Q2L6W9

SS
Gene name
sax-1 (R11G1.4)
Protein name
Serine/threonine-protein kinase sax-1
Names
EC 2.7.11.1 , NDR protein kinase , Sensory axon guidance protein 1
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_R11G1.4
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

STK38, called nuclear Dbf2-related kinase 1 (NDR1 protein kinase), is a subclass of the AGC family of protein kinases that are involved in the regulation of cell division and cell morphology. NDR kinase activity is regulated by phosphorylation and by the Ca2+-binding protein, S100B. MOB1 also stimulates NDR kinase activity and interacts with NDR. <br> A common feature of the NDR family of kinases is an insert in the catalytic domain of 30 - 60 amino acids between subdomains VII and VIII. The insert sequence is not highly conserved but contains in all cases many positively charged amino acids. Mutations of the residues within the insert (autoinhibitory element) increase kinase activity and the binding of MOB1 or S100B to the N-terminal domain (SMA domain) of NDR induces the release of autoinhibition.

Autoinhibitory domains (AIDs)

263-274 (Autoinhibitory sequence) SS

Target domain

87-381 (Protein kinase domain)

Relief mechanism

Partner binding

Assay

Accessory elements

227-239 (Activation loop from InterPro)

Target domain

87-381 (Protein kinase domain)

Relief mechanism

Assay

276-285 (Activation loop from InterPro)

Target domain

87-381 (Protein kinase domain)

Relief mechanism

Assay

227-239 (Activation loop from InterPro)

Target domain

87-381 (Protein kinase domain)

Relief mechanism

Assay

276-285 (Activation loop from InterPro)

Target domain

87-381 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q2L6W9

Entry ID Method Resolution Chain Position Source
AF-Q2L6W9-F1 Predicted AlphaFoldDB

No variants for Q2L6W9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2L6W9

2 associated diseases with Q2L6W9

Without disease ID

10 regional properties for Q2L6W9

Type Name Position InterPro Accession
domain Ras-like guanine nucleotide exchange factor, N-terminal 52 - 177 IPR000651
domain Ras guanine-nucleotide exchange factors catalytic domain 201 - 437 IPR001895
domain EF-hand domain 470 - 521 IPR002048
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 541 - 593 IPR002219
binding_site EF-Hand 1, calcium-binding site 483 - 495 IPR018247-1
binding_site EF-Hand 1, calcium-binding site 510 - 522 IPR018247-2
domain Diacylglycerol/phorbol-ester binding 539 - 553 IPR020454-1
domain Diacylglycerol/phorbol-ester binding 555 - 564 IPR020454-2
domain Diacylglycerol/phorbol-ester binding 568 - 579 IPR020454-3
domain Diacylglycerol/phorbol-ester binding 580 - 592 IPR020454-4

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions
protein serine/threonine kinase activity Catalysis of the reactions

7 GO annotations of biological process

Name Definition
cell projection assembly Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
establishment or maintenance of cell polarity Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of cell growth Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
neuron projection development The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
regulation of cell shape Any process that modulates the surface configuration of a cell.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P53894 CBK1 Serine/threonine-protein kinase CBK1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
A2VDV2 STK38 Serine/threonine-protein kinase 38 Bos taurus (Bovine) SS
Q9NBK5 trc Serine/threonine-protein kinase tricornered Drosophila melanogaster (Fruit fly) SS
Q96LW2 RSKR Ribosomal protein S6 kinase-related protein Homo sapiens (Human) PR
Q15208 STK38 Serine/threonine-protein kinase 38 Homo sapiens (Human) EV
Q9Y2H1 STK38L Serine/threonine-protein kinase 38-like Homo sapiens (Human) EV
Q7TSE6 Stk38l Serine/threonine-protein kinase 38-like Mus musculus (Mouse) SS
Q91VJ4 Stk38 Serine/threonine-protein kinase 38 Mus musculus (Mouse) SS
Q9Y1J3 pdk-1 3-phosphoinositide-dependent protein kinase 1 Caenorhabditis elegans SS
Q19266 pkc-3 Protein kinase C-like 3 Caenorhabditis elegans SS
P34722 tpa-1 Protein kinase C-like 1 Caenorhabditis elegans PR
P90980 pkc-2 Protein kinase C-like 2 Caenorhabditis elegans SS
Q9XTG7 akt-2 Serine/threonine-protein kinase akt-2 Caenorhabditis elegans SS
Q17941 akt-1 Serine/threonine-protein kinase akt-1 Caenorhabditis elegans PR
10 20 30 40 50 60
MGEIAPEMEI SQYTKDKASC TRISIESYYS KRVTQCAERE NRLKKLEEDI SARGLSDEEK
70 80 90 100 110 120
EEKRKIHHSK ETDYLRLKRT RLTVNDFESL KVIGRGAFGE VRLVQKHDTG HIYAMKILRK
130 140 150 160 170 180
SEMVEKEQTA HVRAERDILS EADCDWVVKM YYSFQDYSNL YLVMEFLPGG DMMTLLIKKD
190 200 210 220 230 240
TLTEEATQFY IAEAALAIQF IHSLGFIHRD IKPDNLLLDA RGHVKLSDFG LCTGLKKFHR
250 260 270 280 290 300
TDHYRNWPST LPPDFISKPF ESKRKAETWK RNRRAYAYST VGTPDYIAPE VFQPNGYTKS
310 320 330 340 350 360
CDWWSLGVIM YEMLIGYPPF CSELPQETYR KVINWQQTLV FPSDVPISIE AKATIKRFCC
370 380 390 400 410 420
EAERRLGNHG GLDEIKQCPF VKRIDWNHIR ERPPPIRVTV KSIDDTSNFD DFPDEDLTWP
430 440 450 460 470
TSTLIRPEEQ PGRRGEFVDF TYKRFDGLTQ KMRYSDLKKF QQAKKNKKGG QQGTSD