Q21J46
Gene name |
gloB |
Protein name |
Hydroxyacylglutathione hydrolase |
Names |
Glyoxalase II, Glx II |
Species |
Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024) |
KEGG Pathway |
sde:Sde_2023 |
EC number |
3.1.2.6: Thiolester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q21J46
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q21J46-F1 | Predicted | AlphaFoldDB |
No variants for Q21J46
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q21J46 | |||||
No associated diseases with Q21J46
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.2.6 | Thiolester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| hydroxyacylglutathione hydrolase activity | Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. |
| metal ion binding | Binding to a metal ion. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione | The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNMQLGSPVS | VHPIPIYQGN | YVWVMRHTSQ | NSVVVVDPGS | ASEVIEYITQ | HELTIASIII |
| 70 | 80 | 90 | 100 | 110 | 120 |
| THSHWDHVTG | IAELCANLQL | WRDEEPVVYG | PSVIQDVTHP | VEDGDRIELC | KGVDVPSLQV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IATPGHMPEH | LSYLLPLTTP | KLFCGDTLFS | CGCGRILQGT | HEQLRTSLDA | ISALPSQTEV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YCTHEYTLTN | IKFARTVEPQ | SQALIDYEQR | VRSLRKNDLP | SIPTTIEREK | ALNPFLRYKE |
| 250 | 260 | 270 | |||
| LSIQQAVENH | LRLKGLTAAD | VFKHLRLWKD | SF |