Q2HJF7
SS
Gene name |
CAMK2D |
Protein name |
Calcium/calmodulin-dependent protein kinase type II subunit delta |
Names |
CaM kinase II subunit delta , CaMK-II subunit delta , EC 2.7.11.17 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:532713 |
EC number |
2.7.11.17: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
CaMKII is one of the most important transducers of Ca2+signals in a variety of cell types and is highly conserved across animal species. The calmodulin-responsive regulatory segment forms a coiled coil structure that blocks peptide and ATP binding to the otherwise intrinsically active kinase domain.Ca2+/CaM removes the autoinhibitory regulatory segment located C-terminal to the kinase domain which releases the catalytic activity of the enzyme.
Autoinhibitory domains (AIDs)
Target domain |
14-272 (Protein kinase domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
156-179 (Activation loop from InterPro)
Target domain |
14-272 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Rosenberg OS et al. (2005) "Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme", Cell, 123, 849-60
- Rellos P et al. (2010) "Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation", PLoS biology, 8, e1000426
- Akita T et al. (2018) "De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders", Annals of clinical and translational neurology, 5, 280-296
- Morlot C et al. (2007) "Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3", Acta crystallographica. Section D, Biological crystallography, 63, 961-8
- Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100
- Yang E et al. (1999) "Structural examination of autoregulation of multifunctional calcium/calmodulin-dependent protein kinase II", The Journal of biological chemistry, 274, 26199-208
- Özden C et al. (2022) "CaMKII binds both substrates and activators at the active site", Cell reports, 40, 111064
Autoinhibited structure
Activated structure
1 structures for Q2HJF7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2HJF7-F1 | Predicted | AlphaFoldDB |
50 variants for Q2HJF7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs466943966 | 5 | T>A | No | EVA | |
| rs432354384 | 11 | T>A | No | EVA | |
| rs465218769 | 12 | D>E | No | EVA | |
| rs445164294 | 12 | D>Y | No | EVA | |
| rs436990723 | 14 | Y>N | No | EVA | |
| rs457033788 | 15 | Q>R | No | EVA | |
| rs470242294 | 70 | H>N | No | EVA | |
| rs518898261 | 101 | D>G | No | EVA | |
| rs480524055 | 154 | K>R | No | EVA | |
| rs434513085 | 172 | F>S | No | EVA | |
| rs446119308 | 174 | F>Y | No | EVA | |
| rs460508792 | 179 | G>* | No | EVA | |
| rs470864065 | 232 | D>E | No | EVA | |
| rs480799330 | 234 | P>L | No | EVA | |
| rs442873609 | 235 | S>* | No | EVA | |
| rs459782370 | 238 | W>G | No | EVA | |
| rs479631062 | 243 | P>R | No | EVA | |
| rs464295783 | 252 | M>T | No | EVA | |
| rs477865145 | 256 | N>T | No | EVA | |
| rs449905392 | 257 | P>A | No | EVA | |
| rs469962114 | 263 | A>T | No | EVA | |
| rs435300337 | 264 | S>P | No | EVA | |
| rs465853938 | 269 | H>P | No | EVA | |
| rs451276475 | 271 | W>S | No | EVA | |
| rs481926261 | 274 | Q>L | No | EVA | |
| rs450440043 | 277 | T>P | No | EVA | |
| rs450440043 | 277 | T>S | No | EVA | |
| rs481802629 | 278 | V>G | No | EVA | |
| rs447084759 | 281 | M>K | No | EVA | |
| rs467065427 | 283 | H>N | No | EVA | |
| rs432555954 | 287 | T>S | No | EVA | |
| rs452550923 | 293 | K>E | No | EVA | |
| rs469499751 | 293 | K>N | No | EVA | |
| rs454083088 | 311 | T>A | No | EVA | |
| rs798462032 | 314 | F>S | No | EVA | |
| rs473334006 | 314 | F>V | No | EVA | |
| rs434074000 | 333 | S>W | No | EVA | |
| rs481550257 | 348 | I>V | No | EVA | |
| rs447119461 | 349 | E>Q | No | EVA | |
| rs456790162 | 408 | Y>* | No | EVA | |
| rs442193650 | 409 | F>L | No | EVA | |
| rs476818203 | 409 | F>S | No | EVA | |
| rs455764160 | 411 | N>D | No | EVA | |
| rs472728810 | 412 | A>P | No | EVA | |
| rs800147556 | 417 | N>I | No | EVA | |
| rs445439004 | 466 | H>P | No | EVA | |
| rs465417459 | 468 | R>W | No | EVA | |
| rs482200263 | 469 | D>Y | No | EVA | |
| rs450899502 | 476 | H>P | No | EVA | |
| rs442025636 | 488 | N>K | No | EVA |
No associated diseases with Q2HJF7
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.17 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| sarcolemma | The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. |
| sarcoplasmic reticulum membrane | The lipid bilayer surrounding the sarcoplasmic reticulum. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| calmodulin-dependent protein kinase activity | Calmodulin-dependent catalysis of the reactions |
| protein serine kinase activity | Catalysis of the reactions |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of cardiac muscle hypertrophy | Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of cellular localization | Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. |
44 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3MHJ9 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | Bos taurus (Bovine) | SS |
| Q2KJ16 | PHKG2 | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform | Bos taurus (Bovine) | PR |
| A4IFM7 | MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Bos taurus (Bovine) | SS |
| Q0V7M1 | PSKH1 | Serine/threonine-protein kinase H1 | Bos taurus (Bovine) | SS |
| Q5ZKI0 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II delta chain | Gallus gallus (Chicken) | SS |
| Q24210 | CASK | Peripheral plasma membrane protein CASK | Drosophila melanogaster (Fruit fly) | SS |
| Q00168 | CaMKII | Calcium/calmodulin-dependent protein kinase type II alpha chain | Drosophila melanogaster (Fruit fly) | SS |
| Q13555 | CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Homo sapiens (Human) | EV |
| O14936 | CASK | Peripheral plasma membrane protein CASK | Homo sapiens (Human) | EV |
| Q9UQM7 | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Homo sapiens (Human) | EV |
| Q13554 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | Homo sapiens (Human) | EV |
| Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Homo sapiens (Human) | EV |
| O70589 | Cask | Peripheral plasma membrane protein CASK | Mus musculus (Mouse) | SS |
| P11798 | Camk2a | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Mus musculus (Mouse) | PR |
| P28652 | Camk2b | Calcium/calmodulin-dependent protein kinase type II subunit beta | Mus musculus (Mouse) | SS |
| Q923T9 | Camk2g | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Mus musculus (Mouse) | SS |
| Q6PHZ2 | Camk2d | Calcium/calmodulin-dependent protein kinase type II subunit delta | Mus musculus (Mouse) | SS |
| Q95266 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Sus scrofa (Pig) | SS |
| P11275 | Camk2a | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Rattus norvegicus (Rat) | PR |
| P11730 | Camk2g | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Rattus norvegicus (Rat) | SS |
| P15791 | Camk2d | Calcium/calmodulin-dependent protein kinase type II subunit delta | Rattus norvegicus (Rat) | SS |
| Q5VQQ5 | CPK2 | Calcium-dependent protein kinase 2 | Oryza sativa subsp. japonica (Rice) | SS |
| Q75GE8 | CPK8 | Calcium-dependent protein kinase 8 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6I5I8 | CPK16 | Calcium-dependent protein kinase 16 | Oryza sativa subsp. japonica (Rice) | SS |
| Q84SL0 | CPK20 | Calcium-dependent protein kinase 20 | Oryza sativa subsp. japonica (Rice) | SS |
| Q8LPZ7 | CPK3 | Calcium-dependent protein kinase 3 | Oryza sativa subsp. japonica (Rice) | SS |
| P54936 | lin-2 | Protein lin-2 | Caenorhabditis elegans | SS |
| O62305 | unc-43 | Calcium/calmodulin-dependent protein kinase type II | Caenorhabditis elegans | EV |
| Q9SSF8 | CPK30 | Calcium-dependent protein kinase 30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M9V8 | CPK10 | Calcium-dependent protein kinase 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4I7 | CPK13 | Calcium-dependent protein kinase 13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SIQ7 | CPK24 | Calcium-dependent protein kinase 24 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E9C0 | CPK34 | Calcium-dependent protein kinase 34 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FMP5 | CPK17 | Calcium-dependent protein kinase 17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q42479 | CPK3 | Calcium-dependent protein kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZSA4 | CPK27 | Calcium-dependent protein kinase 27 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q7XJR9 | CPK16 | Calcium-dependent protein kinase 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93759 | GK-1 | Calcium-dependent protein kinase 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6NLQ6 | CPK32 | Calcium-dependent protein kinase 32 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38873 | CPK7 | Calcium-dependent protein kinase 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q1PE17 | CPK18 | Calcium-dependent protein kinase 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FKW4 | CPK28 | Calcium-dependent protein kinase 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q6DEH3 | camk2d1 | Calcium/calmodulin-dependent protein kinase type II delta 1 chain | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6DGS3 | camk2d2 | Calcium/calmodulin-dependent protein kinase type II delta 2 chain | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASTTTCTRF | TDEYQLFEEL | GKGAFSVVRR | CMKIPTGQEY | AAKIINTKKL | SARDHQKLER |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EARICRLLKH | PNIVRLHDSI | SEEGFHYLVF | DLVTGGELFE | DIVAREYYSE | ADASHCIQQI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LESVNHCHLN | GIVHRDLKPE | NLLLASKSKG | AAVKLADFGL | AIEVQGDQQA | WFGFAGTPGY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LSPEVLRKDP | YGKPVDMWAC | GVILYILLVG | YPPFWDEDQH | RLYQQIKAGA | YDFPSPEWDT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VTPEAKDLIN | KMLTINPAKR | ITASEALKHP | WICQRSTVAS | MMHRQETVDC | LKKFNARRKL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KGAILTTMLA | TRNFSAKSLL | KKPDGVKKRK | SSSSVQMMES | TESSNTTIED | EDVKARKQEI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IKVTEQLIEA | INNGDFEAYT | KICDPGLTAF | EPEALGNLVE | GMDFHRFYFE | NALSKSNKPI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HTIILNPHVH | LVGDDAACIA | YIRLTQYMDG | SGMPKTMQSE | ETRVWHRRDG | KWQNVHFHRS |
| GSPTVPIN |