Q2KJ16

PR
Gene name
PHKG2
Protein name
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
Names
PHK-gamma-LT, PHK-gamma-T, Phosphorylase kinase subunit gamma-2
Species
Bos taurus (Bovine)
KEGG Pathway
bta:512670
EC number
2.7.11.19: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

170-192 (Activation loop from InterPro)

Target domain

24-291 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q2KJ16

Entry ID Method Resolution Chain Position Source
AF-Q2KJ16-F1 Predicted AlphaFoldDB

130 variants for Q2KJ16

Variant ID(s) Position Change Description Diseaes Association Provenance
rs461255147 7 P>A No EVA
rs443291717 9 D>E No EVA
rs474891209 9 D>G No EVA
rs477177394 10 E>G No EVA
rs463328457 10 E>Q No EVA
rs445736635 11 L>V No EVA
rs459349044 13 D>H No EVA
rs459349044 13 D>Y No EVA
rs479259537 21 Y>H No EVA
rs455171924 34 V>G No EVA
rs435195804 34 V>M No EVA
rs475335253 53 K>Q No EVA
rs437670300 70 V>G No EVA
rs451347936 76 R>P No EVA
rs460005227 87 H>P No EVA
rs434223916 110 M>I No EVA
rs465725098 110 M>L No EVA
rs447629142 120 T>P No EVA
rs467617660 122 K>* No EVA
rs436322767 123 V>G No EVA
rs456629476 124 A>D No EVA
rs476723183 127 E>D No EVA
rs452545786 132 S>A No EVA
rs452545786 132 S>P No EVA
rs465988224 133 I>L No EVA
rs434520104 137 L>P No EVA
rs443258739 145 H>N No EVA
rs456855894 147 N>S No EVA
rs470741236 148 N>D No EVA
rs439298043 148 N>K No EVA
rs459252619 151 H>Q No EVA
rs479013945 158 N>K No EVA
rs441359906 163 D>H No EVA
rs481754220 175 S>A No EVA
rs450103704 179 E>G No EVA
rs382881623 211 G>S No EVA
rs438748037 217 W>* No EVA
rs452378627 221 V>G No EVA
rs472197170 234 W>R No EVA
rs469972295 268 I>N No EVA
rs432109556 269 S>A No EVA
rs467863044 270 R>S No EVA
rs452468406 270 R>T No EVA
rs440873835 271 L>P No EVA
rs454429403 272 L>R No EVA
rs443317122 274 V>L No EVA
rs463416467 275 D>H No EVA
rs438949765 276 P>H No EVA
rs483034744 276 P>S No EVA
rs459130639 277 V>L No EVA
rs479091412 278 E>A No EVA
rs447684929 279 R>P No EVA
rs450112225 281 T>K No EVA
rs481417978 281 T>P No EVA
rs470270405 282 A>P No EVA
rs432192693 283 E>* No EVA
rs445843468 284 Q>H No EVA
rs466101867 285 A>S No EVA
rs434688321 287 Q>K No EVA
rs454792252 288 H>P No EVA
rs474612371 294 C>S No EVA
rs436745495 295 E>K No EVA
rs457015217 296 G>D No EVA
rs470502280 298 Q>P No EVA
rs438990596 299 A>D No EVA
rs458963959 300 W>C No EVA
rs472570133 301 N>I No EVA
rs441512205 302 L>R No EVA
rs461617081 303 T>P No EVA
rs477483652 305 R>P No EVA
rs463883082 305 R>S No EVA
rs446129903 306 Q>P No EVA
rs434531496 308 F>V No EVA
rs448292109 308 F>Y No EVA
rs435008337 310 V>A No EVA
rs435008337 310 V>G No EVA
rs475176656 311 A>G No EVA
rs443940396 312 V>G No EVA
rs457584970 313 W>G No EVA
rs457584970 313 W>R No EVA
rs470992495 314 T>A No EVA
rs470992495 314 T>P No EVA
rs439620331 315 V>G No EVA
rs459881418 317 A>V No EVA
rs461970632 321 V>G No EVA
rs450701440 322 A>D No EVA
rs477654697 324 S>R No EVA
rs446380171 325 A>P No EVA
rs435292383 326 H>P No EVA
rs455322302 327 R>P No EVA
rs437355485 328 I>L No EVA
rs457668974 330 P>A No EVA
rs471287835 332 T>S No EVA
rs439657053 333 K>R No EVA
rs453263053 334 S>R No EVA
rs473351893 335 A>P No EVA
rs462171464 340 P>H No EVA
rs462171464 340 P>L No EVA
rs442128336 340 P>S No EVA
rs442128336 340 P>T No EVA
rs475654360 344 R>W No EVA
rs444195558 348 R>G No EVA
rs457909589 349 L>V No EVA
rs446665460 351 D>E No EVA
rs477891798 351 D>G No EVA
rs460176078 352 N>S No EVA
rs480227692 353 C>R No EVA
rs448982298 353 C>W No EVA
rs469040312 356 R>G No EVA
rs437437411 361 W>R No EVA
rs464893037 372 A>S No EVA
rs453510448 378 P>H No EVA
rs473430860 379 P>A No EVA
rs435539892 381 P>S No EVA
rs475689637 384 M>I No EVA
rs455863750 384 M>V No EVA
rs444232350 386 G>R No EVA
rs457795216 387 P>T No EVA
rs471384237 390 E>A No EVA
rs460364136 396 I>M No EVA
rs440268955 396 I>T No EVA
rs480290472 397 A>V No EVA
rs462676348 399 D>E No EVA
rs448776944 399 D>H No EVA
rs438467787 401 A>V No EVA
rs482696134 402 M>I No EVA
rs444912259 403 L>V No EVA
rs464782417 404 V>A No EVA
rs464782417 404 V>E No EVA
rs464782417 404 V>G No EVA

No associated diseases with Q2KJ16

3 regional properties for Q2KJ16

Type Name Position InterPro Accession
domain Protein kinase domain 24 - 291 IPR000719
active_site Serine/threonine-protein kinase, active site 149 - 161 IPR008271
binding_site Protein kinase, ATP binding site 30 - 53 IPR017441

Functions

Description
EC Number 2.7.11.19 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
phosphorylase kinase activity Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a.

3 GO annotations of biological process

Name Definition
glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
glycogen catabolic process The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
protein phosphorylation The process of introducing a phosphate group on to a protein.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3MHJ9 CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta Bos taurus (Bovine) SS
Q2HJF7 CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta Bos taurus (Bovine) SS
A4IFM7 MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle Bos taurus (Bovine) SS
Q0V7M1 PSKH1 Serine/threonine-protein kinase H1 Bos taurus (Bovine) SS
Q16816 PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Homo sapiens (Human) PR
P15735 PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Homo sapiens (Human) PR
P07934 Phkg1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Mus musculus (Mouse) SS
Q9DB30 Phkg2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Mus musculus (Mouse) PR
P31325 Phkg2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Rattus norvegicus (Rat) PR
P13286 Phkg1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MTLDVGPEDE LPDWAAAKEF YQKYDPKDVI GRGVSSVVRR CVHRATGQEF AVKIMEVTAE
70 80 90 100 110 120
RLSPEQLEEV REATRRETHI LRQVAGHPHI ITLIDSYESS SFMFLVFDLM RKGELFDYLT
130 140 150 160 170 180
EKVALSEKET RSIMRSLLEA VSFLHNNNIV HRDLKPENIL LDDNMQIRLS DFGFSCHLEP
190 200 210 220 230 240
GEKLRELCGT PGYLAPEILK CSMDETHPGY GKEVDLWACG VILFTLLAGS PPFWHRRQIL
250 260 270 280 290 300
MLRMIMEGQY QFSSPEWDDR SDTVKDLISR LLQVDPVERL TAEQALQHPF FERCEGSQAW
310 320 330 340 350 360
NLTPRQRFRV AVWTVLAAGR VALSAHRIRP LTKSALLRDP YALRPVRRLI DNCAFRLYGH
370 380 390 400
WVKKGEQQNR AALFQHRPPG PFPMMGPEEE GDSATIAEDE AMLVLG