Q28C55
Gene name |
dlg1 (TEgg018e06.1) |
Protein name |
Disks large homolog 1 |
Names |
|
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:733937 |
EC number |
|
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
717-905 (GK domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Target domain |
717-905 (GK domain) |
Relief mechanism |
Partner binding, Others |
Assay |
|
Accessory elements
No accessory elements
References
- Qian Y et al. (2006) "Interdomain interactions in the tumor suppressor discs large regulate binding to the synaptic protein GukHolder", The Journal of biological chemistry, 281, 35757-63
- McGee AW et al. (1999) "Identification of an intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95", The Journal of biological chemistry, 274, 17431-6
- Brenman JE et al. (1998) "Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A", The Journal of neuroscience : the official journal of the Society for Neuroscience, 18, 8805-13
Autoinhibited structure
Activated structure
1 structures for Q28C55
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q28C55-F1 | Predicted | AlphaFoldDB |
No variants for Q28C55
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q28C55 | |||||
No associated diseases with Q28C55
8 regional properties for Q28C55
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Arf GTPase activating protein | 442 - 565 | IPR001164 |
| domain | SH3 domain | 1067 - 1129 | IPR001452 |
| domain | Pleckstrin homology domain | 327 - 421 | IPR001849 |
| repeat | Ankyrin repeat | 589 - 671 | IPR002110 |
| domain | BAR domain | 54 - 286 | IPR004148 |
| domain | ASAP, PH domain | 319 - 425 | IPR037844 |
| domain | ASAP1, BAR domain | 54 - 268 | IPR037928 |
| domain | ASAP1, SH3 domain | 1071 - 1127 | IPR038016 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| neuromuscular junction | The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| postsynaptic density membrane | The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| kinase binding | Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cell-cell adhesion | The attachment of one cell to another cell via adhesion molecules. |
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| embryo development | The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. |
| establishment or maintenance of epithelial cell apical/basal polarity | Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell. |
| neurotransmitter receptor localization to postsynaptic specialization membrane | A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density). |
| receptor clustering | The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P31007 | dlg1 | Disks large 1 tumor suppressor protein | Drosophila melanogaster (Fruit fly) | EV |
| Q92796 | DLG3 | Disks large homolog 3 | Homo sapiens (Human) | SS |
| Q15700 | DLG2 | Disks large homolog 2 | Homo sapiens (Human) | SS |
| Q9BXL7 | CARD11 | Caspase recruitment domain-containing protein 11 | Homo sapiens (Human) | EV |
| P78352 | DLG4 | Disks large homolog 4 | Homo sapiens (Human) | SS |
| Q12959 | DLG1 | Disks large homolog 1 | Homo sapiens (Human) | SS |
| Q62108 | Dlg4 | Disks large homolog 4 | Mus musculus (Mouse) | SS |
| Q8CIS0 | Card11 | Caspase recruitment domain-containing protein 11 | Mus musculus (Mouse) | SS |
| P70175 | Dlg3 | Disks large homolog 3 | Mus musculus (Mouse) | SS |
| Q99KF0 | Card14 | Caspase recruitment domain-containing protein 14 | Mus musculus (Mouse) | PR |
| Q91XM9 | Dlg2 | Disks large homolog 2 | Mus musculus (Mouse) | SS |
| Q811D0 | Dlg1 | Disks large homolog 1 | Mus musculus (Mouse) | SS |
| Q62936 | Dlg3 | Disks large homolog 3 | Rattus norvegicus (Rat) | SS |
| Q63622 | Dlg2 | Disks large homolog 2 | Rattus norvegicus (Rat) | EV |
| P31016 | Dlg4 | Disks large homolog 4 | Rattus norvegicus (Rat) | SS |
| Q62696 | Dlg1 | Disks large homolog 1 | Rattus norvegicus (Rat) | SS |
| G5ECY0 | dlg-1 | Disks large homolog 1 | Caenorhabditis elegans | SS |
| Q6R005 | dlg4 | Disks large homolog 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5PYH7 | dlg2 | Disks large homolog 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5PYH5 | dlg1l | Discs large homolog 1-like protein | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPVRKQDTQR | ALTLLEEYRC | KLHQTEDKQL | RKSIERVIGI | FQSNLFQALI | DIQEFYEVTL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LDNPKSSDNA | KPTEPVQTIN | TWEYSSLPNS | TATCETLPSS | LILNVEKYRY | PDDDITSQEP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SSPHMLNDGR | NVELVQISEK | NISQKENIQG | LVSHSLISPL | KTPEADTPCP | PIVPVIPVIP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VPAESNVIPS | STPQANPPPV | IVNTDLETPA | YVNGTDAEYE | YEEITLERGT | SGLGFSIAGG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TDNPHIGDDI | SIFITKIISG | GAAAQDGRLR | VNDCILRVNE | VDVHDVTHSK | AVEALKEAGS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IVRLYVRRRK | PVTEKIMDIK | LVKGPKGLGF | SIAGGVGNQH | IPGDNSIYVT | KIIEGGAAHK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DGRLQIGDKL | LAVNTVCLEE | VSHEDAVTAL | KNTSDFVNLK | VAKPTTMYMN | DNYAPPDITN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SYSQQVDNHI | SPSGFIGHPL | PPSPGRYSPA | PKGMLEDDDL | TREPRKVVLQ | RGTTGLGFNI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VGGEDGEGIF | ISFILAGGPA | DLSGELQKGD | RIMSVNGVDL | KSATHEQAAA | ALKNAGQTVT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IVAQYRPEEY | SRFEAKIHDL | REQMMNSSIS | SGSGSLRTSQ | KRSLYVRALF | DYDKTKDSGL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PSQGLNFKFG | DILHVVNASD | DEWWQARQVT | ADGESEEIGV | IPSKRRVEKK | ERARLKTVKF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NSKARGDKGQ | SFNDKRKKNL | FSRKFPFYKN | KDQSEMETSD | VDQHVTSNAS | DSESSYRGQE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EYVLSYEPVN | QQEVNYSRPV | IILGPTKDRV | NDDLISEFPE | KFGSCVPHTT | RPKRDYEIDG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RDYHFVTSRE | QMEKDIQDHR | FIEAGQYNSH | LYGTSVQSVK | EVAERGKHCI | LDVSGNAIKR |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LQIAQLYPIA | IFIKPKSVEN | IIEMSKRVTE | EQGRKTYERA | MKLEQEFTEH | FTAIVQGDTL |
| 910 | 920 | ||||
| EEIYNQIKQI | IEEQSSTFIW | VPAKEKL |