Q22516

PR
Gene name
chd-3 (T14G8.1)
Protein name
Chromodomain-helicase-DNA-binding protein 3 homolog
Names
CHD-3
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_T14G8.1
EC number
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

11-100 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q22516

Entry ID Method Resolution Chain Position Source
AF-Q22516-F1 Predicted AlphaFoldDB

No variants for Q22516

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q22516

No associated diseases with Q22516

3 regional properties for Q22516

Type Name Position InterPro Accession
domain 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 236 - 557 IPR002073
domain HD/PDEase domain 309 - 485 IPR003607
conserved_site 3'5'-cyclic nucleotide phosphodiesterase, conserved site 352 - 363 IPR023174

Functions

Description
EC Number 3.6.4.12 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
histone deacetylase complex A protein complex that possesses histone deacetylase activity.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

8 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent chromatin remodeler activity An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling.
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
metal ion binding Binding to a metal ion.

5 GO annotations of biological process

Name Definition
cell fate determination A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.
chromatin remodeling A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.
negative regulation of Ras protein signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
negative regulation of vulval development Any process that stops, prevents, or reduces the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O16102 Chd3 Chromodomain-helicase-DNA-binding protein 3 Drosophila melanogaster (Fruit fly) PR
Q24368 Iswi Chromatin-remodeling complex ATPase chain Iswi Drosophila melanogaster (Fruit fly) SS
Q8TDI0 CHD5 Chromodomain-helicase-DNA-binding protein 5 Homo sapiens (Human) PR
Q12873 CHD3 Chromodomain-helicase-DNA-binding protein 3 Homo sapiens (Human) PR
Q14839 CHD4 Chromodomain-helicase-DNA-binding protein 4 Homo sapiens (Human) PR
O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 Homo sapiens (Human) EV
P28370 SMARCA1 Probable global transcription activator SNF2L1 Homo sapiens (Human) SS
A2A8L1 Chd5 Chromodomain-helicase-DNA-binding protein 5 Mus musculus (Mouse) PR
Q6PDQ2 Chd4 Chromodomain-helicase-DNA-binding protein 4 Mus musculus (Mouse) PR
Q6PGB8 Smarca1 Probable global transcription activator SNF2L1 Mus musculus (Mouse) SS
P40201 Chd1 Chromodomain-helicase-DNA-binding protein 1 Mus musculus (Mouse) PR
Q91ZW3 Smarca5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 Mus musculus (Mouse) SS
D3ZD32 Chd5 Chromodomain-helicase-DNA-binding protein 5 Rattus norvegicus (Rat) PR
P41877 isw-1 Chromatin-remodeling complex ATPase chain isw-1 Caenorhabditis elegans SS
Q9XFH4 DDM1 ATP-dependent DNA helicase DDM1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSDDQHESID GDETMEEDSM LAEGHEDGEE DVGEDEEEVE TEESQGVPTT SEKKKPPPKK
70 80 90 100 110 120
KKGGKKSSKK KNNCDYPDPY KSTSAEISAA IGLTDVDVDY EQEEFQSITN LKNFSSLVKP
130 140 150 160 170 180
YILKVNPGTN VTKMYPLFQV KYKEFQDHMT AHGKSIQKQQ RAKFVPVPVP VTPQEKIIPQ
190 200 210 220 230 240
KTRSSARRKR RDGSDGEGGG HDSDQEFEAL IKQHEKQQDE AEKGKEEARI NRAAAKVDKR
250 260 270 280 290 300
KAALESARAS KRARKEQGVV EENHQENCEV CNQDGELMLC DTCTRAYHVA CIDENMEQPP
310 320 330 340 350 360
EGDWSCPHCE EHGPDVLIVE EEPAKANMDY CRICKETSNI LLCDTCPSSY HAYCIDPPLT
370 380 390 400 410 420
EIPEGEWSCP RCIIPEPAQR IEKILSWRWK EISYPEPLEC KEGEEASKDD VFLKPPRKME
430 440 450 460 470 480
PRREREFFVK WKYLAYWQCE WLSETLMDVY FTALVRMYWR KVDSENPPIF EESTLSRHHS
490 500 510 520 530 540
DHDPYKLRER FYQYGVKPEW MQIHRIINHL SYAKSQQDYL VKWKELSYEH ATWERDDTDI
550 560 570 580 590 600
ANYEDAIIKY WHHRERMLND EVPRNVQKMI AKQREAKGLG PKEDEVTSRR KKREKIDILK
610 620 630 640 650 660
KYEVQPDFIS ETGGNLHPYQ LEGINWLRHC WSNGTDAILA DEMGLGKTVQ SLTFLYTLMK
670 680 690 700 710 720
EGHTKGPFLI AAPLSTIINW EREAELWCPD FYVVTYVGDR ESRMVIREHE FSFVDGAVRG
730 740 750 760 770 780
GPKVSKIKTL ENLKFHVLLT SYECINMDKA ILSSIDWAAL VVDEAHRLKN NQSTFFKNLR
790 800 810 820 830 840
EYNIQYRVLL TGTPLQNNLE ELFHLLNFLA PDRFNQLESF TAEFSEISKE DQIEKLHNLL
850 860 870 880 890 900
GPHMLRRLKA DVLTGMPSKQ ELIVRVELSA MQKKYYKNIL TRNFDALNVK NGGTQMSLIN
910 920 930 940 950 960
IIMELKKCCN HPYLFMKACL EAPKLKNGMY EGSALIKNAG KFVLLQKMLR KLKDGGHRVL
970 980 990 1000 1010 1020
IFSQMTMMLD ILEDFCDVEG YKYERIDGSI TGQQRQDAID RYNAPGAKQF VFLLSTRAGG
1030 1040 1050 1060 1070 1080
LGINLATADT VIIYDSDWNP HNDIQAFSRA HRLGQKHKVM IYRFVTKGSV EERITSVAKK
1090 1100 1110 1120 1130 1140
KMLLTHLVVR AGLGAKDGKS MSKTELDDVL RWGTEELFKE EEAPVEGADG EGTSSKKPNE
1150 1160 1170 1180 1190 1200
QEIVWDDAAV DFLLDRNKEE EGQDGEKKEH WTNEYLSSFK VATYNTKEAD DADDDEDETE
1210 1220 1230 1240 1250 1260
VIKEGTEEQD PNYWEKLLKH HYEQDQETEL QKLGKGKRVR RQVNYASENM GQDWSAQNNQ
1270 1280 1290 1300 1310 1320
QQEEDDGSEY GSDNGELLQT DEDYEERRRR REERSEKLPP LLAKVNGQIE VLGFNPRQRK
1330 1340 1350 1360 1370 1380
AFYNAVMRWG MPPQDLTQSS WQVRDLRNKS EKVFKAYSSL FMRHLCEPVV DNSDSFMDGV
1390 1400 1410 1420 1430 1440
PREGLNRQAV LSRIGLMSIL RKKVQEFEKF NGEWSMPETR EKMLATAAQA SVSNLPGMIK
1450 1460 1470 1480 1490 1500
IKEEPIDIDE TPMDVDQSNI TKTEELASEV KVEEEPKAPR LPYKFNICDG GYTELHSLWI
1510 1520 1530 1540 1550 1560
NEEKVARNGK EYEIWHRRHD FWLLAAVAVY GYGRYQINFQ DIMNDPKFSI VNEPFKQTGA
1570 1580 1590 1600 1610 1620
DPATNFADVK NKFLARRFKL LEQSLVIEEQ LRRAAHINKQ QSPDQVGQLA QHFSELEHTA
1630 1640 1650 1660 1670 1680
DAHVNIARES NNGNRNANAI LHKCLAQLDD LLSDLKTDVA RLPATISQVR PVTERLQMSE
1690 1700 1710 1720 1730 1740
RQILSRLVVA KDPDAAPSKP ALPPSGPFIT PLFNQNFTTI QPKFPSLFDC NLSPDDEPID
1750 1760 1770 1780
IEGSISAAVA EASRASSIAA TKDEPMDTSD KDIPSTSAAA GSSYPRY