Q2KIZ8

PR
Gene name
MCM6
Protein name
DNA replication licensing factor MCM6
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:517812
EC number
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2KIZ8

Entry ID Method Resolution Chain Position Source
AF-Q2KIZ8-F1 Predicted AlphaFoldDB

No variants for Q2KIZ8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2KIZ8

No associated diseases with Q2KIZ8

6 regional properties for Q2KIZ8

Type Name Position InterPro Accession
domain MCM domain 334 - 556 IPR001208
conserved_site Mini-chromosome maintenance, conserved site 455 - 463 IPR018525
domain MCM N-terminal domain 27 - 115 IPR027925
domain MCM OB domain 122 - 251 IPR033762
domain Mcm6, C-terminal winged-helix domain 712 - 817 IPR041024
domain MCM, AAA-lid domain 571 - 656 IPR041562

Functions

Description
EC Number 3.6.4.12 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
  • Chromosome
  • Binds to chromatin during G1 and detaches from it during S phase
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
CMG complex A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication.
MCM complex A hexameric protein complex required for the initiation and regulation of DNA replication.
organelle membrane A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.

2 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
DNA replication initiation The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3ZBH9 MCM7 DNA replication licensing factor MCM7 Bos taurus (Bovine) PR
Q9V461 Mcm6 DNA replication licensing factor Mcm6 Drosophila melanogaster (Fruit fly) PR
Q14566 MCM6 DNA replication licensing factor MCM6 Homo sapiens (Human) PR
P97311 Mcm6 DNA replication licensing factor MCM6 Mus musculus (Mouse) PR
Q62724 Mcm6 DNA replication licensing factor MCM6 Rattus norvegicus (Rat) PR
Q6F353 Os05g0235800 DNA replication licensing factor MCM6 Oryza sativa subsp japonica (Rice) PR
P34647 mcm-6 DNA replication licensing factor mcm-6 Caenorhabditis elegans PR
Q9SF37 MCM8 Probable DNA helicase MCM8 Arabidopsis thaliana (Mouse-ear cress) PR
Q28CM3 mmcm6 Maternal DNA replication licensing factor mcm6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6P1V8 zmcm6 Zygotic DNA replication licensing factor mcm6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MDLAAAAEPG AGSQHLEVRD EVAEKCQKLF LDFLEEFQNS DGEIKYLQLA EELIRPERNT
70 80 90 100 110 120
LVVSFVDLEQ FNQQLSTTIQ EEFYRVYPYL CRALKTFVKD RKEIPLAKDF YVAFQDLPTR
130 140 150 160 170 180
HKIRELTSSR IGLLTRISGQ VVRTHPVHPE LVSGTFLCLD CQTVIKDVEQ QFKYTQPNIC
190 200 210 220 230 240
RNPVCANRRR FLLDTNKSRF VDFQKVRIQE TQAELPRGSI PRSLEVILRA EAVESAQAGD
250 260 270 280 290 300
KCDFTGTLIV VPDVSKLSTP GARAETDSRV SGVDGYETEG VRGLRALGVR DLSYRLVFLA
310 320 330 340 350 360
CCVAPTNPRF GGKELRDEEQ TAESIKNQMT VKEWEKVFEM SQDKNLYHNL CTSLFPTIHG
370 380 390 400 410 420
NDEVKRGVLL MLFGGVPKTT GEGTSLRGDI NVCIVGDPST AKSQFLKHVE EFSPRAVYTS
430 440 450 460 470 480
GKASIAAGLT AAVVRDEESH EFVIEAGALM LADNGVCCID EFDKMDVRDQ VAIHEAMEQQ
490 500 510 520 530 540
TISITKAGVK ATLNARTSIL AAANPISGHY DRSKSLKQNI NLSAPIMSRF DLFFILVDEC
550 560 570 580 590 600
NEVTDYAIAR RIVDLHSRIE DSIDRVYSLD EIRRYLLFAR QFKPKISKES EDFIVEQYKR
610 620 630 640 650 660
LRQRDGSGVT KSSWRITVRQ LESMIRLSEA MARMHCCDEV QPKHVKEAFR LLNKSIIRVE
670 680 690 700 710 720
TPDVNLDQEE DAQMEVDEGP DGINGHADSP APASGINGHS EDMNQDSVPK ASLRLGFSEY
730 740 750 760 770 780
CRISNLIVLH LRKMEEEEDE SALKRSELVN WYLKEIESEI DSEEELINKK RIIEKVIYRL
790 800 810 820
THYDHVLIEL TQAGLKGSTE GSESYEEDPY LVVNPNYLLE D