Q28EC1

PR
Gene name
rasgef1b (TNeu048b05.1)
Protein name
Ras-GEF domain-containing family member 1B
Names
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:549667
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

122-211 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q28EC1

Entry ID Method Resolution Chain Position Source
AF-Q28EC1-F1 Predicted AlphaFoldDB

No variants for Q28EC1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q28EC1

No associated diseases with Q28EC1

3 regional properties for Q28EC1

Type Name Position InterPro Accession
domain Ras-like guanine nucleotide exchange factor, N-terminal 33 - 166 IPR000651
domain Ras guanine-nucleotide exchange factors catalytic domain 200 - 453 IPR001895
conserved_site Ras guanine-nucleotide exchange factor, conserved site 370 - 400 IPR019804

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

2 GO annotations of biological process

Name Definition
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.
Ras protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8N9B8 RASGEF1A Ras-GEF domain-containing family member 1A Homo sapiens (Human) PR
Q8N431 RASGEF1C Ras-GEF domain-containing family member 1C Homo sapiens (Human) PR
Q9D300 Rasgef1c Ras-GEF domain-containing family member 1C Mus musculus (Mouse) PR
A0JM95 rasgef1a Ras-GEF domain-containing family member 1A Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
A4IJ06 rasgrp1 RAS guanyl-releasing protein 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
10 20 30 40 50 60
MPQTPTLVAM FDSSSFHRNL YQSKEESCSE LYYQDNNLLS GSLEALIQHL VPNVDYYPDR
70 80 90 100 110 120
TYIFTFLLSS RLFIHPSELM ARVCHVCMEQ QRLNEPGLDK SQVRKIAPKI LQLLTEWTET
130 140 150 160 170 180
FPYDFRDERM MRNLKDTAHR ITNGDEMYRK NVQQIIQNLI RKLASLTQYE ELITKINAQS
190 200 210 220 230 240
TDRMTVLKTK PQSIQRDIIT VCSDPYTVAQ QLTHIELERL SYIGPEEFVQ AFVQKDPLDN
250 260 270 280 290 300
NENCYSDRKK PRNLEAYVEW FNRLSYLVAT EICMPVKKKH RARMIEFFID VARECFNIGN
310 320 330 340 350 360
FNSLMAIISG MNMSPVSRLK KTWAKVKTAK FDILEHQMDP SSNFYNYRTA LRGAAQRSLT
370 380 390 400 410 420
AHSNREKIVI PFCSLLIKDI YFLNEGCTSR LPNGHVNFEK FWELAKQVSE FMTWKQVECP
430 440 450 460 470
FEKDRKILHY VLTAPIFSED ALYLASYESE GPENHIEKDR WKTLRSALLG RA