Q2KI41

SS
Gene name
CYTH2 (PSCD2)
Protein name
Cytohesin-2
Names
PH, SEC7 and coiled-coil domain-containing protein 2
Species
Bos taurus (Bovine)
KEGG Pathway
bta:768035
EC number
Protein Class

Descriptions

Cytohesin-3 (CYTH3) promotes guanine-nucleotide exchange on Arf1 and Arf6. Cytohesins share a modular architecture consisting of heptad repeats, a Sec7 domain with exchange activity for Arf1 and Arf6, a PH domain that binds phosphatidylinositol (PI) polyphosphates, and a C-terminal helix (CtH) that overlaps with a polybasic region (PBR). Cytohesins are autoinhibited by the Sec7-PH linker (252-264) and CtH/PBR (380-399), which obstruct substrate binding. The autoinhibition can be relieved by Arf6-GTP binding in the presence of the PIP3 head group.

Autoinhibitory domains (AIDs)

247-259 (Sec7-PH linker) SS

Target domain

58-246 (Sec7 domain)

Relief mechanism

Partner binding

Assay

385-404 (C-terminal helix/polybasic region) SS

Target domain

58-246 (Sec7 domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2KI41

Entry ID Method Resolution Chain Position Source
AF-Q2KI41-F1 Predicted AlphaFoldDB

No variants for Q2KI41

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2KI41

No associated diseases with Q2KI41

2 regional properties for Q2KI41

Type Name Position InterPro Accession
domain Sec7 domain 54 - 243 IPR000904
domain Pleckstrin homology domain 259 - 388 IPR001849

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
  • Cytoplasm
  • Cell projection
  • Cell projection, growth cone
  • Recruited to the cell membrane through its association with ARL4A, ARL4C and ARL4D
  • Requires also interaction with phosphoinositides for targeting to plasma membrane
  • In differentiating neuroblastoma cells, colocalizes with CCDC120 in both neurite shaft and growth cone areas
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
growth cone The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
inositol 1,4,5 trisphosphate binding Binding to inositol 1,4,5 trisphosphate.
lipid binding Binding to a lipid.

1 GO annotations of biological process

Name Definition
regulation of ARF protein signal transduction Any process that modulates the frequency, rate or extent of ARF protein signal transduction.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O46382 ARFGEF1 Brefeldin A-inhibited guanine nucleotide-exchange protein 1 Bos taurus (Bovine) PR
Q9UIA0 CYTH4 Cytohesin-4 Homo sapiens (Human) SS
O43739 CYTH3 Cytohesin-3 Homo sapiens (Human) EV
Q15438 CYTH1 Cytohesin-1 Homo sapiens (Human) SS
Q99418 CYTH2 Cytohesin-2 Homo sapiens (Human) SS
Q9QX11 Cyth1 Cytohesin-1 Mus musculus (Mouse) SS
Q80YW0 Cyth4 Cytohesin-4 Mus musculus (Mouse) SS
O08967 Cyth3 Cytohesin-3 Mus musculus (Mouse) EV
P63034 Cyth2 Cytohesin-2 Mus musculus (Mouse) SS
P97696 Cyth3 Cytohesin-3 Rattus norvegicus (Rat) SS
P97694 Cyth1 Cytohesin-1 Rattus norvegicus (Rat) SS
P63035 Cyth2 Cytohesin-2 Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MEDGVYEPPD LTPEERMELE NIRRRKQELL VEIQRLREEL SEAMSEVEGL EANEGSKTLQ
70 80 90 100 110 120
RNRKMAMGRK KFNMDPKKGI QFLVENELLQ NTPEEIARFL YKGEGLNKTA IGDYLGEREE
130 140 150 160 170 180
LNLAVLHAFV DLHEFTDLNL VQALRQFLWS FRLPGEAQKI DRMMEAFAQR YCLCNPGVFQ
190 200 210 220 230 240
STDTCYVLSF AVIMLNTSLH NPNVRDKPGL ERFVAMNRGI NEGGDLPEEL LRNLYDSIRN
250 260 270 280 290 300
EPFKIPEDDG NDLTHTFFNP DREGWLLKLG AQAPSPPSLP GGRVKTWKRR WFILTDNCLY
310 320 330 340 350 360
YFEYTTDKEP RGIIPLENLS IREVDDPRKP NCFELYIPNN KGQLIKACKT EADGRVVEGN
370 380 390 400
HMVYRISAPT QEEKDEWIKS IQAAVSVDPF YEMLAARKKR ISVKKKQEQP