Q2M2N2
Gene name |
Spopl |
Protein name |
Speckle-type POZ protein-like |
Names |
HIB homolog 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:76857 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2M2N2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2M2N2-F1 | Predicted | AlphaFoldDB |
13 variants for Q2M2N2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388530837 | 6 | T>I | No | EVA | |
| rs3388530897 | 116 | A>VSDG* | No | EVA | |
| rs3412902064 | 129 | K>* | No | EVA | |
| rs3388532406 | 134 | K>* | No | EVA | |
| rs1134353154 | 139 | R>M | No | EVA | |
| rs1131708416 | 142 | L>F | No | EVA | |
| rs1134553693 | 144 | D>N | No | EVA | |
| rs3388528709 | 208 | G>V | No | EVA | |
| rs3388534831 | 212 | K>N | No | EVA | |
| rs3391344353 | 270 | A>ANKLSAILSRFGAFPV* | No | EVA | |
| rs3388531891 | 317 | L>S | No | EVA | |
| rs3388532842 | 319 | A>S | No | EVA | |
| rs3388532435 | 340 | K>N | No | EVA |
No associated diseases with Q2M2N2
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| Cul3-RING ubiquitin ligase complex | A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of protein ubiquitination | Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein. |
| proteasome-mediated ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
| regulation of proteolysis | Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6IQ16 | SPOPL | Speckle-type POZ protein-like | Homo sapiens (Human) | PR |
| Q9CTN4 | Rhobtb3 | Rho-related BTB domain-containing protein 3 | Mus musculus (Mouse) | SS |
| Q6YCH2 | Tdpoz4 | TD and POZ domain-containing protein 4 | Mus musculus (Mouse) | PR |
| P34371 | bath-42 | BTB and MATH domain-containing protein 42 | Caenorhabditis elegans | PR |
| Q9ZUA7 | At2g01790 | MATH domain and coiled-coil domain-containing protein At2g01790 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4IN32 | At2g42460 | MATH domain and coiled-coil domain-containing protein At2g42460 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P0DKG7 | At2g42480 | MATH domain and coiled-coil domain-containing protein At2g42480 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSD2 | At3g27040 | MATH domain and coiled-coil domain-containing protein At3g27040 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4J4A0 | At3g44790 | MATH domain and coiled-coil domain-containing protein At3g44790 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4J4A1 | At3g44800 | MATH domain and coiled-coil domain-containing protein At3g44800 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M2J5 | At3g58210 | MATH domain and coiled-coil domain-containing protein At3g58210 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4J4P8 | At3g58220 | MATH domain and coiled-coil domain-containing protein At3g58220 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M2J0 | At3g58260 | MATH domain and coiled-coil domain-containing protein At3g58260 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M2I2 | At3g58340 | MATH domain and coiled-coil domain-containing protein At3g58340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSREPTPPLP | GDMSTSPVAE | SWCYTQVKVV | KFSYMWTINN | FSFCREEMGE | VLKSSTFSSG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PNDKMKWCLR | VNPKGLDDES | KDYLSLYLLL | VSCPKSEVRA | KFKFSLLNDK | REETKAMESQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RAYRFVQGKD | WGFKKFIRRD | FLLDEANGLL | PDDKLTLFCE | VSVVQDSVNV | SGHTSTNTLK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VPECRLAEDL | GNLWENTRFT | DCCFFVRGKE | FKAHKSVLAA | RSPVFNAMFE | HEMEECTKNR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VEINDLDPEV | FKEMMRFVYT | GKAPNLDKMA | DNLLAAADKY | ALERLKVMCE | EALCSNLSVE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NVADTLVLAD | LHSAEQLKAQ | AIDFINRCSV | LRQLGCKDGK | NWNNNQATDI | METSGWKSMI |
| 370 | 380 | 390 | |||
| QSHPHLVAEA | FRALASSQCP | QFGIPRKRLK | QS |