Q2PQA9

SS
Gene name
Kif5b (Khc)
Protein name
Kinesin-1 heavy chain
Names
Conventional kinesin heavy chain , Ubiquitous kinesin heavy chain , UKHC
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:117550
EC number
Protein Class

Descriptions

Autoinhibitory domains (AIDs)

914-926 (tail) SS

Target domain

6-333 (Kinesin motor domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q2PQA9

Entry ID Method Resolution Chain Position Source
4ATX EM 820 A C 1-340 PDB
AF-Q2PQA9-F1 Predicted AlphaFoldDB

No variants for Q2PQA9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2PQA9

No associated diseases with Q2PQA9

2 regional properties for Q2PQA9

Type Name Position InterPro Accession
domain Kinesin motor domain 6 - 333 IPR001752
conserved_site Kinesin motor domain, conserved site 225 - 236 IPR019821

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Cytolytic granule membrane
  • Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Uniformly distributed between soma and neurites in hippocampal neurons
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

16 GO annotations of cellular component

Name Definition
axon cytoplasm Any cytoplasm that is part of a axon.
axonal growth cone The migrating motile tip of a growing nerve cell axon.
ciliary rootlet A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm.
cytolytic granule membrane The lipid bilayer surrounding the cytolytic granule.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
dendrite cytoplasm All of the contents of a dendrite, excluding the surrounding plasma membrane.
endocytic vesicle A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
kinesin complex Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.
membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
microtubule cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
vesicle Any small, fluid-filled, spherical organelle enclosed by membrane.

9 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction
identical protein binding Binding to an identical protein or proteins.
JUN kinase binding Binding to JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family.
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.
microtubule lateral binding Binding to the side of a microtubule.
microtubule motor activity A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.
plus-end-directed microtubule motor activity A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis.
protein-containing complex binding Binding to a macromolecular complex.

24 GO annotations of biological process

Name Definition
anterograde axonal protein transport The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons.
anterograde dendritic transport of neurotransmitter receptor complex The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse.
axon guidance The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
cellular response to type II interferon Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
centrosome localization Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell.
cytoplasm organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
hippocampus development The progression of the hippocampus over time from its initial formation until its mature state.
lysosome localization Any process in which a lysosome is transported to, and/or maintained in, a specific location.
mitochondrion transport along microtubule The directed movement of a mitochondrion along a microtubule, mediated by motor proteins.
mitocytosis A migrasome-mediated selective removal of damaged mitochondria process that maintains mitochondrion homeostasis in migrating cells.
mitotic cell cycle Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
natural killer cell mediated cytotoxicity The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
plus-end-directed vesicle transport along microtubule The directed movement of a vesicle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.
positive regulation of insulin secretion involved in cellular response to glucose stimulus Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
positive regulation of intracellular protein transport Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells.
positive regulation of potassium ion transport Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of protein localization to plasma membrane Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
positive regulation of synaptic transmission, GABAergic Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
positive regulation of vesicle fusion Any process that activates or increases the frequency, rate or extent of vesicle fusion.
regulation of membrane potential Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
retrograde neuronal dense core vesicle transport The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body.
stress granule disassembly The disaggregation of a stress granule into its constituent protein and RNA parts.
synaptic vesicle transport The directed movement of synaptic vesicles.
vesicle transport along microtubule The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P17210 Khc Kinesin heavy chain Drosophila melanogaster (Fruit fly) EV
O60282 KIF5C Kinesin heavy chain isoform 5C Homo sapiens (Human) EV
P33176 KIF5B Kinesin-1 heavy chain Homo sapiens (Human) EV
Q12840 KIF5A Kinesin heavy chain isoform 5A Homo sapiens (Human) EV
P33175 Kif5a Kinesin heavy chain isoform 5A Mus musculus (Mouse) SS
P28738 Kif5c Kinesin heavy chain isoform 5C Mus musculus (Mouse) SS
Q61768 Kif5b Kinesin-1 heavy chain Mus musculus (Mouse) EV
F1M5N7 Kif21b Kinesin-like protein KIF21B Rattus norvegicus (Rat) SS
Q7M6Z5 Kif27 Kinesin-like protein KIF27 Rattus norvegicus (Rat) SS
Q6QLM7 Kif5a Kinesin heavy chain isoform 5A Rattus norvegicus (Rat) SS
Q9WV63 Kif2a Kinesin-like protein KIF2A Rattus norvegicus (Rat) PR
P34540 unc-116 Kinesin heavy chain Caenorhabditis elegans SS
Q9SV36 KINUC Kinesin-like protein KIN-UC Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MADPAECNIK VMCRFRPLNE SEVNRGDKYV AKFQGEDTVM IASKPYAFDR VFQSSTSQEQ
70 80 90 100 110 120
VYNDCAKKIV KDVLEGYNGT IFAYGQTSSG KTHTMEGKLH DPEGMGIIPR IVQDIFNYIY
130 140 150 160 170 180
SMDENLEFHI KVSYFEIYLD KIRDLLDVSK TNLSVHEDKN RVPYVKGCTE RFVCSPDEVM
190 200 210 220 230 240
DTIDEGKSNR HVAVTNMNEH SSRSHSIFLI NVKQENTQTE QKLSGKLYLV DLAGSEKVSK
250 260 270 280 290 300
TGAEGAVLDE AKNINKSLSA LGNVISALAE GSTYVPYRDS KMTRILQDSL GGNCRTTIVI
310 320 330 340 350 360
CCSPSSYNES ETKSTLLFGQ RAKTIKNTVC VNVELTAEQW KKKYEKEKEK NKTLRNTIQW
370 380 390 400 410 420
LENELNRWRN GETVPIDEQF DKEKANLEAF TADKDVAITN DKPAAAIGMA GSFTDAERRK
430 440 450 460 470 480
CEEEIAKLYK QLDDKDEEIN QQSQLVEKLK TQMLDQEELL ASTRRDQDNM QAELNRLQAE
490 500 510 520 530 540
NDASKEEVKE VLQALEELAV NYDQKSQEVE DKTKEYELLS DELNQKSATL ASIDAELQKL
550 560 570 580 590 600
KEMTNHQKKR AAEMMASLLK DLAEIGIAVG NNDVKQPEGT GMIDEEFTVA RLYISKMKSE
610 620 630 640 650 660
VKTMVKRCKQ LESTQTESNK KMEENEKELA ACQLRISQHE AKIKSLTEYL QNVEQKKRQL
670 680 690 700 710 720
EESVDSLGEE LVQLRAQEKV HEMEKEHLNK VQTANEVKQA VEQQIQSHRE THQKQISSLR
730 740 750 760 770 780
DEVEAKEKLI TDLQDQNQKM VLEQERLRVE HERLKAVDQE KSRKLHELTV MQDRREQARQ
790 800 810 820 830 840
DLKGLEETVA KELQTLHNLR KLFVQDLATR VKKSAEVDSD DTGGSAAQKQ KISFLENNLE
850 860 870 880 890 900
QLTKVHKQLV RDNADLRCEL PKLEKRLRAT AERVKALESA LKEAKENASR DRKRYQQEVD
910 920 930 940 950 960
RIKEAVRSKN MARRGHSAQI AKPIRPGQHP AASPTHPGAV RGGGSFVQNN QPVGLRGGGG
KQA