Q2HJ21

SS
Gene name
MDM4 (MDMX)
Protein name
Protein Mdm4
Names
Double minute 4 protein, Mdm2-like p53-binding protein, Protein Mdmx, p53-binding protein Mdm4
Species
Bos taurus (Bovine)
KEGG Pathway
bta:514225
EC number
Protein Class

Descriptions

MDM4 is a homologous protein that binds to p53 and regulates its activity. Residues 190-210 in that intrinsically disordered region constitute an inhibitory module. It competes with the p53TAD for binding to the NTD of MDM4, thus lowering the affinity of MDMX for p53. Efficient binding of MDM4 to p53 requires a mechanism to relieve the allosteric self-inhibition.

Autoinhibitory domains (AIDs)

190-210 (Tryptohpan-rich segment) SS

Target domain

25-108 (N-terminal SWIB-like domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2HJ21

Entry ID Method Resolution Chain Position Source
AF-Q2HJ21-F1 Predicted AlphaFoldDB

No variants for Q2HJ21

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2HJ21

No associated diseases with Q2HJ21

3 regional properties for Q2HJ21

Type Name Position InterPro Accession
domain Zinc finger, RING-type 438 - 479 IPR001841
domain Zinc finger, RanBP2-type 300 - 329 IPR001876
domain SWIB/MDM2 domain 25 - 108 IPR003121

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
E1C4B0 MDM4 Double minute 4 protein Gallus gallus (Chicken) SS
O15151 MDM4 Protein Mdm4 Homo sapiens (Human) EV
O35618 Mdm4 Protein Mdm4 Mus musculus (Mouse) SS
Q5XIN1 Mdm4 Protein Mdm4 Rattus norvegicus (Rat) SS
Q7ZUW7 mdm4 Protein Mdm4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MTSFSTSAPC SAPDSARRIS PEQTNQVRPK LPLLKILQAA GAQGEMFTVK EVMHYLGQYI
70 80 90 100 110 120
MVKQLYDQQE QHMVYCGGDL LGELLGRQSF SVKDPSPLYD MLRKNLVTLA TAATDAAQTL
130 140 150 160 170 180
AIAQEHSMDI PSQDHLKQSV EESSNSRKRT EEGNIPTLPT SQYKCKNSRE DEDLVANLTQ
190 200 210 220 230 240
EETSRLDLGF EEWDVAGLPW WFLGNLRNNY TPRSNGSTDL QTNQDIGTAI VSDTTDDLWF
250 260 270 280 290 300
LNESVSEQFG VGKKVEAADP EQTSEEVGKL IDKKVTEVGK NDDLEDPKSI SDDTDIEVTS
310 320 330 340 350 360
EDEWQCTECK KFNSPSKRYC FRCWALRKDW YSDCSKLTHS LSTSDITAIP EKQESEGVDV
370 380 390 400 410 420
PDCRRTVSAP VVRPKDTYVK EESSKHFDPC NSVEFLDLAH SSESQETISS MGEQSDNLFE
430 440 450 460 470 480
QRKDTENMED CQNLLKPCSL CEKRPRNGNI IHGRTGHLVT CFHCARRLKK AGASCPICKK
490
EIQLVIKVFV A