Q24564

SS
Gene name
Mer (EMR2, CG14228)
Protein name
Moesin/ezrin/radixin homolog 2
Names
Ezrin-moesin-radixin 2 , Merlin , dMerlin
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG14228
EC number
Protein Class

Descriptions

Ezrin is a multidomain protein providing regulated membrane-cytoskeleton contacts that play a role in cell differentiation, adhesion, and migration. Within the cytosol of resting cells ezrin resides in an autoinhibited conformation in which the N- and C-terminal ezrin/radixin/moesin (ERM) association domains (ERMADs) interact with one another. The N-terminal ERMAD is also known as the FERM domain. The two domains inhibit each other. Activation of the ezrin membrane-cytoskeleton linker function requires an opening of this interdomain association that can result from phosphatidylinositol 4,5-bisphosphate binding to the N-ERMAD and threonine 567 phosphorylation in the C-ERMAD. Ezrin can also be activated by Ca2+-dependent binding of the EF-hand protein S100P.

Autoinhibitory domains (AIDs)

12-305 (FERM domain) SS

Target domain

552-635 (C-terminal ERM)

Relief mechanism

Ligand binding, Partner binding

Assay

552-635 (C-terminal ERM) SS

Target domain

12-305 (FERM domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q24564

Entry ID Method Resolution Chain Position Source
7EDR X-ray 253 A PDB
AF-Q24564-F1 Predicted AlphaFoldDB

No variants for Q24564

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q24564

No associated diseases with Q24564

8 regional properties for Q24564

Type Name Position InterPro Accession
domain FERM domain 12 - 305 IPR000299
domain Ezrin/radixin/moesin, C-terminal 560 - 635 IPR011259
domain FERM, N-terminal 20 - 76 IPR018979
domain FERM, C-terminal PH-like domain 220 - 309 IPR018980
domain FERM central domain 101 - 216 IPR019748
domain Band 4.1 domain 8 - 216 IPR019749
domain ERM family, FERM domain C-lobe 210 - 306 IPR041789
domain Ezrin/radixin/moesin, alpha-helical domain 340 - 459 IPR046810

Functions

Description
EC Number
Subcellular Localization
  • Cell junction, adherens junction
  • Cell membrane; Peripheral membrane protein; Cytoplasmic side
  • Cytoplasm, cytoskeleton
  • Apical cell membrane
  • Cell projection, rhabdomere
  • Membrane-associated, adherens junctions and endocytic compartments
  • Cytoplasmic, punctate
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

15 GO annotations of cellular component

Name Definition
adherens junction A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
apical part of cell The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
apicomedial cortex The region that lies just beneath the plasma membrane in the middle of the apical edge of a cell.
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic side of apical plasma membrane The side (leaflet) of the apical region of the plasma membrane that faces the cytoplasm.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
filopodium Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
Kibra-Ex-Mer complex An apical protein complex that contains the proteins Kibra, Expanded and Merlin (Mer), or orthologs thereof. In humans, the complex contains KIBRA, FDM6 and NF2.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
Nebenkern A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
rhabdomere The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction.
subapical part of cell The region of a polarized cell that is just below the apical region. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue so the subapical region is further from the exposed surface and closer to the basal lamina.

3 GO annotations of molecular function

Name Definition
actin binding Binding to monomeric or multimeric forms of actin, including actin filaments.
identical protein binding Binding to an identical protein or proteins.
integrin binding Binding to an integrin.

34 GO annotations of biological process

Name Definition
axis specification The establishment, maintenance and elaboration of a pattern along a line or around a point.
cell-cell signaling Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
compound eye morphogenesis The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
compound eye photoreceptor cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.
endocytic recycling The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle.
epithelial structure maintenance A tissue homeostatic process required for the maintenance of epithelial structure.
hippo signaling The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.
male meiosis cytokinesis A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells.
meiotic chromosome separation The process in which chromosomes are physically detached from each other during meiosis.
negative regulation of cell population proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of glial cell proliferation Any process that stops or decreases the rate or extent of glial cell proliferation.
negative regulation of organ growth Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism.
pole plasm mRNA localization Any process in which mRNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster.
positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of cell-cell adhesion Any process that activates or increases the rate or extent of cell adhesion to another cell.
positive regulation of early endosome to late endosome transport Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport.
positive regulation of hippo signaling Any process that activates or increases the frequency, rate or extent of hippo signaling.
positive regulation of protein localization to early endosome Any process that activates or increases the frequency, rate or extent of protein localization to early endosome.
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
protein localization to plasma membrane A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
R8 cell development The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium.
R8 cell fate specification The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
regulation of cell differentiation Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
regulation of cell growth Any process that modulates the frequency, rate, extent or direction of cell growth.
regulation of cell population proliferation Any process that modulates the frequency, rate or extent of cell proliferation.
regulation of cell shape Any process that modulates the surface configuration of a cell.
regulation of compound eye retinal cell programmed cell death Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.
regulation of gliogenesis Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia.
regulation of hippo signaling Any process that modulates the frequency, rate or extent of hippo signaling.
regulation of organelle assembly Any process that modulates the frequency, rate or extent of organelle assembly.
regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction.
sperm individualization The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

21 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P31976 EZR Ezrin Bos taurus (Bovine) PR
Q2HJ49 MSN Moesin Bos taurus (Bovine) PR
Q32LP2 RDX Radixin Bos taurus (Bovine) SS
Q9PU45 RDX Radixin Gallus gallus (Chicken) PR
P46150 Moe Moesin/ezrin/radixin homolog 1 Drosophila melanogaster (Fruit fly) SS
Q3KP66 INAVA Innate immunity activator protein Homo sapiens (Human) PR
P15311 EZR Ezrin Homo sapiens (Human) EV
P26038 MSN Moesin Homo sapiens (Human) EV
P35241 RDX Radixin Homo sapiens (Human) SS
P35240 NF2 Merlin Homo sapiens (Human) EV
A2AD83 Frmd7 FERM domain-containing protein 7 Mus musculus (Mouse) PR
P26040 Ezr Ezrin Mus musculus (Mouse) SS
P26041 Msn Moesin Mus musculus (Mouse) SS
P26043 Rdx Radixin Mus musculus (Mouse) SS
P46662 Nf2 Merlin Mus musculus (Mouse) SS
P26042 MSN Moesin Sus scrofa (Pig) PR
P26044 RDX Radixin Sus scrofa (Pig) SS
O35763 Msn Moesin Rattus norvegicus (Rat) SS
P31977 Ezr Ezrin Rattus norvegicus (Rat) SS
Q63648 Nf2 Merlin Rattus norvegicus (Rat) SS
Q6Q413 nf2b NF2, moesin-ezrin-radixin-like Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MSPFGSKKNR SLSVRVSTFD SELEFKLEPR ASGQDLFDLV CRTIGLRESW YFGLQYVDTR
70 80 90 100 110 120
SNVSWLKMEK RVRDQRVELH ASNNVYVFSF YAKFFPENVS EELIQEITQH LFFLQVKQSI
130 140 150 160 170 180
LSMDIYCRPE ASVLLASYAV HVQYGPYDYE TYKDGMLAGG ELLPKGVTDQ YQMTPEMWEE
190 200 210 220 230 240
RIKTWYMDHE PMTRDEVEME YLKIAQDLDM YGVNYFPITN KNKTKLWLGV TSVGLNIYDE
250 260 270 280 290 300
RDKLTPKTTF QWNEIRHVSF DDKKFTIRLV DAKVSNFIFY SQDLHINKMI LDLCKGNHDL
310 320 330 340 350 360
YMRRRKPDTM EIQQMKAQAK EEKQRRQIER KKFIREKKLR EKAEHERYEL EKSMEHLQNE
370 380 390 400 410 420
MRMANDALRR SEETKELYFE KSRVNEEQMQ LTECKANHFK TEMDRLRERQ MKIEREKHDL
430 440 450 460 470 480
EKKIRDADFY VHQLTVENDK REAETEKLRK ELICAKMAER EATARLLEFL NSGRKSSTDS
490 500 510 520 530 540
LLTASSVSHA ANTASSMAAI STPSLITSSS TNDLETAGGA ELTTHSSHYL VQGDNSSGIS
550 560 570 580 590 600
DDFEPKEFIL TDNEMEQITN EMERNHLDYL RNSKQVQSQL QTLRSEIAPH KIEENQSNLD
610 620 630
ILSEAQIKAG ENKYSTLKKL KSGSTKARVA FFEEL