Q23551
EV
Gene name |
unc-22 |
Protein name |
Twitchin |
Names |
Uncoordinated protein 22 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
|
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3 (PTHR14340) |
Descriptions
Twitchin kinase is a regulator of muscle contraction and relaxation by unfolding. Twitchin kinase is autoinhibited by a 60-residue-long regulatory tail that lies just C-terminal of the kinase catalytic core (called the C-terminal regulatory domain, CRD). The CRD wedges itself between the two subdomains of the catalytic core, blocking binding sites for ATP and protein substrates. In addition, an N-terminal linker (NL) of 45 residues lying between the Fn3 domain and the kinase catalytic core inhibits kinase activity. The CRD of twitchin is important for binding to MAK-1, which is an activator of twitchin kinase. Molecular dynamics simulation revealed that the NL is released by pulling force.
Autoinhibitory domains (AIDs)
Target domain |
6261-6516 (Protein kinase domain) |
Relief mechanism |
Partner binding |
Assay |
Structural analysis, Deletion assay |
Target domain |
6261-6516 (Protein kinase domain) |
Relief mechanism |
Others |
Assay |
Structural analysis, Deletion assay |
Accessory elements
6401-6423 (Activation loop from InterPro)
Target domain |
6261-6516 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Hu SH et al. (1994) "Insights into autoregulation from the crystal structure of twitchin kinase", Nature, 369, 581-4
- von Castelmur E et al. (2012) "Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase", Proceedings of the National Academy of Sciences of the United States of America, 109, 13608-13
- Matsunaga Y et al. (2015) "Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle", Molecular biology of the cell, 26, 2096-111
- Kobe B et al. (1996) "Giant protein kinases: domain interactions and structural basis of autoregulation", The EMBO journal, 15, 6810-21
No variants for Q23551
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q23551 | |||||
No associated diseases with Q23551
137 regional properties for Q23551
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 6261 - 6516 | IPR000719 |
| domain | Immunoglobulin subtype 2 | 16 - 88 | IPR003598-1 |
| domain | Immunoglobulin subtype 2 | 123 - 195 | IPR003598-2 |
| domain | Immunoglobulin subtype 2 | 390 - 457 | IPR003598-3 |
| domain | Immunoglobulin subtype 2 | 992 - 1061 | IPR003598-4 |
| domain | Immunoglobulin subtype 2 | 1141 - 1208 | IPR003598-5 |
| domain | Immunoglobulin subtype 2 | 1234 - 1302 | IPR003598-6 |
| domain | Immunoglobulin subtype 2 | 1326 - 1393 | IPR003598-7 |
| domain | Immunoglobulin subtype 2 | 1808 - 1875 | IPR003598-8 |
| domain | Immunoglobulin subtype 2 | 2104 - 2172 | IPR003598-9 |
| domain | Immunoglobulin subtype 2 | 2400 - 2466 | IPR003598-10 |
| domain | Immunoglobulin subtype 2 | 2692 - 2758 | IPR003598-11 |
| domain | Immunoglobulin subtype 2 | 2985 - 3053 | IPR003598-12 |
| domain | Immunoglobulin subtype 2 | 3282 - 3349 | IPR003598-13 |
| domain | Immunoglobulin subtype 2 | 3576 - 3644 | IPR003598-14 |
| domain | Immunoglobulin subtype 2 | 3870 - 3937 | IPR003598-15 |
| domain | Immunoglobulin subtype 2 | 4459 - 4522 | IPR003598-16 |
| domain | Immunoglobulin subtype 2 | 5545 - 5612 | IPR003598-17 |
| domain | Immunoglobulin subtype 2 | 5935 - 6002 | IPR003598-18 |
| domain | Immunoglobulin subtype 2 | 6031 - 6098 | IPR003598-19 |
| domain | Immunoglobulin subtype 2 | 6597 - 6664 | IPR003598-20 |
| domain | Immunoglobulin subtype 2 | 6720 - 6786 | IPR003598-21 |
| domain | Immunoglobulin subtype 2 | 6875 - 6943 | IPR003598-22 |
| domain | Immunoglobulin subtype 2 | 6984 - 7050 | IPR003598-23 |
| domain | Immunoglobulin subtype 2 | 7079 - 7146 | IPR003598-24 |
| domain | Immunoglobulin subtype | 10 - 99 | IPR003599-1 |
| domain | Immunoglobulin subtype | 117 - 206 | IPR003599-2 |
| domain | Immunoglobulin subtype | 384 - 468 | IPR003599-3 |
| domain | Immunoglobulin subtype | 986 - 1072 | IPR003599-4 |
| domain | Immunoglobulin subtype | 1135 - 1215 | IPR003599-5 |
| domain | Immunoglobulin subtype | 1228 - 1310 | IPR003599-6 |
| domain | Immunoglobulin subtype | 1320 - 1400 | IPR003599-7 |
| domain | Immunoglobulin subtype | 1409 - 1490 | IPR003599-8 |
| domain | Immunoglobulin subtype | 1502 - 1592 | IPR003599-9 |
| domain | Immunoglobulin subtype | 1802 - 1886 | IPR003599-10 |
| domain | Immunoglobulin subtype | 2098 - 2183 | IPR003599-11 |
| domain | Immunoglobulin subtype | 2394 - 2477 | IPR003599-12 |
| domain | Immunoglobulin subtype | 2686 - 2769 | IPR003599-13 |
| domain | Immunoglobulin subtype | 2979 - 3064 | IPR003599-14 |
| domain | Immunoglobulin subtype | 3276 - 3360 | IPR003599-15 |
| domain | Immunoglobulin subtype | 3570 - 3655 | IPR003599-16 |
| domain | Immunoglobulin subtype | 3864 - 3948 | IPR003599-17 |
| domain | Immunoglobulin subtype | 4156 - 4240 | IPR003599-18 |
| domain | Immunoglobulin subtype | 4453 - 4533 | IPR003599-19 |
| domain | Immunoglobulin subtype | 4845 - 4930 | IPR003599-20 |
| domain | Immunoglobulin subtype | 5141 - 5226 | IPR003599-21 |
| domain | Immunoglobulin subtype | 5538 - 5623 | IPR003599-22 |
| domain | Immunoglobulin subtype | 5632 - 5717 | IPR003599-23 |
| domain | Immunoglobulin subtype | 5929 - 6013 | IPR003599-24 |
| domain | Immunoglobulin subtype | 6025 - 6109 | IPR003599-25 |
| domain | Immunoglobulin subtype | 6591 - 6675 | IPR003599-26 |
| domain | Immunoglobulin subtype | 6714 - 6797 | IPR003599-27 |
| domain | Immunoglobulin subtype | 6869 - 6954 | IPR003599-28 |
| domain | Immunoglobulin subtype | 6978 - 7061 | IPR003599-29 |
| domain | Immunoglobulin subtype | 7073 - 7157 | IPR003599-30 |
| domain | Fibronectin type III | 1595 - 1690 | IPR003961-1 |
| domain | Fibronectin type III | 1694 - 1791 | IPR003961-2 |
| domain | Fibronectin type III | 1889 - 1988 | IPR003961-3 |
| domain | Fibronectin type III | 1992 - 2087 | IPR003961-4 |
| domain | Fibronectin type III | 2186 - 2282 | IPR003961-5 |
| domain | Fibronectin type III | 2286 - 2383 | IPR003961-6 |
| domain | Fibronectin type III | 2480 - 2576 | IPR003961-7 |
| domain | Fibronectin type III | 2579 - 2675 | IPR003961-8 |
| domain | Fibronectin type III | 2772 - 2868 | IPR003961-9 |
| domain | Fibronectin type III | 2872 - 2968 | IPR003961-10 |
| domain | Fibronectin type III | 2976 - 3055 | IPR003961-11 |
| domain | Fibronectin type III | 3067 - 3165 | IPR003961-12 |
| domain | Fibronectin type III | 3169 - 3265 | IPR003961-13 |
| domain | Fibronectin type III | 3363 - 3459 | IPR003961-14 |
| domain | Fibronectin type III | 3463 - 3559 | IPR003961-15 |
| domain | Fibronectin type III | 3658 - 3753 | IPR003961-16 |
| domain | Fibronectin type III | 3757 - 3853 | IPR003961-17 |
| domain | Fibronectin type III | 3951 - 4047 | IPR003961-18 |
| domain | Fibronectin type III | 4051 - 4146 | IPR003961-19 |
| domain | Fibronectin type III | 4243 - 4340 | IPR003961-20 |
| domain | Fibronectin type III | 4344 - 4440 | IPR003961-21 |
| domain | Fibronectin type III | 4536 - 4631 | IPR003961-22 |
| domain | Fibronectin type III | 4635 - 4733 | IPR003961-23 |
| domain | Fibronectin type III | 4737 - 4834 | IPR003961-24 |
| domain | Fibronectin type III | 4933 - 5028 | IPR003961-25 |
| domain | Fibronectin type III | 5032 - 5129 | IPR003961-26 |
| domain | Fibronectin type III | 5229 - 5326 | IPR003961-27 |
| domain | Fibronectin type III | 5331 - 5427 | IPR003961-28 |
| domain | Fibronectin type III | 5430 - 5528 | IPR003961-29 |
| domain | Fibronectin type III | 5720 - 5817 | IPR003961-30 |
| domain | Fibronectin type III | 5821 - 5919 | IPR003961-31 |
| domain | Fibronectin type III | 6112 - 6207 | IPR003961-32 |
| domain | Immunoglobulin-like domain | 5 - 97 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 111 - 204 | IPR007110-2 |
| domain | Immunoglobulin-like domain | 377 - 466 | IPR007110-3 |
| domain | Immunoglobulin-like domain | 980 - 1072 | IPR007110-4 |
| domain | Immunoglobulin-like domain | 1122 - 1213 | IPR007110-5 |
| domain | Immunoglobulin-like domain | 1217 - 1306 | IPR007110-6 |
| domain | Immunoglobulin-like domain | 1312 - 1398 | IPR007110-7 |
| domain | Immunoglobulin-like domain | 2086 - 2181 | IPR007110-8 |
| domain | Immunoglobulin-like domain | 2679 - 2763 | IPR007110-9 |
| domain | Immunoglobulin-like domain | 2972 - 3062 | IPR007110-10 |
| domain | Immunoglobulin-like domain | 3268 - 3358 | IPR007110-11 |
| domain | Immunoglobulin-like domain | 3563 - 3653 | IPR007110-12 |
| domain | Immunoglobulin-like domain | 4445 - 4531 | IPR007110-13 |
| domain | Immunoglobulin-like domain | 5533 - 5621 | IPR007110-14 |
| domain | Immunoglobulin-like domain | 5923 - 6011 | IPR007110-15 |
| domain | Immunoglobulin-like domain | 6016 - 6107 | IPR007110-16 |
| domain | Immunoglobulin-like domain | 6585 - 6673 | IPR007110-17 |
| domain | Immunoglobulin-like domain | 6696 - 6795 | IPR007110-18 |
| domain | Immunoglobulin-like domain | 6863 - 6952 | IPR007110-19 |
| domain | Immunoglobulin-like domain | 6958 - 7059 | IPR007110-20 |
| domain | Immunoglobulin-like domain | 7067 - 7149 | IPR007110-21 |
| active_site | Serine/threonine-protein kinase, active site | 6378 - 6390 | IPR008271 |
| domain | Immunoglobulin I-set | 5 - 97 | IPR013098-1 |
| domain | Immunoglobulin I-set | 111 - 204 | IPR013098-2 |
| domain | Immunoglobulin I-set | 382 - 467 | IPR013098-3 |
| domain | Immunoglobulin I-set | 980 - 1071 | IPR013098-4 |
| domain | Immunoglobulin I-set | 1136 - 1204 | IPR013098-5 |
| domain | Immunoglobulin I-set | 1316 - 1389 | IPR013098-6 |
| domain | Immunoglobulin I-set | 1404 - 1477 | IPR013098-7 |
| domain | Immunoglobulin I-set | 1802 - 1885 | IPR013098-8 |
| domain | Immunoglobulin I-set | 2097 - 2182 | IPR013098-9 |
| domain | Immunoglobulin I-set | 2393 - 2476 | IPR013098-10 |
| domain | Immunoglobulin I-set | 2685 - 2768 | IPR013098-11 |
| domain | Immunoglobulin I-set | 2978 - 3063 | IPR013098-12 |
| domain | Immunoglobulin I-set | 3270 - 3359 | IPR013098-13 |
| domain | Immunoglobulin I-set | 3572 - 3654 | IPR013098-14 |
| domain | Immunoglobulin I-set | 3866 - 3947 | IPR013098-15 |
| domain | Immunoglobulin I-set | 4150 - 4239 | IPR013098-16 |
| domain | Immunoglobulin I-set | 4454 - 4532 | IPR013098-17 |
| domain | Immunoglobulin I-set | 4844 - 4929 | IPR013098-18 |
| domain | Immunoglobulin I-set | 5142 - 5225 | IPR013098-19 |
| domain | Immunoglobulin I-set | 5533 - 5622 | IPR013098-20 |
| domain | Immunoglobulin I-set | 5923 - 6012 | IPR013098-21 |
| domain | Immunoglobulin I-set | 6029 - 6108 | IPR013098-22 |
| domain | Immunoglobulin I-set | 6585 - 6674 | IPR013098-23 |
| domain | Immunoglobulin I-set | 6709 - 6796 | IPR013098-24 |
| domain | Immunoglobulin I-set | 6863 - 6953 | IPR013098-25 |
| domain | Immunoglobulin I-set | 6981 - 7058 | IPR013098-26 |
| domain | Immunoglobulin I-set | 7068 - 7144 | IPR013098-27 |
| binding_site | Protein kinase, ATP binding site | 6267 - 6290 | IPR017441 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | PTHR14340 | MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3 |
| PANTHER Subfamily | PTHR14340:SF24 | SUBFAMILY NOT NAMED |
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| A band | The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| metal ion binding | Binding to a metal ion. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein serine/threonine/tyrosine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| adult locomotory behavior | Locomotory behavior in a fully developed and mature organism. |
| behavioral response to nicotine | Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus. |
| modulation of age-related behavioral decline | OBSOLETE. Any process that modulates the processes that arise as an organism progresses toward the end of its lifespan that results in a decline in behavioral activities such as locomotory behavior, and learning or memory. |
| negative regulation of cell division | Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| peptidyl-threonine phosphorylation | The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. |
| positive regulation of locomotion | Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. |
| positive regulation of sarcomere organization | Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. |
| positive regulation of striated muscle contraction | Any process that activates or increases the frequency, rate or extent of striated muscle contraction. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P11799 | Mylk | Myosin light chain kinase, smooth muscle | Gallus gallus (Chicken) | SS |
| Q15746 | MYLK | Myosin light chain kinase, smooth muscle | Homo sapiens (Human) | SS |
| Q8WZ42 | TTN | Titin | Homo sapiens (Human) | EV |
| Q6PDN3 | Mylk | Myosin light chain kinase, smooth muscle | Mus musculus (Mouse) | EV |
| Q62407 | Speg | Striated muscle-specific serine/threonine-protein kinase | Mus musculus (Mouse) | SS |
| A2ASS6 | Ttn | Titin | Mus musculus (Mouse) | SS |
| Q63638 | Speg | Striated muscle-specific serine/threonine-protein kinase | Rattus norvegicus (Rat) | SS |
| P97924 | Kalrn | Kalirin | Rattus norvegicus (Rat) | SS |
| G4SLH0 | ttn-1 | Titin homolog | Caenorhabditis elegans | EV |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVGAPRFTQK | PSIQQTPTGD | LLMECHLEAD | PQPTIAWQHS | GNLLEPSGRV | VQTLTPLGGS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LYKATLVIKE | PNAGDGGAYK | CTARNQLGES | NANINLNFAG | AGGDEAKSRG | PSFVGKPRII |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PKDGGALIVM | ECKVKSASTP | VAKWMKDGVP | LSMGGLYHAI | FSDLGDQTYL | CQLEIRGPSS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SDAGQYRCNI | RNDQGETNAN | LALNFEEPDP | SERQERKRST | ASPRPSSRGP | GSRPSSPKKS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MKSREGTPKR | TLKPREGSPS | KKLRSRTSTP | VNEEVSQSES | RRSSRTDKME | VDQVSGASKR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KPDGLPPPGG | DEKKLRAGSP | STRKSPSRKS | ASPTPSRKGS | SAGGAASGTT | GASASATSAT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SGGSASSDAS | RDKYTRPPIV | LEASRSQTGR | IGGSVVLEVQ | WQCHSSTIIE | WYRDGTLVRN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SSEYSQSFNG | SIAKLQVNKL | TEEKSGLYKC | HAKCDYGEGQ | SSAMVKIEQS | DVEEELMKHR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KDAEDEYQKE | EQKSQTLQAE | TKKRVARRSK | SKSKSPAPQA | KKSTTSESGR | QEASEVEHKR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SSSVRPDPDE | ESQLDEIPSS | GLTIPEERRR | ELLGQVGESD | DEVSESISEL | PSFAGGKPRR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KTDSPPKQDD | MFSRDTLLRK | TTTSTKNESS | TVEEKTKLRK | TVKKVDGELD | FKAMVKLKKV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KKEEGGTTEK | SGFPLDHADS | TSSVLSQESR | SRRGSNAPFA | KDGLPEQPAN | PFAQLKKVKS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GAGGLEKSDS | MASLKKLDLK | KGKIDDNSDG | AFKVQLKKVV | KKEVKESTIS | VKEKNGTESG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| IKTEFKMEKR | ERTTLQKYEK | TDSDGSKKED | KPKKVSIAPV | STNKSSDDEP | STPRHHKEVE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| EKSTSEELKA | KVAGRQVGQK | RNGAQKPEEP | KNLLSQIQLK | KVTKKAHDDT | NELEGIKLKK |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VTTVPKHVAD | DDSQSESESR | RGSVFGELRR | GSRAPRDSAD | NSRRDSIRRS | SIDMRRESVQ |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| EILEKTSTPL | VPSGASGSAP | KIVEVPENVT | VVENETAILT | CKVSGSPAPT | FRWFKGSREV |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| ISGGRFKHIT | DGKEHTVALA | LLKCRSQDEG | PYTLTIENVH | GTDSADVKLL | VTSDNGLDFR |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| AMLKHRESQA | GFQKDGEGGG | AGGGGGEKKP | MTEAERRQSL | FPGKKVEKWD | IPLPEKTVQQ |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| QVDKICEWKC | TYSRPNAKIR | WYKDRKEIFS | GGLKYKIVIE | KNVCTLIINN | PEVDDTGKYT |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| CEANGVPTHA | QLTVLEPPMK | YSFLNPLPNT | QEIYRTKQAV | LTCKVNTPRA | PLVWYRGSKA |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| IQEGDPRFII | EKDAVGRCTL | TIKEVEEDDQ | AEWTARITQD | VFSKVQVYVE | EPRHTFVVPM |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| KSQKVNESDL | ATLETDVNDK | DAEVVWWHDG | KRIDIDGVKF | KVESSNRKRR | LIINGARIED |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| HGEYKCTTKD | DRTMAQLIVD | AKNKFIVALK | DTEVIEKDDV | TLMCQTKDTK | TPGIWFRNGK |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| QISSMPGGKF | ETQSRNGTHT | LKIGKIEMNE | ADVYEIDQAG | LRGSCNVTVL | EAEKRPILNW |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| KPKKIEAKAG | EPCVVKVPFQ | IKGTRRGDPK | AQILKNGKPI | DEEMRKLVEV | IIKDDVAEIV |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| FKNPQLADTG | KWALELGNSA | GTALAPFELF | VKDKPKPPKG | PLETKNVTAE | GLDLVWGTPD |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| PDEGAPVKAY | IIEMQEGRSG | NWAKVGETKG | TDFKVKDLKE | HGEYKFRVKA | LNECGLSDPL |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| TGESVLAKNP | YGVPGKPKNM | DAIDVDKDHC | TLAWEPPEED | GGAPITGYII | ERREKSEKDW |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| HQVGQTKPDC | CELTDKKVVE | DKEYLYRVKA | VNKAGPGDPC | DHGKPIKMKA | KKASPEFTGG |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| GIKDLRLKVG | ETIKYDVPIS | GEPLPECLWV | VNGKPLKAVG | RVKMSSERGK | HIMKIENAVR |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| ADSGKFTITL | KNSSGSCDST | ATVTVVGRPT | PPKGPLDIAD | VCADGATLSW | NPPDDDGGDP |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| LTGYIVEAQD | MDNKGKYIEV | GKVDPNTTTL | KVNGLRNKGN | YKFRVKAVNN | EGESEPLSAD |
| 1990 | 2000 | 2010 | 2020 | 2030 | 2040 |
| QYTQIKDPWD | EPGKPGRPEI | TDFDADRIDI | AWEPPHKDGG | APIEEYIVEV | RDPDTKEWKE |
| 2050 | 2060 | 2070 | 2080 | 2090 | 2100 |
| VKRVPDTNAS | ISGLKEGKEY | QFRVRAVNKA | GPGQPSEPSE | KQLAKPKFIP | AWLKHDNLKS |
| 2110 | 2120 | 2130 | 2140 | 2150 | 2160 |
| ITVKAGATVR | WEVKIGGEPI | PEVKWFKGNQ | QLENGIQLTI | DTRKNEHTIL | CIPSAMRSDV |
| 2170 | 2180 | 2190 | 2200 | 2210 | 2220 |
| GEYRLTVKNS | HGADEEKANL | TVLDRPSKPN | GPLEVSDVFE | DNLNLSWKPP | DDDGGEPIEY |
| 2230 | 2240 | 2250 | 2260 | 2270 | 2280 |
| YEVEKLDTAT | GRWVPCAKVK | DTKAHIDGLK | KGQTYQFRVK | AVNKEGASDA | LSTDKDTKAK |
| 2290 | 2300 | 2310 | 2320 | 2330 | 2340 |
| NPYDEPGKTG | TPDVVDWDAD | RVSLEWEPPK | SDGGAPITQY | VIEKKGKHGR | DWQECGKVSG |
| 2350 | 2360 | 2370 | 2380 | 2390 | 2400 |
| DQTNAEILGL | KEGEEYQFRV | KAVNKAGPGE | ASDPSRKVVA | KPRNLKPWID | REAMKTITIK |
| 2410 | 2420 | 2430 | 2440 | 2450 | 2460 |
| VGNDVEFDVP | VRGEPPPKKE | WIFNEKPVDD | QKIRIESEDY | KTRFVLRGAT | RKHAGLYTLT |
| 2470 | 2480 | 2490 | 2500 | 2510 | 2520 |
| ATNASGSDKH | SVEVIVLGKP | SSPLGPLEVS | NVYEDRADLE | WKVPEDDGGA | PIDHYEIEKM |
| 2530 | 2540 | 2550 | 2560 | 2570 | 2580 |
| DLATGRWVPC | GRSETTKTTV | PNLQPGHEYK | FRVRAVNKEG | ESDPLTTNTA | ILAKNPYEVP |
| 2590 | 2600 | 2610 | 2620 | 2630 | 2640 |
| GKVDKPELVD | WDKDHVDLAW | NAPDDGGAPI | EAFVIEKKDK | NGRWEEALVV | PGDQKTATVP |
| 2650 | 2660 | 2670 | 2680 | 2690 | 2700 |
| NLKEGEEYQF | RISARNKAGT | GDPSDPSDRV | VAKPRNLAPR | IHREDLSDTT | VKVGATLKFI |
| 2710 | 2720 | 2730 | 2740 | 2750 | 2760 |
| VHIDGEPAPD | VTWSFNGKGI | GESKAQIENE | PYISRFALPK | ALRKQSGKYT | ITATNINGTD |
| 2770 | 2780 | 2790 | 2800 | 2810 | 2820 |
| SVTINIKVKS | KPTKPKGPIE | VTDVFEDRAT | LDWKPPEDDG | GEPIEFYEIE | KMNTKDGIWV |
| 2830 | 2840 | 2850 | 2860 | 2870 | 2880 |
| PCGRSGDTHF | TVDSLNKGDH | YKFRVKAVNS | EGPSDPLETE | TDILAKNPFD | RPDRPGRPEP |
| 2890 | 2900 | 2910 | 2920 | 2930 | 2940 |
| TDWDSDHVDL | KWDPPLSDGG | APIEEYQIEK | RTKYGRWEPA | ITVPGGQTTA | TVPDLTPNEE |
| 2950 | 2960 | 2970 | 2980 | 2990 | 3000 |
| YEFRVVAVNK | GGPSDPSDAS | KAVIAKPRNL | KPHIDRDALK | NLTIKAGQSI | SFDVPVSGEP |
| 3010 | 3020 | 3030 | 3040 | 3050 | 3060 |
| APTVTWHWPD | NREIRNGGRV | KLDNPEYQSK | LVVKQMERGD | SGTFTIKAVN | ANGEDEATVK |
| 3070 | 3080 | 3090 | 3100 | 3110 | 3120 |
| INVIDKPTSP | NGPLDVSDVH | GDHVTLNWRA | PDDDGGIPIE | NYVIEKYDTA | SGRWVPAAKV |
| 3130 | 3140 | 3150 | 3160 | 3170 | 3180 |
| AGDKTTAVVD | GLIPGHEYKF | RVAAVNAEGE | SDPLETFGTT | LAKDPFDKPG | KTNAPEITDW |
| 3190 | 3200 | 3210 | 3220 | 3230 | 3240 |
| DKDHVDLEWK | PPANDGGAPI | EEYVVEMKDE | FSPFWNDVAH | VPAGQTNATV | GNLKEGSKYE |
| 3250 | 3260 | 3270 | 3280 | 3290 | 3300 |
| FRIRAKNKAG | LGDPSDSASA | VAKARNVPPV | IDRNSIQEIK | VKAGQDFSLN | IPVSGEPTPT |
| 3310 | 3320 | 3330 | 3340 | 3350 | 3360 |
| ITWTFEGTPV | ESDDRMKLNN | EDGKTKFHVK | RALRSDTGTY | IIKAENENGT | DTAEVKVTVL |
| 3370 | 3380 | 3390 | 3400 | 3410 | 3420 |
| DHPSSPRGPL | DVTNIVKDGC | DLAWKEPEDD | GGAEISHYVI | EKQDAATGRW | TACGESKDTN |
| 3430 | 3440 | 3450 | 3460 | 3470 | 3480 |
| FHVDDLTQGH | EYKFRVKAVN | RHGDSDPLEA | REAIIAKDPF | DRADKPGTPE | IVDWDKDHAD |
| 3490 | 3500 | 3510 | 3520 | 3530 | 3540 |
| LKWTPPADDG | GAPIEGYLVE | MRTPSGDWVP | AVTVGAGELT | ATVDGLKPGQ | TYQFRVKALN |
| 3550 | 3560 | 3570 | 3580 | 3590 | 3600 |
| KAGESTPSDP | SRTMVAKPRH | LAPKINRDMF | VAQRVKAGQT | LNFDVNVEGE | PAPKIEWFLN |
| 3610 | 3620 | 3630 | 3640 | 3650 | 3660 |
| GSPLSSGGNT | HIDNNTDNNT | KLTTKSTARA | DSGKYKIVAT | NESGKDEHEV | DVNILDIPGA |
| 3670 | 3680 | 3690 | 3700 | 3710 | 3720 |
| PEGPLRHKDI | TKESVVLKWD | EPLDDGGSPI | TNYVVEKQED | GGRWVPCGET | SDTSLKVNKL |
| 3730 | 3740 | 3750 | 3760 | 3770 | 3780 |
| SEGHEYKFRV | KAVNRQGTSA | PLTSDHAIVA | KNPFDEPDAP | TDVTPVDWDK | DHVDLEWKPP |
| 3790 | 3800 | 3810 | 3820 | 3830 | 3840 |
| ANDGGAPIDA | YIVEKKDKFG | DWVECARVDG | KTTKATADNL | TPGETYQFRV | KAVNKAGPGK |
| 3850 | 3860 | 3870 | 3880 | 3890 | 3900 |
| PSDPTGNVVA | KPRRMAPKLN | LAGLLDLRIK | AGTPIKLDIA | FEGEPAPVAK | WKANDATIDT |
| 3910 | 3920 | 3930 | 3940 | 3950 | 3960 |
| GARADVTNTP | TSSAIHIFSA | VRGDTGVYKI | IVENEHGKDT | AQCNVTVLDV | PGTPEGPLKI |
| 3970 | 3980 | 3990 | 4000 | 4010 | 4020 |
| DEIHKEGCTL | NWKPPTDNGG | TDVLHYIVEK | MDTSRGTWQE | VGTFPDCTAK | VNKLVPGKEY |
| 4030 | 4040 | 4050 | 4060 | 4070 | 4080 |
| AFRVKAVNLQ | GESKPLEAEE | PIIAKNQFDV | PDPVDKPEVT | DWDKDRIDIK | WNPTANNGGA |
| 4090 | 4100 | 4110 | 4120 | 4130 | 4140 |
| PVTGYIVEKK | EKGSAIWTEA | GKTPGTTFSA | DNLKPGVEYE | FRVIAVNAAG | PSDPSDPTDP |
| 4150 | 4160 | 4170 | 4180 | 4190 | 4200 |
| QITKARYLKP | KILTASRKIK | IKAGFTHNLE | VDFIGAPDPT | ATWTVGDSGA | ALAPELLVDA |
| 4210 | 4220 | 4230 | 4240 | 4250 | 4260 |
| KSSTTSIFFP | SAKRADSGNY | KLKVKNELGE | DEAIFEVIVQ | DRPSAPEGPL | EVSDVTKDSC |
| 4270 | 4280 | 4290 | 4300 | 4310 | 4320 |
| VLNWKPPKDD | GGAEISNYVV | EKRDTKTNTW | VPVSAFVTGT | SITVPKLTEG | HEYEFRVMAE |
| 4330 | 4340 | 4350 | 4360 | 4370 | 4380 |
| NTFGRSDSLN | TDEPVLAKDP | FGTPGKPGRP | EIVDTDNDHI | DIKWDPPRDN | GGSPVDHYDI |
| 4390 | 4400 | 4410 | 4420 | 4430 | 4440 |
| ERKDAKTGRW | IKVNTSPVQG | TAFSDTRVQK | GHTYEYRVVA | VNKAGPGQPS | DSSAAATAKP |
| 4450 | 4460 | 4470 | 4480 | 4490 | 4500 |
| MHEAPKFDLD | LDGKEFRVKA | GEPLVITIPF | TASPQPDISW | TKEGGKPLAG | VETTDSQTKL |
| 4510 | 4520 | 4530 | 4540 | 4550 | 4560 |
| VIPSTRRSDS | GPVKIKAVNP | YGEAEANIKI | TVIDKPGAPE | NITYPAVSRH | TCTLNWDAPK |
| 4570 | 4580 | 4590 | 4600 | 4610 | 4620 |
| DDGGAEIAGY | KIEYQEVGSQ | IWDKVPGLIS | GTAYTVRGLE | HGQQYRFRIR | AENAVGLSDY |
| 4630 | 4640 | 4650 | 4660 | 4670 | 4680 |
| CQGVPVVIKD | PFDPPGAPST | PEITGYDTNQ | VSLAWNPPRD | DGGSPILGYV | VERFEKRGGG |
| 4690 | 4700 | 4710 | 4720 | 4730 | 4740 |
| DWAPVKMPMV | KGTECIVPGL | HENETYQFRV | RAVNAAGHGE | PSNGSEPVTC | RPYVEKPGAP |
| 4750 | 4760 | 4770 | 4780 | 4790 | 4800 |
| DAPRVGKITK | NSAELTWNRP | LRDGGAPIDG | YIVEKKKLGD | NDWTRCNDKP | VRDTAFEVKN |
| 4810 | 4820 | 4830 | 4840 | 4850 | 4860 |
| LGEKEEYEFR | VIAVNSAGEG | EPSKPSDLVL | IEEQPGRPIF | DINNLKDITV | RAGETIQIRI |
| 4870 | 4880 | 4890 | 4900 | 4910 | 4920 |
| PYAGGNPKPI | IDLFNGNSPI | FENERTVVDV | NPGEIVITTT | GSKRSDAGPY | KISATNKYGK |
| 4930 | 4940 | 4950 | 4960 | 4970 | 4980 |
| DTCKLNVFVL | DAPGKPTGPI | RATDIQADAM | TLSWRPPKDN | GGDAITNYVV | EKRTPGGDWV |
| 4990 | 5000 | 5010 | 5020 | 5030 | 5040 |
| TVGHPVGTTL | RVRNLDANTP | YEFRVRAENQ | YGVGEPLETD | DAIVAKNPFD | TPGAPGQPEA |
| 5050 | 5060 | 5070 | 5080 | 5090 | 5100 |
| VETSEEAITL | QWTRPTSDGG | APIQGYVIEK | REVGSTEWTK | AAFGNILDTK | HRVTGLTPKK |
| 5110 | 5120 | 5130 | 5140 | 5150 | 5160 |
| TYEFRVAAYN | AAGQGEYSVN | SVPITADNAP | TRPKINMGML | TRDILAYAGE | RAKILVPFAA |
| 5170 | 5180 | 5190 | 5200 | 5210 | 5220 |
| SPAPKVTFSK | GENKISPTDP | RVKVEYSDFL | ATLTIEKSEL | TDGGLYFVEL | ENSQGSDSAS |
| 5230 | 5240 | 5250 | 5260 | 5270 | 5280 |
| IRLKVVDKPA | SPQHIRVEDI | APDCCTLYWM | PPSSDGGSPI | TNYIVEKLDL | RHSDGKWEKV |
| 5290 | 5300 | 5310 | 5320 | 5330 | 5340 |
| SSFVRNLNYT | VGGLIKDNRY | RFRVRAETQY | GVSEPCELAD | VVVAKYQFEV | PNQPEAPTVR |
| 5350 | 5360 | 5370 | 5380 | 5390 | 5400 |
| DKDSTWAELE | WDPPRDGGSK | IIGYQVQYRD | TSSGRWINAK | MDLSEQCHAR | VTGLRQNGEF |
| 5410 | 5420 | 5430 | 5440 | 5450 | 5460 |
| EFRIIAKNAA | GFSKPSPPSE | RCQLKSRFGP | PGPPIHVGAK | SIGRNHCTIT | WMAPLEDGGS |
| 5470 | 5480 | 5490 | 5500 | 5510 | 5520 |
| KITGYNVEIR | EYGSTLWTVA | SDYNVREPEF | TVDKLREFND | YEFRVVAINA | AGKGIPSLPS |
| 5530 | 5540 | 5550 | 5560 | 5570 | 5580 |
| GPIKIQESGG | SRPQIVVKPE | DTAQPYNRRA | VFTCEAVGRP | EPTARWLRNG | RELPESSRYR |
| 5590 | 5600 | 5610 | 5620 | 5630 | 5640 |
| FEASDGVYKF | TIKEVWDIDA | GEYTVEVSNP | YGSDTATANL | VVQAPPVIEK | DVPNTILPSG |
| 5650 | 5660 | 5670 | 5680 | 5690 | 5700 |
| DLVRLKIYFS | GTAPFRHSLV | LNREEIDMDH | PTIRIVEFDD | HILITIPALS | VREAGRYEYT |
| 5710 | 5720 | 5730 | 5740 | 5750 | 5760 |
| VSNDSGEATT | GFWLNVTGLP | EAPQGPLHIS | NIGPSTATLS | WRPPVTDGGS | KITSYVVEKR |
| 5770 | 5780 | 5790 | 5800 | 5810 | 5820 |
| DLSKDEWVTV | TSNVKDMNYI | VTGLFENHEY | EFRVSAQNEN | GIGAPLVSEH | PIIARLPFDP |
| 5830 | 5840 | 5850 | 5860 | 5870 | 5880 |
| PTSPLNLEIV | QVGGDYVTLS | WQRPLSDGGG | RLRGYIVEKQ | EEEHDEWFRC | NQNPSPPNNY |
| 5890 | 5900 | 5910 | 5920 | 5930 | 5940 |
| NVPNLIDGRK | YRYRVFAVND | AGLSDLAELD | QTLFQASGSG | EGPKIVSPLS | DLNEEVGRCV |
| 5950 | 5960 | 5970 | 5980 | 5990 | 6000 |
| TFECEISGSP | RPEYRWFKGC | KELVDTSKYT | LINKGDKQVL | IINDLTSDDA | DEYTCRATNS |
| 6010 | 6020 | 6030 | 6040 | 6050 | 6060 |
| SGTRSTRANL | RIKTKPRVFI | PPKYHGGYEA | QKGETIELKI | PYKAYPQGEA | RWTKDGEKIE |
| 6070 | 6080 | 6090 | 6100 | 6110 | 6120 |
| NNSKFSITTD | DKFATLRISN | ASREDYGEYR | VVVENSVGSD | SGTVNVTVAD | VPEPPRFPII |
| 6130 | 6140 | 6150 | 6160 | 6170 | 6180 |
| ENILDEAVIL | SWKPPALDGG | SLVTNYTIEK | REAMGGSWSP | CAKSRYTYTT | IEGLRAGKQY |
| 6190 | 6200 | 6210 | 6220 | 6230 | 6240 |
| EFRIIAENKH | GQSKPCEPTA | PVLIPGDERK | RRRGYDVDEQ | GKIVRGKGTV | SSNYDNYVFD |
| 6250 | 6260 | 6270 | 6280 | 6290 | 6300 |
| IWKQYYPQPV | EIKHDHVLDH | YDIHEELGTG | AFGVVHRVTE | RATGNNFAAK | FVMTPHESDK |
| 6310 | 6320 | 6330 | 6340 | 6350 | 6360 |
| ETVRKEIQTM | SVLRHPTLVN | LHDAFEDDNE | MVMIYEFMSG | GELFEKVADE | HNKMSEDEAV |
| 6370 | 6380 | 6390 | 6400 | 6410 | 6420 |
| EYMRQVCKGL | CHMHENNYVH | LDLKPENIMF | TTKRSNELKL | IDFGLTAHLD | PKQSVKVTTG |
| 6430 | 6440 | 6450 | 6460 | 6470 | 6480 |
| TAEFAAPEVA | EGKPVGYYTD | MWSVGVLSYI | LLSGLSPFGG | ENDDETLRNV | KSCDWNMDDS |
| 6490 | 6500 | 6510 | 6520 | 6530 | 6540 |
| AFSGISEDGK | DFIRKLLLAD | PNTRMTIHQA | LEHPWLTPGN | APGRDSQIPS | SRYTKIRDSI |
| 6550 | 6560 | 6570 | 6580 | 6590 | 6600 |
| KTKYDAWPEP | LPPLGRISNY | SSLRKHRPQE | YSIRDAFWDR | SEAQPRFIVK | PYGTEVGEGQ |
| 6610 | 6620 | 6630 | 6640 | 6650 | 6660 |
| SANFYCRVIA | SSPPVVTWHK | DDRELKQSVK | YMKRYNGNDY | GLTINRVKGD | DKGEYTVRAK |
| 6670 | 6680 | 6690 | 6700 | 6710 | 6720 |
| NSYGTKEEIV | FLNVTRHSEP | LKFEPLEPMK | KAPSPPRVEE | FKERRSAPFF | TFHLRNRLIQ |
| 6730 | 6740 | 6750 | 6760 | 6770 | 6780 |
| KNHQCKLTCS | LQGNPNPTIE | WMKDGHPVDE | DRVQVSFRSG | VCSLEIFNAR | VDDAGTYTVT |
| 6790 | 6800 | 6810 | 6820 | 6830 | 6840 |
| ATNDLGVDVS | ECVLTVQTKG | GEPIPRVSSF | RPRRAYDTLS | TGTDVERSHS | YADMRRRSLI |
| 6850 | 6860 | 6870 | 6880 | 6890 | 6900 |
| RDVSPDVRSA | ADDLKTKITN | ELPSFTAQLS | DSETEVGGSA | EFSAAVSGQP | EPLIEWLHNG |
| 6910 | 6920 | 6930 | 6940 | 6950 | 6960 |
| ERISESDSRF | RASYVAGKAT | LRISDAKKSD | EGQYLCRASN | SAGQEQTRAT | LTVKGDQPLL |
| 6970 | 6980 | 6990 | 7000 | 7010 | 7020 |
| NGHAGQAVES | ELRVTKHLGG | EIVNNGESVT | FEARVQGTPE | EVLWMRNGQE | LTNGDKTSIS |
| 7030 | 7040 | 7050 | 7060 | 7070 | 7080 |
| QDGETLSFTI | NSADASDAGH | YQLEVRSKGT | NLVSVASLVV | VGEKADPPVT | RLPSSVSAPL |
| 7090 | 7100 | 7110 | 7120 | 7130 | 7140 |
| GGSTAFTIEF | ENVEGLTVQW | FRGSEKIEKN | ERVKSVKTGN | TFKLDIKNVE | QDDDGIYVAK |
| 7150 | |||||
| VVKEKKAIAK | YAAALLLV |