Q2QQS5

PR
Gene name
CYCT1-1 (Os12g0485400, LOC_Os12g30020)
Protein name
Cyclin-T1-4
Names
CycT14
Species
Oryza sativa subsp japonica (Rice)
KEGG Pathway
osa:4352229
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2QQS5

Entry ID Method Resolution Chain Position Source
AF-Q2QQS5-F1 Predicted AlphaFoldDB

No variants for Q2QQS5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2QQS5

No associated diseases with Q2QQS5

9 regional properties for Q2QQS5

Type Name Position InterPro Accession
domain Protein kinase domain 68 - 326 IPR000719
domain EF-hand domain 369 - 440 IPR002048-1
domain EF-hand domain 441 - 511 IPR002048-2
active_site Serine/threonine-protein kinase, active site 188 - 200 IPR008271
binding_site Protein kinase, ATP binding site 74 - 101 IPR017441
binding_site EF-Hand 1, calcium-binding site 382 - 394 IPR018247-1
binding_site EF-Hand 1, calcium-binding site 418 - 430 IPR018247-2
binding_site EF-Hand 1, calcium-binding site 454 - 466 IPR018247-3
binding_site EF-Hand 1, calcium-binding site 489 - 501 IPR018247-4

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cyclin/CDK positive transcription elongation factor complex A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
cyclin-dependent protein serine/threonine kinase activator activity Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase.
cyclin-dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.

4 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
positive regulation of DNA-templated transcription, elongation Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6T8E9 CCNT1 Cyclin-T1 Bos taurus (Bovine) SS
Q8HXN7 CCNT1 Cyclin-T1 Pan troglodytes (Chimpanzee) SS
Q9XT26 CCNT1 Cyclin-T1 Equus caballus (Horse) SS
Q8N1B3 CCNQ Cyclin-Q Homo sapiens (Human) PR
O60563 CCNT1 Cyclin-T1 Homo sapiens (Human) EV
O75909 CCNK Cyclin-K Homo sapiens (Human) PR
Q9QWV9 Ccnt1 Cyclin-T1 Mus musculus (Mouse) SS
O88874 Ccnk Cyclin-K Mus musculus (Mouse) PR
Q6Z7H3 CYCT1_2 Cyclin-T1-2 Oryza sativa subsp japonica (Rice) PR
Q2RAC5 CYCT1-3 Cyclin-T1-3 Oryza sativa subsp japonica (Rice) PR
Q8GYM6 CYCT1-4 Cyclin-T1-4 Arabidopsis thaliana (Mouse-ear cress) PR
Q503D6 ccnq Cyclin-Q Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MAMMPSDSSH HGIVENSPYR TTQGRNEETG ELGASWYFSR KEIEENSPSR RDGIDLKKES
70 80 90 100 110 120
YLRKSYCTFL QDLGMRLKVP QVTIATAIVF CHRFYLRQSH AKNDRRTIAT VCMFLAGKVE
130 140 150 160 170 180
ETPRPLKDVI LVSYEIIHKK DPAAGQRIKQ KEVYDQQKEL ILLAERVVLA TLGFDLNVHH
190 200 210 220 230 240
PYKPLVEAIR KFKVAQNALA QVAWNFVNDG LRTSLCLQFK PHHIAAGAIF LAAKFLKVKL
250 260 270 280 290 300
PSDGEKVWWQ EFDVTPRQLE EVSNQMLELY EQNCAAQAQP SHGNEAEGSS ASVPNQRVSV
310 320 330 340 350 360
KSEETPLPHQ SKQSSSQHST GAPSHHGVEH SNLEKQTVDQ KMLQNDNGDH GSNKTRSNQS
370 380 390 400 410 420
GSRVDFGAND GLHHDKQSMT ENKNLPSHGN SSEIRDVNRN GNDGTNVTSL MVNKIDKDKV
430 440 450 460 470 480
KAQMEKQRKL KGDVARKVEV IDDDDDLERQ LEHDIELAVE DNKIKQERKQ SSPHVMHRGD
490 500 510 520 530 540
HRNADQVTGN GHLGKQNTPE TAQDAPMDDI KEQRNSHGSK HHDSHDTAHE RGERDYKRPR
PEG