Q2HJJ0

SS
Gene name
KLC4 (KNSL8)
Protein name
Kinesin light chain 4
Names
KLC 4 , Kinesin-like protein 8
Species
Bos taurus (Bovine)
KEGG Pathway
EC number
Protein Class

Descriptions

The Kinesin-1 light chains (KLCs) exhibit autoinhibition through an intramolecular interaction between the TPR domain and a highly conserved peptide motif within an unstructured region, occluding a key cargo binding site. Cargo binding displaces this interaction, leading to a global conformational change in the KLCs, resulting in a more extended conformation which is essential for the regulation of the motor activity.

Autoinhibitory domains (AIDs)

149-206 (the flexible linker region) SS

Target domain

207-494 (Cargo binding site on the TPR domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2HJJ0

Entry ID Method Resolution Chain Position Source
AF-Q2HJJ0-F1 Predicted AlphaFoldDB

No variants for Q2HJJ0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2HJJ0

No associated diseases with Q2HJJ0

2 regional properties for Q2HJJ0

Type Name Position InterPro Accession
domain Protein kinase domain 88 - 396 IPR000719
active_site Serine/threonine-protein kinase, active site 209 - 221 IPR008271

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
kinesin complex Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

1 GO annotations of molecular function

Name Definition
kinesin binding Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.

1 GO annotations of biological process

Name Definition
microtubule-based movement A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2TBQ9 KLC3 Kinesin light chain 3 Bos taurus (Bovine) SS
P46824 Klc Kinesin light chain Drosophila melanogaster (Fruit fly) SS
Q6P597 KLC3 Kinesin light chain 3 Homo sapiens (Human) SS
Q9H0B6 KLC2 Kinesin light chain 2 Homo sapiens (Human) SS
Q07866 KLC1 Kinesin light chain 1 Homo sapiens (Human) SS
Q9NSK0 KLC4 Kinesin light chain 4 Homo sapiens (Human) SS
O88447 Klc1 Kinesin light chain 1 Mus musculus (Mouse) SS
Q91W40 Klc3 Kinesin light chain 3 Mus musculus (Mouse) SS
O88448 Klc2 Kinesin light chain 2 Mus musculus (Mouse) EV
Q9DBS5 Klc4 Kinesin light chain 4 Mus musculus (Mouse) SS
P37285 Klc1 Kinesin light chain 1 Rattus norvegicus (Rat) SS
Q68G30 Klc3 Kinesin light chain 3 Rattus norvegicus (Rat) SS
Q5PQM2 Klc4 Kinesin light chain 4 Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MSGLVLGQRD EPAGHRLSQE EILGSTRLVS QGLEALHSEH QAVLQSLSQT IECLQQGGHE
70 80 90 100 110 120
EGLVHEKARQ LRRSMENIEL GLSEAQVMLA LANHLSTVES EKQKLRAQVR RLCQENQWLR
130 140 150 160 170 180
DELAGTQQRL QRSEQAVAQL EEEKKHLEFL GQLRQYDEDG HAAEEKEGDA SKDSLDDLFP
190 200 210 220 230 240
NEEEEDPSNG LSRGQGAQHS GYEIPARLRT LHNLVIQYAA QGRYEVAVPL CKQALEDLER
250 260 270 280 290 300
TSGRGHPVVA TMLNILALVY RGQNKYKEAA LLLNDALSIR ESTLGRDHPA VAATLNNLAV
310 320 330 340 350 360
LYGKRGKYKE AEPLCQRALE IREKVLGTNH PDVAKQLNNL ALLCQNQGKY EAVERYYRRA
370 380 390 400 410 420
LAIYEGQLGP DNPNVARTKN NLASCYLKQG KYAEAETLYK EILTRAHVQE FGSVDDDHKP
430 440 450 460 470 480
IWMHAEEREE MSKIRHREGS TPYAEYGGWY KACKVSSPTV NTTLRNLGAL YRRQGKLEAA
490 500 510 520 530 540
ETLEECALRS RKQGTDPISQ TKVAELLGEG DSGRTSQEGL GGSVKFEGGE DASVAVEWSG
550 560 570 580 590 600
DGSGALQRSG SLGKIRDVLR RSSELLVRKL QGSEPRPSSS NMKRAASLNY LNQPSAAPLQ
610
VSRGLSASSM DLSSSS