Q24488
Gene name |
Ror (CG4926) |
Protein name |
Tyrosine-protein kinase transmembrane receptor Ror |
Names |
dRor , EC 2.7.10.1 |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG4926 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
410-670 (Protein kinase domain) |
Relief mechanism |
Others |
Assay |
|
Accessory elements
556-581 (Activation loop from InterPro)
Target domain |
410-677 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Artim SC et al. (2012) "Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family", The Biochemical journal, 448, 213-20
- Uchikawa E et al. (2019) "Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex", eLife, 8,
- Nielsen J et al. (2022) "Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling", Journal of molecular biology, 434, 167458
- Chen YS et al. (2021) "Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone-receptor activation", Proceedings of the National Academy of Sciences of the United States of America, 118,
- Craddock BP et al. (2007) "Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region", FEBS letters, 581, 3235-40
Autoinhibited structure
Activated structure
1 structures for Q24488
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q24488-F1 | Predicted | AlphaFoldDB |
No variants for Q24488
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q24488 | |||||
No associated diseases with Q24488
17 regional properties for Q24488
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 582 - 910 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 582 - 910 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class III, conserved site | 641 - 654 | IPR001824 |
| domain | Immunoglobulin subtype 2 | 215 - 285 | IPR003598-1 |
| domain | Immunoglobulin subtype 2 | 410 - 492 | IPR003598-2 |
| domain | Immunoglobulin subtype | 27 - 102 | IPR003599-1 |
| domain | Immunoglobulin subtype | 112 - 196 | IPR003599-2 |
| domain | Immunoglobulin subtype | 209 - 296 | IPR003599-3 |
| domain | Immunoglobulin subtype | 308 - 399 | IPR003599-4 |
| domain | Immunoglobulin subtype | 404 - 504 | IPR003599-5 |
| domain | Immunoglobulin-like domain | 21 - 85 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 203 - 290 | IPR007110-2 |
| domain | Immunoglobulin-like domain | 402 - 502 | IPR007110-3 |
| active_site | Tyrosine-protein kinase, active site | 774 - 786 | IPR008266 |
| domain | Immunoglobulin | 209 - 292 | IPR013151 |
| binding_site | Protein kinase, ATP binding site | 588 - 616 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 582 - 910 | IPR020635 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein tyrosine kinase activity | Catalysis of the reaction |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction |
| Wnt-protein binding | Binding to a Wnt-protein, a secreted growth factor involved in signaling. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| central nervous system development | The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. |
| positive regulation of neuron projection development | Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
32 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q91044 | NTRK3 | NT-3 growth factor receptor | Gallus gallus (Chicken) | SS |
| Q91987 | NTRK2 | BDNF/NT-3 growth factors receptor | Gallus gallus (Chicken) | SS |
| Q91009 | NTRK1 | High affinity nerve growth factor receptor | Gallus gallus (Chicken) | SS |
| Q8AXY6 | MUSK | Muscle, skeletal receptor tyrosine protein kinase | Gallus gallus (Chicken) | SS |
| Q5IS37 | NTRK3 | NT-3 growth factor receptor | Pan troglodytes (Chimpanzee) | SS |
| Q9V6K3 | Nrk | Tyrosine-protein kinase transmembrane receptor Ror2 | Drosophila melanogaster (Fruit fly) | SS |
| P09208 | InR | Insulin-like receptor | Drosophila melanogaster (Fruit fly) | SS |
| Q07407 | htl | Fibroblast growth factor receptor homolog 1 | Drosophila melanogaster (Fruit fly) | PR |
| O15146 | MUSK | Muscle, skeletal receptor tyrosine-protein kinase | Homo sapiens (Human) | EV |
| P04629 | NTRK1 | High affinity nerve growth factor receptor | Homo sapiens (Human) | EV |
| Q16288 | NTRK3 | NT-3 growth factor receptor | Homo sapiens (Human) | SS |
| Q16620 | NTRK2 | BDNF/NT-3 growth factors receptor | Homo sapiens (Human) | EV |
| Q01974 | ROR2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Homo sapiens (Human) | EV |
| Q01973 | ROR1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Homo sapiens (Human) | PR |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| Q9Z139 | Ror1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Mus musculus (Mouse) | PR |
| P24786 | NTRK3 | NT-3 growth factor receptor | Sus scrofa (Pig) | SS |
| Q62838 | Musk | Muscle, skeletal receptor tyrosine protein kinase | Rattus norvegicus (Rat) | SS |
| P35739 | Ntrk1 | High affinity nerve growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q03351 | Ntrk3 | NT-3 growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q63604 | Ntrk2 | BDNF/NT-3 growth factors receptor | Rattus norvegicus (Rat) | SS |
| G5EGK5 | cam-1 | Tyrosine-protein kinase receptor cam-1 | Caenorhabditis elegans | SS |
| P93050 | BSH | Probable LRR receptor-like serine/threonine-protein kinase RKF3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1G4 | LECRK15 | Probable L-type lectin-domain containing receptor kinase I.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M345 | LECRK42 | L-type lectin-domain containing receptor kinase IV.2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96285 | LECRK55 | L-type lectin-domain containing receptor kinase V.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FNE1 | CRK42 | Cysteine-rich receptor-like protein kinase 42 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDQ3 | CRK34 | Cysteine-rich receptor-like protein kinase 34 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNKYSAFIVC | ISLVLLFTKK | DVGSHNVDSR | IYGFQQSSGI | CHIYNGTICR | DVLSNAHVFV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SPNLTMNDLE | ERLKAAYGVI | KESKDMNANC | RMYALPSLCF | SSMPICRTPE | RTNLLYFANV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ATNAKQLKNV | SIRRKRTKSK | DIKNISIFKK | KSTIYEDVFS | TDISSKYPPT | RESENLKRIC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| REECELLENE | LCQKEYAIAK | RHPVIGMVGV | EDCQKLPQHK | DCLSLGITIE | VDKTENCYWE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DGSTYRGVAN | VSASGKPCLR | WSWLMKEISD | FPELIGQNYC | RNPGSVENSP | WCFVDSSRER |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IIELCDIPKC | ADKIWIAIVG | TTAAIILIFI | IIFAIILFKR | RTIMHYGMRN | IHNINTPSAD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KNIYGNSQLN | NAQDAGRGNL | GNLSDHVALN | SKLIERNTLL | RINHFTLQDV | EFLEELGEGA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FGKVYKGQLL | QPNKTTITVA | IKALKENASV | KTQQDFKREI | ELISDLKHQN | IVCILGVVLN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KEPYCMLFEY | MANGDLHEFL | ISNSPTEGKS | LSQLEFLQIA | LQISEGMQYL | SAHHYVHRDL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AARNCLVNEG | LVVKISDFGL | SRDIYSSDYY | RVQSKSLLPV | RWMPSESILY | GKFTTESDVW |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SFGVVLWEIY | SYGMQPYYGF | SNQEVINLIR | SRQLLSAPEN | CPTAVYSLMI | ECWHEQSVKR |
| 670 | 680 | ||||
| PTFTDISNRL | KTWHEGHFKA | SNPEM |