Q2LKU9
Gene name |
Nlrp1a |
Protein name |
NACHT, LRR and PYD domains-containing protein 1a |
Names |
Caspase recruitment domain-containing protein 7, Death effector filament-forming ced-4-like apoptosis protein, Nucleotide-binding domain and caspase recruitment domain |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:195046 |
EC number |
|
Protein Class |
|

Descriptions
Autoinhibitory domains (AIDs)
Target domain |
133-442 (NACHT domain) |
Relief mechanism |
Cleavage |
Assay |
|
Accessory elements
No accessory elements
References
- Neiman-Zenevich J et al. (2014) "Distinct regions of NLRP1B are required to respond to anthrax lethal toxin and metabolic inhibition", Infection and immunity, 82, 3697-703
- Manji GA et al. (2002) "PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B", The Journal of biological chemistry, 277, 11570-5
- Robinson KS et al. (2020) "Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia", Science (New York, N.Y.), 370,
Autoinhibited structure

Activated structure

1 structures for Q2LKU9
Entry ID | Method | Resolution | Chain | Position | Source |
---|---|---|---|---|---|
AF-Q2LKU9-F1 | Predicted | AlphaFoldDB |
234 variants for Q2LKU9
Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
---|---|---|---|---|---|
rs26891737 | 3 | E>K | No | Ensembl | |
rs1133635292 | 5 | Q>P | No | Ensembl | |
rs1134465205 | 6 | S>P | No | Ensembl | |
rs1134064682 | 9 | E>K | No | Ensembl | |
rs1132732230 | 11 | S>N | No | Ensembl | |
rs1132521357 | 21 | E>Q | No | Ensembl | |
rs1133428197 | 27 | F>L | No | Ensembl | |
rs1132351409 | 28 | K>N | No | Ensembl | |
rs1133611431 | 30 | K>T | No | Ensembl | |
rs1134749006 | 31 | K>R | No | Ensembl | |
rs1134145913 | 32 | L>H | No | Ensembl | |
rs1134584218 | 34 | E>D | No | Ensembl | |
rs1133091981 | 34 | E>K | No | Ensembl | |
rs225815361 | 47 | N>D | No | Ensembl | |
rs580324507 | 79 | F>I | No | Ensembl | |
rs582286336 | 84 | K>N | No | Ensembl | |
rs586021673 | 84 | K>R | No | Ensembl | |
rs1133941944 | 87 | L>I | No | Ensembl | |
rs578599322 | 88 | F>L | No | Ensembl | |
rs262554410 | 88 | F>Y | No | Ensembl | |
rs585214551 | 89 | K>Q | No | Ensembl | |
rs1134028044 | 93 | Q>K | No | Ensembl | |
rs581991541 | 93 | Q>P | No | Ensembl | |
rs578372297 | 94 | R>K | No | Ensembl | |
rs585276537 | 95 | G>D | No | Ensembl | |
rs581372246 | 96 | S>P | No | Ensembl | |
rs584819182 | 99 | L>M | No | Ensembl | |
rs581171121 | 102 | E>K | No | Ensembl | |
rs1133011274 | 104 | W>R | No | Ensembl | |
rs587008293 | 105 | Y>H | No | Ensembl | |
rs584281078 | 105 | Y>S | No | Ensembl | |
rs580843345 | 106 | P>S | No | Ensembl | |
rs586255352 | 108 | V>I | No | Ensembl | |
rs3148102 | 112 | E>G | No | Ensembl | |
rs261708874 | 112 | E>K | No | Ensembl | |
rs232045877 | 113 | A>G | No | Ensembl | |
rs1133564911 | 114 | H>Y | No | Ensembl | |
rs241292543 | 117 | D>E | No | Ensembl | |
rs256861050 | 117 | D>N | No | Ensembl | |
rs235746361 | 126 | L>I | No | Ensembl | |
rs255344627 | 167 | H>L | No | Ensembl | |
rs235634652 | 167 | H>Q | No | Ensembl | |
rs243719877 | 190 | V>A | No | Ensembl | |
rs237250311 | 197 | T>I | No | Ensembl | |
rs1133967511 | 225 | A>G | No | Ensembl | |
rs214531848 | 227 | Q>R | No | Ensembl | |
rs1132323608 | 229 | P>L | No | Ensembl | |
rs1133444001 | 230 | E>D | No | Ensembl | |
rs1134508647 | 231 | L>F | No | Ensembl | |
rs1132973857 | 238 | T>I | No | Ensembl | |
rs26891747 | 256 | G>E | No | Ensembl | |
rs1134596179 | 271 | F>I | No | Ensembl | |
rs585137606 | 276 | E>A | No | Ensembl | |
rs579180719 | 276 | E>Q | No | Ensembl | |
rs1134974424 | 279 | C>Y | No | Ensembl | |
rs1132823202 | 281 | V>L | No | Ensembl | |
rs580814326 | 282 | E>K | No | Ensembl | |
rs586672697 | 287 | T>S | No | Ensembl | |
rs581732672 | 288 | L>* | No | Ensembl | |
rs583948917 | 288 | L>V | No | Ensembl | |
rs587578372 | 289 | F>I | No | Ensembl | |
rs241843742 | 291 | R>Q | No | Ensembl | |
rs584026835 | 292 | K>E | No | Ensembl | |
rs1134548762 | 293 | N>D | No | Ensembl | |
rs586693243 | 296 | Y>H | No | Ensembl | |
rs583402941 | 300 | G>A | No | Ensembl | |
rs585495181 | 301 | K>N | No | Ensembl | |
rs582073927 | 302 | K>Q | No | Ensembl | |
rs243753591 | 303 | K>R | No | Ensembl | |
rs586485939 | 304 | G>D | No | Ensembl | |
rs579522607 | 304 | G>R | No | Ensembl | |
rs582868581 | 305 | G>A | No | Ensembl | |
rs579037212 | 306 | V>I | No | Ensembl | |
rs584500063 | 308 | T>A | No | Ensembl | |
rs582245607 | 310 | T>I | No | Ensembl | |
rs584587051 | 311 | L>I | No | Ensembl | |
rs578393315 | 313 | K>E | No | Ensembl | |
rs587276818 | 316 | S>P | No | Ensembl | |
rs583389720 | 317 | A>V | No | Ensembl | |
rs1134919025 | 333 | T>I | No | Ensembl | |
rs583417474 | 337 | K>N | No | Ensembl | |
rs1132987690 | 342 | G>S | No | Ensembl | |
rs1132885489 | 350 | Q>R | No | Ensembl | |
rs1133548329 | 354 | A>S | No | Ensembl | |
rs1134918819 | 362 | L>Q | No | Ensembl | |
rs1131809511 | 375 | D>A | No | Ensembl | |
rs1134985555 | 384 | V>I | No | Ensembl | |
rs1132404129 | 385 | C>F | No | Ensembl | |
rs1132284519 | 392 | S>N | No | Ensembl | |
rs1134940127 | 402 | D>E | No | Ensembl | |
rs1134517481 | 404 | H>D | No | Ensembl | |
rs1135348020 | 407 | A>S | No | Ensembl | |
rs1134979580 | 408 | S>T | No | Ensembl | |
rs1132239158 | 413 | G>D | No | Ensembl | |
rs1133166582 | 414 | V>I | No | Ensembl | |
rs1135257944 | 419 | A>P | No | Ensembl | |
rs1132980218 | 422 | L>P | No | Ensembl | |
rs1134599063 | 450 | A>G | No | Ensembl | |
rs1132973703 | 453 | K>E | No | Ensembl | |
rs1134411499 | 455 | D>N | No | Ensembl | |
rs1134307347 | 473 | A>V | No | Ensembl | |
rs1131841995 | 477 | R>S | No | Ensembl | |
rs26891750 | 484 | S>G | No | Ensembl | |
rs1132809813 | 504 | K>N | No | Ensembl | |
rs1133374377 | 521 | P>S | No | Ensembl | |
rs1133281860 | 532 | N>Y | No | Ensembl | |
rs1131928492 | 534 | D>E | No | Ensembl | |
rs579791870 | 535 | M>T | No | Ensembl | |
rs1132333219 | 536 | E>A | No | Ensembl | |
rs1132602265 | 536 | E>D | No | Ensembl | |
rs1131760233 | 536 | E>K | No | Ensembl | |
rs1132227787 | 540 | H>N | No | Ensembl | |
rs26891751 | 541 | V>M | No | Ensembl | |
rs1134884134 | 544 | D>Y | No | Ensembl | |
rs1135352568 | 546 | Q>E | No | Ensembl | |
rs1133878449 | 554 | D>N | No | Ensembl | |
rs1132838582 | 561 | L>F | No | Ensembl | |
rs1131838156 | 561 | L>S | No | Ensembl | |
rs1132278901 | 565 | V>E | No | Ensembl | |
rs1133851547 | 567 | H>Y | No | Ensembl | |
rs1134502625 | 575 | D>E | No | Ensembl | |
rs1134939598 | 584 | K>Q | No | Ensembl | |
rs1133930529 | 585 | F>L | No | Ensembl | |
rs1133569068 | 585 | F>S | No | Ensembl | |
rs1134370056 | 590 | R>K | No | Ensembl | |
rs1133753547 | 598 | V>G | No | Ensembl | |
rs1134525653 | 604 | F>L | No | Ensembl | |
rs1132711376 | 608 | G>R | No | Ensembl | |
rs1133746951 | 615 | T>A | No | Ensembl | |
rs1132571475 | 619 | D>N | No | Ensembl | |
rs1133342071 | 632 | A>P | No | Ensembl | |
rs1134232703 | 636 | E>K | No | Ensembl | |
rs26891763 | 660 | R>H | No | Ensembl | |
rs230250085 | 664 | L>I | No | Ensembl | |
rs245322665 | 671 | E>K | No | Ensembl | |
rs229324638 | 677 | T>R | No | Ensembl | |
rs1134301304 | 685 | V>I | No | Ensembl | |
rs1132587780 | 686 | L>I | No | Ensembl | |
rs1134809259 | 688 | A>T | No | Ensembl | |
rs1135150461 | 689 | R>C | No | Ensembl | |
rs1134113202 | 689 | R>H | No | Ensembl | |
rs1132874517 | 691 | S>N | No | Ensembl | |
rs1133772074 | 696 | D>Y | No | Ensembl | |
rs220382370 | 705 | G>D | No | Ensembl | |
rs1131835780 | 705 | G>S | No | Ensembl | |
rs16791983 | 707 | V>L | No | Ensembl | |
rs262915705 | 708 | K>R | No | Ensembl | |
rs16791984 | 709 | M>I | No | Ensembl | |
rs1132161758 | 709 | M>L | No | Ensembl | |
rs1134166950 | 712 | E>K | No | Ensembl | |
rs1131742399 | 713 | G>V | No | Ensembl | |
rs1132687086 | 714 | L>I | No | Ensembl | |
rs1134687413 | 717 | P>H | No | Ensembl | |
rs225316350 | 718 | A>G | No | Ensembl | |
rs225316350 | 718 | A>V | No | Ensembl | |
rs16791986 | 719 | C>* | No | Ensembl | |
rs1131834490 | 725 | W>R | No | Ensembl | |
rs16791992 | 740 | R>K | No | Ensembl | |
rs1134860346 | 744 | A>E | No | Ensembl | |
rs1131985525 | 750 | L>H | No | Ensembl | |
rs1135203330 | 762 | P>S | No | Ensembl | |
rs1133666154 | 764 | M>K | No | Ensembl | |
rs1133959073 | 765 | N>K | No | Ensembl | |
rs1134159979 | 767 | D>E | No | Ensembl | |
rs1134036338 | 767 | D>N | No | Ensembl | |
rs1134454656 | 773 | D>G | No | Ensembl | |
rs1133132836 | 780 | Q>K | No | Ensembl | |
rs1131874734 | 788 | K>R | No | Ensembl | |
rs1132672852 | 789 | H>Q | No | Ensembl | |
rs1134548173 | 796 | E>* | No | Ensembl | |
rs1132094596 | 796 | E>D | No | Ensembl | |
rs1133067974 | 798 | E>Q | No | Ensembl | |
rs1132238646 | 807 | T>A | No | Ensembl | |
rs26891770 | 810 | V>L | No | Ensembl | |
rs1133571092 | 813 | R>K | No | Ensembl | |
rs1134756738 | 814 | E>D | No | Ensembl | |
rs221615633 | 819 | R>* | No | Ensembl | |
rs1131948655 | 824 | M>V | No | Ensembl | |
rs1134068134 | 827 | S>T | No | Ensembl | |
rs26891772 | 829 | H>R | No | Ensembl | |
rs1132231583 | 839 | V>M | No | Ensembl | |
rs1133402733 | 855 | Y>F | No | Ensembl | |
rs214600904 | 857 | D>N | No | Ensembl | |
rs16792024 | 858 | K>E | No | Ensembl | |
rs16792028 | 862 | Q>K | No | Ensembl | |
rs16792030 | 863 | Q>H | No | Ensembl | |
rs1133481215 | 868 | V>A | No | Ensembl | |
rs1133904945 | 897 | V>M | No | Ensembl | |
rs242991162 | 925 | A>T | No | Ensembl | |
rs578964391 | 935 | M>V | No | Ensembl | |
rs16792090 | 937 | I>V | No | Ensembl | |
rs16792091 | 954 | T>I | No | Ensembl | |
rs580821962 | 963 | L>H | No | Ensembl | |
rs16792092 | 964 | E>K | No | Ensembl | |
rs587582493 | 965 | D>G | No | Ensembl | |
rs108056181 | 978 | S>G | No | Ensembl | |
rs108154720 | 978 | S>T | No | Ensembl | |
rs1135276204 | 985 | D>E | No | Ensembl | |
rs1131701701 | 994 | R>S | No | Ensembl | |
rs1132318932 | 1001 | V>I | No | Ensembl | |
rs1135110746 | 1011 | I>V | No | Ensembl | |
rs26891774 | 1014 | S>A | No | Ensembl | |
rs1133884431 | 1014 | S>C | No | Ensembl | |
rs1132200044 | 1017 | L>* | No | Ensembl | |
rs1133197203 | 1017 | L>M | No | Ensembl | |
rs214093433 | 1021 | I>F | No | Ensembl | |
rs3148133 | 1030 | R>Q | No | Ensembl | |
rs232457493 | 1043 | I>F | No | Ensembl | |
rs1133920975 | 1055 | K>R | No | Ensembl | |
rs1133493529 | 1063 | K>I | No | Ensembl | |
rs16792123 | 1081 | A>T | No | Ensembl | |
rs1133499574 | 1090 | L>F | No | Ensembl | |
rs26891784 | 1110 | P>S | No | Ensembl | |
rs1134093626 | 1130 | S>A | No | Ensembl | |
rs240403397 | 1168 | V>I | No | Ensembl | |
rs3142796 | 1181 | K>R | No | Ensembl | |
3 | E>K | strain: CAST/EiJ [UniProt] | No | ||
88 | F>Y | strain: PWK/PhJ [UniProt] | No | ||
112 | E>G | strain: CAST/EiJ, DBA/2J and PWK/PhJ [UniProt] | No | ||
227 | Q>R | strain: PWK/PhJ [UniProt] | No | ||
256 | G>E | strain: CAST/EiJ, DBA/2J and PWK/PhJ [UniProt] | No | ||
291 | R>Q | strain: DBA/2J [UniProt] | No | ||
337 | K>N | strain: PWK/PhJ [UniProt] | No | ||
484 | S>G | strain: DBA/2J and CAST/EiJ [UniProt] | No | ||
541 | V>M | strain: PWK/PhJ [UniProt] | No | ||
660 | R>H | strain: AKR/J [UniProt] | No | ||
664 | L>I | strain: PWK/PhJ [UniProt] | No | ||
705 | G>D | strain: DBA/2J [UniProt] | No | ||
857 | D>N | strain: PWK/PhJ [UniProt] | No | ||
975 | N>S | strain: PWK/PhJ [UniProt] | No | ||
1030 | R>Q | strain: DBA/2J [UniProt] | No | ||
1043 | I>F | strain: CAST/EiJ [UniProt] | No | ||
1110 | P>S | strain: DBA/2J [UniProt] | No | ||
1181 | K>R | strain: CAST/EiJ and DBA/2J [UniProt] | No |
No associated diseases with Q2LKU9
7 regional properties for Q2LKU9
Type | Name | Position | InterPro Accession |
---|---|---|---|
domain | Protein kinase domain | 267 - 517 | IPR000719 |
domain | SH2 domain | 146 - 245 | IPR000980 |
domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 268 - 516 | IPR001245 |
domain | SH3 domain | 81 - 142 | IPR001452 |
active_site | Tyrosine-protein kinase, active site | 382 - 394 | IPR008266 |
binding_site | Protein kinase, ATP binding site | 273 - 295 | IPR017441 |
domain | Tyrosine-protein kinase, catalytic domain | 267 - 516 | IPR020635 |
Functions
5 GO annotations of cellular component
Name | Definition |
---|---|
cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
inflammasome complex | A cytosolic protein complex that is capable of activating caspase-1. |
NLRP1 inflammasome complex | An inflammasome complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential. |
nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
8 GO annotations of molecular function
Name | Definition |
---|---|
ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
cysteine-type endopeptidase activator activity | Binds to and increases the activity of a cysteine-type endopeptidase. |
double-stranded DNA binding | Binding to double-stranded DNA. |
double-stranded RNA binding | Binding to double-stranded RNA. |
enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
peptidase activity | Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. |
protein domain specific binding | Binding to a specific domain of a protein. |
protein self-association | Binding to a domain within the same polypeptide. |
14 GO annotations of biological process
Name | Definition |
---|---|
activation of cysteine-type endopeptidase activity involved in apoptotic process | Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. |
antiviral innate immune response | A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens. |
defense response to bacterium | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
defense response to virus | Reactions triggered in response to the presence of a virus that act to protect the cell or organism. |
inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
neuron apoptotic process | Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. |
NLRP1 inflammasome complex assembly | The aggregation, arrangement and bonding together of a set of components to form a NLRP1 inflammasome complex. |
positive regulation of interleukin-1 beta production | Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production. |
programmed necrotic cell death | A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. |
protein homooligomerization | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
pyroptosis | A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18. |
regulation of apoptotic process | Any process that modulates the occurrence or rate of cell death by apoptotic process. |
response to muramyl dipeptide | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan. |
self proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds. |
5 homologous proteins in AiPD
UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
---|---|---|---|---|
Q9C000 | NLRP1 | NACHT, LRR and PYD domains-containing protein 1 | Homo sapiens (Human) | EV |
Q96P20 | NLRP3 | NACHT, LRR and PYD domains-containing protein 3 | Homo sapiens (Human) | EV |
P59046 | NLRP12 | NACHT, LRR and PYD domains-containing protein 12 | Homo sapiens (Human) | SS |
A1Z198 | Nlrp1b | NACHT, LRR and PYD domains-containing protein 1b allele 2 | Mus musculus (Mouse) | SS |
Q9EPB4 | Pycard | Apoptosis-associated speck-like protein containing a CARD | Mus musculus (Mouse) | PR |
10 | 20 | 30 | 40 | 50 | 60 |
MEESQSKQES | STKVAQHEGQ | EDVDPTFKTK | KLMEVELMKH | RVQLERNLKL | RTFPGARTKQ |
70 | 80 | 90 | 100 | 110 | 120 |
VKEALYPLLT | WSSKSKNLFQ | NFTKLLLFKK | LCQRGSENLV | RESWYPCVPE | EEAHMIDIQD |
130 | 140 | 150 | 160 | 170 | 180 |
LFGPNLGTQK | KPQLVIIEGA | AGIGKSTLAR | LVKRAWKEGK | LYRNDFHHVF | FFSCRELAQY |
190 | 200 | 210 | 220 | 230 | 240 |
EQLSLAELIV | QGQEVPTAPI | RQILSHPEKL | LFILDGIDEP | AWVLADQNPE | LCLHWSQTQP |
250 | 260 | 270 | 280 | 290 | 300 |
VHTLLGSLLG | KSILPGASFL | LTTRTTALQK | FIPSLEQPCQ | VEVLGFTLFE | RKNYFYKYFG |
310 | 320 | 330 | 340 | 350 | 360 |
KKKGGVTTFT | LVKSNSALLT | LCEVPWVCWL | VCTCLKKQME | QGGELSLTSQ | TTTALCLKYL |
370 | 380 | 390 | 400 | 410 | 420 |
SLTIPGQHMR | TQLRDLCSLA | AEGVCQRRTL | FSESDLCKQG | LDEHAIASFL | KIGVLQKQAS |
430 | 440 | 450 | 460 | 470 | 480 |
SLSYSFAHLC | LQEFFAAMSY | ILDDSEERHA | DMKNDRIVET | LVERYGRQNL | FEAPTVRFLF |
490 | 500 | 510 | 520 | 530 | 540 |
GLLSKEELKK | IEKLFSCSLH | GKTKLKLLWH | ILGKSQPHQP | PCLGLLHCLY | ENQDMELLTH |
550 | 560 | 570 | 580 | 590 | 600 |
VMHDLQGTIV | PGPDDLAHTV | LQTNVKHLVI | QTDMDLMVVT | FCIKFCCHVR | SLQLNRKVQQ |
610 | 620 | 630 | 640 | 650 | 660 |
GHKFTAPGMV | LYRWTPITDA | SWKIFFSNLK | LARNLEELDL | SGNPLSYYAV | HSLCTTLRKR |
670 | 680 | 690 | 700 | 710 | 720 |
GCQLKTLWLV | ECGLTSTYCS | LLASVLSARS | SLTELDLQLN | DLGDGGVKML | CEGLRNPACN |
730 | 740 | 750 | 760 | 770 | 780 |
LSILWLDQAS | LSDQVIAELR | TLEAKNPKLL | ISSTWKPHVM | VPTMNMDKEE | VGDSQALLKQ |
790 | 800 | 810 | 820 | 830 | 840 |
QRQQSGDKHM | EPLGTEDEFW | GPTGPVTTEV | VDRERNLYRV | QLPMAGSYHC | PSTGLHFVVT |
850 | 860 | 870 | 880 | 890 | 900 |
RAVTIEIEFC | AWSQYLDKTP | LQQSHMVVGP | LFDIKAEQGA | VTAVYLPHFV | ALQEGIVDSS |
910 | 920 | 930 | 940 | 950 | 960 |
LFHVAHFQEH | GMVLETPARV | EQHYAVLENP | SFSPMGILLR | MIPAVGHFIP | ITSTTLIYYH |
970 | 980 | 990 | 1000 | 1010 | 1020 |
LYLEDVTFHL | YLVPNDCSIR | KAIDDEEMKF | QFVRINKPPP | VDALYLGSRY | IVSSSKLVEI |
1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
IPKELELCYR | SPGESQLFSE | IDIGHMDSEI | KLQIKDKRHM | NLKWEALLKP | GDLRPALPKI |
1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
ATAPKDAPSL | LHFMDQHREQ | LVARVTSVDP | LLDKLHGLVL | SEDSYEVVRS | ETTNQDKMRK |
1150 | 1160 | 1170 | 1180 | ||
LFSLSRSWSW | DCKDQFYQAL | KETHPHLVMD | ILEKLGGVSV | KS |