Q2HXK8

SS
Gene name
fgf16
Protein name
Fibroblast growth factor 16
Names
FGF16
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:692065
EC number
Protein Class

Descriptions

The mammalian fibroblast growth factor (FGF)1 family contains at least 22 distinct polypeptides (FGF1–FGF22) that are expressed in a specific spatial and temporal pattern. FGF9 was originally described as a glia-activating factor and is expressed in the nervous system as a potent mitogen for glia cells. FGF9 adopts a beta-trefoil fold similar to other FGFs, but the N- and C-terminal regions outside the beta-trefoil core are ordered (typical FGFs have disordered tails) and involved in reversible dimerization. Due to the dimerization, a significant surface area is buried in the dimer interface that occludes a major receptor binding site of FGF9 within the beta-trefoil core.

Autoinhibitory domains (AIDs)

48-55 (N-terminal helix) SS

Target domain

58-185 (beta-trefoil core)

Relief mechanism

Assay

195-198 (C-terminal helix) SS

Target domain

58-185 (beta-trefoil core)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2HXK8

Entry ID Method Resolution Chain Position Source
AF-Q2HXK8-F1 Predicted AlphaFoldDB

No variants for Q2HXK8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2HXK8

No associated diseases with Q2HXK8

4 regional properties for Q2HXK8

Type Name Position InterPro Accession
domain SH3 domain 339 - 402 IPR001452
domain IMD/I-BAR domain 1 - 249 IPR013606
domain Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1, I-BAR domain 6 - 231 IPR030060
domain IRTKS, SH3 domain 342 - 399 IPR035592

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

2 GO annotations of molecular function

Name Definition
fibroblast growth factor receptor binding Binding to a fibroblast growth factor receptor (FGFR).
growth factor activity The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

17 GO annotations of biological process

Name Definition
animal organ morphogenesis Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
cell differentiation The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population.
cell proliferation in forebrain The creation of greater cell numbers in the forebrain due to cell division of progenitor cells.
cell proliferation in midbrain The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain.
diencephalon development The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex.
fibroblast growth factor receptor signaling pathway The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
forebrain development The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
GABAergic neuron differentiation The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron.
oligodendrocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system.
pectoral fin development The process whose specific outcome is the progression of the pectoral fin over time, from its formation to the mature structure.
pectoral fin morphogenesis The process in which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of endothelial cell chemotaxis to fibroblast growth factor Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
subpallium development The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon.

28 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P48801 FGF3 Fibroblast growth factor 3 Gallus gallus (Chicken) SS
P08620 FGF4 Fibroblast growth factor 4 Homo sapiens (Human) PR
Q9NP95 FGF20 Fibroblast growth factor 20 Homo sapiens (Human) SS
Q9HCT0 FGF22 Fibroblast growth factor 22 Homo sapiens (Human) SS
P10767 FGF6 Fibroblast growth factor 6 Homo sapiens (Human) SS
O15520 FGF10 Fibroblast growth factor 10 Homo sapiens (Human) SS
Q92914 FGF11 Fibroblast growth factor 11 Homo sapiens (Human) SS
P11487 FGF3 Fibroblast growth factor 3 Homo sapiens (Human) SS
P31371 FGF9 Fibroblast growth factor 9 Homo sapiens (Human) EV
Q9NSA1 FGF21 Fibroblast growth factor 21 Homo sapiens (Human) PR
O43320 FGF16 Fibroblast growth factor 16 Homo sapiens (Human) EV SS
P21658 Fgf6 Fibroblast growth factor 6 Mus musculus (Mouse) SS
Q9ESS2 Fgf22 Fibroblast growth factor 22 Mus musculus (Mouse) SS
O35565 Fgf10 Fibroblast growth factor 10 Mus musculus (Mouse) SS
P54130 Fgf9 Fibroblast growth factor 9 Mus musculus (Mouse) SS
Q9JJN1 Fgf21 Fibroblast growth factor 21 Mus musculus (Mouse) PR
Q9ESL9 Fgf20 Fibroblast growth factor 20 Mus musculus (Mouse) SS
P11403 Fgf4 Fibroblast growth factor 4 Mus musculus (Mouse) PR
P61329 Fgf12 Fibroblast growth factor 12 Mus musculus (Mouse) PR
P05524 Fgf3 Fibroblast growth factor 3 Mus musculus (Mouse) SS
Q9ESL8 Fgf16 Fibroblast growth factor 16 Mus musculus (Mouse) SS
Q95L12 FGF9 Fibroblast growth factor 9 Sus scrofa (Pig) SS
Q9EST9 Fgf20 Fibroblast growth factor 20 Rattus norvegicus (Rat) SS
P36364 Fgf9 Fibroblast growth factor 9 Rattus norvegicus (Rat) SS
P70492 Fgf10 Fibroblast growth factor 10 Rattus norvegicus (Rat) SS
O54769 Fgf16 Fibroblast growth factor 16 Rattus norvegicus (Rat) SS
P48802 fgf3 Fibroblast growth factor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q6PBT8 fgf1 Putative fibroblast growth factor 1 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MAEVAGFLGS IDLDLQAFPA LGNVPLSDGL NERLGLIEGR LQRGSLTDFG HLKGILRRRQ
70 80 90 100 110 120
LYCRTGFQLE IFPNGTVHGT RQDHSRFGIL EFISLAVGLV SIRGVDAGLY LGMNEKGELY
130 140 150 160 170 180
GSKKLTAECV FREQFEENWY NTYASTLFKH ADTGRYYYVA LNKDGSPREG SRTKKHQKLT
190 200
HFLPRPVEIE KIPQAYRELF QHR