Descriptions

Nlrp1a is a potential sensor component of the NLRP1 inflammasome and plays a crucial role in innate immunity and inflammation. The leucine-rich repeat domain in a mouse homolog NRLP1a interacts with NACHT domain within the same protein and is involved in autoinhibition.

Autoinhibitory domains (AIDs)

Target domain

133-442 (NACHT domain)

Relief mechanism

Cleavage

Assay

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q2LKU9

Entry ID Method Resolution Chain Position Source
AF-Q2LKU9-F1 Predicted AlphaFoldDB

234 variants for Q2LKU9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs26891737 3 E>K No Ensembl
rs1133635292 5 Q>P No Ensembl
rs1134465205 6 S>P No Ensembl
rs1134064682 9 E>K No Ensembl
rs1132732230 11 S>N No Ensembl
rs1132521357 21 E>Q No Ensembl
rs1133428197 27 F>L No Ensembl
rs1132351409 28 K>N No Ensembl
rs1133611431 30 K>T No Ensembl
rs1134749006 31 K>R No Ensembl
rs1134145913 32 L>H No Ensembl
rs1134584218 34 E>D No Ensembl
rs1133091981 34 E>K No Ensembl
rs225815361 47 N>D No Ensembl
rs580324507 79 F>I No Ensembl
rs582286336 84 K>N No Ensembl
rs586021673 84 K>R No Ensembl
rs1133941944 87 L>I No Ensembl
rs578599322 88 F>L No Ensembl
rs262554410 88 F>Y No Ensembl
rs585214551 89 K>Q No Ensembl
rs1134028044 93 Q>K No Ensembl
rs581991541 93 Q>P No Ensembl
rs578372297 94 R>K No Ensembl
rs585276537 95 G>D No Ensembl
rs581372246 96 S>P No Ensembl
rs584819182 99 L>M No Ensembl
rs581171121 102 E>K No Ensembl
rs1133011274 104 W>R No Ensembl
rs587008293 105 Y>H No Ensembl
rs584281078 105 Y>S No Ensembl
rs580843345 106 P>S No Ensembl
rs586255352 108 V>I No Ensembl
rs3148102 112 E>G No Ensembl
rs261708874 112 E>K No Ensembl
rs232045877 113 A>G No Ensembl
rs1133564911 114 H>Y No Ensembl
rs241292543 117 D>E No Ensembl
rs256861050 117 D>N No Ensembl
rs235746361 126 L>I No Ensembl
rs255344627 167 H>L No Ensembl
rs235634652 167 H>Q No Ensembl
rs243719877 190 V>A No Ensembl
rs237250311 197 T>I No Ensembl
rs1133967511 225 A>G No Ensembl
rs214531848 227 Q>R No Ensembl
rs1132323608 229 P>L No Ensembl
rs1133444001 230 E>D No Ensembl
rs1134508647 231 L>F No Ensembl
rs1132973857 238 T>I No Ensembl
rs26891747 256 G>E No Ensembl
rs1134596179 271 F>I No Ensembl
rs585137606 276 E>A No Ensembl
rs579180719 276 E>Q No Ensembl
rs1134974424 279 C>Y No Ensembl
rs1132823202 281 V>L No Ensembl
rs580814326 282 E>K No Ensembl
rs586672697 287 T>S No Ensembl
rs581732672 288 L>* No Ensembl
rs583948917 288 L>V No Ensembl
rs587578372 289 F>I No Ensembl
rs241843742 291 R>Q No Ensembl
rs584026835 292 K>E No Ensembl
rs1134548762 293 N>D No Ensembl
rs586693243 296 Y>H No Ensembl
rs583402941 300 G>A No Ensembl
rs585495181 301 K>N No Ensembl
rs582073927 302 K>Q No Ensembl
rs243753591 303 K>R No Ensembl
rs586485939 304 G>D No Ensembl
rs579522607 304 G>R No Ensembl
rs582868581 305 G>A No Ensembl
rs579037212 306 V>I No Ensembl
rs584500063 308 T>A No Ensembl
rs582245607 310 T>I No Ensembl
rs584587051 311 L>I No Ensembl
rs578393315 313 K>E No Ensembl
rs587276818 316 S>P No Ensembl
rs583389720 317 A>V No Ensembl
rs1134919025 333 T>I No Ensembl
rs583417474 337 K>N No Ensembl
rs1132987690 342 G>S No Ensembl
rs1132885489 350 Q>R No Ensembl
rs1133548329 354 A>S No Ensembl
rs1134918819 362 L>Q No Ensembl
rs1131809511 375 D>A No Ensembl
rs1134985555 384 V>I No Ensembl
rs1132404129 385 C>F No Ensembl
rs1132284519 392 S>N No Ensembl
rs1134940127 402 D>E No Ensembl
rs1134517481 404 H>D No Ensembl
rs1135348020 407 A>S No Ensembl
rs1134979580 408 S>T No Ensembl
rs1132239158 413 G>D No Ensembl
rs1133166582 414 V>I No Ensembl
rs1135257944 419 A>P No Ensembl
rs1132980218 422 L>P No Ensembl
rs1134599063 450 A>G No Ensembl
rs1132973703 453 K>E No Ensembl
rs1134411499 455 D>N No Ensembl
rs1134307347 473 A>V No Ensembl
rs1131841995 477 R>S No Ensembl
rs26891750 484 S>G No Ensembl
rs1132809813 504 K>N No Ensembl
rs1133374377 521 P>S No Ensembl
rs1133281860 532 N>Y No Ensembl
rs1131928492 534 D>E No Ensembl
rs579791870 535 M>T No Ensembl
rs1132333219 536 E>A No Ensembl
rs1132602265 536 E>D No Ensembl
rs1131760233 536 E>K No Ensembl
rs1132227787 540 H>N No Ensembl
rs26891751 541 V>M No Ensembl
rs1134884134 544 D>Y No Ensembl
rs1135352568 546 Q>E No Ensembl
rs1133878449 554 D>N No Ensembl
rs1132838582 561 L>F No Ensembl
rs1131838156 561 L>S No Ensembl
rs1132278901 565 V>E No Ensembl
rs1133851547 567 H>Y No Ensembl
rs1134502625 575 D>E No Ensembl
rs1134939598 584 K>Q No Ensembl
rs1133930529 585 F>L No Ensembl
rs1133569068 585 F>S No Ensembl
rs1134370056 590 R>K No Ensembl
rs1133753547 598 V>G No Ensembl
rs1134525653 604 F>L No Ensembl
rs1132711376 608 G>R No Ensembl
rs1133746951 615 T>A No Ensembl
rs1132571475 619 D>N No Ensembl
rs1133342071 632 A>P No Ensembl
rs1134232703 636 E>K No Ensembl
rs26891763 660 R>H No Ensembl
rs230250085 664 L>I No Ensembl
rs245322665 671 E>K No Ensembl
rs229324638 677 T>R No Ensembl
rs1134301304 685 V>I No Ensembl
rs1132587780 686 L>I No Ensembl
rs1134809259 688 A>T No Ensembl
rs1135150461 689 R>C No Ensembl
rs1134113202 689 R>H No Ensembl
rs1132874517 691 S>N No Ensembl
rs1133772074 696 D>Y No Ensembl
rs220382370 705 G>D No Ensembl
rs1131835780 705 G>S No Ensembl
rs16791983 707 V>L No Ensembl
rs262915705 708 K>R No Ensembl
rs16791984 709 M>I No Ensembl
rs1132161758 709 M>L No Ensembl
rs1134166950 712 E>K No Ensembl
rs1131742399 713 G>V No Ensembl
rs1132687086 714 L>I No Ensembl
rs1134687413 717 P>H No Ensembl
rs225316350 718 A>G No Ensembl
rs225316350 718 A>V No Ensembl
rs16791986 719 C>* No Ensembl
rs1131834490 725 W>R No Ensembl
rs16791992 740 R>K No Ensembl
rs1134860346 744 A>E No Ensembl
rs1131985525 750 L>H No Ensembl
rs1135203330 762 P>S No Ensembl
rs1133666154 764 M>K No Ensembl
rs1133959073 765 N>K No Ensembl
rs1134159979 767 D>E No Ensembl
rs1134036338 767 D>N No Ensembl
rs1134454656 773 D>G No Ensembl
rs1133132836 780 Q>K No Ensembl
rs1131874734 788 K>R No Ensembl
rs1132672852 789 H>Q No Ensembl
rs1134548173 796 E>* No Ensembl
rs1132094596 796 E>D No Ensembl
rs1133067974 798 E>Q No Ensembl
rs1132238646 807 T>A No Ensembl
rs26891770 810 V>L No Ensembl
rs1133571092 813 R>K No Ensembl
rs1134756738 814 E>D No Ensembl
rs221615633 819 R>* No Ensembl
rs1131948655 824 M>V No Ensembl
rs1134068134 827 S>T No Ensembl
rs26891772 829 H>R No Ensembl
rs1132231583 839 V>M No Ensembl
rs1133402733 855 Y>F No Ensembl
rs214600904 857 D>N No Ensembl
rs16792024 858 K>E No Ensembl
rs16792028 862 Q>K No Ensembl
rs16792030 863 Q>H No Ensembl
rs1133481215 868 V>A No Ensembl
rs1133904945 897 V>M No Ensembl
rs242991162 925 A>T No Ensembl
rs578964391 935 M>V No Ensembl
rs16792090 937 I>V No Ensembl
rs16792091 954 T>I No Ensembl
rs580821962 963 L>H No Ensembl
rs16792092 964 E>K No Ensembl
rs587582493 965 D>G No Ensembl
rs108056181 978 S>G No Ensembl
rs108154720 978 S>T No Ensembl
rs1135276204 985 D>E No Ensembl
rs1131701701 994 R>S No Ensembl
rs1132318932 1001 V>I No Ensembl
rs1135110746 1011 I>V No Ensembl
rs26891774 1014 S>A No Ensembl
rs1133884431 1014 S>C No Ensembl
rs1132200044 1017 L>* No Ensembl
rs1133197203 1017 L>M No Ensembl
rs214093433 1021 I>F No Ensembl
rs3148133 1030 R>Q No Ensembl
rs232457493 1043 I>F No Ensembl
rs1133920975 1055 K>R No Ensembl
rs1133493529 1063 K>I No Ensembl
rs16792123 1081 A>T No Ensembl
rs1133499574 1090 L>F No Ensembl
rs26891784 1110 P>S No Ensembl
rs1134093626 1130 S>A No Ensembl
rs240403397 1168 V>I No Ensembl
rs3142796 1181 K>R No Ensembl
3 E>K strain: CAST/EiJ [UniProt] No
88 F>Y strain: PWK/PhJ [UniProt] No
112 E>G strain: CAST/EiJ, DBA/2J and PWK/PhJ [UniProt] No
227 Q>R strain: PWK/PhJ [UniProt] No
256 G>E strain: CAST/EiJ, DBA/2J and PWK/PhJ [UniProt] No
291 R>Q strain: DBA/2J [UniProt] No
337 K>N strain: PWK/PhJ [UniProt] No
484 S>G strain: DBA/2J and CAST/EiJ [UniProt] No
541 V>M strain: PWK/PhJ [UniProt] No
660 R>H strain: AKR/J [UniProt] No
664 L>I strain: PWK/PhJ [UniProt] No
705 G>D strain: DBA/2J [UniProt] No
857 D>N strain: PWK/PhJ [UniProt] No
975 N>S strain: PWK/PhJ [UniProt] No
1030 R>Q strain: DBA/2J [UniProt] No
1043 I>F strain: CAST/EiJ [UniProt] No
1110 P>S strain: DBA/2J [UniProt] No
1181 K>R strain: CAST/EiJ and DBA/2J [UniProt] No

No associated diseases with Q2LKU9

7 regional properties for Q2LKU9

Type Name Position InterPro Accession
domain Protein kinase domain 267 - 517 IPR000719
domain SH2 domain 146 - 245 IPR000980
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 268 - 516 IPR001245
domain SH3 domain 81 - 142 IPR001452
active_site Tyrosine-protein kinase, active site 382 - 394 IPR008266
binding_site Protein kinase, ATP binding site 273 - 295 IPR017441
domain Tyrosine-protein kinase, catalytic domain 267 - 516 IPR020635

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Cytoplasm
  • Nucleus
  • Nucleocytoplasmic distribution in lymphoid organs (probably in T-cells) and in neurons
  • In epithelial cells, predominantly cytoplasmic
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
inflammasome complex A cytosolic protein complex that is capable of activating caspase-1.
NLRP1 inflammasome complex An inflammasome complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

8 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cysteine-type endopeptidase activator activity Binds to and increases the activity of a cysteine-type endopeptidase.
double-stranded DNA binding Binding to double-stranded DNA.
double-stranded RNA binding Binding to double-stranded RNA.
enzyme binding Binding to an enzyme, a protein with catalytic activity.
peptidase activity Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
protein domain specific binding Binding to a specific domain of a protein.
protein self-association Binding to a domain within the same polypeptide.

14 GO annotations of biological process

Name Definition
activation of cysteine-type endopeptidase activity involved in apoptotic process Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
antiviral innate immune response A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens.
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
neuron apoptotic process Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
NLRP1 inflammasome complex assembly The aggregation, arrangement and bonding together of a set of components to form a NLRP1 inflammasome complex.
positive regulation of interleukin-1 beta production Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production.
programmed necrotic cell death A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.
protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
pyroptosis A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.
regulation of apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process.
response to muramyl dipeptide Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.
self proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9C000 NLRP1 NACHT, LRR and PYD domains-containing protein 1 Homo sapiens (Human) EV
Q96P20 NLRP3 NACHT, LRR and PYD domains-containing protein 3 Homo sapiens (Human) EV
P59046 NLRP12 NACHT, LRR and PYD domains-containing protein 12 Homo sapiens (Human) SS
A1Z198 Nlrp1b NACHT, LRR and PYD domains-containing protein 1b allele 2 Mus musculus (Mouse) SS
Q9EPB4 Pycard Apoptosis-associated speck-like protein containing a CARD Mus musculus (Mouse) PR
10 20 30 40 50 60
MEESQSKQES STKVAQHEGQ EDVDPTFKTK KLMEVELMKH RVQLERNLKL RTFPGARTKQ
70 80 90 100 110 120
VKEALYPLLT WSSKSKNLFQ NFTKLLLFKK LCQRGSENLV RESWYPCVPE EEAHMIDIQD
130 140 150 160 170 180
LFGPNLGTQK KPQLVIIEGA AGIGKSTLAR LVKRAWKEGK LYRNDFHHVF FFSCRELAQY
190 200 210 220 230 240
EQLSLAELIV QGQEVPTAPI RQILSHPEKL LFILDGIDEP AWVLADQNPE LCLHWSQTQP
250 260 270 280 290 300
VHTLLGSLLG KSILPGASFL LTTRTTALQK FIPSLEQPCQ VEVLGFTLFE RKNYFYKYFG
310 320 330 340 350 360
KKKGGVTTFT LVKSNSALLT LCEVPWVCWL VCTCLKKQME QGGELSLTSQ TTTALCLKYL
370 380 390 400 410 420
SLTIPGQHMR TQLRDLCSLA AEGVCQRRTL FSESDLCKQG LDEHAIASFL KIGVLQKQAS
430 440 450 460 470 480
SLSYSFAHLC LQEFFAAMSY ILDDSEERHA DMKNDRIVET LVERYGRQNL FEAPTVRFLF
490 500 510 520 530 540
GLLSKEELKK IEKLFSCSLH GKTKLKLLWH ILGKSQPHQP PCLGLLHCLY ENQDMELLTH
550 560 570 580 590 600
VMHDLQGTIV PGPDDLAHTV LQTNVKHLVI QTDMDLMVVT FCIKFCCHVR SLQLNRKVQQ
610 620 630 640 650 660
GHKFTAPGMV LYRWTPITDA SWKIFFSNLK LARNLEELDL SGNPLSYYAV HSLCTTLRKR
670 680 690 700 710 720
GCQLKTLWLV ECGLTSTYCS LLASVLSARS SLTELDLQLN DLGDGGVKML CEGLRNPACN
730 740 750 760 770 780
LSILWLDQAS LSDQVIAELR TLEAKNPKLL ISSTWKPHVM VPTMNMDKEE VGDSQALLKQ
790 800 810 820 830 840
QRQQSGDKHM EPLGTEDEFW GPTGPVTTEV VDRERNLYRV QLPMAGSYHC PSTGLHFVVT
850 860 870 880 890 900
RAVTIEIEFC AWSQYLDKTP LQQSHMVVGP LFDIKAEQGA VTAVYLPHFV ALQEGIVDSS
910 920 930 940 950 960
LFHVAHFQEH GMVLETPARV EQHYAVLENP SFSPMGILLR MIPAVGHFIP ITSTTLIYYH
970 980 990 1000 1010 1020
LYLEDVTFHL YLVPNDCSIR KAIDDEEMKF QFVRINKPPP VDALYLGSRY IVSSSKLVEI
1030 1040 1050 1060 1070 1080
IPKELELCYR SPGESQLFSE IDIGHMDSEI KLQIKDKRHM NLKWEALLKP GDLRPALPKI
1090 1100 1110 1120 1130 1140
ATAPKDAPSL LHFMDQHREQ LVARVTSVDP LLDKLHGLVL SEDSYEVVRS ETTNQDKMRK
1150 1160 1170 1180
LFSLSRSWSW DCKDQFYQAL KETHPHLVMD ILEKLGGVSV KS