Q24008
PR
Gene name |
inaD (CG3504) |
Protein name |
Inactivation-no-after-potential D protein |
Names |
|
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG3504 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
9 structures for Q24008
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1IHJ | X-ray | 180 A | A/B | 11-107 | PDB |
| 2LA8 | NMR | - | A | 580-665 | PDB |
| 2QKT | X-ray | 205 A | A/B | 580-665 | PDB |
| 2QKU | X-ray | 220 A | A/B/C | 580-665 | PDB |
| 2QKV | X-ray | 155 A | A/B | 580-665 | PDB |
| 3R0H | X-ray | 260 A | A/B/C/D/E/F/G/H | 473-674 | PDB |
| 5F67 | X-ray | 176 A | A/B | 345-448 | PDB |
| 6IRE | X-ray | 325 A | B | 478-671 | PDB |
| AF-Q24008-F1 | Predicted | AlphaFoldDB |
No variants for Q24008
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q24008 | |||||
No associated diseases with Q24008
5 regional properties for Q24008
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PDZ domain | 17 - 106 | IPR001478-1 |
| domain | PDZ domain | 249 - 333 | IPR001478-2 |
| domain | PDZ domain | 364 - 448 | IPR001478-3 |
| domain | PDZ domain | 489 - 576 | IPR001478-4 |
| domain | PDZ domain | 584 - 664 | IPR001478-5 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| inaD signaling complex | A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD. |
| rhabdomere | The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| myosin binding | Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. |
| myosin III binding | Binding to a class III myosin; myosin III is monomeric and has an N terminal kinase domain. |
| photoreceptor activity | The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. |
| signaling receptor complex adaptor activity | The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to light stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. |
| deactivation of rhodopsin mediated signaling | The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon). |
| detection of light stimulus involved in sensory perception | The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. |
| phototransduction | The sequence of reactions within a cell required to convert absorbed photons into a molecular signal. |
| protein localization | Any process in which a protein is transported to, or maintained in, a specific location. |
| sensory perception of sound | The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. |
| visual perception | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SZK8 | NHERF1 | Na | Bos taurus (Bovine) | SS |
| Q5ZM14 | NHERF1 | Na | Gallus gallus (Chicken) | SS |
| Q9Y6N9 | USH1C | Harmonin | Homo sapiens (Human) | PR |
| O14745 | SLC9A3R1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | Homo sapiens (Human) | EV |
| Q86UT5 | PDZD3 | Na(+)/H(+) exchange regulatory cofactor NHE-RF4 | Homo sapiens (Human) | PR |
| Q6ZWJ1 | STXBP4 | Syntaxin-binding protein 4 | Homo sapiens (Human) | PR |
| P70441 | Slc9a3r1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | Mus musculus (Mouse) | PR |
| Q99MJ6 | Pdzd3 | Na(+)/H(+) exchange regulatory cofactor NHE-RF4 | Mus musculus (Mouse) | PR |
| Q9JIL4 | Pdzk1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF3 | Mus musculus (Mouse) | PR |
| Q0QWG9 | Grid2ip | Delphilin | Mus musculus (Mouse) | PR |
| Q9JJ40 | Pdzk1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF3 | Rattus norvegicus (Rat) | PR |
| Q9JJ19 | Nherf1 | Na | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVQFLGKQGT | AGELIHMVTL | DKTGKKSFGI | CIVRGEVKDS | PNTKTTGIFI | KGIVPDSPAH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LCGRLKVGDR | ILSLNGKDVR | NSTEQAVIDL | IKEADFKIEL | EIQTFDKSDE | QQAKSDPRSN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GYMQAKNKFN | QEQTTNNNAS | GGQGMGQGQG | QGQGMAGMNR | QQSMQKRNTT | FTASMRQKHS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NYADEDDEDT | RDMTGRIRTE | AGYEIDRASA | GNCKLNKQEK | DRDKEQEDEF | GYTMAKINKR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YNMMKDLRRI | EVQRDASKPL | GLALAGHKDR | QKMACFVAGV | DPNGALGSVD | IKPGDEIVEV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NGNVLKNRCH | LNASAVFKNV | DGDKLVMITS | RRKPNDEGMC | VKPIKKFPTA | SDETKFIFDQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FPKARTVQVR | KEGFLGIMVI | YGKHAEVGSG | IFISDLREGS | NAELAGVKVG | DMLLAVNQDV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TLESNYDDAT | GLLKRAEGVV | TMILLTLKSE | EAIKAEKAAE | EKKKEEAKKE | EEKPQEPATA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EIKPNKKILI | ELKVEKKPMG | VIVCGGKNNH | VTTGCVITHV | YPEGQVAADK | RLKIFDHICD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| INGTPIHVGS | MTTLKVHQLF | HTTYEKAVTL | TVFRADPPEL | EKFNVDLMKK | AGKELGLSLS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PNEIGCTIAD | LIQGQYPEID | SKLQRGDIIT | KFNGDALEGL | PFQVCYALFK | GANGKVSMEV |
| 670 | |||||
| TRPKPTLRTE | APKA |