Q2TBL8

PR
Gene name
CDK10
Protein name
Cyclin-dependent kinase 10
Names
Cell division protein kinase 10
Species
Bos taurus (Bovine)
KEGG Pathway
bta:615171
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

178-201 (Activation loop from InterPro)

Target domain

29-337 (Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q2TBL8

Entry ID Method Resolution Chain Position Source
AF-Q2TBL8-F1 Predicted AlphaFoldDB

126 variants for Q2TBL8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs476492548 3 E>G No EVA
rs438630760 6 P>S No EVA
rs458670841 8 Q>P No EVA
rs440415766 11 L>S No EVA
rs460397471 14 V>F No EVA
rs460397471 14 V>L No EVA
rs480385757 18 G>C No EVA
rs442764074 23 P>H No EVA
rs463294926 26 H>P No EVA
rs458840584 42 R>L No EVA
rs479171700 51 V>E No EVA
rs460728291 65 L>M No EVA
rs480967410 67 K>Q No EVA
rs449475010 68 V>E No EVA
rs469509804 75 D>Y No EVA
rs447359418 102 V>G No EVA
rs449659431 105 G>A No EVA
rs481105013 105 G>W No EVA
rs432210313 107 H>D No EVA
rs445872256 110 S>R No EVA
rs465885820 111 I>S No EVA
rs479442998 118 C>S No EVA
rs448266775 121 D>A No EVA
rs436454505 127 E>G No EVA
rs456474577 129 M>T No EVA
rs470152290 135 E>Q No EVA
rs432659729 137 Q>H No EVA
rs435092428 138 V>D No EVA
rs468829528 143 L>R No EVA
rs473003183 153 H>P No EVA
rs473003183 153 H>R No EVA
rs447782957 202 Y>D No EVA
rs467826870 202 Y>S No EVA
rs436416621 205 P>H No EVA
rs436416621 205 P>R No EVA
rs450100442 206 E>V No EVA
rs470478414 208 L>R No EVA
rs132710145 209 L>R No EVA
rs452647354 210 G>A No EVA
rs432601090 210 G>R No EVA
rs452647354 210 G>V No EVA
rs137104503 212 T>P No EVA
rs434965668 214 Q>E No EVA
rs454654989 220 M>L No EVA
rs475696136 222 A>P No EVA
rs451480137 226 I>L No EVA
rs471122839 227 L>Q No EVA
rs439662123 228 A>T No EVA
rs459825867 234 K>T No EVA
rs473423513 236 L>R No EVA
rs482277389 243 I>L No EVA
rs451006964 243 I>N No EVA
rs451006964 243 I>S No EVA
rs458233404 245 Q>P No EVA
rs446543365 247 D>V No EVA
rs477962850 247 D>Y No EVA
rs435227568 248 L>P No EVA
rs469282105 250 V>G No EVA
rs437865479 251 Q>* No EVA
rs433751713 254 G>R No EVA
rs433751713 254 G>W No EVA
rs453377081 255 T>A No EVA
rs473524624 255 T>S No EVA
rs475926601 256 P>H No EVA
rs461935277 256 P>S No EVA
rs444667688 257 S>R No EVA
rs458422802 258 E>A No EVA
rs458422802 258 E>G No EVA
rs478491178 260 I>S No EVA
rs447038762 262 P>A No EVA
rs447038762 262 P>S No EVA
rs482655175 263 G>A No EVA
rs444825561 264 F>S No EVA
rs465225047 266 Q>R No EVA
rs478913952 269 L>Q No EVA
rs478913952 269 L>R No EVA
rs467372316 270 A>D No EVA
rs447405150 270 A>P No EVA
rs436126977 293 A>P No EVA
rs455706677 293 A>V No EVA
rs469309454 294 G>D No EVA
rs469309454 294 G>V No EVA
rs451642378 296 R>C No EVA
rs451642378 296 R>G No EVA
rs472092379 296 R>P No EVA
rs454401977 299 N>S No EVA
rs443034460 302 F>V No EVA
rs482723322 303 M>K No EVA
rs462693185 303 M>L No EVA
rs458515891 305 D>A No EVA
rs447574646 306 P>R No EVA
rs481057071 307 K>M No EVA
rs469321550 308 K>E No EVA
rs438056371 308 K>T No EVA
rs436651948 313 G>D No EVA
rs476865859 314 D>A No EVA
rs476865859 314 D>G No EVA
rs472269980 317 E>D No EVA
rs452217615 317 E>G No EVA
rs432558784 317 E>K No EVA
rs440778188 319 S>A No EVA
rs460749841 319 S>F No EVA
rs474734431 320 Y>S No EVA
rs463604253 323 E>G No EVA
rs445791203 325 P>L No EVA
rs477282864 325 P>T No EVA
rs441368417 328 C>S No EVA
rs461425415 329 E>G No EVA
rs481451249 330 P>A No EVA
rs449997894 331 E>G No EVA
rs477724859 333 M>I No EVA
rs446249398 334 P>T No EVA
rs434936061 335 T>N No EVA
rs466233787 335 T>P No EVA
rs454518860 336 F>L No EVA
rs468103711 336 F>Y No EVA
rs436762964 338 H>D No EVA
rs456837250 341 N>T No EVA
rs721946855 342 K>N No EVA
rs439459422 345 T>N No EVA
rs473225920 347 A>D No EVA
rs461488498 353 E>* No EVA
rs481463815 354 S>R No EVA
rs443632011 355 Q>H No EVA
rs446344744 361 P>A No EVA
rs466295142 362 P>R No EVA

No associated diseases with Q2TBL8

4 regional properties for Q2TBL8

Type Name Position InterPro Accession
domain Protein kinase domain 37 - 321 IPR000719
active_site Serine/threonine-protein kinase, active site 157 - 169 IPR008271
binding_site Protein kinase, ATP binding site 43 - 66 IPR017441
domain Cyclin-dependent kinase 10, catalytic domain 29 - 337 IPR044093

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm, cytoskeleton, cilium basal body
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
ciliary basal body A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

7 GO annotations of biological process

Name Definition
cell projection organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
negative regulation of cilium assembly Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly.
peptidyl-threonine phosphorylation The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of actin cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of mitotic cell cycle Any process that modulates the rate or extent of progress through the mitotic cell cycle.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5EAB2 CDK9 Cyclin-dependent kinase 9 Bos taurus (Bovine) PR
P21127 CDK11B Cyclin-dependent kinase 11B Homo sapiens (Human) PR
Q15131 CDK10 Cyclin-dependent kinase 10 Homo sapiens (Human) PR
Q3UMM4 Cdk10 Cyclin-dependent kinase 10 Mus musculus (Mouse) PR
Q4KM47 Cdk10 Cyclin-dependent kinase 10 Rattus norvegicus (Rat) PR
Q09437 cdk-11.1 Cyclin-dependent kinase 11.1 Caenorhabditis elegans PR
Q9FGW5 CDKG1 Cyclin-dependent kinase G1 Arabidopsis thaliana (Mouse-ear cress) PR
F4I114 At1g09600 Probable serine/threonine-protein kinase At1g09600 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGEPEPEQIR LKCVRKEGFF TVPPEHRLGR CRSVKEFEKL NRIGEGTYGI VYRARDTHTD
70 80 90 100 110 120
EIVALKKVRM DKEKDGVPIS SLREITLLLR LRHPNIVELK EVVVGNHLES IFLVMGYCEQ
130 140 150 160 170 180
DLASLLENMP TPFSEAQVKC IVLQVLRGLQ YLHRNFIIHR DLKVSNLLMT DKGCVKTADF
190 200 210 220 230 240
GLARAYGIPV KPMTPKVVTL WYRAPELLLG TTTQTTSIDM WAVGCILAEL LAHKPLLPGT
250 260 270 280 290 300
SEIHQVDLIV QLLGTPSENI WPGFSQLPLA SQYSLRKQPY NNLKHKFPWL SEAGLRLMNL
310 320 330 340 350 360
LFMYDPKKRA TAGDCLESSY FKEKPLPCEP ELMPTFPHHR NKRATPATSL GTESQSRRGR
P