Q28F72

PR
Gene name
ccnc (TGas144o20.1)
Protein name
Cyclin-C
Names
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:394762
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

222-283 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q28F72

Entry ID Method Resolution Chain Position Source
AF-Q28F72-F1 Predicted AlphaFoldDB

No variants for Q28F72

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q28F72

No associated diseases with Q28F72

1 regional properties for Q28F72

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 71 - 233 IPR005225

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
cyclin-dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.

2 GO annotations of biological process

Name Definition
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P47821 SSN8 RNA polymerase II holoenzyme cyclin-like subunit Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q3ZCK5 CCNC Cyclin-C Bos taurus (Bovine) PR
P55168 CCNC Cyclin-C Gallus gallus (Chicken) PR
P25008 CycC Cyclin-C Drosophila melanogaster (Fruit fly) PR
P24863 CCNC Cyclin-C Homo sapiens (Human) PR
Q62447 Ccnc Cyclin-C Mus musculus (Mouse) PR
P39947 Ccnc Cyclin-C Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA LGEHLKLRQQ
70 80 90 100 110 120
VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF GVVSNTRLIS AATSVLKTRF
130 140 150 160 170 180
SYAFPKEFPY RMNHILECEF YLLELMDCCL IVYHPYRPLL QYVQDMGQED MLLPLAWRIV
190 200 210 220 230 240
NDTYRTDLCL LYPPFMIALA CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ
250 260 270 280
WKNFDERKEM ATILNKMPKP KPPPNSEGEQ GTNGSQSSGY SQS