Q2NL08

PR
Gene name
DDX55
Protein name
ATP-dependent RNA helicase DDX55
Names
DEAD box protein 55
Species
Bos taurus (Bovine)
KEGG Pathway
bta:508581
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

190-270 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2NL08

Entry ID Method Resolution Chain Position Source
AF-Q2NL08-F1 Predicted AlphaFoldDB

No variants for Q2NL08

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2NL08

No associated diseases with Q2NL08

12 regional properties for Q2NL08

Type Name Position InterPro Accession
domain B-box-type zinc finger 94 - 135 IPR000315
domain Zinc finger, RING-type 16 - 61 IPR001841
domain B30.2/SPRY domain 292 - 486 IPR001870
domain SPRY domain 362 - 485 IPR003877
domain Butyrophylin-like, SPRY domain 308 - 325 IPR003879-1
domain Butyrophylin-like, SPRY domain 325 - 342 IPR003879-2
domain Butyrophylin-like, SPRY domain 347 - 371 IPR003879-3
domain Butyrophylin-like, SPRY domain 379 - 392 IPR003879-4
domain Butyrophylin-like, SPRY domain 422 - 446 IPR003879-5
domain Butyrophylin-like, SPRY domain 452 - 470 IPR003879-6
domain SPRY-associated 309 - 361 IPR006574
conserved_site Zinc finger, RING-type, conserved site 31 - 40 IPR017907

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

20 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SZ54 EIF4A1 Eukaryotic initiation factor 4A-I Bos taurus (Bovine) PR
Q29S22 DDX47 Probable ATP-dependent RNA helicase DDX47 Bos taurus (Bovine) PR
Q3SZ40 DDX56 Probable ATP-dependent RNA helicase DDX56 Bos taurus (Bovine) PR
Q5ZLN8 DDX55 ATP-dependent RNA helicase DDX55 Gallus gallus (Chicken) PR
P17844 DDX5 Probable ATP-dependent RNA helicase DDX5 Homo sapiens (Human) PR
Q8NHQ9 DDX55 ATP-dependent RNA helicase DDX55 Homo sapiens (Human) PR
Q99MJ9 Ddx50 ATP-dependent RNA helicase DDX50 Mus musculus (Mouse) PR
Q61656 Ddx5 Probable ATP-dependent RNA helicase DDX5 Mus musculus (Mouse) PR
Q501J6 Ddx17 Probable ATP-dependent RNA helicase DDX17 Mus musculus (Mouse) PR
Q6ZPL9 Ddx55 ATP-dependent RNA helicase DDX55 Mus musculus (Mouse) PR
Q5QMN3 Os01g0197200 DEAD-box ATP-dependent RNA helicase 20 Oryza sativa subsp japonica (Rice) PR
Q5N7W4 Os01g0911100 DEAD-box ATP-dependent RNA helicase 30 Oryza sativa subsp japonica (Rice) PR
Q0E2Z7 Os02g0201900 DEAD-box ATP-dependent RNA helicase 41 Oryza sativa subsp japonica (Rice) PR
P34640 ZK512.2 Probable ATP-dependent RNA helicase DDX55 homolog Caenorhabditis elegans PR
Q9C718 RH20 DEAD-box ATP-dependent RNA helicase 20 Arabidopsis thaliana (Mouse-ear cress) PR
Q8H136 RH14 DEAD-box ATP-dependent RNA helicase 14 Arabidopsis thaliana (Mouse-ear cress) PR
Q56X76 RH39 DEAD-box ATP-dependent RNA helicase 39 Arabidopsis thaliana (Mouse-ear cress) PR
Q8W4R3 RH30 DEAD-box ATP-dependent RNA helicase 30 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FVV4 RH55 DEAD-box ATP-dependent RNA helicase 55 Arabidopsis thaliana (Mouse-ear cress) PR
Q8JHJ2 ddx55 ATP-dependent RNA helicase DDX55 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MEHVTEGSWE SLPVPLHPKV LSVLRELGFP YMTPVQSATI PLFMKNKDVA AEAVTGSGKT
70 80 90 100 110 120
LAFVIPIEEI LLRREEKFKK SQVGAIIITP TRELAVQIEE VLSHFTKPFP QFSQILWIGG
130 140 150 160 170 180
RNPGEDVARF KELGGNIIVA TPGRLEDMFR RKAEGLDLAS CVRSLEVLVL DEADRLLDMG
190 200 210 220 230 240
FETSINTILE FLPKQRRTGL FSATQTQEVE NLVRAGLRNP VRISVKEKGV AASSTQKTPS
250 260 270 280 290 300
RLENHYMVCK ADEKFNQLVH FLRNHKQEKH LVFFSTCACV EYYGKALETL VKGVKIMCIH
310 320 330 340 350 360
GKMKYKRNKI FMEFRKLQSG ILVCTDVMAR GIDIPEVNWV LQYDPPSNAS AFVHRCGRTA
370 380 390 400 410 420
RIGHGGSALV FLLPMEESYI SFLAINQKCP LQEMKLQKNT ADLLPKLKAM ALGDRAVFEK
430 440 450 460 470 480
GMKAFVSYVQ AYAKHECNLI FRLKDLDFAS LARGFALLRM PKMPELRGKQ FPDFVPVDVN
490 500 510 520 530 540
TDTIPFKDKI REKQRQKQLL EQQRKEKTEN DGRRKFIKNK AWSKQKAKKE KKKKLTEKRK
550 560 570 580 590 600
REEGSDVEDE DMEELLNDTR LLKKFKKGKI TEEEFEKGLL TSGKRSTNKA DLEISDLEDD
C