rs472092379 | 296 | R>P | No | EVA | |
rs454401977 | 299 | N>S | No | EVA | |
rs443034460 | 302 | F>V | No | EVA | |
rs482723322 | 303 | M>K | No | EVA | |
rs462693185 | 303 | M>L | No | EVA | |
rs458515891 | 305 | D>A | No | EVA | |
rs447574646 | 306 | P>R | No | EVA | |
rs481057071 | 307 | K>M | No | EVA | |
rs469321550 | 308 | K>E | No | EVA | |
rs438056371 | 308 | K>T | No | EVA | |
rs436651948 | 313 | G>D | No | EVA | |
rs476865859 | 314 | D>A | No | EVA | |
rs476865859 | 314 | D>G | No | EVA | |
rs472269980 | 317 | E>D | No | EVA | |
rs452217615 | 317 | E>G | No | EVA | |
rs432558784 | 317 | E>K | No | EVA | |
rs440778188 | 319 | S>A | No | EVA | |
rs460749841 | 319 | S>F | No | EVA | |
rs474734431 | 320 | Y>S | No | EVA | |
rs463604253 | 323 | E>G | No | EVA | |
rs445791203 | 325 | P>L | No | EVA | |
rs477282864 | 325 | P>T | No | EVA | |
rs441368417 | 328 | C>S | No | EVA | |
rs461425415 | 329 | E>G | No | EVA | |
rs481451249 | 330 | P>A | No | EVA | |
rs449997894 | 331 | E>G | No | EVA | |
rs477724859 | 333 | M>I | No | EVA | |
rs446249398 | 334 | P>T | No | EVA | |
rs434936061 | 335 | T>N | No | EVA | |
rs466233787 | 335 | T>P | No | EVA | |
rs454518860 | 336 | F>L | No | EVA | |
rs468103711 | 336 | F>Y | No | EVA | |
rs436762964 | 338 | H>D | No | EVA | |
rs456837250 | 341 | N>T | No | EVA | |
rs721946855 | 342 | K>N | No | EVA | |
rs439459422 | 345 | T>N | No | EVA | |
rs473225920 | 347 | A>D | No | EVA | |
rs461488498 | 353 | E>* | No | EVA | |
rs481463815 | 354 | S>R | No | EVA | |
rs443632011 | 355 | Q>H | No | EVA | |
rs446344744 | 361 | P>A | No | EVA | |
rs466295142 | 362 | P>R | No | EVA |
No associated diseases with Q2TBL8
4 regional properties for Q2TBL8
Functions
Description | ||
---|---|---|
EC Number | 2.7.11.22 | Protein-serine/threonine kinases |
Subcellular Localization |
|
|
PANTHER Family | ||
PANTHER Subfamily | ||
PANTHER Protein Class | ||
PANTHER Pathway Category | No pathway information available |
3 GO annotations of cellular component
Name | Definition |
---|---|
ciliary basal body | A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. |
cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
Name | Definition |
---|---|
ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
cyclin-dependent protein serine/threonine kinase activity | Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
7 GO annotations of biological process
Name | Definition |
---|---|
cell projection organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. |
negative regulation of cilium assembly | Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly. |
peptidyl-threonine phosphorylation | The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. |
positive regulation of MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. |
protein phosphorylation | The process of introducing a phosphate group on to a protein. |
regulation of actin cytoskeleton organization | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
regulation of mitotic cell cycle | Any process that modulates the rate or extent of progress through the mitotic cell cycle. |
8 homologous proteins in AiPD
UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
---|---|---|---|---|
Q5EAB2 | CDK9 | Cyclin-dependent kinase 9 | Bos taurus (Bovine) | PR |
P21127 | CDK11B | Cyclin-dependent kinase 11B | Homo sapiens (Human) | PR |
Q15131 | CDK10 | Cyclin-dependent kinase 10 | Homo sapiens (Human) | PR |
Q3UMM4 | Cdk10 | Cyclin-dependent kinase 10 | Mus musculus (Mouse) | PR |
Q4KM47 | Cdk10 | Cyclin-dependent kinase 10 | Rattus norvegicus (Rat) | PR |
Q09437 | cdk-11.1 | Cyclin-dependent kinase 11.1 | Caenorhabditis elegans | PR |
Q9FGW5 | CDKG1 | Cyclin-dependent kinase G1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
F4I114 | At1g09600 | Probable serine/threonine-protein kinase At1g09600 | Arabidopsis thaliana (Mouse-ear cress) | PR |
10 | 20 | 30 | 40 | 50 | 60 |
MGEPEPEQIR | LKCVRKEGFF | TVPPEHRLGR | CRSVKEFEKL | NRIGEGTYGI | VYRARDTHTD |
70 | 80 | 90 | 100 | 110 | 120 |
EIVALKKVRM | DKEKDGVPIS | SLREITLLLR | LRHPNIVELK | EVVVGNHLES | IFLVMGYCEQ |
130 | 140 | 150 | 160 | 170 | 180 |
DLASLLENMP | TPFSEAQVKC | IVLQVLRGLQ | YLHRNFIIHR | DLKVSNLLMT | DKGCVKTADF |
190 | 200 | 210 | 220 | 230 | 240 |
GLARAYGIPV | KPMTPKVVTL | WYRAPELLLG | TTTQTTSIDM | WAVGCILAEL | LAHKPLLPGT |
250 | 260 | 270 | 280 | 290 | 300 |
SEIHQVDLIV | QLLGTPSENI | WPGFSQLPLA | SQYSLRKQPY | NNLKHKFPWL | SEAGLRLMNL |
310 | 320 | 330 | 340 | 350 | 360 |
LFMYDPKKRA | TAGDCLESSY | FKEKPLPCEP | ELMPTFPHHR | NKRATPATSL | GTESQSRRGR |
P |