Q20845

PR
Gene name
plk-3 (plc2, F55G1.8)
Protein name
Serine/threonine-protein kinase plk-3
Names
Polo-like kinase 3
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_F55G1.8
EC number
2.7.11.21: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

300-408 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q20845

Entry ID Method Resolution Chain Position Source
AF-Q20845-F1 Predicted AlphaFoldDB

No variants for Q20845

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q20845

No associated diseases with Q20845

7 regional properties for Q20845

Type Name Position InterPro Accession
domain Protein kinase domain 35 - 286 IPR000719
domain POLO box domain 402 - 463 IPR000959-1
domain POLO box domain 505 - 573 IPR000959-2
active_site Serine/threonine-protein kinase, active site 154 - 166 IPR008271
binding_site Protein kinase, ATP binding site 41 - 64 IPR017441
domain Second polo-box domain 499 - 579 IPR033695
domain First polo-box domain 390 - 474 IPR033701

Functions

Description
EC Number 2.7.11.21 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

3 GO annotations of biological process

Name Definition
mitotic cell cycle Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of cytokinesis Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2TA25 PLK1 Serine/threonine-protein kinase PLK1 Bos taurus (Bovine) SS
O97143 SAK Serine/threonine-protein kinase PLK4 Drosophila melanogaster (Fruit fly) EV
P52304 polo Serine/threonine-protein kinase polo Drosophila melanogaster (Fruit fly) SS
P53350 PLK1 Serine/threonine-protein kinase PLK1 Homo sapiens (Human) EV
Q07832 Plk1 Serine/threonine-protein kinase PLK1 Mus musculus (Mouse) EV
Q62673 Plk1 Serine/threonine-protein kinase PLK1 Rattus norvegicus (Rat) SS
Q9N2L7 plk-2 Serine/threonine-protein kinase plk-2 Caenorhabditis elegans SS
P34331 plk-1 Serine/threonine-protein kinase plk-1 Caenorhabditis elegans SS
P62205 plk1 Serine/threonine-protein kinase PLK1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
10 20 30 40 50 60
MQHVLRTRGN SAQDKNKKHV PNVPPIIYDD MQVPYEKGAF LGEGGFAHCF EFRKLDCNDR
70 80 90 100 110 120
LAVKVVPKVI LLKSTAREKL TREVEIHRQL SHRNIVQFHH FFEDSQNVYF TLELCSKNSL
130 140 150 160 170 180
MELNKQRGPL TEHEARFYTI QVAEGVKHLH NLQIIHRDLK LGNLFLNEHL QVKIGDFGLA
190 200 210 220 230 240
TFCEKNEKKM TRGGTPNYIA PEVLNETGHA FEVDIWAIGC ILYVLLFGSP PFESRRVQET
250 260 270 280 290 300
YVRIKNNDYV VPENASPTAN RLIRSLLDPV PDRRPTAEAV LLDQFFKTTI EPTYPPVHQQ
310 320 330 340 350 360
LHKEQDVKYF APINPVLPHV EEPISPIYQE VANEETSEIR RFVKTEQASS FGDELSQLQA
370 380 390 400 410 420
QISHILQNVV ASKNKSSTRF GLNHSPEATP IFWVSQWVHF PNHGIGYRLC ENSSGMLFND
430 440 450 460 470 480
NTQMKVNSAG NQLTFVDENN TEQFYTMNDQ VPMNLQTKIN IFSNVQSYMN THLEADTHLE
490 500 510 520 530 540
AEDQCVNKVP PLRNFARLPT IQNWFETKSA VIFHLSNGTV QINFLDHVKM VLCPLLKSVT
550 560 570 580 590 600
FIEENKRVST FTFANILTNS CPKKYLSRIE YAQAKIKLLR PTNNQEHVVY VDSPCRPTTS
610
NTAHGAPLAS SRYLA