Q2KIC2
SS
Gene name |
ETV1 |
Protein name |
ETS translocation variant 1 |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:540846 |
EC number |
|
Protein Class |
|
Descriptions
ETS translocation variant 4 is a transcriptional activator that plays a vital role in keratinocyte differentiation. Inhibitory segments that hinders DNA binding sites in regions N- and C-terminal of the ETS domain. Acetylation of selected lysines within the N-terminal inhibitory domain activates DNA binding.
Autoinhibitory domains (AIDs)
Target domain |
331-424 (ETS domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q2KIC2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2KIC2-F1 | Predicted | AlphaFoldDB |
44 variants for Q2KIC2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs435224319 | 14 | T>S | No | EVA | |
| rs463897212 | 41 | H>N | No | EVA | |
| rs477891879 | 63 | V>G | No | EVA | |
| rs473961303 | 65 | D>E | No | EVA | |
| rs441070640 | 65 | D>Y | No | EVA | |
| rs462168720 | 68 | E>G | No | EVA | |
| rs443666129 | 71 | V>L | No | EVA | |
| rs468335352 | 119 | Y>D | No | EVA | |
| rs1114970188 | 120 | N>S | No | EVA | |
| rs797835586 | 130 | V>M | No | EVA | |
| rs381107458 | 143 | T>S | No | EVA | |
| rs1114482339 | 164 | A>T | No | EVA | |
| rs384601443 | 239 | N>S | No | EVA | |
| rs717578821 | 245 | A>T | No | EVA | |
| rs434892584 | 260 | P>H | No | EVA | |
| rs465422227 | 289 | T>S | No | EVA | |
| rs472060025 | 329 | Y>D | No | EVA | |
| rs478789497 | 334 | S>A | No | EVA | |
| rs441887242 | 336 | Q>* | No | EVA | |
| rs474805025 | 336 | Q>P | No | EVA | |
| rs444364106 | 338 | W>* | No | EVA | |
| rs444364106 | 338 | W>S | No | EVA | |
| rs470946301 | 339 | Q>E | No | EVA | |
| rs452510908 | 339 | Q>P | No | EVA | |
| rs434061286 | 340 | F>I | No | EVA | |
| rs434061286 | 340 | F>V | No | EVA | |
| rs473573646 | 342 | V>A | No | EVA | |
| rs454877148 | 352 | H>P | No | EVA | |
| rs436512770 | 354 | I>L | No | EVA | |
| rs469423439 | 354 | I>S | No | EVA | |
| rs451070308 | 355 | A>D | No | EVA | |
| rs432694050 | 359 | R>S | No | EVA | |
| rs379067748 | 371 | V>G | No | EVA | |
| rs468758728 | 411 | V>F | No | EVA | |
| rs450361013 | 429 | N>T | No | EVA | |
| rs483243696 | 457 | M>I | No | EVA | |
| rs466816870 | 461 | P>Q | No | EVA | |
| rs458333912 | 464 | G>V | No | EVA | |
| rs439899726 | 467 | N>T | No | EVA | |
| rs477829561 | 469 | H>L | No | EVA | |
| rs477829561 | 469 | H>P | No | EVA | |
| rs477829561 | 469 | H>R | No | EVA | |
| rs459212772 | 473 | E>Q | No | EVA | |
| rs440853875 | 474 | G>A | No | EVA |
No associated diseases with Q2KIC2
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
35 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A1A4L6 | ETS2 | Protein C-ets-2 | Bos taurus (Bovine) | SS |
| Q0VC65 | ETV6 | Transcription factor ETV6 | Bos taurus (Bovine) | SS |
| Q58DT0 | ELF5 | ETS-related transcription factor Elf-5 | Bos taurus (Bovine) | SS |
| P15062 | ETS1 | Transforming protein p68/c-ets-1 | Gallus gallus (Chicken) | SS |
| P10157 | ETS2 | Protein C-ets-2 | Gallus gallus (Chicken) | SS |
| Q90837 | ERG | Transcriptional regulator Erg | Gallus gallus (Chicken) | SS |
| A2T762 | ETV3 | ETS translocation variant 3 | Pan troglodytes (Chimpanzee) | PR |
| Q04688 | Ets97D | DNA-binding protein Ets97D | Drosophila melanogaster (Fruit fly) | PR |
| P50548 | ERF | ETS domain-containing transcription factor ERF | Homo sapiens (Human) | PR |
| P41970 | ELK3 | ETS domain-containing protein Elk-3 | Homo sapiens (Human) | SS |
| P41161 | ETV5 | ETS translocation variant 5 | Homo sapiens (Human) | SS |
| P43268 | ETV4 | ETS translocation variant 4 | Homo sapiens (Human) | EV |
| Q06546 | GABPA | GA-binding protein alpha chain | Homo sapiens (Human) | SS |
| P28324 | ELK4 | ETS domain-containing protein Elk-4 | Homo sapiens (Human) | EV |
| P15036 | ETS2 | Protein C-ets-2 | Homo sapiens (Human) | EV |
| P41162 | ETV3 | ETS translocation variant 3 | Homo sapiens (Human) | PR |
| P14921 | ETS1 | Protein C-ets-1 | Homo sapiens (Human) | EV |
| P11308 | ERG | Transcriptional regulator ERG | Homo sapiens (Human) | EV |
| P19419 | ELK1 | ETS domain-containing protein Elk-1 | Homo sapiens (Human) | EV |
| P50549 | ETV1 | ETS translocation variant 1 | Homo sapiens (Human) | EV |
| P41971 | Elk3 | ETS domain-containing protein Elk-3 | Mus musculus (Mouse) | EV |
| Q00422 | Gabpa | GA-binding protein alpha chain | Mus musculus (Mouse) | EV |
| P41969 | Elk1 | ETS domain-containing protein Elk-1 | Mus musculus (Mouse) | PR |
| P28322 | Etv4 | ETS translocation variant 4 | Mus musculus (Mouse) | SS |
| P15037 | Ets2 | Protein C-ets-2 | Mus musculus (Mouse) | SS |
| P27577 | Ets1 | Protein C-ets-1 | Mus musculus (Mouse) | EV |
| P70459 | Erf | ETS domain-containing transcription factor ERF | Mus musculus (Mouse) | PR |
| Q9CXC9 | Etv5 | ETS translocation variant 5 | Mus musculus (Mouse) | SS |
| P41158 | Elk4 | ETS domain-containing protein Elk-4 | Mus musculus (Mouse) | PR |
| P81270 | Erg | Transcriptional regulator ERG | Mus musculus (Mouse) | SS |
| P41164 | Etv1 | ETS translocation variant 1 | Mus musculus (Mouse) | SS |
| P41156 | Ets1 | Protein C-ets-1 | Rattus norvegicus (Rat) | SS |
| A4GTP4 | Elk1 | ETS domain-containing protein Elk-1 | Rattus norvegicus (Rat) | PR |
| Q9PUQ1 | etv4 | ETS translocation variant 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| A3FEM2 | fev | Protein FEV | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDGFYDQQVP | YMVTNNQRGR | NCNEKPTNVR | KRKFINRDLA | HDSEELFQDL | SQLQETWLAE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AQVPDNDEQF | VPDYQAESLA | FHGLPLKIKK | EPHSPCSELG | SACSQEQPFK | FSYGEKCLYN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VSAYDQKPQV | GMRPSNPPTP | SSTPVSPLHH | ASPNSAHTSK | PDRAFPAHLP | PSQPIQDSSY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PMDHRFRRQL | SEPCNSFPPL | PTMPREGRPM | YQRQMSEPNI | PFPPQGFKQE | YHDPVYEHNT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MVGGAASQSF | PPPLMIKQEP | RDFAYDSEVP | SCHSIYMRQE | GFLTHPSRTE | GCMFEKGPRQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FYDDTCVVPE | KFDGDIKQEP | GMYREGPTYQ | RRGSLQLWQF | LVALLDDPSN | SHFIAWTGRG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MEFKLIEPEE | VARRWGIQKN | RPAMNYDKLS | RSLRYYYEKG | IMQKVAGERY | VYKFVCDPEA |
| 430 | 440 | 450 | 460 | 470 | |
| LFSMAFPDNQ | RPLLKTDMER | HINEEDTVPL | SHFDESMAYM | PEGGCCNPHP | YNEGYVY |