Q28GG8
PR
Gene name |
tbp |
Protein name |
TATA-box-binding protein |
Names |
TATA sequence-binding protein, TATA-binding factor, TATA-box factor, Transcription initiation factor TFIID TBP subunit |
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:549093 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q28GG8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q28GG8-F1 | Predicted | AlphaFoldDB |
No variants for Q28GG8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q28GG8 | |||||
No associated diseases with Q28GG8
1 regional properties for Q28GG8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | TATA-box binding protein, conserved site | 241 - 290 | IPR030491 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| transcription factor TFIID complex | A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| general transcription initiation factor activity | A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary. |
| RNA polymerase II general transcription initiation factor activity | A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription. |
| RNA polymerase III general transcription initiation factor activity | A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-templated transcription initiation | The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place. |
| embryo development ending in birth or egg hatching | The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. |
| transcription by RNA polymerase II | The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). |
| transcription by RNA polymerase III | The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q02879 | TBP2 | TATA-box-binding protein 2 | Triticum aestivum (Wheat) | PR |
| P26356 | TBP1 | TATA-box-binding protein 1 | Triticum aestivum (Wheat) | PR |
| P13393 | SPT15 | TATA-box-binding protein | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | EV |
| Q2HJ52 | TBP | TATA-box-binding protein | Bos taurus (Bovine) | PR |
| O13270 | TBP | TATA-box-binding protein | Gallus gallus (Chicken) | PR |
| A6H907 | TBPL2 | TATA box-binding protein-like 2 | Pan troglodytes (Chimpanzee) | PR |
| Q27896 | Trf | TBP-related factor | Drosophila melanogaster (Fruit fly) | PR |
| Q6SJ96 | TBPL2 | TATA box-binding protein-like 2 | Homo sapiens (Human) | PR |
| P20226 | TBP | TATA-box-binding protein | Homo sapiens (Human) | EV |
| P50158 | TBP1 | TATA-box-binding protein 1 | Zea mays (Maize) | PR |
| P50159 | TBP2 | TATA-box-binding protein 2 | Zea mays (Maize) | PR |
| P29037 | Tbp | TATA-box-binding protein | Mus musculus (Mouse) | PR |
| Q6SJ95 | Tbpl2 | TATA box-binding protein-like 2 | Mus musculus (Mouse) | PR |
| P26357 | TBP | TATA-box-binding protein | Solanum tuberosum (Potato) | PR |
| A6H909 | Tbpl2 | TATA box-binding protein-like 2 | Rattus norvegicus (Rat) | PR |
| Q8W0W4 | TBP2 | TATA-binding protein 2 | Oryza sativa subsp japonica (Rice) | PR |
| B2D6P4 | tlf-1 | TATA box-binding protein-like 1 | Caenorhabditis elegans | SS |
| O45211 | Tbp | TATA-box-binding protein | Bombyx mori (Silk moth) | PR |
| Q42808 | TBP1 | TATA-box-binding protein | Glycine max (Soybean) (Glycine hispida) | PR |
| P28148 | TBP2 | TATA-box-binding protein 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P28147 | TBP1 | TATA-box-binding protein 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q28DH2 | tbpl2 | TATA box-binding protein-like 2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q1JPY4 | tbpl2 | TATA box-binding protein-like 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q7SXL3 | tbp | TATA-box-binding protein | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDQNNSIPPF | QGLASPQGSL | TPGINIFSPL | MPYGTGLTPQ | PVQTTNSLSI | LEEQQRQQQQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AQQSTSQQGN | QGSGQTPQLF | HPQTLTTAPL | PGNTPLYPSP | MTPMTPITPA | TPASESSGIV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PQLQNIVSTV | NLGCKLDLKT | IALRARNAEY | NPKRFAAVIM | RIREPRTTAL | IFSSGKMVCT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GAKSEEQSRL | AARKYARVVQ | KLGFPAKFLD | FKIQNMVGSC | DVKFPIRLEG | LVLTHQQFSS |
| 250 | 260 | 270 | 280 | 290 | |
| YEPELFPGLI | YRMIKPRIVL | LIFVSGKVVL | TGAKVRAEIY | EAFENIYPIL | KGFRKTT |