Q24K06
PR
Gene name |
LRRC10 |
Protein name |
Leucine-rich repeat-containing protein 10 |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:517750 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q24K06
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q24K06-F1 | Predicted | AlphaFoldDB |
70 variants for Q24K06
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs467481905 | 3 | N>D | No | EVA | |
| rs466571072 | 5 | I>L | No | EVA | |
| rs431942505 | 5 | I>S | No | EVA | |
| rs475486314 | 7 | A>G | No | EVA | |
| rs437777336 | 9 | V>G | No | EVA | |
| rs454543556 | 10 | A>G | No | EVA | |
| rs442850693 | 13 | P>A | No | EVA | |
| rs459846049 | 15 | D>E | No | EVA | |
| rs473431830 | 16 | R>H | No | EVA | |
| rs459271820 | 20 | Y>H | No | EVA | |
| rs482490952 | 20 | Y>S | No | EVA | |
| rs715967436 | 21 | V>M | No | EVA | |
| rs444652344 | 22 | A>S | No | EVA | |
| rs481661549 | 23 | R>K | No | EVA | |
| rs446545311 | 24 | D>A | No | EVA | |
| rs466669401 | 25 | L>V | No | EVA | |
| rs445576175 | 28 | M>I | No | EVA | |
| rs469123496 | 31 | D>Y | No | EVA | |
| rs437816251 | 34 | V>G | No | EVA | |
| rs454580511 | 35 | D>G | No | EVA | |
| rs468256552 | 41 | L>P | No | EVA | |
| rs433759814 | 46 | V>A | No | EVA | |
| rs453373060 | 49 | C>G | No | EVA | |
| rs473510257 | 50 | S>T | No | EVA | |
| rs452484602 | 53 | E>D | No | EVA | |
| rs438807470 | 53 | E>G | No | EVA | |
| rs476102881 | 55 | V>F | No | EVA | |
| rs461629740 | 60 | S>R | No | EVA | |
| rs444791120 | 60 | S>T | No | EVA | |
| rs481707136 | 62 | N>T | No | EVA | |
| rs440564337 | 63 | R>L | No | EVA | |
| rs460223589 | 72 | G>V | No | EVA | |
| rs477105021 | 73 | Q>P | No | EVA | |
| rs445614962 | 75 | Q>L | No | EVA | |
| rs468759520 | 76 | N>S | No | EVA | |
| rs482422912 | 78 | Q>P | No | EVA | |
| rs1118163537 | 79 | I>T | No | EVA | |
| rs468484568 | 87 | F>S | No | EVA | |
| rs433801609 | 112 | D>A | No | EVA | |
| rs453867227 | 115 | R>G | No | EVA | |
| rs432396800 | 116 | E>D | No | EVA | |
| rs452623525 | 117 | L>R | No | EVA | |
| rs475837069 | 118 | S>N | No | EVA | |
| rs444429132 | 130 | A>S | No | EVA | |
| rs439311501 | 149 | L>F | No | EVA | |
| rs462475293 | 150 | H>Y | No | EVA | |
| rs447972678 | 155 | A>G | No | EVA | |
| rs432936035 | 166 | L>P | No | EVA | |
| rs446195186 | 182 | F>L | No | EVA | |
| rs469451182 | 185 | V>L | No | EVA | |
| rs454884274 | 194 | I>T | No | EVA | |
| rs475315886 | 195 | I>S | No | EVA | |
| rs434226443 | 201 | S>T | No | EVA | |
| rs471247443 | 204 | Y>F | No | EVA | |
| rs462514071 | 206 | P>L | No | EVA | |
| rs476088035 | 209 | A>P | No | EVA | |
| rs461721035 | 210 | H>P | No | EVA | |
| rs441584851 | 210 | H>Y | No | EVA | |
| rs447586734 | 231 | A>D | No | EVA | |
| rs457947566 | 232 | K>N | No | EVA | |
| rs478024828 | 235 | R>P | No | EVA | |
| rs469489890 | 243 | E>A | No | EVA | |
| rs438064678 | 244 | T>S | No | EVA | |
| rs468644722 | 246 | E>A | No | EVA | |
| rs471086883 | 257 | L>S | No | EVA | |
| rs433373609 | 262 | S>G | No | EVA | |
| rs456541597 | 264 | E>G | No | EVA | |
| rs441750496 | 268 | P>L | No | EVA | |
| rs472263429 | 272 | P>A | No | EVA | |
| rs440770863 | 275 | P>R | No | EVA |
No associated diseases with Q24K06
1 regional properties for Q24K06
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 7 - 162 | IPR005225 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| sarcomere | The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| alpha-actinin binding | Binding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| cardiac muscle cell development | The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state. |
36 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3MHH9 | ECM2 | Extracellular matrix protein 2 | Bos taurus (Bovine) | PR |
| P58874 | OPTC | Opticin | Bos taurus (Bovine) | PR |
| Q9V780 | Lap1 | Protein lap1 | Drosophila melanogaster (Fruit fly) | PR |
| Q96NW7 | LRRC7 | Leucine-rich repeat-containing protein 7 | Homo sapiens (Human) | PR |
| Q8IWT6 | LRRC8A | Volume-regulated anion channel subunit LRRC8A | Homo sapiens (Human) | PR |
| Q9HCJ2 | LRRC4C | Leucine-rich repeat-containing protein 4C | Homo sapiens (Human) | PR |
| Q9UFC0 | LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1 | Homo sapiens (Human) | PR |
| Q96L50 | LRR1 | Leucine-rich repeat protein 1 | Homo sapiens (Human) | PR |
| Q86UN2 | RTN4RL1 | Reticulon-4 receptor-like 1 | Homo sapiens (Human) | PR |
| Q8IWK6 | ADGRA3 | Adhesion G protein-coupled receptor A3 | Homo sapiens (Human) | PR |
| Q7L1W4 | LRRC8D | Volume-regulated anion channel subunit LRRC8D | Homo sapiens (Human) | PR |
| Q96FE5 | LINGO1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Homo sapiens (Human) | PR |
| Q8TDW0 | LRRC8C | Volume-regulated anion channel subunit LRRC8C | Homo sapiens (Human) | PR |
| Q38SD2 | LRRK1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Homo sapiens (Human) | EV |
| A6H694 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Mus musculus (Mouse) | PR |
| Q9D9Q0 | Lrrc69 | Leucine-rich repeat-containing protein 69 | Mus musculus (Mouse) | PR |
| Q8BGI7 | Lrrc39 | Leucine-rich repeat-containing protein 39 | Mus musculus (Mouse) | PR |
| Q7TT36 | Adgra3 | Adhesion G protein-coupled receptor A3 | Mus musculus (Mouse) | PR |
| P59383 | Lrrn4 | Leucine-rich repeat neuronal protein 4 | Mus musculus (Mouse) | PR |
| Q9D1T0 | Lingo1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Mus musculus (Mouse) | PR |
| Q8R502 | Lrrc8c | Volume-regulated anion channel subunit LRRC8C | Mus musculus (Mouse) | PR |
| Q80WG5 | Lrrc8a | Volume-regulated anion channel subunit LRRC8A | Mus musculus (Mouse) | PR |
| Q8K0S5 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Mus musculus (Mouse) | PR |
| Q80TE7 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Mus musculus (Mouse) | PR |
| Q5DU41 | Lrrc8b | Volume-regulated anion channel subunit LRRC8B | Mus musculus (Mouse) | PR |
| Q5RKR3 | Islr2 | Immunoglobulin superfamily containing leucine-rich repeat protein 2 | Mus musculus (Mouse) | PR |
| Q8C031 | Lrrc4c | Leucine-rich repeat-containing protein 4C | Mus musculus (Mouse) | PR |
| P70587 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Rattus norvegicus (Rat) | PR |
| Q4V8G0 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Rattus norvegicus (Rat) | PR |
| Q80WD0 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Rattus norvegicus (Rat) | PR |
| Q9TZM3 | lrk-1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Caenorhabditis elegans | SS |
| Q9SHI4 | RLP3 | Receptor-like protein 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5G5E0 | PIRL5 | Plant intracellular Ras-group-related LRR protein 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| B0JZ65 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q68F79 | lrrc8e | Volume-regulated anion channel subunit LRRC8E | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| B0R160 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGNTIRAFVA | FIPADRCQNY | VARDLREMPL | DRMVDLSGSQ | LRRFPVHVCS | FQELVKLYLS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DNRLNSLPPE | LGQLQNLQIL | ALDFNNFKAL | PQVVCTLKQL | CILYLGNNKL | CDLPRELSLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QNLRTLWVEA | NYLTKLPEVV | CELSLLKTLH | AGSNALRLLP | GQLQRLRELR | TIWLSGNLLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DFPPVLLHMP | FLEIIDVDRN | SIRYFPSLAH | LSSLKLVIYD | HNPCRNAPKV | AKGVRRVGRW |
| 250 | 260 | 270 | |||
| AEETPEPDPR | KARRYALARE | ESQEAQLPAL | PPLPPTNS |