Q28279
Gene name |
CNGA1 (CNCG, CNCG1) |
Protein name |
cGMP-gated cation channel alpha-1 |
Names |
Cyclic nucleotide-gated cation channel 1, Cyclic nucleotide-gated channel alpha-1, CNG channel alpha-1, CNG-1, CNG1, Cyclic nucleotide-gated channel, photoreceptor, Rod photoreceptor cGMP-gated channel subunit alpha |
Species |
Canis lupus familiaris (Dog) (Canis familiaris) |
KEGG Pathway |
cfa:403891 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q28279
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q28279-F1 | Predicted | AlphaFoldDB |
No variants for Q28279
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q28279 | |||||
No associated diseases with Q28279
5 regional properties for Q28279
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclic nucleotide-binding domain | 478 - 602 | IPR000595 |
| domain | Ion transport domain | 166 - 405 | IPR005821 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 505 - 521 | IPR018488-1 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 543 - 566 | IPR018488-2 |
| domain | Cyclic nucleotide-gated channel, C-terminal leucine zipper domain | 594 - 663 | IPR032406 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| intracellular cyclic nucleotide activated cation channel complex | A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| cGMP binding | Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). |
| intracellular cAMP-activated cation channel activity | Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts. |
| intracellular cGMP-activated cation channel activity | Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts. |
| protein-containing complex binding | Binding to a macromolecular complex. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cation transmembrane transport | The process in which a cation is transported across a membrane. |
| response to stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. |
| visual perception | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q00194 | CNGA1 | cGMP-gated cation channel alpha-1 | Bos taurus (Bovine) | PR |
| Q90980 | Cyclic nucleotide-gated channel rod photoreceptor subunit alpha | Gallus gallus (Chicken) | PR | |
| P29973 | CNGA1 | cGMP-gated cation channel alpha-1 | Homo sapiens (Human) | PR |
| P29974 | Cnga1 | cGMP-gated cation channel alpha-1 | Mus musculus (Mouse) | PR |
| Q62927 | Cnga1 | cGMP-gated cation channel alpha-1 | Rattus norvegicus (Rat) | PR |
| Q9SU64 | CNGC16 | Probable cyclic nucleotide-gated ion channel 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SKD7 | CNGC3 | Probable cyclic nucleotide-gated ion channel 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDR2 | CNGC19 | Putative cyclic nucleotide-gated ion channel 19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKKNIINTWY | SFVNIPNVIV | PDIEKEIRRM | ENGARSSFSD | DDGDDDSASM | FEESENETPH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ARDSCRNNSQ | RRDPSQREQY | LPGAIALFNV | NNSSNKEQEP | KEKKKKKKEK | KSKSGDKNEN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KKDSEKKKKK | EKEKEKKNKE | EKGKDKKEEE | KKEVMVIDPA | GNMYYNWLFC | ITLPVMYNWT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MVIARACFDE | LQSDYLEYWI | IFDYLSDIVY | LLDMFVRTRT | GYLEQGLLVR | EEAKLIEKYK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SNLQFKLDFL | SVIPTDLLYF | KLGWNYPEIR | LNRLLRISRM | FEFFQRTETR | TNYPNIFRIS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NLVMYIVIII | HWNACVYFSI | SKAIGFGNDT | WVYPDVNDPE | FGRLARKYVY | SLYWSTLTLT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TIGETPPPVR | DSEYVFVVVD | FLIGVLIFAT | IVGNIGSMIS | NMNAARAEFQ | ARIDAIKQYM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HFRNVSKDME | KRVIKWFDYL | WTNKKTVDEK | EVLKYLPDKL | RAEIAINVHL | DTLKKVRIFA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DCEAGLLVEL | VLKLQPQVYS | PGDYICKKGD | IGREMYIIKE | GKLAVVADDG | ITQFVVLSDG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SYFGEISILN | IKGSKAGNRR | TANIKSIGYS | DLFCLSKDDL | MEALTEYPDA | KTMLEEKGKQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ILMKDGLLDI | NIANAGSDPK | DLEEKVTRME | GSVDLLQTRF | ARILAEYESM | QQKLKQRLTK |
| 670 | 680 | 690 | |||
| VERFLKPIID | TEFSALEGTG | DESRPLDSTQ | D |