Q21307

PR
Gene name
mek-1
Protein name
Dual specificity mitogen-activated protein kinase kinase mek-1
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_K08A8.1
EC number
2.7.12.2: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-94 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

210-232 (Activation loop from InterPro)

Target domain

72-325 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q21307

Entry ID Method Resolution Chain Position Source
AF-Q21307-F1 Predicted AlphaFoldDB

No variants for Q21307

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q21307

No associated diseases with Q21307

3 regional properties for Q21307

Type Name Position InterPro Accession
domain Basic-leucine zipper domain 71 - 135 IPR004827
domain Vertebrate interleukin-3 regulated transcription factor 130 - 461 IPR010533
domain Nuclear factor interleukin-3-regulated protein-like, bZIP domain 72 - 131 IPR047106

Functions

Description
EC Number 2.7.12.2 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

8 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
JUN kinase kinase activity Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase.
MAP kinase kinase activity Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
SH2 domain binding Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.

16 GO annotations of biological process

Name Definition
determination of adult lifespan The pathways that regulate the duration of the adult phase of the life-cycle of an animal.
JNK cascade An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
male meiotic nuclear division A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.
MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
oocyte development The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
p38MAPK cascade An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
positive regulation of axon extension involved in regeneration Any process that activates, maintains or increases the rate of axon extension involved in regeneration.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of growth rate Any process that modulates the rate of growth of all or part of an organism.
reproduction The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.
response to cadmium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
response to copper ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
response to starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
response to temperature stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.
stress response to copper ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a copper ion stimulus.
stress-activated MAPK cascade The series of molecular signals in which a stress-activated MAP kinase cascade relays a signal; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5E9X2 MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 Bos taurus (Bovine) EV
O14733 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens (Human) PR
P46734 MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 Homo sapiens (Human) SS
P45985 MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens (Human) EV
P70236 Map2k6 Dual specificity mitogen-activated protein kinase kinase 6 Mus musculus (Mouse) EV
Q8CE90 Map2k7 Dual specificity mitogen-activated protein kinase kinase 7 Mus musculus (Mouse) PR
P47809 Map2k4 Dual specificity mitogen-activated protein kinase kinase 4 Mus musculus (Mouse) EV
O09110 Map2k3 Dual specificity mitogen-activated protein kinase kinase 3 Mus musculus (Mouse) PR
Q4KSH7 Map2k7 Dual specificity mitogen-activated protein kinase kinase 7 Rattus norvegicus (Rat) PR
G5EDT6 jkk-1 Dual specificity mitogen-activated protein kinase kinase jkk-1 Caenorhabditis elegans PR
G5EDF7 sek-1 Dual specificity mitogen-activated protein kinase kinase sek-1 Caenorhabditis elegans PR
Q10664 mek-2 Dual specificity mitogen-activated protein kinase kinase mek-2 Caenorhabditis elegans PR
Q9DGE0 map2k6 Dual specificity mitogen-activated protein kinase kinase 6 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MERDFDLGMG RPGGLGGLGG EPIMQQMPQP APHHPSRSSN DHNVKNLMKQ AEENSGYLTL
70 80 90 100 110 120
QGNRRKADLK ELQFVEDIGH GSCGTVTKCR YKSVIMAVKT MPRTSNSYEM SRILMDLDVI
130 140 150 160 170 180
CLSFDCPYIV RCFGYFITNF DVRVCMECMA TCLDRLLIRI KQPIPERIIG KLSVSIIKAL
190 200 210 220 230 240
HYLKTKHQIM HRDVKPSNIL LDWSGVIKLC DFGIAGRLIE SRAHSKQAGC PLYMGPERLD
250 260 270 280 290 300
PNNFDSYDIR SDVWSFGVTL VELATGQYPY AGTEFDMMSK ILNDEPPRLD PAKFSPDFCQ
310 320 330 340
LVESCLQRDP TMRPNYDMLL QHPFVVHHEK IETDVEEWFA DVMGECG