Q29S22

PR
Gene name
DDX47
Protein name
Probable ATP-dependent RNA helicase DDX47
Names
DEAD box protein 47
Species
Bos taurus (Bovine)
KEGG Pathway
bta:534721
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q29S22

Entry ID Method Resolution Chain Position Source
AF-Q29S22-F1 Predicted AlphaFoldDB

48 variants for Q29S22

Variant ID(s) Position Change Description Diseaes Association Provenance
rs473718208 5 V>L No EVA
rs453509965 7 H>N No EVA
rs436625539 9 S>T No EVA
rs467887612 10 L>P No EVA
rs450851186 14 E>A No EVA
rs437301345 15 A>G No EVA
rs465292316 17 Q>P No EVA
rs445252279 21 E>* No EVA
rs479494002 21 E>G No EVA
rs481352323 69 L>Q No EVA
rs461251917 83 P>H No EVA
rs438429958 93 Q>H No EVA
rs472934710 102 P>A No EVA
rs452777118 103 T>P No EVA
rs475339963 105 E>G No EVA
rs435994053 105 E>K No EVA
rs455100490 106 L>M No EVA
rs469526075 107 A>G No EVA
rs438293886 107 A>P No EVA
rs446286703 109 Q>K No EVA
rs467106005 121 I>M No EVA
rs481429169 125 C>F No EVA
rs461357511 125 C>W No EVA
rs450663244 126 A>S No EVA
rs437206945 142 A>T No EVA
rs443050378 179 D>N No EVA
rs433689007 230 V>A No EVA
rs464606828 259 I>N No EVA
rs436344457 309 N>T No EVA
rs450664697 310 K>E No EVA
rs481945136 310 K>N No EVA
rs464976242 311 F>L No EVA
rs445034317 319 L>F No EVA
rs459497085 320 L>R No EVA
rs442499334 321 A>S No EVA
rs432866233 355 R>L No EVA
rs447232201 356 T>S No EVA
rs445750987 407 E>D No EVA
rs445866882 415 E>A No EVA
rs477369724 417 R>M No EVA
rs460288797 419 H>P No EVA
rs480922779 423 K>N No EVA
rs444111456 424 K>N No EVA
rs460837376 424 K>Q No EVA
rs475175894 426 S>* No EVA
rs42312273 430 V>A No EVA
rs439875006 432 D>G No EVA
rs43706525 457 R>H No EVA

No associated diseases with Q29S22

6 regional properties for Q29S22

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 174 - 182 IPR000629
domain Helicase, C-terminal 239 - 399 IPR001650
domain DEAD/DEAH box helicase domain 50 - 217 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 45 - 243 IPR014001
domain RNA helicase, DEAD-box type, Q motif 26 - 54 IPR014014
domain DDX47/Rrp3, DEAD-box helicase domain 27 - 229 IPR044765

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus, nucleolus
  • Localizes in the nucleolar-organizing region during ribosome biogenesis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

4 GO annotations of biological process

Name Definition
extrinsic apoptotic signaling pathway via death domain receptors The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P53166 MRH4 ATP-dependent RNA helicase MRH4, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P15424 MSS116 ATP-dependent RNA helicase MSS116, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q3SZ54 EIF4A1 Eukaryotic initiation factor 4A-I Bos taurus (Bovine) PR
Q3SZ40 DDX56 Probable ATP-dependent RNA helicase DDX56 Bos taurus (Bovine) PR
Q2NL08 DDX55 ATP-dependent RNA helicase DDX55 Bos taurus (Bovine) PR
Q9NUL7 DDX28 Probable ATP-dependent RNA helicase DDX28 Homo sapiens (Human) PR
Q9H0S4 DDX47 Probable ATP-dependent RNA helicase DDX47 Homo sapiens (Human) PR
Q9CWT6 Ddx28 Probable ATP-dependent RNA helicase DDX28 Mus musculus (Mouse) PR
Q9CWX9 Ddx47 Probable ATP-dependent RNA helicase DDX47 Mus musculus (Mouse) PR
Q7Y183 RH10 DEAD-box ATP-dependent RNA helicase 10 Oryza sativa subsp japonica (Rice) PR
Q8L4E9 Os07g0633500 DEAD-box ATP-dependent RNA helicase 36 Oryza sativa subsp japonica (Rice) PR
P34580 T26G10.1 Putative ATP-dependent RNA helicase T26G10.1 Caenorhabditis elegans PR
P34668 ZK686.2 Putative ATP-dependent RNA helicase ZK686.2 Caenorhabditis elegans PR
Q8GY84 RH10 DEAD-box ATP-dependent RNA helicase 10 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SA27 RH36 DEAD-box ATP-dependent RNA helicase 36 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAASVEHDSL ESMEAPQTAV EVEETKTFKD LGVTDVLCEA CDQLGWTKPT KIQIEAIPLA
70 80 90 100 110 120
LQGRDIIGLA ETGSGKTGAF ALPILNALLE TPQRLFALVL TPTRELAFQI SEQFEALGSS
130 140 150 160 170 180
IGVQCAVIVG GIDSMSQSLA LAKKPHIVIA TPGRLIDHLE NTKGFNLRAL KYLVMDEADR
190 200 210 220 230 240
ILNMDFETEV DKILKVIPRD RKTFLFSATM TKKVQKLQRA ALKNPVKCAV SSKYQTVEKL
250 260 270 280 290 300
QQYYLFIPSK FKDTYLVYIL NELAGNSFMI FCSTCNNTQR TALLLRNLGF TAIPLHGQMS
310 320 330 340 350 360
QSKRLGSLNK FKAKARSILL ATDVASRGLD IPHVDVVVNF DIPTHSKDYI HRVGRTARAG
370 380 390 400 410 420
RSGKAITFVT QYDVELFQRI EHLIGKKLPV FPTQDDEVMM LTERVTEAQR FARMELREHG
430 440 450
EKKKRSREDV GDNDDTEGAI GVRNKVAGGK MKKRKGR