Q2T9M1

SS
Gene name
PICK1 (PRKCABP)
Protein name
PRKCA-binding protein
Names
Protein interacting with C kinase 1 , Protein kinase C-alpha-binding protein
Species
Bos taurus (Bovine)
KEGG Pathway
EC number
Protein Class

Descriptions

PRCKA-binding protein (PICK1) is a modular scaffold protein that regulates the activity and trafficking of several neural proteins. The membrane vesiculation capacity of the BAR domain is autoinhibited by PDZ and an acidic C-terminal tail (ACT). Upon deletion of ACT or PDZ domain, PICK1 clusters on vesicle-like structures that colocalize with the trans-Golgi network marker TGN38, driven by BAR domain. The ACT of one subunit of the PICK1 homodimer interacts with the PDZ and BAR domains of the other subunit. The autoinhibition is released by the binding of PDZ domain to receptor proteins or

Autoinhibitory domains (AIDs)

15-108 (PDZ domain) SS

Target domain

147-355 (BAR domain)

Relief mechanism

Partner binding

Assay

356-417 (acidic C-terminal tail, ACT) SS

Target domain

147-355 (BAR domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2T9M1

Entry ID Method Resolution Chain Position Source
AF-Q2T9M1-F1 Predicted AlphaFoldDB

No variants for Q2T9M1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2T9M1

No associated diseases with Q2T9M1

4 regional properties for Q2T9M1

Type Name Position InterPro Accession
domain Homeobox domain 505 - 569 IPR001356
conserved_site Homeobox, conserved site 540 - 563 IPR017970
domain Homeobox domain, metazoa 529 - 540 IPR020479-1
domain Homeobox domain, metazoa 544 - 563 IPR020479-2

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, perinuclear region
  • Membrane ; Peripheral membrane protein
  • Membrane ; Lipid-anchor
  • Postsynaptic density
  • Synapse, synaptosome
  • Cytoplasm, cytoskeleton
  • Also membrane-associated, present at excitatory synapses
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic density An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
postsynaptic early endosome An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling.
synaptic vesicle A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
trans-Golgi network membrane The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.

6 GO annotations of molecular function

Name Definition
actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
Arp2/3 complex binding Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5).
metal ion binding Binding to a metal ion.
phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.
protein domain specific binding Binding to a specific domain of a protein.
protein kinase C binding Binding to protein kinase C.

11 GO annotations of biological process

Name Definition
cellular response to decreased oxygen levels Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.
cellular response to glucose starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
dendritic spine maintenance The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.
dendritic spine organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.
glial cell development The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
long-term synaptic depression A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse.
negative regulation of Arp2/3 complex-mediated actin nucleation Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins.
positive regulation of receptor internalization Any process that activates or increases the frequency, rate or extent of receptor internalization.
receptor clustering The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
regulation of Arp2/3 complex-mediated actin nucleation Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9NRD5 PICK1 PRKCA-binding protein Homo sapiens (Human) EV
Q62083 Pick1 PRKCA-binding protein Mus musculus (Mouse) SS
Q9EP80 Pick1 PRKCA-binding protein Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MFADLGYDIE EDKLGIPTVP GKVTLQKDAQ NLIGISIGGG AQYCPCLYIV QVFDNTPAAL
70 80 90 100 110 120
DGTVAAGDEI TGVNGRSIKG KTKVEVAKMI QEVKGEVTIH YNKLQADPKQ GMSLDIVLKK
130 140 150 160 170 180
VKHRLVENMS SGTADALGLS RAILCNDGLV KRLEELERTA ELYKGMTEHT KNLLRAFYEL
190 200 210 220 230 240
SQTHRAFGDV FSVIGVREPQ PAASEAFVKF ADAHRSIEKF GIRLLKTIKP MLTDLNTYLN
250 260 270 280 290 300
KAIPDTRLTI KKYLDVKFEY LSYCLKVKEM DDEEYSCIAL GEPLYRVSTG NYEYRLILRC
310 320 330 340 350 360
RQEARARFSQ MRKDVLEKME LLDQEHVQDI VLQLQRFVST MSKYYNDCYS VLRDADVFPI
370 380 390 400 410
EVDLAHTTLA YGLSQDEFTD GEDEEDEDEE DTAAGEPPRD SRGAAGPLDK GGSWCNS