Q28864

SS
Gene name
TFPI (TFPI1)
Protein name
Tissue factor pathway inhibitor
Names
TFPI , Extrinsic pathway inhibitor , EPI , Lipoprotein-associated coagulation inhibitor , LACI
Species
Macaca mulatta (Rhesus macaque)
KEGG Pathway
mcc:613026
EC number
Protein Class

Descriptions

Kunitz-type protease inhibitor 2 (or hepatocyte growth factor activator inhibitor type 2 (HAI-2)) is an integral membrane Kunitz-type serine protease inhibitor that regulates the proteolysis of matriptase and prostasin in a cell-type selective manner. The vast majority of non-glycosylated HAI-2 is synthesized into multiple disulfide-linked oligomers, which lack protease inhibitory function, likely due to distorted conformations caused by the disarrayed disulfide linkages. N-glycosylation on Asn-57 is required for folding into a functional HAI-2 with full protease suppressive activity and correct subcellular targeting signal.

Autoinhibitory domains (AIDs)

73-74 (N-glycosylation site) SS

Target domain

51-105 (Pancreatic trypsin inhibitor Kunitz domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q28864

Entry ID Method Resolution Chain Position Source
AF-Q28864-F1 Predicted AlphaFoldDB

No variants for Q28864

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q28864

No associated diseases with Q28864

6 regional properties for Q28864

Type Name Position InterPro Accession
domain Pancreatic trypsin inhibitor Kunitz domain 51 - 105 IPR002223-1
domain Pancreatic trypsin inhibitor Kunitz domain 123 - 176 IPR002223-2
domain Pancreatic trypsin inhibitor Kunitz domain 215 - 268 IPR002223-3
conserved_site Proteinase inhibitor I2, Kunitz, conserved site 82 - 100 IPR020901-1
conserved_site Proteinase inhibitor I2, Kunitz, conserved site 153 - 171 IPR020901-2
conserved_site Proteinase inhibitor I2, Kunitz, conserved site 245 - 263 IPR020901-3

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase.

1 GO annotations of biological process

Name Definition
blood coagulation The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q7YRQ8 TFPI2 Tissue factor pathway inhibitor 2 Bos taurus (Bovine) SS
Q868Z9 Ppn Papilin Drosophila melanogaster (Fruit fly) SS
M9PE65 axo Axotactin Drosophila melanogaster (Fruit fly) SS
P49223 SPINT3 Kunitz-type protease inhibitor 3 Homo sapiens (Human) SS
P48307 TFPI2 Tissue factor pathway inhibitor 2 Homo sapiens (Human) SS
O43291 SPINT2 Kunitz-type protease inhibitor 2 Homo sapiens (Human) EV
O43278 SPINT1 Kunitz-type protease inhibitor 1 Homo sapiens (Human) EV
P10646 TFPI Tissue factor pathway inhibitor Homo sapiens (Human) SS
Q9R097 Spint1 Kunitz-type protease inhibitor 1 Mus musculus (Mouse) SS
O35536 Tfpi2 Tissue factor pathway inhibitor 2 Mus musculus (Mouse) SS
Q9WU03 Spint2 Kunitz-type protease inhibitor 2 Mus musculus (Mouse) SS
O54819 Tfpi Tissue factor pathway inhibitor Mus musculus (Mouse) SS
Q02445 Tfpi Tissue factor pathway inhibitor Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MIYTMKKVHA LWVSICLMLN LAPAPLNADS EEDEEYTIIT DTELPPLKLM HSFCAFKPDD
70 80 90 100 110 120
GPCKAIMKRF FFNIFTRQCE EFIYGGCGGN QNRFESMEEC KKVCTRDNVH RIIQTALQQE
130 140 150 160 170 180
KPDFCFLEED PGICRGYITR YFYNNQSKQC ERFKYGGCLG NMNNFETLEE CKNTCEDGLN
190 200 210 220 230 240
GFQVDNYGTQ LNAVNNSQTP QSTKVPSFFE FHGPSWCLAP ADRGLCRANE NRFYYNSVIG
250 260 270 280 290 300
KCRPFKYSGC GGNENNFTSK RECLRACKKG FIQRISKGGL IKTKRKRKKQ RVKIAYEEVF
VKNM