Q2QLA9
Gene name |
MET |
Protein name |
Hepatocyte growth factor receptor |
Names |
HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met |
Species |
Equus caballus (Horse) |
KEGG Pathway |
ecb:100056013 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
1221-1248 (Activation loop from InterPro)
Target domain |
1078-1345 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q2QLA9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2QLA9-F1 | Predicted | AlphaFoldDB |
10 variants for Q2QLA9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs1142013244 | 55 | V>I | No | EVA | |
| rs3091792739 | 144 | H>Q | No | EVA | |
| rs1147122045 | 154 | I>L | No | EVA | |
| rs782849046 | 171 | Q>R | No | EVA | |
| rs3440863393 | 246 | P>H | No | EVA | |
| rs1138083750 | 262 | L>V | No | EVA | |
| rs782887930 | 325 | P>A | No | EVA | |
| rs1141031989 | 487 | S>Y | No | EVA | |
| rs3444309718 | 722 | V>I | No | EVA | |
| rs393971567 | 882 | C>R | No | EVA |
No associated diseases with Q2QLA9
12 regional properties for Q2QLA9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 1078 - 1345 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 1078 - 1336 | IPR001245 |
| domain | Sema domain | 27 - 515 | IPR001627 |
| repeat | Plexin repeat | 520 - 561 | IPR002165 |
| domain | IPT domain | 562 - 655 | IPR002909-1 |
| domain | IPT domain | 656 - 739 | IPR002909-2 |
| domain | IPT domain | 741 - 836 | IPR002909-3 |
| domain | IPT domain | 838 - 934 | IPR002909-4 |
| active_site | Tyrosine-protein kinase, active site | 1200 - 1212 | IPR008266 |
| domain | PSI domain | 519 - 562 | IPR016201 |
| binding_site | Protein kinase, ATP binding site | 1084 - 1110 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 1078 - 1337 | IPR020635 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| basal plasma membrane | The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| hepatocyte growth factor receptor activity | Combining with hepatocyte growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| semaphorin receptor activity | Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. |
| liver development | The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| neuron differentiation | The process in which a relatively unspecialized cell acquires specialized features of a neuron. |
| pancreas development | The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes. |
| phagocytosis | A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. |
| positive chemotaxis | The directed movement of a motile cell or organism towards a higher concentration of a chemical. |
| positive regulation of endothelial cell chemotaxis | Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis. |
| positive regulation of kinase activity | Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| positive regulation of protein kinase B signaling | Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
| semaphorin-plexin signaling pathway | The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q769I5 | MET | Hepatocyte growth factor receptor | Bos taurus (Bovine) | PR |
| A0M8S8 | MET | Hepatocyte growth factor receptor | Felis catus (Cat) (Felis silvestris catus) | PR |
| Q75ZY9 | MET | Hepatocyte growth factor receptor | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| P08581 | MET | Hepatocyte growth factor receptor | Homo sapiens (Human) | EV |
| P16056 | Met | Hepatocyte growth factor receptor | Mus musculus (Mouse) | PR |
| Q2QLE0 | MET | Hepatocyte growth factor receptor | Sus scrofa (Pig) | PR |
| P97523 | Met | Hepatocyte growth factor receptor | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKAPAVLAPG | ILVLLFTLVQ | KSDGECKEAL | VKSEMNVNMK | YQLPNFTAET | PIQNVVLHKH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HIYLGATNYI | YVLNDKDLQK | VAEYKTGPVL | EHPDCFPCQD | CSRKANLSGG | AWKDNINMAL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVDTYYDDQL | ISCGSVHRGT | CQRHVLPLNN | VADIQSEVYC | MYSPQAEEPH | QCPDCVVSAL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GTKVLLSEKD | RFVTFFVGNT | INSSYLPDHS | LHSISVRRLK | ETQDGFKFLT | DQSYIDVLPE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FRDSYPIKYI | HAFESNHFIY | FLTVQRETLD | AQTFHTRIIR | FCSVDSGLHS | YMEMPLECIL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TEKRRKRSTS | EEVFNILQAA | YVSKPGAHLA | KQIGANLNDD | ILYGVFAQSK | PDSAEPMNRS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AVCAFPVKYV | NEFFNKIVNK | NNVRCLQHFY | GPHHEHCFNR | TLLRNSSGCE | VRNDEYRTEF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TTALQRVDLF | MGQFNQVLLT | SISTFIKGNL | TIANLGTSEG | RFMQVVVSRS | GSSTPHVNFH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LDSHPVSPEV | IVEHPLNQNG | YTLVVTGKKI | TKIPLNGLGC | EHFQSCSQCL | SAPPFVQCGW |
| 550 | 560 | 570 | 580 | 590 | 600 |
| CHDKCVRLEE | CHNGTWTQEI | CLPTIYKVFP | TSAPLEGGTT | LTVCGWDFGF | RKNNKLDSKK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TKVLLGNESC | TLTLSESTSN | TLKCTVGPAM | NERFNISITV | SNSRGTARYS | TFSYVDPIIT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SISPSYGPKT | GGTLLTLTGK | YLNSGNSRHI | SIGGKTCTLK | SVSDSILECY | TPAQTTPTEF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PVKLKIDLAN | REMNSFSYRE | DPIVYEIHPT | KSFISGGSTI | TGVGKNLNSV | SVLRMVINVR |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EAGRNFTVAC | QHRSNSEIIC | CTTPSLQQLN | LQLPLKTKAF | FMLDGIHSKY | FDLIYVHNPV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| FKPFEKPVMI | SIGNENVLEI | KGNDIDPEAV | KGEVLKVGNK | SCENIHSHSE | AVLCTVPSDL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LKLNSELNIE | WKQAVSSTIL | GKVIVQPDQN | FTGLIVGVVS | ISIILLLLLG | LFLWLKRRKQ |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| IKDLGSELVR | YDARVHTPHL | DRLVSARSVS | PTTEMVSNES | VDYRATFPED | QFPNSSQNGS |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| CRQVQYPLTD | LSPILTSGDS | DISSPLLQNT | VHIDLSALNP | ELVQAVQHVV | IGPSSLIVHF |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| NEVIGRGHFG | CVYHGTLLDN | DDKKIHCAVK | SLNRITDIGE | VSQFLTEGII | MKDFSHPNVL |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| SLLGICLRSE | GSPLVVLPYM | KHGDLRNFIR | NETHNPTVKD | LIGFGLQVAK | GMKYLASKKF |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| VHRDLAARNC | MLDEKFTVKV | ADFGLARDMY | DKEYYSVHNK | TGAKLPVKWM | ALESLQTQKF |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| TTKSDVWSFG | VLLWELMTRG | APPYPDVNTF | DITVYLLQGR | RLLQPEYCPD | PLYEVMLKCW |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| HPKAELRPSF | SELVSRISAI | FSTFIGEHYV | HVNATYVNVK | CVAPYPSLLS | SQDNVDGEVD |
| T |