Q2TBH7
PR
Gene name |
RAB4A |
Protein name |
Ras-related protein Rab-4A |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:615849 |
EC number |
3.6.5.2: Acting on GTP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2TBH7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2TBH7-F1 | Predicted | AlphaFoldDB |
21 variants for Q2TBH7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs480447159 | 12 | F>C | No | EVA | |
| rs449264450 | 12 | F>L | No | EVA | |
| rs480108160 | 13 | L>F | No | EVA | |
| rs460039651 | 13 | L>S | No | EVA | |
| rs461623700 | 44 | H>N | No | EVA | |
| rs482942610 | 113 | M>L | No | EVA | |
| rs468380904 | 126 | N>K | No | EVA | |
| rs478834330 | 137 | T>I | No | EVA | |
| rs478834330 | 137 | T>N | No | EVA | |
| rs467060859 | 140 | E>G | No | EVA | |
| rs447012641 | 140 | E>Q | No | EVA | |
| rs452482861 | 141 | A>D | No | EVA | |
| rs477984375 | 170 | C>W | No | EVA | |
| rs446193095 | 176 | N>Y | No | EVA | |
| rs480447828 | 181 | G>C | No | EVA | |
| rs108961398 | 194 | Y>* | No | EVA | |
| rs450352202 | 196 | D>E | No | EVA | |
| rs436249735 | 207 | R>C | No | EVA | |
| rs466629840 | 211 | P>A | No | EVA | |
| rs451734854 | 214 | Q>R | No | EVA | |
| rs471838438 | 216 | C>G | No | EVA |
No associated diseases with Q2TBH7
1 regional properties for Q2TBH7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 15 - 167 | IPR005225 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.5.2 | Acting on GTP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| early endosome membrane | The lipid bilayer surrounding an early endosome. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| extracellular exosome | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
| insulin-responsive compartment | A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic recycling endosome | A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signalling and so can play a role in long term potentiation. |
| recycling endosome | An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. |
| recycling endosome membrane | The lipid bilayer surrounding a recycling endosome. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein activity | A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP). |
| GDP binding | Binding to GDP, guanosine 5'-diphosphate. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| antigen processing and presentation | The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| Rab protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state. |
| regulation of endocytosis | Any process that modulates the frequency, rate or extent of endocytosis. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3MHP2 | RAB11B | Ras-related protein Rab-11B | Bos taurus (Bovine) | PR |
| Q2TA29 | RAB11A | Ras-related protein Rab-11A | Bos taurus (Bovine) | PR |
| P61018 | RAB4B | Ras-related protein Rab-4B | Homo sapiens (Human) | PR |
| P20338 | RAB4A | Ras-related protein Rab-4A | Homo sapiens (Human) | PR |
| Q91ZR1 | Rab4b | Ras-related protein Rab-4B | Mus musculus (Mouse) | PR |
| P51146 | Rab4b | Ras-related protein Rab-4B | Rattus norvegicus (Rat) | PR |
| P05714 | Rab4a | Ras-related protein Rab-4A | Rattus norvegicus (Rat) | PR |
| Q68EK7 | rab4b | Ras-related protein Rab-4B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q6PHI9 | rab4a | Ras-related protein Rab-4A | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSQTAMSETY | DFLFKFLVIG | NAGTGKSCLL | HQFIEKKFKD | DSNHTIGVEF | GSKIINVGGK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YVKLQIWDTA | GQERFRSVTR | SYYRGAAGAL | LVYDITSRET | YNALTNWLTD | ARMLASQNIV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IILCGNKKDL | DTDREVTFLE | ASRFAQENEL | MFLETSALTG | ENVEEAFVQC | ARKILNKIES |
| 190 | 200 | 210 | |||
| GELDPERMGS | GIQYGDAALR | QLRSPRRAQA | PSAQECGC |