AiPD: Autoinhibited Protein Database

Q2NKX8

Gene name	ERCC6L
Protein name	DNA excision repair protein ERCC-6-like
Names	ATP-dependent helicase ERCC6-like, PLK1-interacting checkpoint helicase, Tumor antigen BJ-HCC-15
Species	Homo sapiens (Human)
KEGG Pathway	hsa:54821
EC number	3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

720-797 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

720-797 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q2NKX8

Entry ID	Method	Resolution	Chain	Position	Source
5JNO	X-ray	220 A	B	10-66	PDB
AF-Q2NKX8-F1	Predicted				AlphaFoldDB

466 variants for Q2NKX8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs868842692 CA331060277	3	A>E		No	ClinGen Ensembl
rs1402657839 CA413559495	3	A>P		No	ClinGen TOPMed gnomAD
TCGA novel	5	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413559366 rs1279095840	6	R>K		No	ClinGen gnomAD
rs1467210521 CA413559322	7	F>L		No	ClinGen TOPMed
rs1332305566 CA413559303	8	P>A		No	ClinGen gnomAD
CA10449736 rs751353457	9	E>D		No	ClinGen ExAC gnomAD
rs1417449046 CA413559197	10	A>D		No	ClinGen gnomAD
rs1478299622 CA413559184	11	E>K		No	ClinGen gnomAD
CA413559142 rs1377036783	12	A>T		No	ClinGen gnomAD
rs1196405486 CA413559125	12	A>V		No	ClinGen gnomAD
rs1197607301 CA413559051	14	S>I		No	ClinGen gnomAD
rs1456206336 CA413559029	15	P>S		No	ClinGen TOPMed gnomAD
rs764754545 CA10449732	18	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1219337943 CA413558883	20	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA413589788 rs1441347523	23	R>S		No	ClinGen gnomAD
rs1275963968 CA413589781	24	Y>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1356513448 CA413589776	25	V>L		No	ClinGen gnomAD
rs781476893 CA10449718	28	A>V		No	ClinGen ExAC gnomAD
CA10449717 rs200564074	31	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs746922344 CA10449716	34	N>K		No	ClinGen ExAC gnomAD
CA10449715 CA10449714 rs765734663	42	K>N		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	48	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1345122062 CA413589608	49	D>G		No	ClinGen TOPMed
CA10449713 rs551073390	50	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA331075222 rs368590575	53	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs754693469 CA10449711	55	K>R		No	ClinGen ExAC gnomAD
rs1182070616 CA413589501	63	I>V		No	ClinGen gnomAD
CA10449707 rs774754864	68	E>K		No	ClinGen ExAC gnomAD
CA10449706 rs146213399	70	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA413589372 rs1602437750	71	A>E		No	ClinGen Ensembl
rs141181241 CA10449705	72	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	76	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10449704 rs775985483	77	E>V		No	ClinGen ExAC gnomAD
CA10449703 rs770124131	78	F>C		No	ClinGen ExAC gnomAD
CA413589210 rs1315497088	81	V>L		No	ClinGen TOPMed gnomAD
rs148217488 CA331075105	89	Y>C		No	ClinGen ESP TOPMed
RCV000897740 CA10449701 rs140278755	90	R>Q		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA413589047 rs1256436914	92	L>R		No	ClinGen TOPMed gnomAD
rs1291464310 CA413589008	95	Q>K		No	ClinGen gnomAD
rs906824207 CA331075092	100	Q>H		No	ClinGen Ensembl
CA413588865 rs1184771212	104	I>T		No	ClinGen TOPMed
CA10449700 rs771164487	104	I>V		No	ClinGen ExAC TOPMed gnomAD
rs746914949 CA10449699	111	Y>H		No	ClinGen ExAC gnomAD
CA10449698 rs777548557	112	R>K		No	ClinGen ExAC
CA331075083 rs901022791	119	I>M		No	ClinGen TOPMed gnomAD
rs756922577 CA331075080	124	M>V		No	ClinGen Ensembl
CA10449696 rs190982446	126	L>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA10449695 rs761082445	130	V>I		No	ClinGen 1000Genomes ExAC gnomAD
CA10449693 rs201242720	138	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA331075017 rs146896703	143	S>L		No	ClinGen ESP
rs1261916661 CA413588404	147	H>R		No	ClinGen gnomAD
CA413588408 rs1430623621	147	H>Y		No	ClinGen TOPMed
rs1602437589 CA413588312	155	N>T		No	ClinGen Ensembl
rs779502950 CA10449692	157	I>V		No	ClinGen ExAC gnomAD
CA413588279 rs1222803231	158	N>D		No	ClinGen gnomAD
rs1271513463 CA413588255	159	T>I		No	ClinGen gnomAD
CA413588190 rs1231598772	164	F>L		No	ClinGen gnomAD
CA413588170 rs1318679855	165	I>T		No	ClinGen gnomAD
rs1212702932 CA413588104	170	G>A		No	ClinGen TOPMed gnomAD
rs1290427733 CA413587998	178	G>D		No	ClinGen TOPMed
CA10449685 rs759122393	179	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs1391739315 CA413587987	180	S>T		No	ClinGen gnomAD
rs777014115 CA10449684	181	K>T		No	ClinGen ExAC gnomAD
rs760640928 CA10449682	183	E>K		No	ClinGen ExAC gnomAD
rs918253192 CA331074945	184	R>W		No	ClinGen Ensembl
rs773897881 CA10449681	186	R>K		No	ClinGen 1000Genomes ExAC gnomAD
CA10449680 rs142549919 RCV000969343	189	N>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs778615639 CA10449678	190	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10449679 rs748131332	190	R>W		No	ClinGen ExAC gnomAD
TCGA novel	194	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	205	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413587642 rs1200753032	207	N>K		No	ClinGen TOPMed gnomAD
CA413587566 rs1250808056	212	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs200143714 CA10449672 CA10449673	228	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	232	K>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10449671 rs758762458	235	T>N		No	ClinGen ExAC gnomAD
rs151269287 CA10449667	245	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA413587159 rs1295908830	247	I>V		No	ClinGen gnomAD
CA10449665 rs201800132	252	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	253	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	258	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413587088 rs1316695947	258	T>S		No	ClinGen TOPMed
CA10449663 rs374124933	260	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	265	Q>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	266	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774298340 CA10449661	268	W>R		No	ClinGen ExAC gnomAD
CA413587003 rs1602437320	270	L>Q		No	ClinGen Ensembl
TCGA novel	277	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1194077779 CA413586947	278	S>A		No	ClinGen gnomAD
rs1484282759 CA413586930	281	G>E		No	ClinGen gnomAD
CA413586883 rs1602437292	288	M>V		No	ClinGen Ensembl
CA10449658 rs775318402	302	A>V		No	ClinGen ExAC TOPMed gnomAD
CA413586771 rs1569489976	303	T>N		No	ClinGen Ensembl
rs1287835827 CA413586760	305	G>E		No	ClinGen gnomAD
TCGA novel	306	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1240641997 CA413586736	308	A>V		No	ClinGen gnomAD
TCGA novel	310	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	312	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1334740118 CA413586685	313	I>V		No	ClinGen TOPMed gnomAD
CA413586607 rs1304432204	319	A>V		No	ClinGen gnomAD
CA10449657 rs769270474	324	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	331	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746565139 CA10449654 COSM1570029	333	V>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs746565139 CA10449653	333	V>L		No	ClinGen ExAC TOPMed gnomAD
rs779530243 CA10449652	342	E>G		No	ClinGen ExAC gnomAD
rs200073614 CA10449651	343	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs754242682 CA10449650	344	R>G		No	ClinGen ExAC gnomAD
TCGA novel	344	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10449648 rs149128529	346	N>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs149128529 CA10449649	346	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA413586262 rs1425825702	349	N>D		No	ClinGen gnomAD
CA10449647 rs765230986	349	N>S		No	ClinGen ExAC TOPMed gnomAD
CA331074701 rs765230986	349	N>T		No	ClinGen ExAC TOPMed gnomAD
CA10449646 rs767450780	350	P>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	361	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1184080116 CA413586103	363	R>T		No	ClinGen TOPMed
TCGA novel	365	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1469834817 CA413586075	365	N>S		No	ClinGen TOPMed
TCGA novel	365	N>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1216998343 CA413585979	372	R>*		No	ClinGen gnomAD
COSM1125067 CA413585977 rs1157150843	372	R>Q	large_intestine Variant assessed as Somatic; impact. endometrium [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1006787494 CA331074684	373	L>P		No	ClinGen Ensembl
rs764001801 CA10449643	375	P>S		No	ClinGen ExAC gnomAD
CA413585915 rs1159206272	376	L>S		No	ClinGen gnomAD
rs1569489930 CA413585869	378	E>D		No	ClinGen Ensembl
CA413585816 rs1258814503	382	R>G		No	ClinGen gnomAD
TCGA novel	382	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762887752 CA10449642	385	V>M		No	ClinGen ExAC gnomAD
CA10449641 rs775077750	387	L>S		No	ClinGen ExAC gnomAD
CA10449639 rs189810726	397	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10449637 rs144123832	398	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs139313430 COSM195473 CA10449636	398	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1334765481 CA413585564	402	A>V		No	ClinGen TOPMed
CA331074618 rs868768343	409	K>R		No	ClinGen Ensembl
TCGA novel	417	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755486370 CA10449634	420	R>W		No	ClinGen ExAC TOPMed gnomAD
CA413585293 rs1474275861	423	C>Y		No	ClinGen gnomAD
rs749819014 CA10449633	426	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1261100793 CA413585159	431	S>C		No	ClinGen TOPMed
TCGA novel	434	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs865790063 CA331074595	435	G>E		No	ClinGen Ensembl
CA413585037 rs1211437556	438	G>W		No	ClinGen gnomAD
rs1569489887 CA413584977	441	S>Y		No	ClinGen Ensembl
rs756526817 CA10449631	443	D>E		No	ClinGen ExAC gnomAD
CA413584947 rs1488579280	443	D>H		No	ClinGen gnomAD
CA10449630 rs750805759	449	Q>E		No	ClinGen ExAC gnomAD
CA413584779 rs1228769983	452	D>N		No	ClinGen gnomAD
CA10449628 rs367844894	454	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA10449629 rs367844894	454	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA331074575 rs923238793	462	M>T		No	ClinGen TOPMed gnomAD
TCGA novel	466	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10449627 rs202048178	467	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1325461838 CA413584456	469	L>F		No	ClinGen gnomAD
CA413584459 rs1325461838	469	L>V		No	ClinGen gnomAD
CA331074569 rs976090150	471	R>S		No	ClinGen TOPMed
CA413584405 rs1268887460	473	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	476	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413584354 rs1487091722	476	G>R		No	ClinGen TOPMed
rs1460133986 CA413584310	479	T>A		No	ClinGen gnomAD
TCGA novel	479	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1425831962 CA413584265	483	S>A		No	ClinGen TOPMed gnomAD
COSM1125064 rs762834270 CA10449625	485	S>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs933735259 CA331074562	492	I>T		No	ClinGen TOPMed gnomAD
CA10449623 rs765128241	494	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA413584115 rs1252203341	497	K>R		No	ClinGen gnomAD
CA413584057 rs1258093199	501	F>L		No	ClinGen gnomAD
rs770702617 CA10449620	504	L>S		No	ClinGen ExAC TOPMed gnomAD
COSM195472 CA413584015 rs1339227994	505	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1236148995 CA413583944	512	H>Y		No	ClinGen gnomAD
CA10449619 rs187128885	513	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	513	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	513	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	517	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	519	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA331074520 rs150532018	521	N>H		No	ClinGen ESP
CA10449616 rs749715424	524	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs1329575694 CA413583795	525	Q>E		No	ClinGen gnomAD
rs1265759918 CA413583725	530	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA413583660 rs1174231068	537	Q>R		No	ClinGen gnomAD
rs746226184 CA10449613	541	V>I		No	ClinGen ExAC TOPMed gnomAD
rs757416133 CA10449611	553	I>S		No	ClinGen ExAC gnomAD
rs1238414796 CA413583375	564	A>G		No	ClinGen gnomAD
CA331074485 rs370873689	566	A>V		No	ClinGen ESP TOPMed gnomAD
TCGA novel	571	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10449609 rs777793094	571	Y>H		No	ClinGen ExAC gnomAD
COSM1125062 CA413583297 rs1423637771	572	R>Q	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs758443175 CA10449608	577	E>K		No	ClinGen ExAC gnomAD
TCGA novel	579	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765208217 CA10449606	602	D>E		No	ClinGen ExAC gnomAD
TCGA novel	604	L>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs905645046 CA331074460	605	I>T		No	ClinGen TOPMed
rs1379308095 CA413582857	613	K>E		No	ClinGen TOPMed gnomAD
TCGA novel	616	F>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1334048330 CA413582805	617	R>Q		No	ClinGen TOPMed gnomAD
CA10449601 rs760354023	621	K>E		No	ClinGen ExAC gnomAD
TCGA novel	623	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	624	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	626	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10449598 rs201713434	629	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs967229543 CA331074411	630	I>V		No	ClinGen Ensembl
COSM1125061 rs147328766 CA10449596	631	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA10449597 rs147328766	631	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA10449595 rs746378490	632	D>G		No	ClinGen ExAC TOPMed gnomAD
rs914713203 CA331074395	634	Q>H		No	ClinGen TOPMed
TCGA novel	641	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	657	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771318389 CA10449593	658	E>K		No	ClinGen ExAC TOPMed gnomAD
rs747415869 CA10449592	660	I>V		No	ClinGen ExAC TOPMed gnomAD
rs777951082 CA10449591	669	A>V		No	ClinGen ExAC gnomAD
rs372955235 CA10449590	671	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA413578975 rs1569489786	675	D>G		No	ClinGen Ensembl
rs778863624 CA10449588	677	M>T		No	ClinGen ExAC gnomAD
CA10449587 rs754886880	680	C>R		No	ClinGen ExAC gnomAD
CA10449586 rs753740022	685	K>R		No	ClinGen ExAC gnomAD
CA10449584 rs188646020	689	D>N		No	ClinGen 1000Genomes ExAC
TCGA novel	690	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs976522853 CA331074351	694	S>Y		No	ClinGen TOPMed
rs1401840923 CA413578620	698	Q>R		No	ClinGen gnomAD
CA331074325 CA331074341 rs1011347533	700	R>S		No	ClinGen Ensembl
CA331074319 rs964737805	701	V>A		No	ClinGen TOPMed gnomAD
TCGA novel	702	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs958041304 CA331074298	708	V>D		No	ClinGen TOPMed gnomAD
rs1317439506 CA413578499	708	V>I		No	ClinGen gnomAD
rs1474602140 CA413578450	711	E>A		No	ClinGen gnomAD
rs750289131 CA10449582 COSM1125059	711	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA331074283 rs200234671	714	N>D		No	ClinGen 1000Genomes
CA413578264 rs1245518499	719	M>I		No	ClinGen TOPMed
rs1310770071 CA413578258	720	E>K		No	ClinGen TOPMed
rs761435400 CA10449580	722	Q>R		No	ClinGen ExAC gnomAD
CA10449579 rs773857138	723	R>I		No	ClinGen ExAC gnomAD
rs865972418 CA331074216	724	T>I		No	ClinGen TOPMed
CA10449578 rs763537928	728	G>E		No	ClinGen ExAC gnomAD
CA10449577 rs760051206	735	V>L		No	ClinGen ExAC gnomAD
TCGA novel	742	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	743	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10449576 rs777094514	750	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10449575 rs369492714	753	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1334249905 CA413577463	756	P>T		No	ClinGen TOPMed gnomAD
rs45448501 CA10449574	759	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10449573 rs773634562	762	H>Q		No	ClinGen ExAC gnomAD
CA10449572 rs375177556	763	T>I		No	ClinGen ESP ExAC gnomAD
CA413577247 rs1243203630	764	Q>L		No	ClinGen TOPMed
rs1428388180 CA413577143	768	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs748332306 CA10449571	769	S>C		No	ClinGen ExAC gnomAD
rs779001189 CA10449570	774	S>T		No	ClinGen ExAC gnomAD
CA10449568 rs138539407	777	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs780115534 CA10449567	778	D>E		No	ClinGen ExAC gnomAD
rs373087197 CA10449566	781	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA413576769 rs1420858572	784	G>A		No	ClinGen gnomAD
CA413576682 rs1186239180	788	D>A		No	ClinGen gnomAD
rs1419336051 CA413576633	790	S>F		No	ClinGen TOPMed
rs1158066973 CA413576630	791	S>G		No	ClinGen TOPMed
rs1454242938 CA413576439	798	T>N		No	ClinGen gnomAD
rs200118335 CA331074187	798	T>S		No	ClinGen Ensembl
rs1569489748 CA413576432	799	L>V		No	ClinGen Ensembl
rs767437755 CA10449564	802	G>R		No	ClinGen ExAC gnomAD
CA413576334 rs1409547407	803	K>E		No	ClinGen TOPMed
rs756889450 CA10449563	807	S>N		No	ClinGen ExAC TOPMed gnomAD
CA10449562 rs751204906	808	A>T		No	ClinGen ExAC gnomAD
CA331074162 rs183569692	812	A>T		No	ClinGen 1000Genomes
rs763850827 CA10449561	813	T>I		No	ClinGen ExAC gnomAD
rs1212794517 CA413576090	815	P>S		No	ClinGen TOPMed gnomAD
rs767335608 CA10449560	817	G>R		No	ClinGen 1000Genomes ExAC gnomAD
rs759241784 CA10449559	818	F>L		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	823	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs368694497 CA10449557	827	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1602436157 CA413575821	827	N>T		No	ClinGen Ensembl
TCGA novel	833	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	835	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	835	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413575523 rs1353479990	837	A>V		No	ClinGen gnomAD
CA10449555 rs143780574	840	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA413575414 rs1408754751	842	A>G		No	ClinGen gnomAD
TCGA novel	844	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10449554 rs149400438	846	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs748360100 CA10449553	847	T>I		No	ClinGen ExAC gnomAD
TCGA novel	855	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA331074125 rs1011305166	856	A>T		No	ClinGen TOPMed
TCGA novel	857	L>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780344606 CA10449549	861	P>S		No	ClinGen ExAC gnomAD
CA413574933 rs1250896050	863	E>A		No	ClinGen gnomAD
CA413574907 rs1327596330	864	S>T		No	ClinGen TOPMed
rs377308473 CA10449546	866	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10449547 rs745826258	866	N>S		No	ClinGen ExAC gnomAD
rs1264226223 CA413574809	867	Y>C		No	ClinGen TOPMed
CA10449543 rs777279256	869	L>I		No	ClinGen ExAC TOPMed gnomAD
rs1308679803 CA413574727	871	K>N		No	ClinGen gnomAD
CA413574638 rs1602436027	876	D>H		No	ClinGen Ensembl
TCGA novel	879	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764741520 CA10449540	882	D>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	883	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10449539 rs761121796	884	L>I		No	ClinGen ExAC gnomAD
TCGA novel	886	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413574385 rs1249347499	887	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA413574378 rs1481259015	887	D>V		No	ClinGen TOPMed
TCGA novel	889	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10449538 rs750959799	891	R>C		No	ClinGen ExAC gnomAD
CA10449537 rs146534560	891	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA331074022 rs923557190	894	N>D		No	ClinGen TOPMed
rs372744705 CA331074018	896	W>C		No	ClinGen ESP TOPMed gnomAD
CA10449536 rs762060768	898	I>V		No	ClinGen ExAC gnomAD
rs1174001109 CA413573973	901	I>L		No	ClinGen TOPMed
CA10449535 rs774834145	901	I>T		No	ClinGen ExAC gnomAD
CA413573897 rs1249879328	904	E>A		No	ClinGen gnomAD
CA413573693 rs1356401293	911	N>S		No	ClinGen TOPMed
CA10449534 rs763268011	913	S>F		No	ClinGen ExAC TOPMed gnomAD
CA10449533 rs763268011	913	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA331074003 rs75816027	914	I>L		No	ClinGen Ensembl
rs1486586718 CA413573607	915	I>T		No	ClinGen gnomAD
CA331073990 rs928229001	916	E>K		No	ClinGen Ensembl
rs1307730552 CA413573558	917	I>L		No	ClinGen TOPMed
rs1258157181 CA413573385	925	H>Y		No	ClinGen gnomAD
rs775667202 CA10449531	926	S>R		No	ClinGen ExAC gnomAD
CA413573255 rs1569489699	931	A>V		No	ClinGen Ensembl
CA10449530 rs770028893	932	Q>H		No	ClinGen ExAC gnomAD
CA10449529 rs745987590	934	S>T		No	ClinGen ExAC TOPMed gnomAD
RCV000413459 rs1057518449	935	E>missing		No	ClinVar dbSNP
rs780972657 CA10449528	935	E>D		No	ClinGen ExAC TOPMed
CA413573200 rs1284362256	935	E>K		No	ClinGen TOPMed
CA10449527 rs770961426	942	P>H		No	ClinGen ExAC gnomAD
TCGA novel	942	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10449526 rs566814162	945	S>F		No	ClinGen 1000Genomes ExAC gnomAD
rs1357849071 CA413572968	949	Y>C		No	ClinGen gnomAD
rs777628747 CA10449525	949	Y>H		No	ClinGen ExAC gnomAD
rs1414786443 CA413572953	950	A>S		No	ClinGen TOPMed gnomAD
rs757988944 CA10449524	951	C>Y		No	ClinGen ExAC gnomAD
rs1009264830 CA331073972	955	L>I		No	ClinGen Ensembl
CA331073945 rs910523781	958	E>G		No	ClinGen TOPMed
CA331073968 rs943373271	958	E>K		No	ClinGen TOPMed gnomAD
CA10449521 rs368349813	963	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs753436230 CA10449520	969	S>G		No	ClinGen ExAC gnomAD
CA331073932 rs930752891	973	E>Q		No	ClinGen TOPMed
rs767894899 CA10449519	974	H>P		No	ClinGen ExAC gnomAD
CA331073919 rs989591724	975	V>I		No	ClinGen Ensembl
TCGA novel	976	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751800190 CA10449517	988	S>C		No	ClinGen ExAC TOPMed gnomAD
rs201618175 CA10449516	989	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs763231109 COSM1644073 CA10449515	989	R>K	stomach [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA10449513 rs759679045	990	A>G		No	ClinGen ExAC TOPMed gnomAD
rs759679045 CA10449512	990	A>V		No	ClinGen ExAC TOPMed gnomAD
CA10449511 rs776838613	991	G>E		No	ClinGen ExAC gnomAD
CA10449510 rs770709541	993	V>M		No	ClinGen ExAC gnomAD
CA413572150 rs1298127579	999	L>R		No	ClinGen gnomAD
CA413572142 rs1383127586	1000	S>N		No	ClinGen gnomAD
CA10449508 rs771884439	1007	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1318784089 CA413572051	1007	D>G		No	ClinGen gnomAD
rs1368895777 CA413572055	1007	D>N		No	ClinGen TOPMed
rs747976435 CA10449506	1008	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1602435649 CA413572014	1010	P>Q		No	ClinGen Ensembl
rs1474162780 CA413572020	1010	P>T		No	ClinGen gnomAD
TCGA novel	1012	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs368082499 CA10449504	1012	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs748741011 CA10449503	1012	E>V		No	ClinGen ExAC
rs1029564947 CA331073799	1021	S>N		No	ClinGen Ensembl
rs1226969333 CA413571824	1022	K>E		No	ClinGen TOPMed
CA413571793 rs1259477860	1024	R>G		No	ClinGen gnomAD
TCGA novel	1027	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1215144132 CA413571736	1027	V>G		No	ClinGen gnomAD
rs1468681436 CA413571706	1029	D>E		No	ClinGen gnomAD
rs752142569 COSM1125054 CA10449499	1031	E>K	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1288859585 CA413571589	1035	D>G		No	ClinGen TOPMed
CA413571469 rs1253607709	1042	S>N		No	ClinGen gnomAD
rs746430905 CA331073774	1043	I>V		No	ClinGen Ensembl
rs764742655 CA10449498	1050	L>H		No	ClinGen ExAC TOPMed gnomAD
rs1326183987 CA413571294	1053	F>L		No	ClinGen gnomAD
CA10449497 rs201813772	1055	S>P		No	ClinGen ExAC gnomAD
rs201813772 CA413571262	1055	S>T		No	ClinGen ExAC gnomAD
rs1475055921 CA413571157	1061	A>T		No	ClinGen TOPMed
rs1187969714 CA413571123	1063	T>A		No	ClinGen TOPMed
CA10449496 rs753173693	1066	N>Y		No	ClinGen ExAC gnomAD
rs765552856 CA10449495	1068	I>V		No	ClinGen ExAC gnomAD
rs1325229102 CA413571008	1069	S>I		No	ClinGen TOPMed gnomAD
CA413570990 rs1403690944	1070	P>L		No	ClinGen gnomAD
CA413570975 rs1168419976	1071	P>Q		No	ClinGen gnomAD
rs1398804632 CA413570988	1071	P>T		No	ClinGen gnomAD
CA10449494 rs367691365	1073	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed
CA413570883 rs1388064711	1076	S>T		No	ClinGen gnomAD
CA413570840 rs776516099	1078	Q>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1079	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1082	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1251991529 CA413570758	1082	S>R		No	ClinGen TOPMed gnomAD
rs766504041 CA10449492	1082	S>T		No	ClinGen ExAC gnomAD
rs760489524 CA10449491	1083	V>I		No	ClinGen ExAC gnomAD
rs1602435455 COSM1125051 CA413570664	1087	M>I	endometrium [Cosmic]	No	ClinGen cosmic curated Ensembl
rs969727890 CA413570644	1088	N>K		No	ClinGen TOPMed gnomAD
rs781535055 CA331073716	1089	S>C		No	ClinGen Ensembl
CA413570619 rs1434421525	1090	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA331073702 rs888194690	1091	R>*		No	ClinGen Ensembl
CA413570602 rs1054753460	1091	R>I		No	ClinGen gnomAD
CA331073695 rs1054753460	1091	R>T		No	ClinGen gnomAD
CA10449489 rs772044139	1099	L>P		No	ClinGen ExAC
rs769073969	1100	I>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA331073661 rs906802464	1100	I>T		No	ClinGen TOPMed
CA10449487 rs747924522	1102	M>T		No	ClinGen ExAC gnomAD
rs772332054 CA10449486	1107	V>M		No	ClinGen 1000Genomes ExAC gnomAD
CA331073645 rs200436150	1110	M>I		No	ClinGen 1000Genomes
CA10449485 rs748979456	1115	D>E		No	ClinGen ExAC TOPMed gnomAD
rs779379313 CA10449483	1116	D>N		No	ClinGen ExAC TOPMed gnomAD
rs140453884 CA10449481	1117	S>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs868101885 CA331073591	1118	S>N		No	ClinGen Ensembl
TCGA novel	1121	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1121	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778413231 CA10449479	1122	G>C		No	ClinGen ExAC TOPMed gnomAD
CA331073587 rs746653103	1123	P>S		No	ClinGen Ensembl
TCGA novel	1123	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1435115337 CA413569958	1124	E>K		No	ClinGen gnomAD
CA10449478 rs142136151	1128	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs780485401	1129	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1232907765 CA413569814	1131	V>E		No	ClinGen gnomAD
CA10449476 rs374591932	1131	V>M		No	ClinGen ESP ExAC gnomAD
rs754122902 CA10449473	1137	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1216228000 CA413569651	1138	A>T		No	ClinGen gnomAD
CA413569458 rs1337324202	1144	E>G		No	ClinGen gnomAD
rs144948480 CA331073574	1144	E>K		No	ClinGen ESP TOPMed gnomAD
TCGA novel	1146	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413569177 rs78660817	1148	G>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1356985455 CA413569176	1148	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs78660817 CA10449469 COSM1469293	1148	G>R	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs774071692 CA10449467	1151	L>Q		No	ClinGen ExAC TOPMed gnomAD
rs1310697871 CA413569117	1151	L>V		No	ClinGen gnomAD
rs768514070 CA10449466	1157	S>F		No	ClinGen ExAC gnomAD
rs139547199 CA10449465	1159	W>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs775189735 CA10449464	1161	M>T		No	ClinGen ExAC gnomAD
CA10449463 rs769393229	1165	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1569489515 CA413568709	1166	S>R		No	ClinGen Ensembl
rs745382389 CA10449462	1169	A>P		No	ClinGen ExAC gnomAD
TCGA novel	1171	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1157427084 CA413568583	1171	E>K		No	ClinGen gnomAD
rs780855497 CA10449461	1171	E>V		No	ClinGen ExAC gnomAD
CA413568520 rs1279907762	1172	T>I		No	ClinGen TOPMed
rs201603911 CA10449460	1176	A>S		No	ClinGen 1000Genomes ExAC gnomAD
CA413568224 rs1190654281	1183	E>Q		No	ClinGen gnomAD
CA10449458 rs376875621	1184	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA413567928 rs1237211298	1190	Q>*		No	ClinGen gnomAD
CA413567869 rs1208499371	1191	D>E		No	ClinGen gnomAD
CA413567815 rs1226349013	1193	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1285235191 CA413567737	1196	A>G		No	ClinGen gnomAD
CA413567671 rs1264861463	1199	D>N		No	ClinGen TOPMed
rs1204832578 CA413567648	1199	D>V		No	ClinGen gnomAD
CA413567544 rs1354777511	1203	L>F		No	ClinGen gnomAD
CA10449452 rs750433514	1204	V>I		No	ClinGen ExAC gnomAD
CA10449453 rs750433514	1204	V>L		No	ClinGen ExAC gnomAD
CA413567502 rs1345632872	1205	K>R		No	ClinGen gnomAD
rs1030720831 CA331073436	1206	R>C		No	ClinGen TOPMed gnomAD
rs140225715 CA10449451	1206	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10449450 rs761685830	1209	E>*		No	ClinGen ExAC gnomAD
rs1413704568 CA413567303	1212	E>G		No	ClinGen gnomAD
CA413567202 rs1243123342	1216	I>V		No	ClinGen TOPMed gnomAD
CA10449446 rs763990925	1224	V>L		No	ClinGen ExAC TOPMed gnomAD
CA331073410 rs150894750	1226	A>V		No	ClinGen ESP gnomAD
CA413566981 rs1171451352	1227	L>I		No	ClinGen TOPMed
CA413566943 rs1214403206	1229	I>L		No	ClinGen gnomAD
TCGA novel	1229	I>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413566946 rs1214403206	1229	I>V		No	ClinGen gnomAD
TCGA novel	1232	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA331073396 rs1015466241	1233	D>H		No	ClinGen TOPMed gnomAD
rs1015466241 CA413566866	1233	D>N		No	ClinGen TOPMed gnomAD
rs749928252 CA10449445	1234	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1349508495 CA413566821	1235	E>*		No	ClinGen TOPMed
CA413566756 rs1407712272	1238	L>F		No	ClinGen TOPMed
CA413566748 rs1284988704	1238	L>R		No	ClinGen TOPMed
CA10449444 rs775218566	1240	T>I		No	ClinGen ExAC TOPMed gnomAD
rs769425306 CA10449443	1242	S>R		No	ClinGen ExAC gnomAD
CA10449442 rs759276710	1248	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1343048635	1251	N>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q2NKX8

5 regional properties for Q2NKX8

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	13 - 268	IPR000719
domain	NAF domain	307 - 366	IPR004041
active_site	Serine/threonine-protein kinase, active site	132 - 144	IPR008271
binding_site	Protein kinase, ATP binding site	19 - 42	IPR017441
domain	NAF/FISL domain	305 - 329	IPR018451

Functions

		Description
EC Number	3.6.4.12	Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization	Chromosome, centromere Chromosome, centromere, kinetochore Chromosome	Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase In prometaphase cells, it mostly concentrates in between kinetochores In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA Evolution from inner centromeres to thin threads takes place in response to tension Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
kinetochore	A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

6 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent chromatin remodeler activity	An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA helicase activity	Unwinding of a DNA helix, driven by ATP hydrolysis.
DNA translocase activity	Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis.

2 GO annotations of biological process

Name	Definition
cell cycle	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A3KMX0	ERCC6L2	DNA excision repair protein ERCC-6-like 2	Bos taurus (Bovine)	PR
Q03468	ERCC6	DNA excision repair protein ERCC-6	Homo sapiens (Human)	EV
F8VPZ5	Ercc6	DNA excision repair protein ERCC-6	Mus musculus (Mouse)	SS
Q9ZV43	CHR8	Protein CHROMATIN REMODELING 8	Arabidopsis thaliana (Mouse-ear cress)	SS

10	20	30	40	50	60
MEASRRFPEA	EALSPEQAAH	YLRYVKEAKE	ATKNGDLEEA	FKLFNLAKDI	FPNEKVLSRI
70	80	90	100	110	120
QKIQEALEEL	AEQGDDEFTD	VCNSGLLLYR	ELHNQLFEHQ	KEGIAFLYSL	YRDGRKGGIL
130	140	150	160	170	180
ADDMGLGKTV	QIIAFLSGMF	DASLVNHVLL	IMPTNLINTW	VKEFIKWTPG	MRVKTFHGPS
190	200	210	220	230	240
KDERTRNLNR	IQQRNGVIIT	TYQMLINNWQ	QLSSFRGQEF	VWDYVILDEA	HKIKTSSTKS
250	260	270	280	290	300
AICARAIPAS	NRLLLTGTPI	QNNLQELWSL	FDFACQGSLL	GTLKTFKMEY	ENPITRAREK
310	320	330	340	350	360
DATPGEKALG	FKISENLMAI	IKPYFLRRTK	EDVQKKKSSN	PEARLNEKNP	DVDAICEMPS
370	380	390	400	410	420
LSRKNDLIIW	IRLVPLQEEI	YRKFVSLDHI	KELLMETRSP	LAELGVLKKL	CDHPRLLSAR
430	440	450	460	470	480
ACCLLNLGTF	SAQDGNEGED	SPDVDHIDQV	TDDTLMEESG	KMIFLMDLLK	RLRDEGHQTL
490	500	510	520	530	540
VFSQSRQILN	IIERLLKNRH	FKTLRIDGTV	THLLEREKRI	NLFQQNKDYS	VFLLTTQVGG
550	560	570	580	590	600
VGLTLTAATR	VVIFDPSWNP	ATDAQAVDRV	YRIGQKENVV	VYRLITCGTV	EEKIYRRQVF
610	620	630	640	650	660
KDSLIRQTTG	EKKNPFRYFS	KQELRELFTI	EDLQNSVTQL	QLQSLHAAQR	KSDIKLDEHI
670	680	690	700	710	720
AYLQSLGIAG	ISDHDLMYTC	DLSVKEELDV	VEESHYIQQR	VQKAQFLVEF	ESQNKEFLME
730	740	750	760	770	780
QQRTRNEGAW	LREPVFPSST	KKKCPKLNKP	QPQPSPLLST	HHTQEEDISS	KMASVVIDDL
790	800	810	820	830	840
PKEGEKQDLS	SIKVNVTTLQ	DGKGTGSADS	IATLPKGFGS	VEELCTNSSL	GMEKSFATKN
850	860	870	880	890	900
EAVQKETLQE	GPKQEALQED	PLESFNYVLS	KSTKADIGPN	LDQLKDDEIL	RHCNPWPIIS
910	920	930	940	950	960
ITNESQNAES	NVSIIEIADD	LSASHSALQD	AQASEAKLEE	EPSASSPQYA	CDFNLFLEDS
970	980	990	1000	1010	1020
ADNRQNFSSQ	SLEHVEKENS	LCGSAPNSRA	GFVHSKTCLS	WEFSEKDDEP	EEVVVKAKIR
1030	1040	1050	1060	1070	1080
SKARRIVSDG	EDEDDSFKDT	SSINPFNTSL	FQFSSVKQFD	ASTPKNDISP	PGRFFSSQIP
1090	1100	1110	1120	1130	1140
SSVNKSMNSR	RSLASRRSLI	NMVLDHVEDM	EERLDDSSEA	KGPEDYPEEG	VEESSGEASK
1150	1160	1170	1180	1190	1200
YTEEDPSGET	LSSENKSSWL	MTSKPSALAQ	ETSLGAPEPL	SGEQLVGSPQ	DKAAEATNDY
1210	1220	1230	1240
ETLVKRGKEL	KECGKIQEAL	NCLVKALDIK	SADPEVMLLT	LSLYKQLNNN